iiinova — where your digital self keeps evolving

Reposted by Javi Martínez-López

IPBLN-CSIC @ipblncsic.bsky.social · 30/06/2026

Hoy, en el Instituto de Parasitología y Biomedicina López-Neyra (IPBLN), Carlos de la Rosa Báez ha dado su seminario WIP en inglés. El título ha sido ‘Novel HLA Class I and II insights into the pathogenesis of systemic sclerosis-associated interstitial lung disease’.

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Inmaculada Rodriguez-Martin @inmaculadaroma.bsky.social · 19/05/2026

📢 ¿Sabías que la esclerodermia no afecta igual a hombres y mujeres? Nuestro último estudio publicado en @thelancetrheum.bsky.social analiza estas diferencias clave para entender mejor la enfermedad Si queréis saber más, podéis leer la nota de prensa @csic.es @ipblncsic.bsky.social👇📖

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CSIC @csic.es · 19/05/2026

🏥La #esclerodermia es una #EnfermedadRara que ataca los tejidos 👩‍🦰Afecta más a mujeres, aunque es más grave en hombres 🔬Un estudio del @ipblncsic.bsky.social arroja luz sobre estas diferencias 🔎Revela marcadores genéticos específicos para cada sexo ➡️ f.mtr.cool/qyinfqsttn

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The Lancet Rheumatology @thelancetrheum.bsky.social · 24/04/2026

NEW RESEARCH—Sex-specific autosomal susceptibility loci in systemic sclerosis: a genome-wide association study bit.ly/3OHY4ys Plus, linked Comment bit.ly/4e8AvJK #Medsky #Rheumsky

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IPBLN-CSIC @ipblncsic.bsky.social · 06/04/2026

Ya está disponible en YouTube la entrevista de la Dr. Ana Márquez Ortiz investigadora principal del IPBLN. 🔸Línea de Investigación: Bases moleculares de la arteritis de células gigantes. 👉 Enlace a la entrevista: youtu.be/uwCsVBEJKvE

youtu.be

Entrevista (Interview) | Ana Márquez Ortiz

YouTube video by Inst. de Parasitología y Biomedicina López-Neyra

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IPBLN-CSIC @ipblncsic.bsky.social · 17/03/2026

At today’s WIP Seminar, Gonzalo Borrego-Yaniz ( @goboru.bsky.social ), a PhD candidate from Dr. Ana Márquez’s lab, presented their latest research on giant cell arteritis, a rare inflammatory disease that mainly affects older adults.

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IPBLN-CSIC @ipblncsic.bsky.social · 27/01/2026

This week’s WIP Seminar at the IPBLN was presented by Javi Martínez-López (@javiml221098.bsky.social), a PhD candidate and researcher at IPBLN-CSIC. He shared part of his work on identifying causal genetic variants associated with Systemic Sclerosis, a rare autoimmune disease, using (+)

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IPBLN-CSIC @ipblncsic.bsky.social · 26/01/2026

📅ACTIVIDADES SEMANA → 26-30/01/2026. MARTES 27 WIP de Javier Martínez: ‘Massively Parallel Reporter Assays (MPRA): a systematic approach in functional genomics'. VIERNES 30. Seminario Dr. Juan Ignacio Peruchena: '¿Cómo protegemos los resultados de investigación en el CSIC (Andalucía)?

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CSIC Andalucía @csicandalucia.bsky.social · 28/10/2025

Identifican nuevas claves moleculares que podrían guiar el manejo clínico de la enfermedad de Erdheim–Chester El @ipblncsic.bsky.social marca un punto de inflexión con su estudio de esta enfermedad, analizando y combinando por primera vez datos de metilación del ADN y expresión génica t.ly/MCs11

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Gonzalo Borrego-Yaniz @goboru.bsky.social · 02/10/2025

We’d like to know too… #graphicmedicine #rheumsky #medsky

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Gonzalo Borrego-Yaniz @goboru.bsky.social · 08/09/2025

