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Alex Keeley

@alexjkeeley.bsky.social
1.8K followers 1.5K following 57 posts

Wellcome Clinical PhD in Global Health @ MRC Gambia/LSHTM. ID SpR @Sheffield. Strep A Immuno-Epi and RHD. Climate, Social and Healthcare Justice. He/him

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Alex Keeley @alexjkeeley.bsky.social · 30/09/2025
so just reading the title - I would say there is a lot more to this than amnesia
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Infinity Bio Inc @infinitybioinc.bsky.social · 08/09/2025
A new study by @thushan-desilva.bsky.social @alexjkeeley.bsky.social & colleagues provides a framework for future Streptococcus pyogenes (Strep A) vaccine development by examining the natural acquisition of humoral immunity! www.nature.com/articles/s41... #Microbiology #Pathogen #VaccineDevelopment
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STITCHES Medicine - the Best of Medical Research @medicine.stitches.today · 17/08/2025
Antibodies to conserved Streptococcus pyogenes antigens correlate with functional activity and protect Gambian children from culture‑confirmed infections, especially under age 2. by Keeley AJ, Camara FE (...) de Silva TI et 33 al. in Nat Med #MedSky 👉 get more here 📖 read the article:
nature.com
Early-life serological profiles and the development of natural protective humoral immunity to Streptococcus pyogenes in a high-burden setting - Nature Medicine
Serological profiles from two observational cohort studies in The Gambia characterize surrogates of protection against Streptococcus pyogenes and reveal an antibody response against antigens that are currently in vaccine development.
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Alex Keeley @alexjkeeley.bsky.social · 08/08/2025
🧵 Our paper out today in @naturemedicine.bsky.social www.nature.com/articles/s41... On development of #StrepA #Immunity over life course in #TheGambia raising hope for #vaccines on the horizon 1/ #Immunosky #IDsky #MicroSky #globalhealth.
nature.com
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Dr Laura Waters @drlaurajwaters.bsky.social · 14/07/2025
Beatriz Grinszetjn Opens #ias2025! While she can't provide a recipe for success in current climate, there are key factors 1. EVIDENCE 2. SOLIDARITY 3. TRUTH Let us make the most of our time together at the conference to "reaffirm, refocus & rebuild!" @iasociety.bsky.social
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Stuart Campbell @sc345.bsky.social · 02/06/2025
Prof de Silva & Dr Keeley speak on Strep A epi & immunity in the Gambia. 🗝️ Hyperendemicity of Strep A 🗝️ Index infections not explained by household contacts 🗝️ Early life immunity develops <2 y/o 🗝️ Ab response to carriage & infection 🗝️ ?protective immunity from SLO, SpyAD, SpyCEP #LISSSD25 #IDsky
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Alex Keeley @alexjkeeley.bsky.social · 17/05/2025
This post just hits the nail on the head for me right now:
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Alex Keeley @alexjkeeley.bsky.social · 14/04/2025
#ESCMIDGlobal2025 threads: Buckets of cool research and breaded meats.... Not seen a single post on #PEPFAR / #USAID cuts. How do we stand together as a community to strongly condemn this tragedy, and work on solutions? If it's not our problem #ESCMID "global" NOW, then who? and when?
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Alex Keeley @alexjkeeley.bsky.social · 07/04/2025
Great thread and paper: Where #StrepA burden greatest frequent lineage replacement seen. Interesting points: "vaccines without broad cross-lineage protection may also lead to S. pyogenes lineage replacement." "need to do better surveillance from carriage and non-invasive disease"
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CMI Communications @cmicomms.bsky.social · 08/03/2025
★ NEW #Communicable out now! Today is Int'l Women's Day & to honour that we give you the first of a 2-part special on gender dynamics in medicine 🎙️ share.transistor.fm/s/21a9df96 #IDSky #clinmicro #IWD2025 @angelahuttner.bsky.social @erinmccreary.bsky.social @anniejoseph.bsky.social & more
share.transistor.fm
Communicable E22: Women & men in medicine: An honest discussion, part 1 | Communicable | Episode 22
In honour of International Women's Day, Communicable releases the first of a two-part special on gender dynamics within the fields of infectious diseases and clinical microbiology. Moderated by Angela...
