Innate immune cells sense pathogenic bacteria like Legionella pneumophila through patterns such as the protein flagellin, a critical component of the bacterial motility apparatus. Recognition of cytos...

NLRP3 normally forms a decamer to interact with trans-Golgi network (TGN) and microtubule organization center (MTOC) for inflammasome activation. Here the authors generate an exon 3-deficient NLRP3 to...

Cell type–specific mechanisms modulate Nod-like receptor family pyrin domain containing 3 inflammasome activation in macrophages and neutrophils, shaping i

The non-canonical inflammasome, comprising caspase-4 in humans, initiates pyroptosis upon sensing cytosolic lipopolysaccharide (LPS) from Gram-negativ…