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Riyue Sunny Bao , PhD

@riyuesunnybao.bsky.social
189 followers 219 following 38 posts

Multiomics • Spatial imaging • I-O • AI. Asso Prof #Medicine. PI @ImmunoTiil . Director #Bioinfo @UPMCHillmanCC. Co-Chair #COWG. Lab: tiilab.org

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Riyue Sunny Bao , PhD @riyuesunnybao.bsky.social · 23/03/2026
Good morning everyone! Would somebody please #endorse me on cs.CV #ComputerVision and #PatternRecognition of #arXiv? We are submitting an article for the first time! Link below ;) arxiv.org/auth/endorse... Or pls visit arxiv.org/auth/endorse... and enter Code: 9I4F67 Thanks in advance!! 😍
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Riyue Sunny Bao , PhD @riyuesunnybao.bsky.social · 30/10/2025
🥳 We’re #hiring! 🎉 🎉 🎉 tiilab.org #Computational #postdoc scholar position open - focusing on leveraging #singlecell, #spatial, #imaging, and #AI to uncover mechanisms and therapeutic targets on overcoming resistance to #immunotherapy. Position is hybrid. DM or Email baor AT upmc DOT edu w CV :)
tiilab.org
TII Laboratory
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Reposted by Riyue Sunny Bao , PhD
Pearl Freier @pearlf.bsky.social · 15/07/2025
The UK's Medicine & Healthcare products Regulatory Agency (MHRA) became the 1st regulator globally to approve the new oral women's health drug by Bayer (originally through KaNDy Therapeutics acquisition) #biosky
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Riyue Sunny Bao , PhD @riyuesunnybao.bsky.social · 15/07/2025
Neoadjuvant and Adjuvant Pembrolizumab in Locally Advanced Head and Neck Cancer | New England Journal of Medicine nejm.org/doi/abs/10.105…
nejm.org
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Riyue Sunny Bao , PhD @riyuesunnybao.bsky.social · 14/07/2025
Great new work from #TRACERx team: Subclonal immune evasion in non-small cell lung cancer! First study ex vivo #NSCLC demonstrating #PDOs are an excellent technology on #subclonal tumor evolution affecting #immuneescape. t.co/1YUzihcY2H #nonanimal #alternative #methods #cancer #immunotherapy
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Reposted by Riyue Sunny Bao , PhD
Waggoner Lab @labwaggoner.bsky.social · 13/07/2025
A high proportion of CD38 (high) CD16 (low) NK cells in tumor patients can interrupt immune surveillance and favor tumor growth link.springer.com/article/10.1...
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Reposted by Riyue Sunny Bao , PhD
Society for Immunotherapy of Cancer @sitcancer.bsky.social · 24/06/2025
New Journal for ImmunoTherapy of Cancer article: Multiomics identifies tumor-intrinsic SREBP1 driving immune exclusion in hepatocellular carcinoma bit.ly/4lcxHLC ‪ @riyuesunnybao.bsky.social @pancpathologist.bsky.social ‪ @zervanto.bsky.social @jasonlukemd.bsky.social #JITC #cancer #MedSky
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Riyue Sunny Bao , PhD @riyuesunnybao.bsky.social · 27/03/2025
🚀First time joining #ENAR2025 and ✨Grateful to share our lab's work leveraging #singlecell #spatial #pathomics #radiomics to understand resistance/response in #cancer #immunotherapy. Had a wonderful time discussing #statistics & #quantitative sciences for #biological #clinical impact w my peers!!
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Riyue Sunny Bao , PhD @riyuesunnybao.bsky.social · 22/03/2025
Looking forward to #ENAR2025!! I will be discussing our lab's new work in using #singlecell omics and #radiomics to understand resistance and response in patients who received #immunotherapy. Here we come - #music, #food, and GREAT #science 🚀💃 @enar-ibs.bsky.social
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Riyue Sunny Bao , PhD @riyuesunnybao.bsky.social · 05/03/2025
We have a #research tech job open 🤩 if you are interested in quickly gaining experience in #translational & #clinical space, DM /send me your CV. #master #graduates who want to go to #PhD or #MD prog w strong motivation + #wetlab exp are welcome to apply!! #standupForScience #standupAgainstCancer
media.tenor.com
a little girl wearing sunglasses and a blue dress is dancing on the floor .
