Reposted by Jason RihelManuel Irimia @mirimiam.bsky.social · 28/04/2025🐠 New pre-print from the lab! 🐠 Neural microexons fine-tune protein function - but how do they impact arousal states and underlying neuronal signaling pathways? www.biorxiv.org/content/10.1... Check out our latest pre-print by @tahneema.bsky.social et al, @upf.edu @crg.eu. 🧵👇 1/9biorxiv.orgNeural microexons modulate arousal states via cAMP signalling in zebrafishArousal states, often dysregulated in neurodevelopmental disorders, shape how organisms perceive and respond to their environment. Here, we show that srrm3, a master regulator of neural microexons, is... 23615
Reposted by Jason RihelLucia Peixoto @sciencenlucia.bsky.social · 15/04/2025The NIH/NHLBI sponsored Neurodevelopment Disorders and Sleep Workshop is now open for registrations. Co-chaired by Jared Saletin and myself. Please share. This event is open to the public #sleep #development www.nhlbi.nih.gov/events/2025/...nhlbi.nih.govNeurodevelopmental Disorders and Sleep WorkshopSleep problems are a common comorbidity in many neurodevelopmental disorders that can exacerbate behavioral manifestations of the disorders. 153
Reposted by Jason RihelRichard Sever @richardsever.bsky.social · 16/04/2025Seth Rogen’s remarks about destruction of US science cut from Breakthrough Prize video www.hollywoodreporter.com/news/general...hollywoodreporter.comSeth Rogen’s Criticism of Silicon Valley’s Support for Trump Was Cut From the “Full” Stream of Breakthrough PrizeWhile presenting an award at the event known as the Oscars of Science, 'The Studio' star pointed out the irony of tech titans' support for the Trump administration's defunding of science. The potentia... 0268
Jason Rihel @jasonrihel.bsky.social · 14/04/2025Good. If Harvard can’t stand up to bullying from Trump, who can? www.washingtonpost.com/education/20...washingtonpost.comHarvard rejects Trump administration’s demands with federal funding at riskThe university’s response comes after the government announced a federal review of nearly $9 billion in funding to Harvard and its affiliates. 041
Reposted by Jason RihelColumbia University's Zuckerman Institute @zuckermanbrain.bsky.social · 11/04/2025Congrats to @columbiauniversity.bsky.social scientists Gary Struhl & Iva Greenwald for winning the @gairdnerawards.bsky.social Award for their research yielding critical insights on how cells communicate with their neighbors during development. Read: zuckermaninstitute.columbia.edu/columbia-gai... 34211
Reposted by Jason RihelMwahahahahahadScientist @mads100tist.bsky.social · 11/04/2025What I find amazing is that we have to wrestle text to make it perfect, accurate and fit in five pages for a 10% chance of it getting funded, and then some people can say "imagine the wolves in game of thrones lol" and they get ten billion buckaroos no strings attached 1319932
Jason Rihel @jasonrihel.bsky.social · 11/04/2025Well this is terrifying: www.nytimes.com/2025/04/11/s...nytimes.comShe Worked in a Harvard Lab to Reverse Aging, Until ICE Jailed HerPresident Trump’s immigration crackdown ensnared Kseniia Petrova, a scientist who fled Russia after protesting its invasion of Ukraine. She fears arrest if she is deported there. 000
Reposted by Jason RihelDavid Ho @davidho.bsky.social · 16/03/2025People might think that whatever destruction is done to science in the US, we can undo in 4 years with a Democratic president and Congress. The problem is that many areas require specialized knowledge and skills built up over years, and once that's lost, it's hard to get back. 9035481037
