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BaglaenkoLab @baglaenkolab.bsky.social · 05/02/2026

I recently had the opportunity to present our work at the Variant Effect Seminar Series. See a recording below if you're interesting in learning more about our recently published paper and on-going projects. www.youtube.com/watch?v=LPUV...

youtube.com

Identifying causal variants with CRISPR editing in primary human cells - Yuriy Baglaenko

YouTube video by Variant Effects

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Reposted by BaglaenkoLab

Atlas of Variant Effects Alliance @varianteffect.bsky.social · 28/01/2026

Two #CRISPR talks on Feb3! 1️⃣ Stephan Riesenberg (Group Leader, Max Planck Leipzig): CRISPR-mediated generation of genetic variants for functional analysis. 2️⃣ Yuriy Baglaenko @baglaenkolab.bsky.social: Causal variants with CRISPR editing in primary human cells www.varianteffect.org/seminar-seri...

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Reposted by BaglaenkoLab

Atlas of Variant Effects Alliance @varianteffect.bsky.social · 20/01/2026

Coming up! with Yuriy Baglaenko @baglaenkolab.bsky.social and Stephan Riesenberg @mpi-eva-leipzig.bsky.social Details ℹ️ ➡️ www.varianteffect.org/seminar-seri...

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BaglaenkoLab @baglaenkolab.bsky.social · 12/01/2026

We recently pushed an updated to our protospacer Base editing design tool (baglaenkolab.shinyapps.io/snpGuide/) to allow for genome modification near a variant regardless or transition. If the region is important, so are the nucleotides around it. Hope this helps somebody out.

baglaenkolab.shinyapps.io

snpGuide v0.4

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BaglaenkoLab @baglaenkolab.bsky.social · 23/07/2025

I am very excited to share our publication, out now in Nature, detailing our developed CRAFTseq methodology for capturing and analysing single cell genomic DNA amplicons alongside the transcriptome and cell surface protein expression. www.nature.com/articles/s41...

nature.com

Precisely defining disease variant effects in CRISPR-edited single cells - Nature

A plate-based assay called CRAFTseq has been developed that uses ‘multi-omic’ single-cell RNA sequencing and direct genotyping of CRISPR edits to test the functional effects of genetic variants o...

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BaglaenkoLab @baglaenkolab.bsky.social · 02/06/2025

My lab thinks a lot about CRISPR editing variants of interest in primary human cells. We made a little tool to help. Hopefully, someone else can get some use out of it. baglaenkolab.shinyapps.io/snpGuide/ github.com/ybaglaenko/s...

shiny.io

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