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Onisillos @onisillos.bsky.social · 01/03/2025
If pubmed is inaccessible at the moment, try @europepmc.org
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Alex Keeley @alexjkeeley.bsky.social · 27/02/2025
Can any other funders step in to take this on? These platforms are invaluable and so much research and health security would be lost "with immediate effect" Hard (and almost feels inappropriate/pointless) to focus on thesis writing right now #globalhealth #IDSky
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Madhu Pai, MD, PhD @madhupai.bsky.social · 26/02/2025
10 years ago, when I began teaching global health, my courses were mostly the 'blue pill' version Slowly but surely, it has become reddish Every year brings more improvement & reflection @shashikalb.bsky.social & @ananyatb.bsky.social have been great co-teachers journals.plos.org/globalpublic...
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medRxivpreprint @medrxivpreprint.bsky.social · 14/02/2025
Early life serological profiles and the development of natural protective humoral immunity to Streptococcus pyogenes in a high burden setting www.medrxiv.org/content/10.1101/202…
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Alex Keeley @alexjkeeley.bsky.social · 15/02/2025
📢 Preprint - not peer-reviewed🤞: Development of #immunity to #StrepA in The Gambia. We assessed IgG to conserved and M protein antigens across the life course, exploring association with protection against infection: www.medrxiv.org/content/10.1... #IDSky #Immunosky
medrxiv.org
Early life serological profiles and the development of natural protective humoral immunity to Streptococcus pyogenes in a high burden setting
Streptococcus pyogenes leads to 500,000 deaths annually; many due to rheumatic heart disease in low-income settings. Limited understanding of natural protective immunity to S. pyogenes hinders vaccine...
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Michael Marks @drmichaelmarks.bsky.social · 17/12/2024
Excited to say that in collaboration with colleagues in Australia @latrobeuni.bsky.social we got NHMRC funding to use SpyCATS cohort to build state of the art #StrepA transmission models. Hope to ultimately better understand household transmission & help target interventions in high burden settings.
thelancet.com
Streptococcus pyogenes carriage and infection within households in The Gambia: a longitudinal cohort study
S pyogenes carriage and infection are common in The Gambia, particularly in children. Most events are non-household acquisitions, but skin carriage and pyoderma have an important role in S pyogenes household transmission and bidirectional transmission between skin and pharynx occurs.
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Dr Steve Taylor @drstevetaylor.bsky.social · 13/12/2024
Healthcare - you get what you pay for £3600 the average Tax/person/year goes to #NHS £165 to General Practice Discussion yesterday with a US expat - £7600 basic US insurance cover for a fit & healthy 26yr old (still pay for use) Without the NHS what could you afford? Private GP appt £79 #Medsky
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Alex Keeley @alexjkeeley.bsky.social · 03/12/2024
Great thread 👇 & 📜: A beautifully told story from complex serological data around @joshosowicki.bsky.social #StrepA human challenge. Amazing how much you can learn from controlled experimental challenge with 25 humans, setting standards for future CHIM / vaccine trials / seroepi ... #IDSky
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Alex Keeley @alexjkeeley.bsky.social · 28/11/2024
Wow - what mischief makers indeed!
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Alex Keeley @alexjkeeley.bsky.social · 12/11/2024
Here's something I missed on #IDTwitter last year: www.nejm.org/doi/full/10.... Phase 3 trial of NmCV-5 (ACWYX) meningitis vaccine in 2-29yo. Randomized, double-blind, noninferiority study vs. quadrivalent MenACWY-D for immunogenicity/safety over 28 days. #IDSky - recreating the space we lost
nejm.org
Meningococcal ACWYX Conjugate Vaccine in 2-to-29-Year-Olds in Mali and Gambia | NEJM
An effective, affordable, multivalent meningococcal conjugate vaccine is needed to prevent epidemic meningitis in the African meningitis belt. Data on the safety and immunogenicity of NmCV-5, a pen...
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Onisillos @onisillos.bsky.social · 09/05/2024
New research article in The Lancet Microbe #Streptococcus pyogenes carriage and infection within households in The Gambia: a longitudinal cohort study www.thelancet.com/journals/lan... #StrepA #MicroSky #IDSky #OpenAccess #OA
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Alex Keeley @alexjkeeley.bsky.social · 07/11/2024
www.tandfonline.com/doi/full/10....
tandfonline.com
The intricate pathogenicity of Group A Streptococcus: A comprehensive update
Group A Streptococcus (GAS) is a versatile pathogen that targets human lymphoid, decidual, skin, and soft tissues. Recent advancements have shed light on its airborne transmission, lymphatic spread...
