Existing pedigree approaches to identifying de novo mutations (DNMs) require at least two parents and a single offspring, limiting applicability. Here, we introduce OOPS (Only One Parent Sequencing), ...

Abstract. Genome sequencing has revealed a tremendous diversity of transposable elements (TEs) in eukaryotes but there is little understanding of the evolu

AbstractSummary. Phylogenetic trees are ubiquitous and central to biology, but most published trees are available only as visual diagrams and not in the ma

Variation in life history strategies is among the most striking features of animal diversity. Simultaneously, the microbes an animal interacts with are a critical and dynamic aspect of the host enviro...

Scientists have long debated the origins of exceptional human achievements. This literature review summarizes recent evidence from multiple domains on the acquisition of world-class performance. We re...

Approaches combining genetic association and Perturb-seq data that link genetic variants to functional programs to traits are described.

A new type of mRNA splicing mechanism discovered in Caenorhabditis elegans that detects and removes inverted repeats also occurs in human cells, thereby providing another strategy to protect against t...

MicroRNAs (miRNAs) are small non-coding RNAs ~ 19–22 nt long that post-transcriptionally regulate their mRNA targets. In Drosophila melanogaster, the role of miRNAs has mostly been studied in regar...

Transcription in trypanosomatids, such as Trypanosoma brucei, is predominantly polycistronic and involves unconventional RNA polymerase II promoters. This study uses precision gene editing, site-satur...

Abstract. Genomic regions that influence sex are hypothesized to play a key role in evolutionary diversification, as sex determination mechanisms may promo

The constraints that govern the evolution of gene expression patterns across development remain unclear. Single-cell RNA sequencing can detail these constraints by systematically profiling homologous ...

Nature Cell Biology - Zhang et al. provide evidence that, during meiosis, recombination proteins assemble into active droplets, the coarsening of which partially explains the phenomenon of...

Perez et al. report that self-assembling nematode towers occur in nature and can function as collective dispersal structures. Using Caenorhabditis elegans, they establish a tractable empirical model t...

Multimodal large language models are shown to develop object concept representations similar to those of humans. These representations closely align with neural activity in brain regions involved in o...

This version introduces Movi Color. Movi rows are augmented with run colors, defined based on the origin of the suffixes within each run. The Movi Color index can be built by either an additional ...

Uncultured open-ocean Asgard archaea can harvest light energy using rhodopsins and diverse hydroxylated carotenoid antennas.

In an iron-sulfide chemical garden experiment that mimics the kind of hydrothermal vents that might have occurred in the early Archaean, mackinawite and greigite are precipitated and abiotic H2 is pro...

Research on horizontal gene transfer (HGT) has surged over the past two decades, revealing its critical role in accelerating evolutionary rates, facil…

Alphaviruses optimize viral polymerase production and polyprotein processing at distinct temperatures via a premature stop codon.

Tenthorey et al. compare the effects of missense and indel mutations on the acquisition of functional novelty by the rapidly evolving antiviral protein TRIM5α. They find that single indel mutations al...

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The position calls for teaching three classes per semester, which may include fundamental classes for biology majors such as cell biology and genetics, and biodiversity (ecology, evolution, and organi...

A spokesperson for the University told WESA Friday that the school has "temporarily paused additional Ph.D. offers of admission," while Pitt works to understand how proposed federal funding cuts could...

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