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Arkadiy Garber

@ironark.bsky.social
197 followers 390 following 123 posts

PhD, Microbiology MS, Geological Sciences BS, Neuroscience Founder of MAB: midauthorbio.com GitHub: github.com/Arkadiy-Garber github.com/Middle-Author-Bioinforma… Google Scholar: scholar.google.com/citations?user=S…

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Reposted by Arkadiy Garber
Alex Rubinsteyn @alexr.bsky.social · 15h
FYI I wrapped a lot of immuno-informatics predictors so you don't have to: openvax.github.io/mhctools/ (eg NetMHCpan, MHCflurry, Pepsickle, DeepTAP, ERAMER, BigMHC, PRIME, &c)
openvax.github.io
mhctools
Run MHC binding, presentation, immunogenicity and antigen-processing predictors through one predict() call
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Reposted by Arkadiy Garber
Lee Henry @henrylabsymbio.bsky.social · 21h
Excited to see our work out in @pnas.org! We asked how mobile genetic elements generate functional diversity in symbionts and found a plasmid that protects aphids from lethal pathogens, helping to explain variation in defence across natural aphid populations. See @ben-parker.bsky.social thread👇
pnas.org
Phenotypic divergence is driven by mobile genetic elements in a heritable insect symbiont | PNAS
Heritable microbes profoundly influence insect biology, yet the traits they confer often evolve rapidly and differ among closely related symbiont s...
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Reposted by Arkadiy Garber
The Daily Pub @thedailypub.bsky.social · 30/09/2026
Parallel evolution of chimeric genes in microbial evolution experiments.
doi.org
Parallel evolution of chimeric genes in microbial evolution experiments.
Published in Microbial genomics
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Reposted by Arkadiy Garber
The Daily Pub @thedailypub.bsky.social · 26/09/2026
Antibiotic-resistant pathogens and heavy metal-tolerant bacteria in Batissa violacea: A study from the Ba River, Fiji.
doi.org
Antibiotic-resistant pathogens and heavy metal-tolerant bacteria in Batissa violacea: A study from the Ba River, Fiji.
Published in PloS one
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Reposted by Arkadiy Garber
Paul Carini @uncultured.carinilab.com · 08/09/2026
We are happy to support an NSF PRFB application that makes use of AI to advance microbial cultivation for biotechnological purposes. Deadline=Sept 29th. More here: uncultured.carinilab.com/p/were-looki...
uncultured.carinilab.com
We're Looking to Sponsor Postdoc Fellows in AI-Driven Microbial Cultivation
NSF Postdoctoral Research Fellowships in Biology
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Reposted by Arkadiy Garber
Laura Ross @laurarossevo.bsky.social · 08/09/2026
Ever wondered why diverse organism shrink their genome in specific cells? We try to make sense of these curious cases of programmed DNA elimination in a review that came out today @naturerevgenet.bsky.social trebuchet.public.springernature.app/get_content/... @sandraduharcourt.bsky.social
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Reposted by Arkadiy Garber
Cameron Thrash @jcamthrash.bsky.social · 02/09/2026
The 100 Diatom Genomes Project journals.plos.org/plosbiology/... #jcampubs
journals.plos.org
The 100 Diatom Genomes Project
This Community Page presents the 100 Diatom Genomes Project, which aims to sequence the genomes and transcriptomes of 100 diatom species across major lineages, life forms and ecological strategies. Th...
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Reposted by Arkadiy Garber
Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 26/08/2026
Foldseek-Interface enables fast search/clustering of the protein interface universe! We clustered 3.1M PDB dimers into 77,167 groups and found new interfaces keep appearing even as fold discovery plateaus. 🧵 📄 www.biorxiv.org/content/10.6... 🔎 search.foldseek.com/interface 🌐 interface.foldseek.com
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Reposted by Arkadiy Garber
microPublication Biology @micropub7n.bsky.social · 11/08/2026
Complete Genome Sequences of Mycobacteriophages TribleTrouble, TClif, Llorens and CallaLilly #micropublication #biology #data #caltechlibrary #Bacteriophage #GenomeAnnouncements #NewFinding micropublication.org/journals/biolo…
Figure 1
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Reposted by Arkadiy Garber
microPublication Biology @micropub7n.bsky.social · 12/08/2026
Genome Sequence and Antimicrobial Production of Pseudomonas crudilactis #micropublication #biology #data #caltechlibrary #Pseudomonas #GenomeAnnouncements #NewFinding micropublication.org/journals/biolo…
Figure 1
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Arkadiy Garber @ironark.bsky.social · 12/08/2026
What lurks in the dark? An innovative framework for studying diverse wild insect microbiota link.springer.com/article/10.1...
link.springer.com
What lurks in the dark? An innovative framework for studying diverse wild insect microbiota - Microbiome
Microbiome - Symbiotic microorganisms can profoundly impact insect biology, including their life history traits, population dynamics, and evolutionary trajectories. However, microbiota remain...