For the next three months I am doing a stay at the University of Manchester! Prof. Gisela Orozco's lab, in a project working on ATAC-seq and CUT&Tag data. Happy to be here!! 🌸 (also my first time in the UK! 😊) @manchester.ac.uk

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Gonzalo Borrego-Yaniz @goboru.bsky.social · 28/08/2025

New paper just out (online first) in Arthritis & Rheumatology! 🎉 We mapped the epigenetic changes (DNA methylation) in GCA-affected arteries. Largest cohort to date; findings point to new pathways relevant to disease mechanisms 🧵 Read: doi.org/10.1002/art.... cc @ipblncsic.bsky.social

doi.org

Genome‐wide DNA methylation study reveals specific signatures in the affected arterial tissue of giant cell arteritis patients

Objectives Giant cell arteritis (GCA) is a large-vessel vasculitis, potentially causing complications such as blindness and strokes. This study aims to gain insights into the pathogenesis of GCA by ...

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Javi Martínez-López @javiml221098.bsky.social · 08/08/2025

To be part of the 19th SSc Workshop in Cambridge was an amazing experience! It was a privilege to have had the opportunity to give a talk about massively parallel reporter assays (MPRAs). And with that… it’s summer time! 🌞✨

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Inmaculada Rodriguez-Martin @inmaculadaroma.bsky.social · 31/07/2025

These past days I had the amazing opportunity to attend the International Workshop on Scleroderma Research in Cambridge. Thanks to the SCTC for awarding me with a Workshop Travel Award 🙌🏻

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Javi Martínez-López @javiml221098.bsky.social · 29/07/2025

If you want some immune cells for your slides, here’s what you’re looking for🙌🏻

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Carl de Boer @carldeboer.bsky.social · 11/07/2025

SOOOO MANY GENOMICS MODELSSSS! 😱 Often unclear which is best since they benchmark differently! In this preprint, we introduce GAME, a new framework that utilizes APIs to enable sustainable, uniform model evaluation so we can see which is actually best for each task. doi.org/10.1101/2025...

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Javi Martínez-López @javiml221098.bsky.social · 16/06/2025

EULAR2025 has come to an end! I learned a lot, met amazing people, and had a great time with @goboru.bsky.social and @lauramg22.bsky.social. Really enjoyed it! ✨✨

A photo of me with the poster I presented about the association of C4 copy number variation in systemic sclerosis subtypes.

A selfie of Laura, Gonzalo and me (left to right) in the EULAR2025 photocall.

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Gonzalo Borrego-Yaniz @goboru.bsky.social · 14/06/2025

Last day of EULAR! Here's a thread 🧵 of my (very personal) takeaways from #EULAR2025 on giant cell arteritis (GCA)! Keep in mind that as someone focused on basic research, my EULAR schedule was definitely biased in that direction #GCA #rheumsky

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Javi Martínez-López @javiml221098.bsky.social · 10/06/2025

Great presentation by my lab mate @inmaculadaroma.bsky.social ✨ Sex-aware science is something to stand strong for ✊

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IPBLN-CSIC @ipblncsic.bsky.social · 10/06/2025

🎓 En el #WIPSeminar de hoy, Inma ha explicado los resultados preliminares de su investigación acerca del perfil genético con enfoque de sexo que revela la relevancia de IL12RB2 como un locus específico en mujeres en la #EsclerosisSistemica 🧬

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Gonzalo Borrego-Yaniz @goboru.bsky.social · 06/06/2025

One thing still missing in many GWAS pipelines: chrX analysis... In this study from @ajhgnews.bsky.social, Mefford et al. explore X-GWAS across 48 UKBB traits and as expected, ~3% of trait heritability comes from chrX. Looks like it’s time we start doing this! www.cell.com/ajhg/fulltex...

cell.com

Role of X chromosome and dosage-compensation mechanisms in complex trait genetics

We show that the X chromosome, understudied in genome-wide association studies, contributes to complex traits in a manner shaped by dosage-compensation mechanisms. We find near-full X inactivation bal...

