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Hayley Bounds

@hayleybounds.bsky.social
244 followers 318 following 17 posts

Systems/computational neuroscience postdoc @ UCL in Carandini & Harris lab. Schmidt Science Fellow. Formerly Adesnik lab @ UC Berkeley.

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Reposted by Hayley Bounds
Enny van Beest @ennyvb.bsky.social · 04/09/2026
Textbook: tracking position during navigation is primarily the job of the hippocampus. Recent findings suggest a more complicated story. Recording >20k neurons brainwide, we indeed find spatial representations in every region! With @kenneth-harris.bsky.social and @carandinilab.net
Brainwide representations of a virtual corridor
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Ian Oldenburg @ianoldenburg.bsky.social · 30/06/2026
Really excited to share our new preprint. Here we use our holographic optogenetics to ask a key question about how neurons need to fire to drive movements. We find a bunch of interesting things about what does, and doesn't drive movements. Brief summary below www.biorxiv.org/content/10.6...
biorxiv.org
The Importance of Synchrony in the Neural Control of Movement
Throughout the mammalian cortex, populations of neurons must work together to enact behaviors. While population recordings in motor cortex have revealed many aspects of when neurons fire during behavi...
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Carsen Stringer @computingnature.bsky.social · 12/02/2026
🔬🧠 Releasing the 1.0 version of #Suite2p and THE PAPER w/ @marius10p.bsky.social! Now with GPU acceleration. Want to use Suite2p but don’t have 100,000 neuron recordings? We show you how to get those with a standard 2p microscope #neuroscience #imaging #neuroAI www.biorxiv.org/content/10.6...
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Hayley Bounds @hayleybounds.bsky.social · 27/01/2026
Really interesting work on sequential activity in the odor system!
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Robert Reich @rbreich.bsky.social · 24/01/2026
Democrats in the Senate must grow a spine. They can rein in this murderous regime next week. Why on Earth would they continue to fund this tyranny? Call your senators now: indivisible.org/campaigns/ho...
indivisible.org
How to Rein in ICE–NOW | Indivisible
Act now with Indivisible to demand Congress rein in ICE, end aggressive enforcement, restrict ICE and Border Patrol funding, and protect communities.
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Karla Kaun @karlakaun.bsky.social · 15/01/2026
It's difficult to know how motivated a fly is, and how motivated behaviors change with experience. To do this, we've been developing new ways to measure operant learning in flies, as described in our new Open-LA paper below.
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Reposted by Hayley Bounds
Matteo Carandini @carandinilab.net · 22/12/2025
Sequences are everywhere! In every brain region. And are written in stone. Invariant Activity Sequences Across the Mouse Brain. Out today, by Célian Bimbard, with @kenneth-harris.bsky.social. Based on data by Célian and by @intlbrainlab.bsky.social. www.biorxiv.org/content/10.6...
Examples of sequences of activity seen in multiple regions of the brain
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The Transmitter @thetransmitter.bsky.social · 14/01/2026
Most iPSC lines come from European donors. Now, two teams in Africa are studying neurodevelopment and neurodegeneration using iPSCs and organoids from African donors. By Lauren Schenkman www.thetransmitter.org/cellular-neu...
thetransmitter.org
Bringing African ancestry into cellular neuroscience
Two independent teams in Africa are developing stem cell lines and organoids from local populations to explore neurodevelopmental and neurodegenerative conditions.
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Jeff Johnston @wjj.bsky.social · 09/01/2026
By the way, if you’re interested in working together on problems like this, I’m starting my lab at UCSF this summer. Get in touch if you’re interested in doing a postdoc! More info here: wj2.github.io/postdoc_ad (7/7)
wj2.github.io
W. Jeffrey Johnston - Postdoctoral position ad
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Jeff Johnston @wjj.bsky.social · 09/01/2026
When and why do modular representations emerge in neural networks? @stefanofusi.bsky.social and I posted a preprint answering this question last year, and now it has been extensively revised, refocused, and generalized. Read more here: doi.org/10.1101/2024... (1/7)
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Mark Histed @markhisted.org · 15/12/2025
Caleb Watney of IFP talking about why academia and science sucks. Broken record here, but we can’t have this discussion without talking about agendas and conflicts of interest. IFP is funded by tech and rightwing billionaires who want to privatize science. 1/
Caleb Watney @calebwatney
NSF is launching one of the most ambitious experiments in federal science funding in 75 years.
The program is called Tech Labs, and the goal is to invest ~$1 billion to seed new institutions of science and technology for the 21st century.
Instead of funding projects, the NSF will fund teams. I'm in the @WSJ today with a piece on why this matters (gift link): wsj.com/opinion/ scienc...
Here's the basic case:
1) Most federal science funding takes the form of small, incremental, project-based grants to individual scientists at universities.
