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Hugh Selway-Clarke

@hughselwayclarke.bsky.social
297 followers 177 following 22 posts

Postdoc making computational models of radiotherapy resistance and copy number evolution with Ben O'Leary and Trevor Graham at the ICR in London. PhD with Sam Janes, Adam Pennycuick and Anob Chakrabarti at UCL. Background in maths at Cambridge. He/him.

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Reposted by Hugh Selway-Clarke
Maria Secrier @mariasecrier.bsky.social · 05/08/2026
Interested in using AI, computational genomics and single-cell/spatial omics to tackle breast cancer dormancy and late recurrence? Join our team and work in collaboration with @magnanilab.bsky.social at ICR on an exciting interdisciplinary postdoc project: www.ucl.ac.uk/work-at-ucl/...
ucl.ac.uk
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
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Reposted by Hugh Selway-Clarke
Debbie Caswell @caswelldrm.bsky.social · 11/03/2026
Our lab is hiring! Please come join our lab in the department of @UCLRespiratory in @uclmedsci.bsky.social We have another fully funded postdoctoral position available, focusing on delineating the earliest stages of lung cancer development 🧪! Please apply using the link below: lnkd.in/gN4UK785
lnkd.in
LinkedIn
This link will take you to a page that’s not on LinkedIn
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Reposted by Hugh Selway-Clarke
Trevor Graham @trevorgraham.bsky.social · 24/02/2026
🔥🔥🔥💥💥💥🌶️🌶️🌶️ Hottest new lab in town, led by the exceptional @calumgabbutt.bsky.social, is recruiting it's first #PhD student. If you love #maths and somatic #evolution it could be your dream come true! 🌶️🌶️🌶️💥💥💥🔥🔥🔥
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Reposted by Hugh Selway-Clarke
Calum Gabbutt @calumgabbutt.bsky.social · 13/02/2026
If you’re interested in machine learning and mathematical modelling, we’re recruiting a PhD student to develop new methods for studying cancer evolution at @imperialimmuno.bsky.social www.findaphd.com/phds/project...
findaphd.com
Developing machine learning methods to infer the evolution of haematological cancers at Imperial College London on FindAPhD.com
PhD Project - Developing machine learning methods to infer the evolution of haematological cancers at Imperial College London, listed on FindAPhD.com
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Reposted by Hugh Selway-Clarke
Our World in Data @ourworldindata.org · 20/01/2026
Check out this very interesting tool from Giving What We Can that relies on our data!
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Reposted by Hugh Selway-Clarke
Trevor Graham @trevorgraham.bsky.social · 19/01/2026
Open postdoc position in our lab @icr.ac.uk to develop a cfDNA test for #early detection of colorectal #cancer in inflammatory bowel disease #IBD: jobs.icr.ac.uk/vacancies/14... It's bench-to-bedside research, translating biology of pre-cancer evolution. Funded by @bowelcanceruk.bsky.social
jobs.icr.ac.uk
Postdoctoral Training Fellow - Genomics and Evolutionary Dynimcs in Sutton | The Institute of Cancer Research
View details and apply for this Postdoctoral Training Fellow - Genomics and Evolutionary Dynimcs vacancy in Sutton. Salary: Dependent on relevant Postdoctoral experience. Durati...
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Reposted by Hugh Selway-Clarke
Calum Gabbutt @calumgabbutt.bsky.social · 10/09/2025
Cancer is an evolutionary disease, but does knowing a cancer’s evolutionary past help predict its future? Out today in @nature, we learnt the evolution of 2000 lymphoid cancers and found it was highly correlated with clinical outcomes! (1/7) rdcu.be/eFrrc
rdcu.be
Fluctuating DNA methylation tracks cancer evolution at clinical scale
Nature - Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.
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Reposted by Hugh Selway-Clarke
Trevor Graham @trevorgraham.bsky.social · 10/09/2025
Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...
nature.com
Fluctuating DNA methylation tracks cancer evolution at clinical scale - Nature
Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.
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Hugh Selway-Clarke @hughselwayclarke.bsky.social · 03/09/2025
My main PhD project is now up on bioRxiv! If you’re interested in somatic evolution or machine learning for simulation-based inference, read on…
 doi.org/10.1101/2025... [1/15]
doi.org
Recovery of human upper airway epithelium after smoking cessation is driven by a slow-cycling stem cell population and immune surveillance
The upper airway epithelium in humans is maintained in homeostasis by a resident population of basal stem cells. In the presence of tobacco smoke these gain mutations that significantly increase their...
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Reposted by Hugh Selway-Clarke
Charlotte Capitanchik @tinycaptain.bsky.social · 02/09/2025
