<p>Giant cell arteritis (GCA) is a complex inflammatory disease affecting individuals over 50 suggesting a strong link with aging-related immune and vascular changes. However, the precise mechanisms u...

Objectives Giant cell arteritis (GCA) is a large-vessel vasculitis, potentially causing complications such as blindness and strokes. This study aims to gain insights into the pathogenesis of GCA by ...

A plate-based assay called CRAFTseq has been developed that uses ‘multi-omic’ single-cell RNA sequencing and direct genotyping of&nbsp;CRISPR edits to test the functional effects of genetic variants o...

We show that the X chromosome, understudied in genome-wide association studies, contributes to complex traits in a manner shaped by dosage-compensation mechanisms. We find near-full X inactivation bal...

Nature Reviews Genetics, Published online: 15 May 2025; doi:10.1038/s41576-025-00839-wNew statistical and machine learning techniques to understand, quantify and correct for the impact of biases in genomic data are emerging. The authors review how the choice of analytical methods used to process, analyse and interpret genomic data can influence genomic research, as well as existing methodological approaches to promote equity and fairness in genomics.

Nature Reviews Rheumatology, Published online: 07 February 2025; doi:10.1038/s41584-025-01218-9Garrido-Mesa and Brown review findings from TCR profiling studies in rheumatic diseases and discuss how improved study design might help elicit information…

Nature Reviews Rheumatology, Published online: 05 February 2025; doi:10.1038/s41584-024-01216-3This Review discusses the current evidence for the association between occupational exposures, particularly silica dust and solvents, and the risk of developing…