Reposted by Jason RihelRicardo J. Salvador @cadwego.bsky.social · 15/03/2025‘“The people who are attacking higher education are talking nonstop,” said Holden Thorp, a chemist and former university administrator who runs the Science family of journals. “And the people leading higher education are not saying very much.”’nytimes.comOpinion | The Authoritarian Endgame on Higher EducationThis is a moment to trumpet the strengths of higher education and address its weaknesses. 211237
Reposted by Jason RihelHumberto Basilio @humbertobasilio.bsky.social · 14/03/2025🚨This week, many Columbia scientists lost grants that funded over half their annual income. Others will no longer be able to do research that helps treat thousands of sick patients across the US. "It hurts," they told me. My story for @nature.com 🧪 www.nature.com/articles/d41...nature.com‘My career is over’: Columbia University scientists hit hard by Trump team’s cutsThe US government has begun slashing US$400 million in research grants at Columbia University over pro-Palestinian campus protests. 13391236
Reposted by Jason RihelElizabeth Anne, PhD @lacksauthority.bsky.social · 09/03/2025I hate you, daylight savings time. I hate you SO MUCH. you are an affront to the natural order and circadian rhythms everywhere. 0257
Reposted by Jason RihelStacey Burns @wentrogue.bsky.social · 08/03/2025I got your waste, fraud, and abuse right here 1102377797155
Reposted by Jason RihelSeth Blackshaw @sethblackshaw.bsky.social · 08/03/2025Standing up for science with lab members in DC yesterday. 0596
Jason Rihel @jasonrihel.bsky.social · 06/03/2025Horrible that PhD offers are being rescinded due to budget fears. My friend Wendy Roth is quoted about her unenviable role in having to tell U Penn students the bad news. The cruelty is the point. www.nytimes.com/2025/03/06/u...nytimes.comAs Trump Goes After Universities, Students Are Now on the Chopping BlockUncertainty about how much money colleges and universities stand to lose has led some schools to reduce the number of doctoral students, in some cases reneging on offers. 010
Jason Rihel @jasonrihel.bsky.social · 02/03/2025Pubmed is down for me in the UK. (12-1PM) PMC Central still works. 011
Jason Rihel @jasonrihel.bsky.social · 28/02/2025American scientists need to get politically organized urgently to combat this! We are sleepwalking into a nightmare! 011
Reposted by Jason RihelSeth Blackshaw @sethblackshaw.bsky.social · 25/02/2025Our new review article with @michelcayouette.bsky.social is out on temporal patterning and glial reprogramming in adult CNS, and its implications for treating degenerative diseases. All work from our lab discussed here was funded by NIH. authors.elsevier.com/a/1kfup3Q9h2...authors.elsevier.com 12710
Jason Rihel @jasonrihel.bsky.social · 24/02/2025Our paper on zebrafish phenotypes in Alzheimer’s risk genes finally is now in its final form at Elife! 1296
Reposted by Jason RihelLukasz Chrobok @chroboklab.bsky.social · 19/02/2025Really successful mini-conference for Sleep and Circadian Rhythms Hub (Bristol Neuroscience). Lots of good talks and mingling 😊. Stay tuned for v2 next year, with @aliceisnotfren1.bsky.social we are determined to do it again! Thanks @jasonrihel.bsky.social for a wonderful keynote talk 🐟 💤 142
Jason Rihel @jasonrihel.bsky.social · 14/02/2025The NIH’s guidance on Sex as a Biological Variable has stamped at the top a rather Orwellian disclaimer: “historical document published prior to Jan 20, 2025: orwh.od.nih.gov/sex-as-biolo...orwh.od.nih.govSex as a Biological VariableHistoric document published prior to January 20, 2025Women now account for roughly half of all participants in NIH-supported clinical research, which is 000
Reposted by Jason RihelSeth Blackshaw @sethblackshaw.bsky.social · 08/02/2025This is the way. Republicans can't pass either a budget or a debt limit increase on their own. Ending this nonsense immediately is the price of cooperation. www.nytimes.com/2025/02/07/u...nytimes.comAs Trump and Musk Upend Washington, Congressional Phones Can’t Keep UpIn the three weeks since President Trump took office and gave Elon Musk free rein inside the federal government, millions of calls have poured in to members of Congress, jamming the system. 072
