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Reuben McGregor

@rhcmcg.bsky.social
28 followers 25 following 6 posts
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Reposted by Reuben McGregor
Katharine Collins @kat-a-collins.bsky.social · 26/05/2026
Today, Coefficient Giving is launching the Strep A Vaccine Fund, a multi-donor initiative to accelerate vaccine development against one of the world's most neglected infectious diseases relative to its scale. Strep A kills ~639,000 people a year. There is no vaccine. I think that can change 🧵
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Reposted by Reuben McGregor
Nikki Moreland @njmoreland.bsky.social · 05/05/2026
As always involved a great team including @rhcmcg.bsky.social @nat-lorenz.bsky.social @drannanz.bsky.social at UoA plus long term collaborators at Otago, the Kids @tbarnett.bsky.social, Menzies @annapralph.bsky.social and many more not on 🦋
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Reposted by Reuben McGregor
francis-middleton.bsky.social @francis-middleton.bsky.social · 05/05/2026
We’re excited to announce our latest paper @natcomms.nature.com: ‘CXCR3 is associated with T-cell-induced heart damage in acute rheumatic fever.’ We found evidence for T cell migration out of the blood and into heart valves during inflammatory rheumatic fever. www.nature.com/articles/s41...
nature.com
CXCR3 is associated with T-cell-induced heart damage in acute rheumatic fever - Nature Communications
Acute rheumatic fever (ARF) is a serious sequela of Strep A infection, for which a diagnostic biomarker is still lacking. Here, the authors demonstrate that CXCR3 directs T cells to heart valves in pa...
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Reposted by Reuben McGregor
JCI insight @insight.jci.org · 11/01/2026
Acute rheumatic fever is an autoinflammatory disease @njmoreland.bsky.social, @rhcmcg.bsky.social report widespread antibody heterogeneity, yet identify a protein expressed in cardiac muscle as an immunodominant autoantigen: doi.org/10.1172/jci....
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Reuben McGregor @rhcmcg.bsky.social · 07/12/2025
New paper out in JCI Insight: PhIP-Seq uncovers marked heterogeneity in Acute Rheumatic Fever Autoantibodies. ARF is a serious sequela of Strep A infection. While autoantibodies are known to drive pathogenesis, the specific human protein targets remain unclear. Link: doi.org/10.1172/jci.... 1/5
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Reposted by Reuben McGregor
Nikki Moreland @njmoreland.bsky.social · 22/07/2025
This deep dive into the clinical phenotype of rheumatic fever highlights extreme diversity in presenting symptoms. An important observation from the START study, and highlights why better diagnostic tests are needed 🧪 @annapralph.bsky.social @rhcmcg.bsky.social bmjopen.bmj.com/content/15/7...
bmjopen.bmj.com
Diverse diagnostic and management approaches for acute rheumatic fever in Australia and New Zealand: findings of a prospective clinical study
Objectives To describe diagnostic and management characteristics of acute rheumatic fever (ARF) among participants in the ‘Searching for a Technology-Driven Acute Rheumatic Fever Test’ study, in order...
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Reposted by Reuben McGregor
Nikki Moreland @njmoreland.bsky.social · 15/12/2024
Following relaxation of #COVID19 restrictions surges in infections from respiratory pathogens like RSV and #StrepA have been seen in many countries including Aotearoa New Zealand. Did waning immunity contribute? We explored this concept in our latest work, see 🧵 academic.oup.com/jid/advance-...
academic.oup.com
Decline of antibodies to major viral and bacterial respiratory pathogens during the COVID-19 pandemic
Antibodies to respiratory syncytial virus and Group A Streptococcus waned significantly in a longitudinal cohort throughout the pandemic. This waning may h
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Reposted by Reuben McGregor
Nikki Moreland @njmoreland.bsky.social · 04/12/2024
Finally jumping into 🦋 - and what better way to do than highlighting this super thread. Wonderful to have been involved in this study with our Strep A friends across the Tasman
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Reposted by Reuben McGregor
Dr Danika Hill @precisionvaxlab.bsky.social · 03/12/2024
🎉 I'm a #newPI , and I'm so excited to share our new paper out in Nature Comms today! 🧵 rdcu.be/d2gBV Quick intro for the new followers: I'm from Monash Uni in Melbourne, and we study T and B cell responses to viruses, bacteria & parasites with the goal of improving vaccines. #ImmunoSky #MicroSky
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