Strep A causes over 600,000 deaths per year — a toll comparable to HIV/AIDS and malaria — but attracts a tiny fraction of the research funding. Today, we're launching the Strep A Vaccine Fund: a multi...

Acute rheumatic fever (ARF) is a serious sequela of Strep A infection, for which a diagnostic biomarker is still lacking. Here, the authors demonstrate that CXCR3 directs T cells to heart valves in pa...

This cohort study estimates the risk of invasive group A streptococcus (iGAS) before and after the implementation of a policy in the Netherlands that expanded antibiotic prophylaxis to household conta...

Emm1 invasive Strep A incurs a high case fatality rate. In this national cohort, 24.4% of those with M1UK iGAS died, though this was not different from anc

This cross-sectional study examines changes in immunity to Streptococcus pyogenes and other common respiratory pathogens among young children in 10 European countries after the introduction of nonphar...

Accurate diagnosis of Streptococcus pyogenes (S. pyogenes) pharyngitis is imperative in high rheumatic heart disease-burden countries. We aimed to assess the diagnostic accuracy of two rapid diagnosti...

Objectives To describe diagnostic and management characteristics of acute rheumatic fever (ARF) among participants in the ‘Searching for a Technology-Driven Acute Rheumatic Fever Test’ study, in order...

Introduction The absence of a diagnostic test for acute rheumatic fever (ARF) is a major impediment in managing this serious childhood condition. ARF is an autoimmune condition triggered by infection ...

Importance The upsurge in invasive disease caused by Streptococcus pyogenes among children reported in several European countries during 2022-2023 has not been fully explained. Objective To test the ...

We developed a tool to quantify the impact of misallocation of person time, then used it to demonstrate that published observational studies have likely ov

Streptococcus pyogenes leads to 500,000 deaths annually; many due to rheumatic heart disease in low-income settings. Limited understanding of natural protective immunity to S. pyogenes hinders vaccine...

AI models have been proposed for hypothesis generation, but testing their ability to drive high-impact research is challenging, since an AI-generated hypothesis can take decades to validate. Here, we ...

An international project into flu immunity could help develop better medications and vaccines to prevent severe disease.

Diabetic infections are a reservoir for the emergence and proliferation of antibiotic resistance in Staphylococcus aureus.

S pyogenes carriage and infection are common in The Gambia, particularly in children. Most events are non-household acquisitions, but skin carriage and pyoderma have an important role in S pyogenes household transmission and bidirectional transmission between skin and pharynx occurs.

Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

In this webinar, Dr Tom Parks and the panel will discuss the BPSU study and provide a refresher on Strep A disease and post-infectious disease at a time when UK children are at increased risk.

Imperial and US scientists are spearheading a multi-institution network to research bacterial cause of sepsis and heart damage in children.