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Gonzalo Borrego-Yaniz @goboru.bsky.social · 28/05/2025

Excited to share that our abstract for #EULAR was selected as one of the Top 10 Abstracts at EULAR 2025 by EMEUNET! 🙌🥰 Huge thanks to the committee, I’m truly honored! Hope to see you in Barcelona! #EMEUNET #EULAR2025

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Nature Reviews Disease Primers @natrevdiseaseprimers.nature.com · 30/04/2025

Today marks #WorldImmunologyDay 2025: The immune system and your brain. Multiple system atrophy is a rare synucleinopathy that affects the nigrostriatal system, pons, cerebellum, inferior olives, brainstem and spinal cord. Learn more: www.nature.c...

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Joaquin Dopazo @xdopazo.bsky.social · 25/04/2025

Happy to see our paper on "The Spanish Polygenic Score reference distribution: a resource for personalized medicine" out nature.com/articles/s41... this is a collaborative effort of the CIBERER, Navarrabiomed and other groups across Spain @ibis-investigacion.bsky.social

nature.com

The Spanish Polygenic Score reference distribution: a resource for personalized medicine - European Journal of Human Genetics

European Journal of Human Genetics - The Spanish Polygenic Score reference distribution: a resource for personalized medicine

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Sociedad Española de Bioquímica y Biología Molecular (SEBBM) @sebbm.bsky.social · 24/04/2025

¿Conoces #HuMicA! 🌟 Investiga el papel de la microglía en enfermedades neurodegenerativas y su potencial terapéutico. Te lo cuentan sus autores en #RevistaSEBBM f.mtr.cool/stowmipiea

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ACR Journals @acr-journals.bsky.social · 01/04/2025

In This Issue: •Epigenetic myeloid dysregulation in SSc •Incidence of JIA increases with latitude in Norway cohort •FoxO1 deficiency in M-MDSCs exacerbates B cell dysfunction in SLE •Journal Club: Body pain diagram to describe nonarticular pain evolution in 1st year of RA dx acr.tw/4hLtPzi #Medsky

April Arthritis & Rheumatology In This Issue & Journal Club banner

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Gonzalo Borrego-Yaniz @goboru.bsky.social · 27/03/2025

Good news! I will be presenting at EULAR 25 our new work about the genetics of GCA-related clinical manifestations ✨

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IPBLN-CSIC @ipblncsic.bsky.social · 25/03/2025

🎓En el WIP de hoy, nuestra compañera, la doctora Miriam Cerván ha explicado sus últimos resultados del análisis del perfil molecular de la enfermedad de #ErdheimChester a partir de la integración del #metiloma y el #transcriptoma de pacientes🧬

wip seminar IPBLN Erdheim Chester Disease

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IPBLN-CSIC @ipblncsic.bsky.social · 24/03/2025

📢 ESTA SEMANA EN EL IPBLN: #WIPSeminar de Miriam Cerván Martín: ‘Unraveling the Molecular Landscape of Erdheim-Chester Disease: New insights from Methylome and Transcriptome Integration’ 📅 Martes 25 de marzo 🕙 10:00h

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Altmetric @altmetric.com · 13/03/2025

Mike spotted this before the rest of us. 🫡 Publications from 2025 are shared more on Bluesky than on X/Twitter.

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Gonzalo Borrego-Yaniz @goboru.bsky.social · 21/02/2025

This month's cover in @science.org by Adam Simpson #CoverArtGallery

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Javi Martínez-López @javiml221098.bsky.social · 21/02/2025

A great example to start this section is Mal-ID (MAchine Learning for Immunological Diagnosis). A cool acronym for the method presented in this paper that uses machine learning to predict disease status from BCR & TCR repertoires. A great name for an impressive work! www.science.org/doi/10.1126/...

science.org

Disease diagnostics using machine learning of B cell and T cell receptor sequences

Clinical diagnosis typically incorporates physical examination, patient history, various laboratory tests, and imaging studies but makes limited use of the human immune system’s own record of antigen ...