ALT: a little girl wearing sunglasses and a blue dress is dancing on the floor .
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Riyue Sunny Bao , PhD @riyuesunnybao.bsky.social · 05/03/2025
Where are the #AI #Agents who can clean up/reformat all publication #figures and #deposit big data cuz I would like to buy one Would even better if AI Agents take care of all the #paperwork and #administrative tasks so that I, a #human, can focus on #science and #curing human diseases
media.tenor.com
a man in a suit sits at a desk with the words " these are busy times " written on the bottom
ALT: a man in a suit sits at a desk with the words " these are busy times " written on the bottom
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Riyue Sunny Bao , PhD @riyuesunnybao.bsky.social · 05/03/2025
Back to #Nak #Won Garden and loving it!!! The best #authentic #korean food in the Burgh. Plus Friendly environment and super nice owners 😍
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Reposted by Riyue Sunny Bao , PhD
Emily R. Trunnell, Ph.D. @ertrunnell.bsky.social · 03/03/2025
Human-relevant neuroscience research is everywhere, but so many many poorly translatable experiments on animals still get funded. Why? One reason: Grant reviewers are mostly animal experimenters themselves. New preprint from @katherineroe.bsky.social & me 🧵 🧪 www.biorxiv.org/content/10.1...
Screenshot from link: "New Results. Predominance of animal-based expertise may bias NIH neuroscience grant review: A pilot study with implications for non-animal methodologies. Emily R. Trunnell, Katherine V. Roe 

doi: https://doi.org/10.1101/2025.02.28.640877 

This article is a preprint and has not been certified by peer review.
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Riyue Sunny Bao , PhD @riyuesunnybao.bsky.social · 02/03/2025
Respect 🫡
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Riyue Sunny Bao , PhD @riyuesunnybao.bsky.social · 02/03/2025
#NIH websites were down with wide spread intermediate #access issues . Have never seen this before
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Riyue Sunny Bao , PhD @riyuesunnybao.bsky.social · 01/03/2025
#flow cytometry experts, which #R or #Python packages do you use to analyze 30+ color #spectral flow data? cyCONDOR? cytofkit2? Other recommendations? Thanks!!
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Riyue Sunny Bao , PhD @riyuesunnybao.bsky.social · 23/02/2025
Here is a growing list of #universities and #programs that have to reduce or pause graduate admission as a consequence of indirect cuts, and funding freeze. We are witnessing an entire generational loss of #science.
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Riyue Sunny Bao , PhD @riyuesunnybao.bsky.social · 20/02/2025
Great #science, #food, and #ski tracks! Plus, it’s snowing 😎🔥⛷️ #TRCCC2025 #cancer #immunotherapy
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Riyue Sunny Bao , PhD @riyuesunnybao.bsky.social · 20/02/2025
Dr Rose Doerfler from our lab #ImmunoTiil presenting her work in #headNeck #cancer patient derived #organoids #TRCCC2025. Looking forward to further developing this scalable ex vivo technology for rapid #oncology #immunooncology #therapeutic #HNSCC!!! Check Rose poster #62 tonight to learn more!
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Riyue Sunny Bao , PhD @riyuesunnybao.bsky.social · 19/02/2025
Dr Alan Hutson, Chair of Biostats and Bioinfo Dept #RoswellPark Cancer center giving keynote #immunoOncology translational network #IOTNmoonshot at #TRCCC2025 annual meeting !!! 🚀Especially important for today’s scientific landscape
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Riyue Sunny Bao , PhD @riyuesunnybao.bsky.social · 18/02/2025
#Glioblastoma #Cortical #Organoids Recapitulate Cell-State Heterogeneity and Intercellular Transfer #precisionOncology #PDO scRNAseq revealing endogenous #malignant #transcripts transfer #EV from malignant to nonmalignant cells, toward #GBM cell states + #astroglia cell types! tinyurl.com/5h2v8tak
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Riyue Sunny Bao , PhD @riyuesunnybao.bsky.social · 14/02/2025
Has it occur to anybody that a non-profit initiative should be put together to #backup all #US #government funded #data #repositories, such as GEO, SRA, GDC, among many others? It could be just all gov funded resources is gone overnight?! Not saying it is happening, but it could.
