Reposted by John JanetzkoBWJones @bwjones.bsky.social · 03/07/2026When I explain to peeps how much we do in research labs for how few $$, they simply don’t believe me. I once explained it to a famous person from Pixar, he looked me square in the eye and said “You mean all the cancer, vision, and Alzheimer’s grants work that way? You’ve gotta be %#ing kidding me!” 8583179
John Janetzko @jjanetzko.bsky.social · 03/07/2026We’re officially into July! Hard to believe it’s been 2 years at @cuanschutz.bsky.social and @cu-bmg.bsky.social A lot has happened - and I am so grateful to my lab who has made coming into work each day such a treat. Kudos to them for the new lab photo design, too. Some highlights 👇🏻 130
Reposted by John JanetzkoDrug Monkey @drugmonkey.bsky.social · 11/03/2026A tomahawk missile costs the taxpayers the same amount of money as one five-year major NIH research grant. Remember that every time they tell us one of those missed the target, blew up paintings of enemy aircraft or tanks, or was the fifth and unnecessary hit on the same target. 5354146
Reposted by John JanetzkoAngelo D’Alessandro @dalessandrolab.bsky.social · 19/11/2025Now out at @cellpress.bsky.social Cell Genomics, we characterized the genetic architecture of the murine red blood cell proteome using omics profiling in 350 genetically diverse mice. The goal was to understand how genetic variation shapes RBC metabolism, redox homeostasis, and storage outcomes. 1/ncell.comGenetic architecture of the murine red blood cell proteome reveals central role of hemoglobin beta cysteine 93 in maintaining redox balanceKeele et al. uncover the genetic architecture of the proteome of fresh and stored red blood cells using a multi-omics analysis of 350 genetically diverse mice. Their work reveals how a hemoglobin redo... 142
Reposted by John JanetzkoJeremy Berg @jeremymberg.bsky.social · 14/11/2025From my perspective, there are many potential problems with this decision. It is likely to disadvantage applications from early stage investigators and for certain classes of proposals. More on this later... 2/13 1274
John Janetzko @jjanetzko.bsky.social · 31/10/2025I’m crushed. She was such a great human being who stood up for their principles like few others. She will be deeply missed 😢 030
John Janetzko @jjanetzko.bsky.social · 13/10/2025The issue of Molecular Pharmacology edited by @nicoleperryhauser.bsky.social and me is finally finished! As always, it was a joy to work together, and I think we succeeded in compiling some great papers from young GPCR investigators 🤩 Check it out 👇 www.sciencedirect.com/science/arti...sciencedirect.com 030
Reposted by John JanetzkoNicki Perry-Hauser @nicoleperryhauser.bsky.social · 13/10/2025A new special issue entitled “Emerging Voices in GPCR Biology” is now available in Molecular Pharmacology, highlighting innovative research led by early-career investigators (ECIs) across key areas of G protein-coupled receptor (GPCR) science. www.sciencedirect.com/science/arti...sciencedirect.comEmerging Voices in GPCR Biology 146
Reposted by John JanetzkoOded Rechavi @odedrechavi.bsky.social · 04/10/2025Thanking the reviewers 113112
John Janetzko @jjanetzko.bsky.social · 06/09/2025A lab that collects data together stays together. Feeling like the luckiest PI to work with such great folks 🤩🔬 @cuanschutz.bsky.social @cu-bmg.bsky.social 080
Reposted by John JanetzkoCU Anschutz Cancer Center @cucancercenter.bsky.social · 17/08/2025We have new members! Welcome to the CU Cancer Center! 👏 032
Reposted by John JanetzkoJeremy Berg @jeremymberg.bsky.social · 04/08/2025The acknowledgements section speaks to considerable privilege. Without a senior author, he and his classmate were provided with lab space, purified protein, and technical help. Their paper was communicated to PNAS. I doubt many undergraduate researchers have received comparable support. 31/n 1114
Reposted by John JanetzkoHarmit Singh Malik @harmitmalik.bsky.social · 29/07/2025With news that NIH grant success rates are now below 5%, consider the effort that goes into one of these grants (apart from you, who submitted 60 AI-written grants)- why would you put in that much effort knowing your chances are only slightly better than winning a lottery? 1/ 810420
Reposted by John JanetzkoArdem Patapoutian @ardemp.bskyverified.social · 22/07/2025No better time to call or email your members of Congress. Next year’s NIH budget is being debated in the Senate. A new nonpartisan campaign is making it easy to defend science and protect America’s innovation. Just follow this link to contact your representatives: www.protectscienceandinnovation.orgprotectscienceandinnovation.orgProtect Science and Innovation 13227
Reposted by John JanetzkoDrug Monkey @drugmonkey.bsky.social · 20/07/2025We are going to hear a lot in the near future about how University brass “has to make hard decisions”. Twill be interesting to see who those hard decisions land upon. 7507
Reposted by John JanetzkoEric Topol @erictopol.bsky.social · 06/07/2025Summary Table of the massive defunding of biomedical research in the United States www.nytimes.com/interactive/... 601545998
