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Jessica Stark

@jcstark.bsky.social
2.3K followers 655 following 49 posts

Learning from glycobiology to understand and engineer immunity | Asst Prof @ MIT BE, MIT ChemE, and Koch Institute for Integrative Cancer Research | jstarklab.com

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Reposted by Jessica Stark
MIT Department of Biological Engineering @mitdeptofbe.bsky.social · 06/10/2026
Congratulations to Jessica Stark on receiving the NIH Director’s ­New Innovator Award from the NIH Common Fund’s High-Risk, High-Reward Research program. This award supports exceptionally creative scientists pursuing transformative research. commonfund.nih.gov/newinnovator/fun…
commonfund.nih.gov
Funded Research
NIH Director's New Innovator Award - Funded Research
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Jessica Stark @jcstark.bsky.social · 06/10/2026
Learn more about the award and our funded research: commonfund.nih.gov/highrisk/new... reporter.nih.gov/search/9pKpX...
commonfund.nih.gov
NIH awards more than $237 million to advance bold biomedical and behavioral research | NIH Common Fund
The 2026 NIH Director’s Awards support exceptionally creative scientists pursuing transformative research.
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Jessica Stark @jcstark.bsky.social · 06/10/2026
Thrilled to receive an NIH Director's New Innovator Award! Our project will engineer proteins to help us understand and rewire signaling at immune synapses, which represent tools for discovery and potential immunotherapies. @mitdeptofbe.bsky.social @mitcheme.bsky.social @mitkochinstitute.bsky.social
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Reposted by Jessica Stark
Stand Up for Science! @standupforscience.net · 17/09/2026
The Trump admin has decimated American science budgets, taking away life saving opportunities, and the potential for groundbreaking discoveries. This is how you destroy American innovation. apnews.com/article/trum...
apnews.com
Trump administration has cut or frozen $177 billion in grants across every state, analysis shows
An analysis finds that the Trump administration has cut or frozen up to $177 billion in federal grants since the president took office for his second term.
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Jessica Stark @jcstark.bsky.social · 10/09/2026
Congratulations, Lara!!
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Jessica Stark @jcstark.bsky.social · 17/08/2026
Thrilled to share that postdoc @megtriesscience.bsky.social was awarded a @cancerresearchinst.bsky.social Irvington Postdoctoral Fellowship! Her funded work is defining a role for glycans in colorectal cancer initiation. Learn more: www.cancerresearch.org/cri-funded-s... Congratulations, Megan! 🍾
cancerresearch.org
Megan Priestley, PhD - Cancer Research Institute
Colorectal cancer is the second deadliest cancer worldwide, and rates are rising alarmingly among younger adults. Although immunotherapy has transformed treatment for some cancers, more than 90% of co...
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Reposted by Jessica Stark
Barbara Mellone 🇺🇦 @centromellone.bsky.social · 21/07/2026
America's R1 universities educate ~8–9 million students (undergraduate + graduate) -> more than 1/3 of U.S. college students (vs. the ~0.6% of Ivies). Undermining this system threatens the institutions that train our workforce and drive scientific innovation. www.science.org/doi/10.1126/...
science.org
An American research crisis with real human consequences
Ivy League universities have dominated recent news headlines, having become popular targets for critics of higher education. But the threats they face—cuts to federal research funding, assaults on aca...
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Jessica Stark @jcstark.bsky.social · 14/07/2026
MIT ACCESS is an opportunity for undergraduates to explore cutting-edge research and graduate education in science and engineering. See for yourself what grad life is like at MIT! Applications due Aug 1: access.mit.edu @mitcheme.bsky.social @mitchemistry.bsky.social
access.mit.edu
MIT ACCESS – Opening doors and promoting diversity in science and engineering
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Reposted by Jessica Stark
Burroughs Wellcome Fund @bwfund.bsky.social · 16/06/2026
📢 LOIs now open for CASI CASI aims to foster investigators who are integrating approaches from quantitative, computational, or physical sciences to address complex biological questions 🔗 Details & information: <https://buff.ly/LRHROHL> #bwfcasi #GrantOpportunity
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Reposted by Jessica Stark
Jenna Norton @jenna-m-norton.bsky.social · 07/07/2026
The next generation of scientists will be a smaller cohort because of the policies of this administration: www.nytimes.com/2026/07/06/u...
nytimes.com
Decline of Ph.D. Admissions Could Imperil a ‘Generation of New Talent’
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Reposted by Jessica Stark
elizabethginexi.bsky.social @elizabethginexi.bsky.social · 29/05/2026
Calling all Scientists! Research Administrators! Deans! Fans of Science! No one is coming to save us. Here is your assignment. I have written a step by step, easy to understand "how-to" document to help you comment on the proposed OMB rule. elizabethginexi.substack.com/p/what-we-ne...