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Arkadiy Garber @ironark.bsky.social · 09/08/2026
Metagenomics deciphers diagenetic processes of ferruginous mineralization in the deep biosphere www.nature.com/articles/s43...
nature.com
Metagenomics deciphers diagenetic processes of ferruginous mineralization in the deep biosphere - Communications Earth & Environment
Authigenic minerals reflect specific respiration and fermentation pathways leading to diagenetic redistribution of iron and carbon isotopes during burial, according to an in-depth characterization of ...
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Arkadiy Garber @ironark.bsky.social · 09/08/2026
Clustering the protein universe of life using DIAMOND DeepClust www.nature.com/articles/s41...
nature.com
Clustering the protein universe of life using DIAMOND DeepClust - Nature Methods
DIAMOND DeepClust provides an ultra-fast clustering method for organizing the protein universe of life at low sequence identity, enabling large-scale dimensionality reduction and improving downstream ...
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Arkadiy Garber @ironark.bsky.social · 08/08/2026
An expanded codebook of human transcription factor DNA-binding specificity www.nature.com/articles/s41...
nature.com
An expanded codebook of human transcription factor DNA-binding specificity - Nature
Results from a panel of assays that analyse different aspects of DNA sequence specificity reveal more than 100 new motifs to aid the characterization of putative human transcription factors.
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Arkadiy Garber @ironark.bsky.social · 08/08/2026
The evolution of the Earth’s surface iron cycle www.pnas.org/doi/10.1073/...
pnas.org
The evolution of the Earth’s surface iron cycle | PNAS
Formation and burial of pyrite (iron sulfide) in marine sediments exert a fundamental control on atmospheric oxygenation and seawater buffering ove...
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Arkadiy Garber @ironark.bsky.social · 08/08/2026
Growth characteristics of natural microbial populations are skewed toward bacteria with low specific growth rates journals.asm.org/doi/10.1128/...
journals.asm.org
Growth characteristics of natural microbial populations are skewed toward bacteria with low specific growth rates | Microbiology Spectrum
All living organisms are constrained by environmental boundaries that govern where growth is possible, such as minimum and maximum temperatures or pH. An organism’s maximum specific growth rate places...
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Arkadiy Garber @ironark.bsky.social · 08/08/2026
Taxonomic Resolution of 16S rRNA, FastANI, Mash, and FastAAI across 30,495 Prokaryotic Type-Strain Genomes www.biorxiv.org/content/10.6...
biorxiv.org
Taxonomic Resolution of 16S rRNA, FastANI, Mash, and FastAAI across 30,495 Prokaryotic Type-Strain Genomes
Prokaryotic taxonomy now relies on both marker-gene and genome-wide sequence comparisons, but these methods differ in taxonomic range, scalability, and sensitivity to genome quality. Here, we benchmar...
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Arkadiy Garber @ironark.bsky.social · 08/08/2026
Experimental verification of the error minimization theory using non-standard genetic codes constructed in vitro elifesciences.org/articles/111...
elifesciences.org
Experimental verification of the error minimization theory using non-standard genetic codes constructed in vitro
The in vitro experiments that used the artificial genetic codes tested here did not provide support for the error minimization theory.
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Arkadiy Garber @ironark.bsky.social · 08/08/2026
Genome-wide dissection of tillering responsiveness to neighbour proximity in sorghum www.biorxiv.org/content/10.6...
biorxiv.org
Genome-wide dissection of tillering responsiveness to neighbour proximity in sorghum
Tillering plasticity is a key adaptive trait in sorghum influencing resource use efficiency via a plant’s ability to adjust branching to neighbour density. Neighbour detection through red:far-red (R:F...
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Arkadiy Garber @ironark.bsky.social · 07/08/2026
I am pleased to share the preprint of our MagicLamp paper, in collaboration with the Penn Geomicrobiology Lab headed by Dr. Pérez-Rodríguez: www.biorxiv.org/content/10.6...
biorxiv.org
MagicLamp: a web server and software toolkit for targeted gene annotation of microbial functions
Genome and metagenome annotation tools designed for large databases are ill-suited to the discovery of specialized, ecologically relevant microbial functions. MagicLamp (<https://github.com/Arkadiy-Ga...
