High-depth sequencing of non-cancerous tissue from patients with metastatic cancer reveals single-base mutational signatures of alcohol, smoking and cancer treatments, and reveals how exogenous factors, including cancer therapies, affect somatic cell evolution.

Abstract. Inhibitors of the oncogene KRAS hold promise for treating metastatic CRC (mCRC). Here we show that a selective, covalent small molecule inhibitor of the active (ON) conformation of RAS-G12D,...

Les pathologies cancéreuses sont mieux combattues. Les récentes découvertes liées à l’immunothérapie viennent s’ajouter aux thérapies ciblées et géniques. Mais des questions se...

L’excellence de Gustave Roussy est une nouvelle fois reconnue par le magazine américain Newsweek, qui a classé l’Institut 1er centre de lutte contre le cancer en France et en Europe, et parmi les meil...

Pioneering research in lung cancer to improve diagnosis, treatment and prevention

YouTube video by Francis Crick Institute

On the value of human-generated scientific writing in the age of large-language models.

Using pancreatic organoids and genetic mouse models, Antonucci et al. show that cellular stress activates an NRF2–EZH2 epigenetic axis leading to metabolic reprogramming and subsequent malignant trans...

Depuis 2022, le Paris Saclay Cancer Cluster porte le projet de faire de cette zone un fer de lance français de la recherche et du développement industriel en oncologie. Les premiers bâtiments ont comm...

Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related condition associated with increased mortality among patients with cancer. CHIP mutations with high variant-allele frequencie...

Cancer is increasingly prevalent worldwide, often coexisting with type 2 diabetes (T2D). Recent breakthroughs reveal the immune system’s pivotal role in eliminating tumors and how the metabolic enviro...

Jailed for killing her children, freed by advances in genomics - Kathleen Folbigg joins experts to explore what can be learnt from her case.

But public-health specialists worry that misinformation and funding cuts could affect vaccination rates.

Conflict zones are plagued by air pollution from warfare-related activities, which exacerbates public health challenges, especially for vulnerable populations and the environments they live in.

L'Université Paris-Saclay, extrêmement préoccupée par les décisions de la nouvelle administration étasunienne, et notamment celles ayant trait à la science, la recherche et à la liberté académique, pi...

La recherche de nouveaux traitements et de meilleurs outils de dépistage du cancer du pancréas s’est largement accélérée. Des avancées concr

As Editors-in-Chief of The Company of Biologists' journals, we have been watching with growing concern the policy changes in the United States of America (USA) and the challenges that these are creati...