elizabethginexi.substack.com
What We Need to do NEXT: OMB’s Proposed Federal Financial Assistance Rule (OMB 2026-10817)
What OMB’s Proposed Federal Financial Assistance Rule Means in Practice
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Reposted by Jessica Stark
Coleen Murphy @ctmurphy1.bsky.social · 29/05/2026
The public comment period closes approximately July 13, 2026 (45 days from May 29 publication). Comments must be submitted to regulations.gov, Docket OMB-2026-0034
regulations.gov
Regulations.gov
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Reposted by Jessica Stark
Jenna Norton @jenna-m-norton.bsky.social · 29/05/2026
Excellent summary of how Vought’s proposed rule will destroy science. Please be ready to comment tomorrow, call Congress, tell your friends. If you’ve been waiting for the right moment to speak up, that moment is now.
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Jessica Stark @jcstark.bsky.social · 21/05/2026
A pleasure to give @stanfordimmunology.bsky.social seminar last week for a few reasons: - to be invited by trainees - to visit the place that got me hooked on immunology - to share results from my lab @mitkochinstitute.bsky.social @mitdeptofbe.bsky.social @mitcheme.bsky.social Thanks for having me!
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Jessica Stark @jcstark.bsky.social · 07/05/2026
Thanks so much, Carolyn! Hope to catch up next week!
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Jessica Stark @jcstark.bsky.social · 07/05/2026
Thanks, Brett!
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Jessica Stark @jcstark.bsky.social · 06/05/2026
Honored to receive a Pershing Square Sohn Cancer Prize and excited about the work this award will support! Learn more about our efforts to target glycans to enable precision immunotherapies for cancer: pershingsquarephilanthropies.org/prize-winner... @mitdeptofbe.bsky.social @mitcheme.bsky.social
pershingsquarephilanthropies.org
Jessica Stark — Pershing Square Philanthropies
Pershing Square Philanthropies - we bet on innovative leaders solving humanity’s big societal, environmental, and health challenges.
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Reposted by Jessica Stark
MIT Koch Institute @mitkochinstitute.bsky.social · 05/05/2026
Congrats to @jcstark.bsky.social on being named a 2026 Pershing Square Sohn Cancer Prize awardee, supporting bold, high-risk ideas w/ potential to transform cancer research. Her work explores how cancer-cell glycans can be harnessed for new approaches to precision immunotherapy. mit-ki.org/42kmCAX
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Jessica Stark @jcstark.bsky.social · 27/04/2026
It is a privilege to work with talented people on exciting problems in immunology and immune engineering! www.jstarklab.com
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Jessica Stark @jcstark.bsky.social · 27/04/2026
Grateful to @natbiotech.nature.com for the opportunity to reflect on my scientific journey, including launching my lab @mitkochinstitute.bsky.social @mitdeptofbe.bsky.social @mitcheme.bsky.social www.nature.com/articles/s41...
nature.com
Five questions with Jessica Stark - Nature Biotechnology
A builder and problem solver at heart, she is developing technologies to understand and engineer the roles of cell-surface sugars, called glycans, in the immune system.
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Reposted by Jessica Stark
Nature Biotechnology @natbiotech.nature.com · 24/04/2026
Five questions with Jessica Stark @jcstark.bsky.social go.nature.com/42sA99y
go.nature.com
Five questions with Jessica Stark - Nature Biotechnology
A builder and problem solver at heart, she is developing technologies to understand and engineer the roles of cell-surface sugars, called glycans, in the immune system.
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Jessica Stark @jcstark.bsky.social · 07/04/2026
We are searching for a talented administrative assistant to provide critical support for our team @mitkochinstitute.bsky.social. Learn more and apply: tinyurl.com/3r9crrbm Please share widely! #hiring #sciencejobs
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Reposted by Jessica Stark
Jeremy Berg @jeremymberg.bsky.social · 13/03/2026
New research grants in essentially all fields (as judged by NIH Institutes and Center missions) fell by 20-25% from fiscal year 2024 to fiscal year 2025. 2/5
A table/graph showing that the number of new and competitive renewal grants across essentially all fields (as judged by NIH Institutes and Centers) fell by 20-25% from fiscal year 2024 to fiscal year 2025.
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Reposted by Jessica Stark
Science Magazine @science.org · 05/03/2026
"There is perhaps no stronger evidence of the [Trump] administration’s objectives to reduce the quality of the US scientific workforce than its treatment of the [NSF]’s flagship Graduate Research Fellowship Program," writes H. Holden Thorp in a new #ScienceEditorial. scim.ag/4d0fi3N
A quote by H. Holden Thorp, Editor-in-chief of Science journals, on a black background. The quote is: "… why curtail a program … that cultivates and grows the number of US graduate students and future researchers?"