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Arkadiy Garber @ironark.bsky.social · 07/08/2026
Comparative transcriptomics of closely related Geobacter sulfurreducens strains uncovers strain-level variations in extracellular electron transfer www.frontiersin.org/journals/mic...
frontiersin.org
Frontiers | Comparative transcriptomics of closely related Geobacter sulfurreducens strains uncovers strain-level variations in extracellular electron transfer
Members of Geobacter sulfurreducens are electroactive bacteria that transfer electrons to extracellular solid electron acceptors using extracellular electron...
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Arkadiy Garber @ironark.bsky.social · 04/08/2026
The last chapter of my PhD work is now live on MBE. This has been an incredible project, combining genomics, proteomics, as well as transcriptomics that resolves total mRNA from ribosome-associated mRNA (which we infer to be in the process of translation).
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Reposted by Arkadiy Garber
The Daily Pub @thedailypub.bsky.social · 31/07/2026
Interspecies exchange of mobile genetic elements during a plant disease outbreak.
doi.org
Interspecies exchange of mobile genetic elements during a plant disease outbreak.
Published in Genome biology and evolution
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Reposted by Arkadiy Garber
sofie.rec @sofie-dot-rec.bsky.social · 27/07/2026
The artist formerly known as #thatmitoriboguy has now become #thatchlororiboguy Check out some cool tomo from @florentwaltz.bsky.social @phaips.vd.st
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Reposted by Arkadiy Garber
Cameron Thrash @jcamthrash.bsky.social · 27/07/2026
Microbial growth control: integrating protein abundance and activity www.sciencedirect.com/science/arti... #jcampubs
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Reposted by Arkadiy Garber
Cameron Thrash @jcamthrash.bsky.social · 27/07/2026
Influence of cell-cell distance on the ecology and evolution of microbial communities academic.oup.com/ismej/advanc... #jcampubs
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Reposted by Arkadiy Garber
Cameron Thrash @jcamthrash.bsky.social · 27/07/2026
metaSMASH: Scalable Biosynthetic Gene Cluster Detection for Large Metagenomic Assemblies www.biorxiv.org/content/10.6... #jcampubs
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Arkadiy Garber @ironark.bsky.social · 23/07/2026
Methyltransferases in Candidate Phyla Radiation: A Weapon or a Simple Shield? www.biorxiv.org/content/10.6...
biorxiv.org
Methyltransferases in Candidate Phyla Radiation: A Weapon or a Simple Shield?
The Candidate Phyla Radiation (CPR) consists of microorganisms with highly reduced genomes and limited metabolic capabilities, including the inability to synthesize nucleotides and amino acids. Previo...
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Reposted by Arkadiy Garber
Torsten Seemann @torstenseemann.bsky.social · 17/07/2026
NCBI Hidden Markov Models (HMM) Release 20.0 18,950 prokaryotic protein HMMs maintained by @ncbi ncbiinsights.ncbi.nlm.nih.gov/2026/07/01/h... #microbiology #bioinforbioinformatics #genomics
ncbiinsights.ncbi.nlm.nih.gov
Now Available! NCBI Hidden Markov Models (HMM) Release 20.0 - NCBI Insights
Download release 20.0 of the NCBI protein profile Hidden Markov models (HMMs) used by the Prokaryotic Genome Annotation Pipeline (PGAP). You can search this collection against your favorite prokaryoti...
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Reposted by Arkadiy Garber
The Daily Pub @thedailypub.bsky.social · 17/07/2026
AllTheBacteria: a community resource empowers biology and discovers novel peptide antibiotics.
doi.org
AllTheBacteria: a community resource empowers biology and discovers novel peptide antibiotics.