Had such a great time at #Londonomics2025 today - excellent talks and discussions - thank you to everyone who came along and shared their ideas with us.
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Reposted by Hugh Selway-Clarke
James Reading @jamesreading.bsky.social · 05/08/2025
🚨 PhD Position available in our lab 🚨 exploring the power of blood immune multi-omics to detect lung cancer years prior to clinical diagnosis in a unique cohort of >10,000 CT screened individuals. ✅ Wet & dry lab ✅ September 2025 enrolment ✅ UK tuition fees only www.ucl.ac.uk/medical-scie...
ucl.ac.uk
Pre-Cancer Immunology
The Pre-Cancer Immunology Lab (James Reading Lab) is mapping pre-invasive T cell dynamics during carcinogenesis to detect and intercept cancer development.
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Hugh Selway-Clarke @hughselwayclarke.bsky.social · 29/07/2025
📣📣 Another Londonomics Symposium! 📣📣 Last year was a great mix of computational biologists from biology, maths and computing backgrounds - I enjoyed it so much I joined the organising committee! Excited to meet people and talk cool science (including AlphaGenome, keynote from @avsecz.bsky.social!)
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Hugh Selway-Clarke @hughselwayclarke.bsky.social · 26/07/2025
A day @ewanbirney.bsky.social posts a thread of "some musings" is a good day - I haven't (yet!) used MR in anger but this is a great checklist for how to do it properly.
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Reposted by Hugh Selway-Clarke
Sophie de Carné (she/her) @sdecarne.bsky.social · 22/07/2025
Writing is thinking. A reminder on why scientists write, and why we should continue writing in the era of large-language models by Nature Review Bioengineering @natureportfolio.nature.com www.nature.com/articles/s44... #AI #LLM 🧪
nature.com
Writing is thinking - Nature Reviews Bioengineering
On the value of human-generated scientific writing in the age of large-language models.
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Hugh Selway-Clarke @hughselwayclarke.bsky.social · 02/05/2025
Great to see this work from @sandra-gl.bsky.social published yesterday, using mouse models to dig into the early stages of lung squamous cell carcinoma. Beautiful work on an important disease, congratulations to all involved!
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Reposted by Hugh Selway-Clarke
lungs4living.bsky.social @lungs4living.bsky.social · 26/03/2025
Congratulation to the SUMMIT team on our publication in Lancet Oncology today: Low-dose CT for lung cancer screening in a high-risk population (SUMMIT): a prospective, longitudinal cohort study. authors.elsevier.com/sd/article/S...
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Nature Reviews Cancer @natrevcancer.nature.com · 03/03/2025
While progress has been made in treating #NSCLC, patients would further benefit from earlier detection & effective interception. Here, Spira and colleagues explore advances in identifying premalignant lesions, and devise approaches for stratification + interventions. bit.ly/3QE86...
bit.ly
Translating premalignant biology to accelerate non-small-cell lung cancer interception - Nature Reviews Cancer
While progress has been made in treating advanced non-small-cell lung cancer, patients would further benefit from methods that detect progressive premalignant lesions and strategies that effectively intercept progression. In this Review, Mazzilli et al. explore recent advances in identifying...
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Reposted by Hugh Selway-Clarke
Bobby Bentham @rbentham.bsky.social · 18/02/2025
🚀 Our paper introducing ImmuneLENS, a new tool that measures T and B cell fractions from WGS data. This builds on our previous method, T cell ExTRECT, that used a signal from V(D)J recombination to measure T cells. Out today in @naturegenet.bsky.social : doi.org/10.1038/s41588-025-02086-5 🧵👇
nature.com
ImmuneLENS characterizes systemic immune dysregulation in aging and cancer - Nature Genetics
Immune lymphocyte estimation from nucleotide sequencing (ImmuneLENS) infers B cell and T cell fractions from whole-genome sequencing data. Applied to the 100,000 Genomes Project datasets, circulating ...
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Reposted by Hugh Selway-Clarke
Ewan Birney @ewanbirney.bsky.social · 01/02/2025
Some musing this grey Saturday morning on one of my evergreen topics - the progress in rare disease diagnosis and treatments. TL;DR the world keeps making steady progress in diagnosing and then improving - sometimes to the point of a cure - rare disease. The rate of both will only increase.
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Hugh Selway-Clarke @hughselwayclarke.bsky.social · 30/01/2025
This is brilliant science: an understanding of the basic biology of early cancer evolution through chromosomal instability, followed through to a new, cheap biomarker that can hopefully start to improve the lives of people with ulcerative colitis+low-grade dysplasia and catch more cancers early!
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