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Reposted by Jessica Stark
Waggoner Lab @labwaggoner.bsky.social · 26/02/2026
@biorxivpreprint.bsky.social Single-Cell and Spatial Methods for Multimodal Functional Glycan Profiling in Tissues www.biorxiv.org/content/10.6... @harvard.edu @broadinstitute.org @shaleklab.bsky.social @ragoninstitute.bsky.social @laurakiessling.bsky.social
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Jessica Stark @jcstark.bsky.social · 23/02/2026
Check out our paper to learn more: www.nature.com/articles/s41... @mitkochinstitute.bsky.social @mitdeptofbe.bsky.social @mitcheme.bsky.social @stanford-chemh.bsky.social @carolynbertozzi.bskyverified.social
nature.com
Antibody-lectin chimeras for glyco-immune checkpoint blockade - Nature Biotechnology
Cancer immunotherapy benefits from antibody-lectin chimeras that block glyco-immune checkpoints.
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Jessica Stark @jcstark.bsky.social · 23/02/2026
Great to see our work to engineer AbLecs as a new immunotherapy modality featured in @natrevdrugdiscov.nature.com! www.nature.com/articles/d41...
nature.com
Antibody–lectin chimeras: new checkpoint inhibitors in the toolbox
Discover the world’s best science and medicine | Nature.com
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Reposted by Jessica Stark
MIT Koch Institute @mitkochinstitute.bsky.social · 15/01/2026
Cancer cells use sugar-based immune checkpoints to suppress immune attack. New work from Jessica Stark & Carolyn Bertozzi shows that blocking these glycan checkpoints with AbLecs can release that brake & boost anti-tumor immunity across cancer types. news.mit.edu/2025/new-imm...
A simple figure of a Y-shaped lectin is in center. In background are 2 photos showing the amount of killed cancer cells, in red, over 5 hours.
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Jessica Stark @jcstark.bsky.social · 17/01/2026
Congrats!! 🥂🍾
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Reposted by Jessica Stark
Eric Topol @erictopol.bsky.social · 07/01/2026
Vaccines, the most impressive public health intervention in medical history, and where we could be headed if there was not efforts to negate truth, facts, and evidence A great, open-access, review and perspective by @scientificdiscovery.dev
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Reposted by Jessica Stark
Science in Boston @scienceinboston.com · 05/01/2026
Researchers led by Dr. Jessica Stark (@jcstark.bsky.social) have developed a new way to stimulate the immune system to attack tumor cells, using a strategy that could make #CancerImmunotherapy work for many more patients. 📰 MIT News: bit.ly/3YlpCeq
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Reposted by Jessica Stark
Rong @rongl.bsky.social · 19/12/2025
New online in @natbiotech.nature.com: Cancer immunotherapy benefits from antibody-lectin chimeras that block glyco-immune checkpoints.
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Reposted by Jessica Stark
Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 16/12/2025
Congratulations @jcstark.bsky.social and the team, antibody-lectin chimeras (AbLecs), a new modality for cancer immune therapy, now published @natbiotech.nature.com. These bispecifics can block glyco-immune checkpoint receptor ligands directly at the immune synapse/activate immune effector functions
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Reposted by Jessica Stark
Nature Biotechnology @natbiotech.nature.com · 16/12/2025
Antibody-lectin chimeras for glyco-immune checkpoint blockade - @jcstark.bsky.social @carolynbertozzi.bskyverified.social go.nature.com/4aRDpk8
go.nature.com
Antibody-lectin chimeras for glyco-immune checkpoint blockade - Nature Biotechnology
Cancer immunotherapy benefits from antibody-lectin chimeras that block glyco-immune checkpoints.
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Reposted by Jessica Stark
Eric Topol @erictopol.bsky.social · 16/12/2025
A new jump forward in cancer immunotherapy blocking glycan sugar molecules (antibodies to lectin, AbLec) that releases the immune system brakes against many types of tumors @carolynbertozzi.bskyverified.social @jcstark.bsky.social www.nature.com/articles/s41...
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Jessica Stark @jcstark.bsky.social · 16/12/2025
This won't be the last you'll hear about AbLecs, stay tuned for updates from the team at Valora Therapeutics (www.valoratherapeutics.com), who are working to bring this technology to patients.
valoratherapeutics.com
Valora Therapeutics
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Jessica Stark @jcstark.bsky.social · 16/12/2025
I also want to acknowledge funding from multiple sources including the NIH, HHMI, @bwfund.bsky.social, @thevfoundation.bsky.social, @sitcancer.bsky.social, and @americancancersoc.bsky.social, which made this work possible.
