iiinova — where your digital self keeps evolving

jaelab.bsky.social @jaelab.bsky.social · 09/08/2026

If you’re into heme, also check out this intriguing study by our friends @riemerlab.bsky.social on the spatial choreography of a key step in heme synthesis, also featuring an evolutionary plot twist: www.science.org/doi/10.1126/...

science.org

ALR couples IMS redox and heme biosynthesis beyond the disulfide relay

CPOX is a direct substrate of the mitochondrial oxidase ALR, linking intermembrane space redox chemistry to heme biosynthesis.

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jaelab.bsky.social @jaelab.bsky.social · 09/08/2026

Spearheaded by XiangZhang & Max-Hinderk Schuler here at @genecenter-lmu.bsky.social @lmu.de, with fantastic collaborators: team Pichlmair @tum.de & Barbara Steigenberger @mpibiochem.bsky.social. Deeply grateful to our funders @erc.europa.eu, @dfg.de, Krupp Foundation & @valleefoundation.bsky.social.

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jaelab.bsky.social @jaelab.bsky.social · 09/08/2026

Check out our new @nature.com paper showing that heme scarcity is surprisingly sensed in #mitochondria by the #DELE1 pathway. Conserved all the way to Hydra, this ancient system takes the heme reading in the very organelle that produces this key metabolite. www.nature.com/articles/s41586-026-10885-x

nature.com

An ancient mitochondrial program tunes translation to haem availability - Nature

An evolutionarily conserved mitochondrial haem-sensing mechanism that predates the emergence of haemoglobin-based oxygen transport could have therapeutic value in iron deficiency disorders.

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jaelab.bsky.social @jaelab.bsky.social · 14/12/2025

Big news this week: results of a very competitive @erc.europa.eu CoG call are in, and I’m happy that our project mitoSCALES (scales of mitochondrial stress response) is among the ~11% funded. Recruiting will begin soon—get in touch if you want to hop on board for the ride! #ERCCoG #Mitochondria #GCM

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Reposted by @jaelab.bsky.social

Gene Center Munich @LMU Munich @genecenter-lmu.bsky.social · 27/05/2025

📣Our guest series continues with Oleh Khalimonchuk! We're happy to welcome him next Monday! 🎉 He’ll be talking about “Regulation of mitochondrial shape and function: From basics to disease” 📅 June 2 🕐 1:15 PM ➡️Lynen Lecture Hall Don’t miss it! 🤗✨ @mitocrue.bsky.social @jaelab.bsky.social

Announcement of Oleh Khalimonchuk's talk, including a photo of him

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Reposted by @jaelab.bsky.social

Gene Center Munich @LMU Munich @genecenter-lmu.bsky.social · 22/05/2025

Wow, so cool!🌟 Excellence in Nucleic Acid Sciences and Technologies: NUCLEATE Cluster selected for national recognition Led by spokesperson Veit Hornung, the NUCLEATE Cluster secures funding in Germany’s Excellence Strategy 🥂🥳🤩 www.lmu.de/en/newsroom/... @v-hornung.bsky.social

lmu.de

NUCLEATE Cluster of Excellence: beacon of nucleic acid research

The new NUCLEATE Cluster of Excellence is all about nucleic acids. The research alliance seeks to better understand their various functions and open up new areas of application.

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Reposted by @jaelab.bsky.social

Pavel Kielkowski @pavelkielkowski.bsky.social · 16/01/2025

Proteoforms matter! We show how AMPylation impacts PLD3 proteolytic processing and catalytic activity. Congratulations to Laura Hoffmann and thanks to all collaborators @jaelab.bsky.social, @v-hornung.bsky.social, @hellmichgroup.bsky.social and Wei Xiang lab! www.biorxiv.org/content/10.1...

biorxiv.org

AMPylation regulates PLD3 processing

The 5’-3’ exonuclease phospholipase D3 (PLD3) is a single-pass transmembrane protein undergoing sequential post-translational modifications (PTM) by N -glycosylation, AMPylation and proteolytic cleava...

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