Published in bioRxiv : the preprint server for biology
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Reposted by Arkadiy Garber
Cameron Thrash @jcamthrash.bsky.social · 17/07/2026
Origin and transport of bacterial hopanoids journals.asm.org/doi/10.1128/... #jcampubs
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Reposted by Arkadiy Garber
Molecular Biology and Evolution @molbioevol.bsky.social · 13/07/2026
@ironark.bsky.social et al. measured transcript abundance, ribosome-associated RNA, and protein abundance in bacterial endosymbionts, suggesting a mechanism for aberrant pseudogene-derived protein removal. 🔗 doi.org/10.1093/molbev/msag153 #societyjournal #evobio #molbio
MBE | The transcriptional and translational outcomes for pseudogenes in bacterial endosymbionts
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Reposted by Arkadiy Garber
STCmicrobeblog @stcmicrobeblog.bsky.social · 06/07/2026
ribosomologists take note👇 #MicroSky
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Reposted by Arkadiy Garber
Evgenii Protasov @evgenii-protasov.bsky.social · 05/07/2026
Predicting oxygen levels in microbial habitats using a metagenome-based approach #microbiology #metagenomics #oxygen @asm.org doi.org/10.1128/msys...
doi.org
Predicting oxygen levels in microbial habitats using a metagenome-based approach | mSystems
Oxygen is one of the most important environmental variables affecting microbial activity and composition, but is often difficult to measure in situ. We developed a tool, OxyMetaG, that leverages differences in bacterial gene content across known aerobic and anaerobic taxa to predict the oxygen level of a given sample directly from shotgun metagenomic reads. OxyMetaG works on samples with low sequencing depth and avoids computationally expensive genome assembly, which often captures only a fraction of the microbial community in a given environment. With OxyMetaG, bacteria can be used as bioindicators of oxygen availability over broader time scales than just a single measurement and provide crucial environmental context in cases where oxygen has not been or cannot be measured. OxyMetaG is publicly available and can be used to answer a wide variety of ecological questions in both environmental and host-associated systems.
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Reposted by Arkadiy Garber
The Daily Pub @thedailypub.bsky.social · 04/07/2026
Host Range Breadth Correlates with Genic Diversity in Honeybee Phages.
doi.org
Host Range Breadth Correlates with Genic Diversity in Honeybee Phages.
Published in Genome biology and evolution
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Reposted by Arkadiy Garber
The Daily Pub @thedailypub.bsky.social · 04/07/2026
Evolution and development of innate immune memory.
doi.org
Evolution and development of innate immune memory.
Published in Science immunology
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Reposted by Arkadiy Garber
Nancy Moran @nancy-moran.bsky.social · 02/07/2026
A step forward in discovering Buchnera's key to the aphid's heart, published today! Thanks to Jerry Maeda and other authors--a great team -- and to the helpful reviewers #SymbioSky doi: doi.org/10.1038/s415...
doi.org
A secreted endosymbiont protein essential for colonizing host cells - Nature
SyeA was present in the Buchnera ancestor, is secreted into the host cytoplasm, is homologous to secreted effectors of bacterial pathogens and is essential for Buchnera transmission.
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Reposted by Arkadiy Garber
Mike Jetten @msmjetten.bsky.social · 30/06/2026
New insights into how chalcopyrite mitigates #nitrous oxide emissions from #denitrification www.sciencedirect.com/science/arti...
sciencedirect.com
New insights into how chalcopyrite mitigates nitrous oxide emissions from denitrification
Green infrastructure, particularly bioretention systems, is an effective nature-based system for enhancing nitrogen removal from stormwater. However, …
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Reposted by Arkadiy Garber
Vaughn Cooper @vscooper.micropopbio.org · 29/06/2026
Important results of collab led by ⭐surgeon-microbiologist Ken Urish w/ @dariavantyne.bsky.social @ironark.bsky.social and us: Chronic suppression of a multidrug-resistant Pseudomonas aeruginosa in prosthetic joint infection using personalized bacteriophage treatment www.nature.com/articles/s41...
nature.com
Chronic suppression of a multidrug-resistant Pseudomonas aeruginosa in prosthetic joint infection using personalized bacteriophage treatment - Nature Communications
This work reports the clinical outcomes of bacteriophage therapy for a recalcitrant Pseudomonas aeruginosa periprosthetic joint infection, demonstrating infection control through biofilm disruption an...