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Alex Keeley @alexjkeeley.bsky.social · 04/11/2024
www.thelancet.com/journals/lan... @madhupai.bsky.social @shashikalb.bsky.social @CKyobutungic A must read: summary on barriers (politics/funders/institutions/culture) to redressing global health power imbalances. But.. “power concedes nothing without a demand. It never did and it never will.”
thelancet.com
Shifting power in global health will require leadership by the Global South and allyship by the Global North
Global health continues to be a field where Global North actors see themselves as leaders.1,2 Although the decolonising global health movement has exposed the deep inequities inherent within the architecture of global health,1 this movement, prone to elite capture, faces several institutional barriers that prevent meaningful shifts in power.3
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Alex Keeley @alexjkeeley.bsky.social · 21/10/2024
World feels pretty overwhelming right now... So please consider supporting: DEC donation.dec.org.uk/middle-east-... MSF msf.org.uk/secure/donate ..and this initiative by @madhupai.bsky.social: crowdfunding.mcgill.ca/ui/main/p/pa... to recognise those striving for equity in health.
crowdfunding.mcgill.ca
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Gabriele Pollara @gpollara.bsky.social · 16/10/2024
Starkly putting out tensions between conferences & carbon footprints Worked example for @escmid.bsky.social confernce but it's generalisable Benefits of in-person meetings are at environmental cost not easily squared #IDSky 🩺 #AcademicSky www.clinicalmicrobiologyandinfection.com/article/S119...
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Alex Keeley @alexjkeeley.bsky.social · 18/10/2024
100% - So challenging to quantify the benefits of the irreplaceable interactions, (whereas the harms can be quantified - www.nature.com/articles/s41...) but we must proactively consider this, given our collective goal to reduce ill-health/suffering. Can to share my own frame work if anyone via DM
nature.com
Quantifying the human cost of global warming - Nature Sustainability
As an alternative to monetary estimates, this study expresses the costs of climate change in terms of numbers of people left outside the ‘human climate niche’, which reflects the historically highly c...
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Ilan Schwartz @germhuntermd.bsky.social · 18/10/2024
Dear IDTwitter refugees I made an #IDSky starter pack which makes it easy to find accounts of ID clinicians, medical microbiologists, ID researchers, ID epidemiologists, ID focused reporters, and of course journals ahead of the curve. Let me know if I missed you! go.bsky.app/LnAQjdq
media.tenor.com
patrick star from spongebob squarepants is standing on a sandy beach next to a black line .
ALT: patrick star from spongebob squarepants is standing on a sandy beach next to a black line .
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Ilan Schwartz @germhuntermd.bsky.social · 18/10/2024
BALANCE is an RCT of 3,608 pts with bloodstream infections randomized to 7 vs 14 days antibiotics Excl: Staph aureus, S lugdunensis, fungi, deep seated infections, severe immunocompromise No dif in 90d mortality or relapse Firmly establishes 7d as SOC #IDSky www.idsociety.org/news--public...
idsociety.org
Antibiotic Treatment Regimen for Bloodstream Infections Can Safely Be Cut by Half
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Alex Keeley @alexjkeeley.bsky.social · 27/09/2024
Awesome! Eish tho does this go into my Zotero virology or microbiology collection?
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Gabriele Pollara @gpollara.bsky.social · 25/09/2024
A case of babesiosis acquired in the UK Increased prevalence of Babesia divergens in Ixodes ticks .... jumped to a human in this instance. #IDSky #MedSky #MicroSky wwwnc.cdc.gov/eid/article/...
wwwnc.cdc.gov
Autochthonous Human <em>Babesia divergens</em> Infection, England
Human <em>B. divergens</em> Infection, England
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Gabriele Pollara @gpollara.bsky.social · 12/08/2024
What we're aiming for in a Shigella vaccine: O-specific polysaccharide (OSP)-specific functional IgA responses #immunosky #IDsky www.thelancet.com/journals/lan...
thelancet.com
Determinants of immune responses predictive of protection against shigellosis in an endemic zone: a systems analysis of antibody profiles and function
Our findings suggest that OSP-specific functional IgA responses contribute to protective immunity against Shigella infection in a high-burden setting. These findings will assist in the development and...
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