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Bobby Bentham

@rbentham.bsky.social
54 followers 77 following 10 posts

Senior Bioinformatician @ LifeArc

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Reposted by Bobby Bentham
Eric Topol @erictopol.bsky.social · 18/02/2025
Using whole genome sequencing to derive circulating T cell fraction, an immune system metric that has prognostic importance for cancer. And B cell fraction for risk of cancer. www.nature.com/articles/s41...
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Bobby Bentham @rbentham.bsky.social · 18/02/2025
www.ucl.ac.uk/news/2025/fe...
ucl.ac.uk
New tool reveals disruption of immune cells in blood is linked to cancer outcomes
The immune systems of cancer patients are highly disrupted, with those who have a higher number of immune cells in their blood having a better survival rate, finds a new study that uses a pioneering t...
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Bobby Bentham @rbentham.bsky.social · 18/02/2025
🚀 Our paper introducing ImmuneLENS, a new tool that measures T and B cell fractions from WGS data. This builds on our previous method, T cell ExTRECT, that used a signal from V(D)J recombination to measure T cells. Out today in @naturegenet.bsky.social : doi.org/10.1038/s41588-025-02086-5 🧵👇
nature.com
ImmuneLENS characterizes systemic immune dysregulation in aging and cancer - Nature Genetics
Immune lymphocyte estimation from nucleotide sequencing (ImmuneLENS) infers B cell and T cell fractions from whole-genome sequencing data. Applied to the 100,000 Genomes Project datasets, circulating ...
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