2) The typical NSF grant is ~ $250k/year to a professor with a couple of grad students and modest equipment over a few years. This is a
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Mark Histed @markhisted.org · 10/10/2025
"pattern completion circuits in lower cortical areas may reinforce activity patterns that match prior expectations..." Yes. That's active filtering. Sensory cortical recurrent networks learn the structure of the sensory world. New paper from Shin, Adesnik et al. 🧠🤖🧪
nature.com
Recurrent pattern completion drives the neocortical representation of sensory inference
Nature Neuroscience - Neurons that respond emergently to illusory contours drive pattern completion in V1. Pattern completion in lower cortical areas may therefore mediate perceptual inference by...
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Qingqing Zhang @qqzhang.bsky.social · 22/09/2025
Does predictive coding work in SPACE or in TIME? Most neuroscientists assume TIME, i.e. neurons predict their future sensory inputs. We show that in visual cortex predictive coding actually works across SPACE, just like the original Rao+Ballard theory #neuroscience www.biorxiv.org/cgi/content/...
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Matteo Carandini @carandinilab.net · 03/09/2025
The two key studies of the International Brain Laboratory @intlbrainlab.bsky.social are out today! A brain-wide map of neural activity during complex behaviour www.nature.com/articles/s41... Brain-wide representations of prior information in mouse decision-making www.nature.com/articles/s41...
nature.com
A brain-wide map of neural activity during complex behaviour - Nature
The International Brain Laboratory presents a brain-wide electrophysiological map obtained from pooling data from 12 laboratories that performed the same standardized perceptual decision-making task i...
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Sandra Romero Pinto @sromeropinto.bsky.social · 13/08/2025
My first paper with @naoshigeuchida.bsky.social is finally out in @natcomms.nature.com ! rdcu.be/eACGf TL;DR: asymmetric learning rates can be induced by shifts in tonic dopamine giving rise to pessimistic/optimistic biases in agents or animals undergoing reinforcement learning .
rdcu.be
Tonic dopamine and biases in value learning linked through a biologically inspired reinforcement learning model
Nature Communications - Accurate future predictions are essential for guiding behavior, and disruptions in this process are associated with psychiatric disorders. Here the authors show that changes...
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Mora Ogando @moraogando.bsky.social · 05/08/2025
Thrilled to share our new Adesnik lab paper!! Using holography in excitatory & inhibitory neurons, we reveal how a single cortical circuit can both complete and cancel predictable sensory activity, sharpening representations 📄https://www.biorxiv.org/content/10.1101/2025.08.02.668307v1 🧵
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carolinehaimerl.bsky.social @carolinehaimerl.bsky.social · 29/07/2025
When neurons change, but behavior doesn’t: Excitability changes driving representational drift New preprint of work with Christian Machens: www.biorxiv.org/content/10.1...
biorxiv.org
Representational drift without synaptic plasticity
Neural computations support stable behavior despite relying on many dynamically changing biological processes. One such process is representational drift (RD), in which neurons' responses change over ...
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Dr Nick @nmwilkinson.eurosky.social · 02/08/2025
Oh! Seems like a big deal, this. Makes sense too. Like, how would the rest of the brain know which neurons to sample, and if it did already know what the stimulus is, then it wouldn't need those neurons' signals to classify it.
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Hayley Bounds @hayleybounds.bsky.social · 01/08/2025
Thanks to @thetransmitter.bsky.social and @ldattaro.bsky.social for this coverage of our recent paper!
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Mark Histed @markhisted.org · 24/07/2025
This is a simplistic but commonly-held view about how science actually works. Doing rigorous& impactful science often means ignoring (some) null results. Intermediate results, null and positive, arise on the way to a publishable contribution, and not all are perfectly rigorous.🧪#neuroscience 1/
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Matteo Carandini @carandinilab.net · 18/07/2025
A new study led by @timothysit.bsky.social reveals that different layers of mouse V1 integrate visual and non-visual signals differently. Activity is dominated by vision (or spontaneous fluctuations) in L2/3 and by movement in L5. This leads to different geometries. www.biorxiv.org/content/10.1...
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Grace Lindsay @neurograce.bsky.social · 07/07/2025
Reminder that we still have time to fight this! This bill is being crafted & debated in the coming days and weeks. Organize NOW to do outreach and get people in your neighborhood contacting their reps. @standupforscience.bsky.social has resources. Instructions for Postcards-for-Science are here:
docs.google.com
Postcards for Science Instructions
Postcard Drive Instructions The main goals for this outreach are: A.) Get individuals to contact their Senators to support funding for NIH, NSF, NOAA, and NASA. B.) Get the public to (continue to) ...
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talia jane @taliajane.bsky.social · 21/06/2025
Mahmoud Khalil is free.
a still of mahmoud khalil as he exited ice detention. he’s wearing a long sleeve khaki button up and a white and black keffiyeh wrapped around his neck. he’s got a big smile on his face and his fist raise in the air, defiant and proud.