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Javi Martínez-López @javiml221098.bsky.social · 21/02/2025

Bioinformatics tools often have odd names—some are straightforward acronyms (e.g., BLAST: 'Basic Local Alignment Search Tool'), while others creatively pick letters to form unique names. I’ll be sharing some of the more interesting and fun ones I come across here! 🖥️✨

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Gonzalo Borrego-Yaniz @goboru.bsky.social · 13/02/2025

I used to compete all the time and I think I only won once 😂 But it was worth it for the extra motivation to polish those plots 🔝

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Javi Martínez-López @javiml221098.bsky.social · 13/02/2025

A few years ago, we started a fun 'Plot of the Month' competition. Each member made a plot with their data and shared the code to learn ggplot2 together. At the end of the month, we’d vote for the best one, and the winner kept a cute trophy for the next month. It made plotting way more fun!

The plot of the month trophy, impressed by a 3D printer and cute googly eyes

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Javi Martínez-López @javiml221098.bsky.social · 13/02/2025

The academic world can be intense and stressful, sometimes leading to friction among colleagues. That’s why it’s so important to plan fun activities that bring the team together and create a positive vibe. I’ll share what we do in our lab and encourage you to share yours in the comments! 🧶🪡

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Gonzalo Borrego-Yaniz @goboru.bsky.social · 13/02/2025

Today, we kicked off our Data Club at the lab! Taking the time to share our data journey with colleagues is so valuable, a great reminder that we all have something to teach and learn! Our first meeting has been about pathway enrichment analysis tips and tools ✨

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Javi Martínez-López @javiml221098.bsky.social · 11/02/2025

¡Feliz #DíaMujeryNiñaCiencia #11F a todas! Por una ciencia igualitaria y universal 💜

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Gonzalo Borrego-Yaniz @goboru.bsky.social · 07/02/2025

Appropiate for your fierce revisions 😂

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Javi Martínez-López @javiml221098.bsky.social · 07/02/2025

Shoutout to @goboru.bsky.social for this cutie! My correcting pen has never looked better! 😅😂

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Javi Martínez-López @javiml221098.bsky.social · 04/02/2025

Recently, both Science Immunology (@science.org) and @natimmunol.bsky.social have highlighted the relevance of the aging in the immune system in their covers. It's great to see this topic getting attention, and the artwork is absolutely stunning! Two of the most beautiful covers I've seen so far!✨

Online cover of the Science Immunology issue dated January 2025.
https://www.science.org/toc/sciimmunol/10/103

Online cover of the Nature Immunology volume 26, issue 2 dated February 2025.
https://www.nature.com/ni/volumes/26/issues/2

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The Struggling Scientists @thestrugglings4.bsky.social · 02/02/2025

"They don't come and throw money at you" -Martin Chalfie In this episode, we talk with Nobel prize laureate Martin Chalfie about how his life changed after winning a Nobel prize Listen here www.youtube.com/watch?v=nA1D...

youtube.com

Life After Winning a Nobel Prize. with Prof Martin Chalfie Nobel Prize Laureate for GFP

YouTube video by The Struggling Scientists

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Gonzalo Borrego-Yaniz @goboru.bsky.social · 31/01/2025

New paper 🚨 What can COVID-19 teach us about systemic sclerosis (SSc)? 🤔 In our newly accepted paper in Rheumatology(Oxford) we explored the shared genetic component between COVID-19 and SSc to better understand their immune mechanisms and lung involvement 🧵👇 academic.oup.com/rheumatology...

academic.oup.com

Cross-trait GWAS in COVID-19 and systemic sclerosis reveals novel genes implicated in fibrotic and inflammation pathways

AbstractObjectives. COVID-19 and systemic sclerosis (SSc) share multiple similarities in their clinical manifestations, alterations in immune response, and

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Javi Martínez-López @javiml221098.bsky.social · 30/01/2025

Reproducibility and validation are vital in science. Nice to see that hundreds of years later the Earth is still round 🤷🏻‍♂️👏🏻

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Gonzalo Borrego-Yaniz @goboru.bsky.social · 30/01/2025

It might take us some time to get a clear mental picture of the nuances of gene expression #omics #doodle

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