Cells generate purine nucleotides through de novo purine biosynthesis (DNPB) and purine salvage. Purine salvage represses DNPB to prevent excessive purine nucleotide synthesis through mechanisms that ...

Researchers are studying why the energy factories are moving between cells and whether the process can be harnessed to treat cancer and other diseases.

Here they show that HDAC6 inhibition regulates fumarate hydratase (FH), disrupts mitochondria, increases fumarate, and causes cancer cell death. This suggests that HDAC6 inhibition could be a strategy...

Bcl-2 family proteins Structural basis of BAK sequestration by MCL-1 in apoptosis Shagun Srivastava, Giridhar Sekar, Adedolapo Ojoawo, Anup Aggarwal, Elisabeth Ferreira, Emiko Uchikawa, Meek Yang, …

Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.

Nature - The histone deacetylase HDAC6 is a sensor of valine levels, and the abundance of valine in cells regulates DNA damage and cell homeostasis functions.

Mechanisms of iron-dependent cell death reveal potential new targets for disease treatment