The patterns and pathways of pathogen adaptation during chronic infections can reveal the gateways microbes must unlock to colonize and persist. In chronic lung infections of cystic fibrosis (CF) pati...

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Diverse E. coli phage genomes have hypermutable DNA regions that promote reversible frameshift mutations through DNA polymerase slippage, generating population heterogeneity that enables host exploita...

The federal government has unexpectedly ended two more research grants at the University of Pittsburgh, which in one case, upends 16 years of research...

Many bacteria, including the opportunistic pathogen Pseudomonas aeruginosa, are chronically infected by viruses that can reproduce without killing the cell. These viruses, called filamentous phages, t...

Vibrio cholerae colonizes estuarine environments and human hosts, where it transitions between motile and sessile states using the second messenger cyclic di-GMP (cdG). cdG levels change in response to a variety of signals and are controlled by the activity of diguanylate cyclases and phosphodiesterase (PDEs), enzymes that make and degrade cdG. In this work, we show that Zn2+ and the cell density regulator HapR repress ZpdA, the PDE present in the Vibrio seventh pandemic 2 island, at the level of transcription, and that Zn2+ unexpectedly alters the PDE activity of ZpdA protein itself. Our study highlights the role of metal availability as an important signaling cue that controls V. cholerae biology.

ASM and fellow societies filed an amicus brief with the Supreme Court, calling for the swift restoration of NIH grant funding supporting early-career scientists, such as the MOSAIC program.

We established a research-education partnership known as EvolvingSTEM that provides secondary school students the opportunity to conduct authentic research experiments centered on microbial evolution....

Scientists at the University of Pittsburgh have been teaching inside local high schools for ten years through the Evolving-STEM program, which now faces potential federal funding cuts.

Klebsiella host strains infected with telomere phages can grow to be the dominant lineage in mixed populations.

Nature Microbiology - ‘Phollow’ is a live imaging-based fluorescence tagging approach that can track phage replication and spread in situ with single-virion resolution.

National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.

Evolutionary biologist Joseph L. Graves Jr argues that — now more than ever — the United States should honour its commitments to Black higher education to diversify the science workforce.