Reposted by Jason RihelSeth Blackshaw @sethblackshaw.bsky.social · 08/02/2025Contact numbers for my fellow Marylanders and Baltimoreans: Senator Chris van Hollen 202-224-4654 Senator Angela Alsobrooks 202-224-4524 Representative Kweisi Mfume: 202-225-474 (MD 7) Representative Johnny Olszewski Jr: 202-225-3061 (MD 2) Representative Sarah Elfreth: 202-225-4016 (MD 3) 033
Jason Rihel @jasonrihel.bsky.social · 08/02/2025In the interest of fairness, to match this insane cut to indirect costs, I demand that all Teslas be priced at the cost of the metal, the engine parts, and the tires. All the costs for factory electricity, maintenance workers, people who handle the company budgets, etc will not be part of the price. 010
Jason Rihel @jasonrihel.bsky.social · 29/01/2025If you are a scientist, watching the nonsense discussed at the RFK jr hearing will make you throw up in your mouth a little bit. www.nytimes.com/live/2025/01...nytimes.comRFK Jr. Faces Grilling Over Vaccines and Medicaid in Confirmation Hearing: Live UpdatesMr. Kennedy, appearing before the Senate Finance Committee, appeared visibly frustrated at points as senators pressed him on past statements, including his advocacy against vaccines. 021
Reposted by Jason RihelDavid Avallone @davallone.bsky.social · 17/01/2025Without Mel Brooks hiring Lynch to make THE ELEPHANT MAN — on the strength of ERASERHEAD alone — he is very likely just a guy who made a weird film at AFI. That whole filmography you love doesn’t happen. We all need sponsors and mentors and patrons. We need people who believe in us. 69148732102
Jason Rihel @jasonrihel.bsky.social · 09/01/2025What was wrong with the old “upload a document that is X pages long” for UKRI grants? Now we have little text boxes and a word count. How do Inget my figures in there? All these drop down menus and text boxes for applications these days— as if we are submitting these grants on our phones. 000
Jason Rihel @jasonrihel.bsky.social · 09/01/2025A cool new paper from my colleague Adrian Isaacs just dropped at Nature Comms. Zebrafish make a guest appearance: Francois Kroll in my lab used Cas13 to target an ALS toxic mRNA form of C9orf72 in a zebrafish model. It rescued the mutant motor phenotype! Figure S4 www.nature.com/articles/s41...nature.comDual-targeting CRISPR-CasRx reduces C9orf72 ALS/FTD sense and antisense repeat RNAs in vitro and in vivo - Nature CommunicationsCRISPR-CasRx effectively reduces ALS- and FTD-causing C9orf72 sense and antisense repeat derived RNAs and proteins in cell lines, patient iPSC-neurons and two independent mouse models of C9orf72 repea... 010
Jason Rihel @jasonrihel.bsky.social · 26/12/2024Forget Barbenheimer or Glicked. I’m going to do A Complete Unferatu 010
Reposted by Jason RihelFilippo Del Bene @filodelbene.bsky.social · 20/12/2024📢 7th European Zebrafish Principal Investigators Meeting 📅 2-5 April 2025 🌍 Paris Brain Institute - ICM #zebrafish @filodelbene @ParisBrainInst Now extend deadline for abstract submission and registration. January 6th! www.europeanzebrafishpimeeting.comeuropeanzebrafishpimeeting.com7th European Zebrafish Principal Investigators Meeting | PI european zebrafish meeting 2025 Paris | Paris, FranceThe 7th European Zebrafish PI Meeting will be held in Paris, France - April 2 to 5, 2025. Principal investigators in zebrafish research will share their discoveries 178
Jason Rihel @jasonrihel.bsky.social · 16/12/2024Wow, killifish almost became a toy in the 1960s! The video is wild. boingboing.net/2024/12/16/h...boingboing.netHow African killifish almost became Wham-O's coolest toy of the 1960sIn the 1960s, Wham-O toys nearly gave kids something far more spectacular than the hideously disappointed Sea-Monkeys — an instant aquarium that would spawn colorful, rainbow-hued fish from a cube… 052