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Reposted by Arkadiy Garber
Daan Speth @daanspeth.bsky.social · 26/06/2026
I'm happy to announce the release of GlobDB r232! This version contains 346,233 bacterial and archaeal genomes, based on 26 datasets. More info globdb.org 🦠🖥️🧬
globdb.org
home | GlobDB
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Reposted by Arkadiy Garber
Arkadiy Garber @ironark.bsky.social · 25/06/2026
Advanced access peer-reviewed version: academic.oup.com/mbe/advance-... We transcriptionally and translationally profiled symbionts with thousands of pseudogenes. We show that pseudogenes are not only transcribed, but their transcripts bind ribosomes to attempt translation. What happens next...
academic.oup.com
The transcriptional and translational outcomes for pseudogenes in bacterial endosymbionts
Abstract. Intracellular bacteria in the early stages of host adaptation often show extraordinarily disrupted genomes, where up to half of their ancestral g
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Reposted by Arkadiy Garber
Rauf Salamzade @raufs.bsky.social · 26/06/2026
Microbes that have the greatest genomic potential for secondary metabolism tend to be multicellular. Here, we show that signatures of ancestral BGC expansions within 3 bacterial phyla and 2 fungal lineages coincide with origins of complex multicellularity [1/12] 🧵 www.nature.com/articles/s41...
nature.com
Complex multicellularity is linked with expanded specialized metabolite production in microorganisms - Nature Microbiology
The evolutionary emergence of complex multicellularity in bacteria and fungi, such as the ability for mycelial growth, is strongly associated with increased genomic carriage of biosynthetic machinery ...
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Arkadiy Garber @ironark.bsky.social · 25/06/2026
Advanced access peer-reviewed version: academic.oup.com/mbe/advance-... We transcriptionally and translationally profiled symbionts with thousands of pseudogenes. We show that pseudogenes are not only transcribed, but their transcripts bind ribosomes to attempt translation. What happens next...
academic.oup.com
The transcriptional and translational outcomes for pseudogenes in bacterial endosymbionts
Abstract. Intracellular bacteria in the early stages of host adaptation often show extraordinarily disrupted genomes, where up to half of their ancestral g
042
Reposted by Arkadiy Garber
Cameron Thrash @jcamthrash.bsky.social · 25/06/2026
The transcriptional and translational outcomes for pseudogenes in bacterial endosymbionts academic.oup.com/mbe/advance-... #jcampubs
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Reposted by Arkadiy Garber
The Daily Pub @thedailypub.bsky.social · 24/06/2026
Genomic investigations of Plocamiomonas psychrophila and Dictyochophyceae sp. CCMP2098 reveal organellar genome complexity in Arctic Stramenopiles.
doi.org
Genomic investigations of Plocamiomonas psychrophila and Dictyochophyceae sp. CCMP2098 reveal organellar genome complexity in Arctic Stramenopiles.
Published in Scientific reports
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Reposted by Arkadiy Garber
Asaf Levy @asaflevylab.bsky.social · 21/06/2026
A relatively recent work with cool finding. Many questions remain open. "A complete DNA repair system assembled by two endosymbionts restores heat tolerance of the insect host" www.pnas.org/doi/10.1073/...
pnas.org
A complete DNA repair system assembled by two endosymbionts restores heat tolerance of the insect host | PNAS
DNA repair systems are essential to maintain genome integrity and stability. Some obligate endosymbionts that experience long-term symbiosis with t...
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Reposted by Arkadiy Garber
Nature Microbiology @natmicrobiol.nature.com · 19/06/2026
Out Now! Deep learning reveals antimicrobial peptides within prions #MicroSky
go.nature.com
Deep learning reveals antimicrobial peptides within prions
Nature Microbiology, Published online: 19 June 2026; doi:10.1038/s41564-026-02408-1Deep learning reveals that prion-related proteins contain hidden ‘prionin’ peptides with antibacterial activity, including two candidates that reduced infections in mice.
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Arkadiy Garber @ironark.bsky.social · 16/06/2026
Inspiration from humans and microbes—and maybe a lot of luck: the “discovery” of Shewanella oneidensis MR-1 and extracellular electron transfer (EET) journals.asm.org/doi/pdf/10.1...
journals.asm.org
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Arkadiy Garber @ironark.bsky.social · 14/06/2026
14-year old Felix Mendelssohn wrote this: www.youtube.com/watch?v=lxYA...
youtube.com
F. Mendelssohn - PIANO QUARTET NO. 2 in F Minor, Op. 2 (With Score/Sheet Music)
YouTube video by Baroque Oboema
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Reposted by Arkadiy Garber
Evgenii Protasov @evgenii-protasov.bsky.social · 14/06/2026
Genome-resolved metagenomic survey of 500 samples from 56 hot springs across the Western US #metagenomics #HotSprings #genomes doi.org/10.1038/s415...
doi.org
Genome-resolved metagenomic survey of 500 samples from 56 hot springs across the Western US - Scientific Data
Scientific Data - Genome-resolved metagenomic survey of 500 samples from 56 hot springs across the Western US
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