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Reposted by Riyue Sunny Bao , PhD
Rejji Kuruvilla @rkuruvi1.bsky.social · 08/02/2025
At these bleak times when the intent seems to be to cripple NIH-funded research, a reminder that NIH funding sustains the economy and creates jobs “In fiscal year 2023, NIH funding generated an estimated $92.89 billion in economic activity.” www.nih.gov/about-nih/wh...
nih.gov
Direct Economic Contributions
NIH directly supports the economy through investments in research institutions and job formation.
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Riyue Sunny Bao , PhD @riyuesunnybao.bsky.social · 07/02/2025
#pathology #AI twitter - recommendations on a reliable predictor of #HPV status directly from #HE images in #HNSCC, that has been validated in large datasets across sites #opensource? We could build our own models but do not wish to reinvent the wheel if great tools already exists. Thank you !!
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Riyue Sunny Bao , PhD @riyuesunnybao.bsky.social · 04/02/2025
🚀 Exciting news! The brand-new #Y2025 #SITC #CompIO Webinar Series is here!!! 🎉 Ten courses focusing on advanced methods and clinical utility for #biomarker #development in IO @sitcancer.bsky.social @roswellpark.bsky.social #NCI 👏 ✨ FREE registration: tinyurl.com/3863jp9t Let's spread the word!🚀
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Reposted by Riyue Sunny Bao , PhD
Eric Topol @erictopol.bsky.social · 03/02/2025
An update with latest data available for graph of life expectancy vs health care expenditures per capita for 20 countries and one outlier.
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Riyue Sunny Bao , PhD @riyuesunnybao.bsky.social · 03/02/2025
An integrated transcriptomic cell #atlas of #human #neural #organoids: 36 #singlecell #transcriptomic datasets spanning 26 protocols, totalling 1.7+ million cells. www.nature.com/articles/s41... Interactive portal: archmap.bio#/ Great resource for all researchers in this field!!
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Riyue Sunny Bao , PhD @riyuesunnybao.bsky.social · 03/02/2025
Convergence of evolving #AI and #ML techniques: #multiomic, #spatial imaging, #pathology, #radiomic technologies enable a deeper understanding of #tumor #biology & #precision #oncology, such as building virtual #digitaltwins to optimize trial design. www.nature.com/articles/s41...
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Riyue Sunny Bao , PhD @riyuesunnybao.bsky.social · 03/02/2025
After battling the impossible parking in lawrenceville 🥷 we had a delicious meal at #Tram’s kitchen #split #rice 🤤 and made to #sungazer concert @ #thunderbird cafe & music hall ☀️ 🎷🎸🥁 which we had missed , for the past three times when they came to #Pittsburgh 🥹
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Riyue Sunny Bao , PhD @riyuesunnybao.bsky.social · 31/01/2025
#Artificialintelligence-based #biomarkers for treatment decisions in #oncology: #radiology #pathology #omics #EHR #LLM clinical implementation requires validation, prospective trials, medicoeconomic eval while extending #personalized #medicine to a broader population. www.cell.com/trends/cance...
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Riyue Sunny Bao , PhD @riyuesunnybao.bsky.social · 31/01/2025
Pluripotent #stemcell-derived #therapies in #clinical #trial: A 2025 update - a timely review on 115 clinical trials testing 83 #hPSCs products, majority targeting #eye #CNS, and #cancer! www.cell.com/cell-stem-ce...
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Riyue Sunny Bao , PhD @riyuesunnybao.bsky.social · 30/01/2025
Happy #LunarNewYear 2025!! 祝大家蛇年吉祥,好运连连,万事顺遂,阖家幸福!
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Riyue Sunny Bao , PhD @riyuesunnybao.bsky.social · 29/01/2025
Rapid and scalable #personalized antisense oligonucleotides #ASOs screening in #patient-derived #organoids - Preclinical evaluation of personalized ASO #therapeutics for a broad range of #rare #diseases!! www.nature.com/articles/s41...
nature.com
Rapid and scalable personalized ASO screening in patient-derived organoids - Nature
A scalable platform for generating patient-specific organoids for testing personalized oligonucleotide therapeutics is described.