Jason Rihel @jasonrihel.bsky.social · 03/12/2024Most circadian/sleep science points to keeping US standard time year round and not switch times twice a year. But politicians seem to always get the wrong end of the stick. Are we going to eliminate this bad practice but in the wrong way? 120
Jason Rihel @jasonrihel.bsky.social · 24/11/2024I don’t get it— the impact factor is about how a journal is cited; what does the peer review model of the journal matter? If the papers are crap, they won’t be cited very much! www.science.org/content/arti...science.orgOpen-access journal elife will lose its ‘impact factor’ over controversial publishing modelWeb of Science index decides to strip key metric because elife’s unusual peer review doesn’t meet its criteria 030
Reposted by Jason RihelKat Toropova @kattoropova.bsky.social · 24/11/2024Sign of the times, no more bluebird on the biorxiv engagement tab.. 635778
Reposted by Jason RihelRyan Boyd @ryanboyd.bsky.social · 14/03/2024I'll read The Critique of Pure Reason before I watch a 2-minute video of someone talking into their phone camera 1440569
Jason Rihel @jasonrihel.bsky.social · 01/02/2024I have to agree with this. I’ve never understood this attitude from some colleagues that the editors and journal teams should be trod upon. 011
Reposted by Jason RihelAddgene @addgene.bsky.social · 11/01/2024Addgene will no longer be using X, formerly Twitter. Instead, we'll be posting our 'microblogging' content here on Bluesky. blog.addgene.org/addgene-is-s...blog.addgene.orgAddgene is Stopping Use of X (formerly Twitter)Addgene will no longer be posting, monitoring, or responding to posts on X. You can find us as @addgene.bsky.social on Bluesky or as @addgene on Instagram, TikTok, Facebook, and LinkedIn. 624283
Jason Rihel @jasonrihel.bsky.social · 19/12/2023Wow, reviewing a paper that uses citations from 1998 for “zebrafish optogenetics” and 2010 for “Crispr”! Are these chatGPT hallucinations? Never seen anything like it. 120
Reposted by Jason RihelAmoyel lab @amoyellab.bsky.social · 18/12/2023New lab preprint! Very excited to share this work, led by Ruoxu Wang. We study how stem cell fate is controlled post-transcriptionally and find a new regulator of translation initiation: www.biorxiv.org/content/10.1...biorxiv.orgNiche signalling regulates eIF3d1 phosphorylation to promote distinct modes of translation initiatio...bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution 051
Jason Rihel @jasonrihel.bsky.social · 11/12/2023I’m sorry, but no paper that claims the mantle of science should have the phrase “beyond a reasonable doubt” in the first sentence of the abstract. journals.sagepub.com/doi/full/10.... 000
Reposted by Jason RihelVenki Murthy @neurovenki.bsky.social · 10/12/2023Some thoughts for the academic recommendation letter season; a poem from the December 2023 issue of Poetry Magazine, by Keith Leonard. #poetry 112152
Jason Rihel @jasonrihel.bsky.social · 30/11/2023As a yearly joke, for Spotify’s Wrapped, I try something odd. This year, I listened to the shortest mainstream song I could think of— the Beatles “Her Majesty”, clocking in at 26 seconds— 10,000+ times in a row. Wrapped says I listened to that song 0 times 😭. Fine print: a song counts after 30 sec 000
Reposted by Jason RihelPiali Sengupta @senguptalab.bsky.social · 29/11/2023Starting Jan 1, 2024, I am taking over as co-Editor-in-Chief (from Amita Sehgal) of Current Opinion in Neurobiology , one of my favorite go-to journals for excellent brief reviews on hot topics in neuroscience. Along with Eunjoon Kim. If you have ideas of topics for issues - write us! 🧪 🧠🟦 6286