Reposted by John JanetzkoJeremy Berg @jeremymberg.bsky.social · 06/07/2025A short Bluetorial about my early days as the Director of the National Institute of General Medical Sciences (NIGMS) at NIH. The importance of feeling responsibility and taking pride in doing the best job you canmedia.tenor.coma cartoon says hey everybody an old man 's talking while bart simpson looks onALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on 525671
Reposted by John JanetzkoJay Hesselberth @jayhesselberth.bsky.social · 20/06/2025Excited to see this collaborative work with Olivia Rissland's lab finally out. We found lots of 2A peptides and an entirely new 2A class. www.cell.com/cell-reports...cell.comSystematic identification and characterization of eukaryotic and viral 2A peptide-bond-skipping sequencesRao et al. identified thousands of previously unknown 2A peptides across both viruses and eukaryotes using an HMMER analysis. The authors further identified a unique class of 2A peptides, class B, who... 26822
John Janetzko @jjanetzko.bsky.social · 14/06/2025The world is in chaos, but we still need to rally with our people! Janetzko-Bell lab and friends happy hour to celebrate grant submissions, new additions and scientific accomplishments 🎉 @cu-bmg.bsky.social 051
Reposted by John JanetzkoSen. Cory Booker @booker.senate.gov · 14/06/2025In America, we have no kings. 1382539567
John Janetzko @jjanetzko.bsky.social · 10/06/2025Setting up a lab has been no joke. Today, I'm stoked to have one more piece of my postdoc work out in the wild. Several more manuscripts to go, and I don't have a lot of time for a blue-torial(?) today, but enjoy and happy to get any feedback on this story. www.biorxiv.org/content/10.1...biorxiv.orgMembrane phosphoinositides allosterically tune β-arrestin dynamics to facilitate GPCR core engagementArrestin proteins bind active G protein-coupled receptors (GPCRs) through coordinated protein-protein, protein-phosphate, and protein-lipid interactions to attenuate G protein signaling and promote GP... 2283
John Janetzko @jjanetzko.bsky.social · 07/06/2025Sometimes this job can feel like a lot. But sometimes it’s the best job you could imagine. Your whole lab tells you they want to come in on Saturday to finish an experiment we’ve worked up to and you get to see the look of amazement on your tech’s face when her first negative stain works 😍 070
Reposted by John JanetzkoDr. David Miller 🏳️🌈 @davidimiller.bsky.social · 18/04/2025So: In 2017, Congress made this happen: NIH: Proposed 22% cut --> 9% increase NSF: Proposed 11% cut --> 4% increase NOAA: Proposed 16% cut --> 4% increase Obviously, 2025 is not 2017. A lot is diff now. But still: 💰 Congress, not WH, sets budgets. 📞 Public support & calls to Congress matter. 219699
Reposted by John JanetzkoJason Shepherd @jasonsynaptic.bsky.social · 22/05/2025Oh FFS! This government is self sabotaging the decades long edge America had in recruiting the most talented people from across the world. 2148
Reposted by John JanetzkoEwa Bomba-Warczak @ebomba.bsky.social · 20/05/2025Well, this didn’t age well 👀 0112
Reposted by John JanetzkoArdem Patapoutian @ardemp.bskyverified.social · 09/04/2025Published an op-ed for @cnn.com: “Nobel laureate: I owe America my success. Today, its scientific future is in danger.” A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world. www.cnn.com/2025/04/09/h...cnn.comNobel laureate: I owe America my success. Today, its scientific future is in danger | CNNDr. Ardem Patapoutian says he watches “with deep sadness as the United States’ remarkable scientific enterprise, which took generations of hard work and national investment to build, faces a concerted... 15893488
Reposted by John JanetzkoJeremy Berg @jeremymberg.bsky.social · 09/04/2025I heard rumors starting yesterday that this same stunt was at least being contemplated with PubMed! This would be very harmful to researchers, but also to patients and the public as they rely of PubMed for access to health information. Doctors also depend on PubMed, often in real time.media.tenor.coma close up of a red light that looks like a heart on make a gif .ALT: a close up of a red light that looks like a heart on make a gif . 66521
Reposted by John JanetzkoCarl T. Bergstrom @carlbergstrom.com · 07/04/2025NIH slashes overheads, fires directors and staff, freezes funds, halts trials, interrupts research, stalls grant review, and terminates 100s of grants on infectious disease, vaccines, mRNA, DEI, LGBTQ health. NIH director, to Bari Weiss: Scientists are just upset because they didn't vote for Trump. 34630198
Reposted by John JanetzkoKarolin Luger @nucleosomepolice.bsky.social · 05/04/2025a bit of nasty weather isnt going to deter Coloradoans from protesting the nasty things that are going on in our country right now? Right? RIGHT???? handsoff2025.com?SQF_SOURCE=i...handsoff2025.comHands Off!Donald Trump and Elon Musk think this country belongs to them. They're taking everything they can get their hands on and daring the world to stop them. On Saturday, April 5th, we're taking to the stre... 071