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Riyue Sunny Bao , PhD @riyuesunnybao.bsky.social · 29/01/2025
#NAS released announcement on "Resources for Researchers and Scholars under Threat in the United States " tinyurl.com/3kvmc8vv
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Riyue Sunny Bao , PhD @riyuesunnybao.bsky.social · 29/01/2025
#Organoid #Community ✨ What cool technologies/strategies have you used to scale up your #PDO expts? 🧫🚀 #academic #labs We’re spending lots time expanding individual cases, tons of pipetting and limited wells per plate. This is prior to drug screening (which is automated by robots). 🙏 Thanks!!
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Riyue Sunny Bao , PhD @riyuesunnybao.bsky.social · 29/01/2025
Integrating #clinical, #pathological, #radiological, #transcriptomic data boosts prediction of #firstline #immunotherapy outcomes in metastatic #NSCLC 🚀 ✨317 patients, PET/CT, bulk RNAseq, digitized pathology => #Multimodal #AI outperform traditional methods! t.co/MfMNwuZaG9
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Reposted by Riyue Sunny Bao , PhD
Katharine Hayhoe @katharinehayhoe.com · 30/12/2024
Did you see this experiment my colleague Kristina conducted not just at my university but *in my department*? She and the male instructor assumed eachothers’ names for an online course: and the difference in feedback they received was horrifying.
slate.com
Student Evaluations Can’t Be Used to Assess Professors. They’re Discriminatory.
And that means they’re illegal.
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Reposted by Riyue Sunny Bao , PhD
Anne Carpenter @drannecarpenter.bsky.social · 09/12/2024
Highly recommend (long) read for anyone who's been leading a lab 10+ years!
I suppose, then, I am well qualified to say something about staying in the game. I have done it for over
twenty years. I have contributed to research on several topics in biology and the social sciences. I hold
a full professorship in a decent research-intensive university. I get some very nice academic invitations.
So it seems I have avoided the ‘exit academia’ arrows, possibly even with aplomb. But—and this is
what qualifies me—I haven’t avoided them nearly as easily as you probably think. If it looks that way
from the outside, that’s only because you lack the data I have. You don’t see the failures, the false
starts, the wasted time, or the awkward conversations with the Dean. (These are ubiquitous, by the
way, just not well written up in the literature.) And opposite the Scylla of the ‘exit academia’ arrows
has always lurked the Charybdis of my own demoralization: walking away from the game even if the
game does not eject me. I gave up completely once, for several years, then eventually clawed my way
back in; a second time I partly gave up but left myself attached by a lifeline, a lifeline I duly climbed up
within a year or so; and probably two or three more times over the years I reached the point of starting
to make other plans. Periodic demoralization and depression are not rare amongst researchers. It’s
not not caring any more, or not being able to be bothered, as depression is often and erroneously
characterized. It is caring so much, being so bothered, that one cannot advance on any front. One
drowns in one’s own disorganized and gradually souring passion. This feeling is probably near-
ubiquitous too.
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Riyue Sunny Bao , PhD @riyuesunnybao.bsky.social · 28/11/2024
Happy #Thanksgiving2024 !!! 😆 We decided to get #Costco #chicken for dinner. NOT BAD
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Riyue Sunny Bao , PhD @riyuesunnybao.bsky.social · 22/11/2024
💫 Excited for our monthly #NCI #Computational #Oncology Working Group #COWG @ #RoswellParkCCC & #CIMAC-#CIDC!! Today we welcome 🌟 Dr. Xianlu (Laura) Peng #UNC_Lineberger to share work decoding #pancreatic cancer #heterogeneity, a aggressive, therapy-resistant cancer🔥!!!#CancerResearch #DataScience
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Riyue Sunny Bao , PhD @riyuesunnybao.bsky.social · 27/10/2023
🚀#SITC2023 is around the corner! Looking to take the next leap in your career #computational #immunoOncology #immunotherapy? Let's set up a time to chat!! We're hiring. From #tenure to #nontenure track faculty, and #staffscientists @UPMCHillmanCC #datasciences !! Please RT. Thank you ☺️
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