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Maggie Astor @maggieastor.bsky.social · 18/06/2025
Breaking: The Trevor Project received a stop-work order last night on its contract with the national 988 suicide prevention hotline. The Trump administration is eliminating the option for LGBTQ callers to the hotline to press 3 and connect with someone who specializes in LGBTQ mental health.
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Matteo Carandini @carandinilab.net · 09/06/2025
The firing of neural populations is high-dim even if their subthreshold activity is low-dim! This work by @bio-emergent.bsky.social and @haydari.bsky.social shows how, with a solvable model, a data analysis technique, and data from mouse visual cortex: www.biorxiv.org/content/10.1...
biorxiv.org
High-dimensional neuronal activity from low-dimensional latent dynamics: a solvable model
Computation in recurrent networks of neurons has been hypothesized to occur at the level of low-dimensional latent dynamics, both in artificial systems and in the brain. This hypothesis seems at odds ...
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Reposted by Hayley Bounds
Aaron Milstein @neurosutras.bsky.social · 27/05/2025
New #NeuroAI #compneurosky preprint! To better understand how target-directed learning works in the brain, we sought to engineer an artificial neural network capable of solving complex image classification tasks that comprises only experimentally-supported biological building blocks. (1/15)
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Pailin Chiaranunt @phagocyticpai.bsky.social · 24/05/2025
We're now appreciating how the immune and nervous systems communicate across body & brain, and there's still more to explore! Had a fun time co-writing this with some amazing immunologists and neuroscientists @nickmroz.bsky.social @arimolofskylab.bsky.social @annamolofskylab.bsky.social 😎🧠
science.org
Cross-regulation between the nervous system and type 2 immunity
The nervous and type 2 immune systems regulate each other via cytokines and neurotransmitters, suggesting previously unidentified therapeutic avenues.
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Qihong (Q) Lu @qlu.bsky.social · 08/05/2025
I’m thrilled to announce that I will start as a presidential assistant professor in Neuroscience at the City U of Hong Kong in Jan 2026! I have RA, PhD, and postdoc positions available! Come work with me on neural network models + experiments on human memory! RT appreciated! (1/5)
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Shahab Bakhtiari @shahabbakht.bsky.social · 17/05/2025
These very cool findings match up perfectly with our human psychophysics data from this paper: jov.arvojournals.org/article.aspx... Brains are fine using dumb (aka suboptimal) strategies when they can get away with it.
jov.arvojournals.org
Asymmetric stimulus representations bias visual perceptual learning | JOV | ARVO Journals
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Hayley Bounds @hayleybounds.bsky.social · 15/05/2025
Excited to share my PhD paper! In it, we use targeted 2-photon optogenetic stimulation to determine how V1 activity is read-out in a detection task. We found that network influence, not visual coding properties, predicted the impact of ensembles on behavior - contradicting our expectations (1/5).
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Phie Jacobs @phiejacobs.bsky.social · 07/05/2025
The Deaf Scientists Pipeline in Rochester, NY offers support for students and researchers from high school to postdoctoral levels. Now, due to NIH funding cuts, this one-of-a-kind initiative has been dismantled. My recent story for @science.org
science.org
Crucial training pipeline for Deaf scientists dismantled by NIH funding cuts
The one-of-a-kind initiative offered support from high school to postdoctoral levels
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Randall Munroe @xkcd.com · 25/04/2025
PhD Timeline xkcd.com/3081
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Mathew Summers @summersathome.bsky.social · 15/04/2025
Check out some of our locus coeruleus reconstructions - the average fully reconstructed LC neuron is about 30 cm in length (in a mouse brain that spans ~1.3 cm front to back)
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Ali Haydaroğlu @haydari.bsky.social · 01/04/2025
If you do multi-plane 2p imaging, you may see the same cells across planes. We built Suite3D exactly for this purpose! It removes duplicates, corrects axial movement, finds more cells with less noise, much faster than alternatives. github.com/alihaydarogl... Try on your data, and reach out!
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Guido Meijer @guidomeijer.com · 27/03/2025
First off, Bombcell is a MATLAB package (python version coming) developed by @juliefabre.bsky.social. It uses several metrics, like waveform shape, spike amplitudes and drift, to determine whether a detected unit is noise, multi-unit activity, axonal or a single neuron. github.com/Julie-Fabre/...
github.com
GitHub - Julie-Fabre/bombcell: Automated quality control, curation and neuron classification of spike-sorted electrophysiology data
Automated quality control, curation and neuron classification of spike-sorted electrophysiology data - Julie-Fabre/bombcell
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Stand Up for Science! @standupforscience.net · 06/03/2025
SO MANY STAND UP FOR SCIENCE EVENTS TO CHOOSE FROM—153 and COUNTING! To get more information on our local events and to register your own, head to www.standupforscience2025.org/local-event-information/ ☀️⬇️🌎
List of Stand Up for Science events—official events in red, solidarity events in blue.
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