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Jessica Stark @jcstark.bsky.social · 16/12/2025
I am grateful to an incredible team of co-authors, including multiple members of my lab, my mentor @carolynbertozzi.bskyverified.social, as well as Rong Li, @barbcheifet.bsky.social, and reviewers @natbiotech.nature.com who helped shape the final version of this story.
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Jessica Stark @jcstark.bsky.social · 16/12/2025
We show that AbLecs effectively block glyco-immune checkpoints, resulting in enhanced antitumor immune responses in vitro and in vivo. AbLecs can be tailored to treat different cancer types and to exhibit various mechanisms of action, thus representing a new immunotherapy modality.
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Jessica Stark @jcstark.bsky.social · 16/12/2025
To address this gap, we engineered AbLecs: bispecific antibody-like molecules composed of a cell-targeting antibody domain and a lectin “decoy receptor” domain. AbLecs bind glycans on the target cell and block their ability to engage inhibitory lectin receptors on immune cells. tinyurl.com/jxvhtv24
news.mit.edu
A new immunotherapy approach could work for many types of cancer
Using molecules called AbLecs that block an immune checkpoint, researchers showed they could stimulate a strong anti-tumor immune response. The approach, which could work for many types of cancer, was...
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Jessica Stark @jcstark.bsky.social · 16/12/2025
Altered glycan structures on cancer cells suppress antitumor immune responses by engaging inhibitory lectin (glycan-binding) receptors. These so-called glyco-immune checkpoints remain difficult to drug, despite decades of effort and multiple therapeutic approaches attempted.
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Jessica Stark @jcstark.bsky.social · 16/12/2025
Out now: We present antibody-lectin chimeras (AbLecs) as a molecular platform to target sugars, or glycans, for cancer immunotherapy. www.nature.com/articles/s41... www.nature.com/articles/s41... @mitkochinstitute.bsky.social @mitdeptofbe.bsky.social @mitcheme.bsky.social @stanford-chemh.bsky.social
nature.com
Antibody-lectin chimeras for glyco-immune checkpoint blockade - Nature Biotechnology
Cancer immunotherapy benefits from antibody-lectin chimeras that block glyco-immune checkpoints.
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Jessica Stark @jcstark.bsky.social · 02/12/2025
Fewer funded grants and graduate fellowships mean fewer innovative technologies and disease cures in our future. www.nytimes.com/interactive/...
nytimes.com
The U.S. Is Funding Fewer Grants in Every Area of Science and Medicine
A quiet policy change means the government is making fewer bets on long-term science.
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Jessica Stark @jcstark.bsky.social · 18/11/2025
🚨 Attention undergraduate scientists and engineers! 🚨 Want to spend a summer doing research at MIT? Join us for the 2026 MIT Summer Research Program! Learn more and apply: oge.mit.edu/msrp/ @mitdeptofbe.bsky.social @mitcheme.bsky.social @mitkochinstitute.bsky.social
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Jessica Stark @jcstark.bsky.social · 06/11/2025
It's a great year to join the Leading Edge community 🕊️🤍
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Jessica Stark @jcstark.bsky.social · 04/11/2025
Congratulations, Abbey and team! Such a cool story.
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Jessica Stark @jcstark.bsky.social · 04/11/2025
Great to see this story in print! Congrats @megtriesscience.bsky.social @douglaspdyer.bsky.social and team! Looking forward to sharing Megan's first contributions as a postdoc in our lab at @mitdeptofbe.bsky.social @mitcheme.bsky.social @mitkochinstitute.bsky.social soon... 👀
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Reposted by Jessica Stark
Eric Topol @erictopol.bsky.social · 29/10/2025
Why fundamental research is fundamental to progress, seeding major breakthroughs Editorial @nature.com this week And 7 basic science discoveries that changed the world nature.com/articles/d41... nature.com/articles/d41...
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Tami Lieberman @contaminatedsci.bsky.social · 14/10/2025
We are recruiting new faculty in IMES at MIT! IMES (Institute for Medical Engineering and Science) is the MIT home of the famous HST program. As faculty are also appointed in a department at MIT, we have diverse research programs, all focused on human health. faculty-searches.mit.edu/imes-search/
faculty-searches.mit.edu
MIT Faculty Searches MIT INSTITUTE FOR MEDICAL ENGINEERING AND SCIENCE FACULTY SEARCH
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Reposted by Jessica Stark
The New York Times @nytimes.com · 14/09/2025
“It will take decades to recover from this, if we ever do.” America’s cancer research system, which has helped save millions of lives and is in one of its most productive moments, is under threat by the Trump administration.
nyti.ms
Trump Is Shutting Down the War On Cancer
America’s cancer research system, which has helped save millions of lives, is under threat in one of its most productive moments.
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