Reposted by John JanetzkoSarah Reisman @reiswoman.bsky.social · 03/04/2025A postdoc in my lab with a MOSAIC K99 was notified today that the program was terminated, no new funds to be awarded after this year. To revoke the pathway to independence award is so demoralizing for an early career researcher. I thought this might be coming but it still sucks. 512039
Reposted by John JanetzkoJeremy Berg @jeremymberg.bsky.social · 29/03/2025Funding curves for K and F mechanisms (Warning: the new F mechanism "curve" is a lot)media.tenor.coma cartoon of homer simpson holding a cardALT: a cartoon of homer simpson holding a card 511257
John Janetzko @jjanetzko.bsky.social · 27/03/2025Our lab's first paper (w @NLKProteomics) is officially online at Analytical Chem today!! @an_chem Excited for the opportunities this work brings to profiling heterogeneous membrane proteins like GPCRs. @cu-bmg.bsky.social @cupharmacology.bsky.social pubs.acs.org/doi/full/10....pubs.acs.orgCapillary Zone Electrophoresis-Mass Spectrometry of Intact G Protein-Coupled Receptors Enables Proteoform ProfilingG protein-coupled receptors (GPCRs) are the largest class of integral membrane receptors and responsible for transmitting diverse signals in response to extracellular stimuli. Post-translational modif... 32610
Reposted by John JanetzkoJeremy Berg @jeremymberg.bsky.social · 07/03/2025With @ascbiology.bsky.social President Sandra Murray after the Stand Up for Science event… 334518
Reposted by John JanetzkoTigist Tamir @phosphotig.bsky.social · 04/03/2025stanforddaily.com/2025/03/03/f...stanforddaily.comFrom the Community | I am more than a researcher, but Stanford doesn’t careAssistant Professor Elliott White Jr. denounces the University's faint response to political threats against DEI, especially compared to the robust support its research initiatives in the wake of NIH ... 0102
Reposted by John JanetzkoJeremy Berg @jeremymberg.bsky.social · 03/03/2025It's Baaaaack... All NIH (and other HHS employees) received another request for their 5 accomplishments for the past week on Friday and were told by HHS to comply. It is early in the day, so that NIHers are likely to get jerked around again several times before midnight... 45320
Reposted by John JanetzkoTracy Bale @thebalelab.bsky.social · 02/03/2025Hey @hankgreen.bsky.social we will be in Denver #StandingUpForScience 📣 on Friday! See you there 🧬🧠🔬 183
Reposted by John JanetzkoAlex Merz 🇺🇸🇨🇦🇺🇦 @merz.bsky.social · 02/03/2025Fauci gets a pass. F. Collins is speaking up, and Varmus (both are former NIH and IC directors). Who else? Total silence from Zerhouni, so far as I can tell. 171
Reposted by John JanetzkoJeremy Berg @jeremymberg.bsky.social · 02/03/2025New post with the WTAE Pittsburgh news story www.wtae.com/article/pitt...wtae.comPittsburgh biomedical research funding hit hard by Trump policies, warns former NIH directorBerg explained that President Donald Trump's first tactic to halt biomedical research came with a general federal funding freeze, which a judge later reversed. His second tactic: Not updating the Fede... 26136
Reposted by John JanetzkoJeremy Berg @jeremymberg.bsky.social · 02/03/2025So here we are… Someone shared this, posted here about 3 weeks ago, based on what happened at/to USAID. Anything sound familiar? /fin (for now) 14261102
Reposted by John JanetzkoEric Topol @erictopol.bsky.social · 01/03/2025Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter www.nytimes.com/2025/03/01/u... 6131251381
Reposted by John JanetzkoJeremy Berg @jeremymberg.bsky.social · 22/02/2025Bluetorial: The path to a new pain medication with little potential for addiction Perhaps a good story to share with folks who want to learn about how biomedical research works and where advances come from.media.tenor.coma cartoon says hey everybody an old man 's talking while bart simpson looks onALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on 118278
Reposted by John JanetzkoDepartment of Biochemistry and Molecular Genetics @cu-bmg.bsky.social · 19/02/2025Congratulations to BMG faculty member @jjanetzko.bsky.social on being elected to the 2025 Executive Committee of the Molecular Pharmacology division of American Society for Pharmacology and Experimental Therapeutics ! 🎉👏 #Pharmacology #ASPET #ScienceLeadership 071
Reposted by John JanetzkoJ Craig Venter @jcv.bsky.social · 19/02/2025All 435 seats in the House will be up for election in 2026. 97933
Reposted by John JanetzkoDepartment of Biochemistry and Molecular Genetics @cu-bmg.bsky.social · 27/01/2025Come join our fantastic department and highly collaborative environment! 031
John Janetzko @jjanetzko.bsky.social · 18/02/2025As a hard pivot from the dog/child action, here's some science to share with ya'll. Excited to share our work on developing a practical approach to resolving intact GPCR proteoforms: go.shr.lc/416MyyQ A short 🧵go.shr.lcCapillary Zone Electrophoresis-Mass Spectrometry of Intact G Protein-Coupled Receptors Enables Proteoform ProfilingG protein-coupled receptors (GPCRs) are the largest class of integral membrane receptors and responsible for transmitting diverse signals in response to extracellular stimuli. Post-translational modif... 121