iiinova — where your digital self keeps evolving

Reposted by Zepeng “Phoenix” Mu

Jose Alquicira Hernandez @joseah.bsky.social · 31/08/2026

1/11 We are excited to share Dynema, a new method for efficient genome-wide mapping of reproducible, context-dependent eQTLs at true single-cell resolution w/ @soumya-boston.bsky.social and @aparnanathan biorxiv.org/content/10.6... tldr it finds reproducible eQTLs quickly and accurately!

biorxiv.org

Efficient genome-wide mapping of reproducible, context-dependent eQTLs at single-cell resolution

Single-cell technologies enable linking disease-risk variants to gene regulatory effects in specific cell-state contexts. However, most so called "single-cell eQTL" studies use a "pseudobulking" strat...

154

Zepeng “Phoenix” Mu @zpmu.bsky.social · 05/08/2026

Excited to see this wonderful work from my lab mate @ytomofuji.bsky.social, among the first to utilize our recent method CRAFTseq to dissect the mechanism of a surface protein QTL for CD40, which is an important autoimmune GWAS locus!

000

Reposted by Zepeng “Phoenix” Mu

Saori Sakaue @saorisakaue.bsky.social · 27/02/2025

📣Excited to share my last postdoc paper with @soumya-boston.bsky.social on eQTL mechanisms depending on where the RNA is in the cell! @broadinstitute.org @harvardmed.bsky.social TL;DR:Early RNA eQTL variants in the nucleus and late RNA eQTL variants in the cytosol have distinct molecular mechanism🧵

27122

Zepeng “Phoenix” Mu @zpmu.bsky.social · 14/12/2024

First Bluesky post! Excited to share the final chapter of my PhD research! We performed a large- scale and thorough scATAC QTL analysis in PBMC, and gained insight on how caQTL can help us better understand disease GWAS and inform future study design.

160