The Polygenic Score Catalog Calculator is a nextflow pipeline for polygenic score calculation - PGScatalog/pgsc_calc

PhD Project - The overlapping microbiome: ecology, function and resilience beyond species boundaries at University of Bath, listed on FindAPhD.com

Our study offers new insights into recent cardiovascular disease patterns and reveals important health inequalities at a whole-population scale for multiple cardiovascular diseases, during and after t...

Background: Current cardiovascular disease (CVD) risk prediction models place many individuals in an intermediate risk category where clinical decision-making remains uncertain, highlighting a…

Manikpurage et al. evaluate the association between existing polygenic risk scores (PRS) and myocardial infarction (MI) as well as the extent of coronary artery lesions at coronary angiography. The co...

Discover why JACC is the ultimate publishing partner for your cardiovascular research.

There is currently no medical therapy for calcific aortic valve stenosis. We aimed to identify transcriptomic signatures of the disease severity. We p…

imageimageUsing genetically predicted metabolic reaction fluxes, the authors identify reactions that can amplify or buffer the effect of coronary artery disease (CAD) risk alleles on disease susceptib...

The cobraa model extends the pairwise sequentially Markovian coalescent to identify structured population history by examination of the model transition matrix. Applied to human polymorphism data, cob...

Reflecting on the core values of early data sharing agreements, the Bermuda Principles and the Fort Lauderdale Agreement, Kathryn E. Holt and Michael Inouye emphasize the need to reaffirm our commitme...

People of South Asian descent are more likely to be affected by heart disease, but their risks often go unnoticed. Researchers are looking to genetics to learn more and prevent early deaths.

Estimating the genetic risk of coronary artery disease (CAD) is now possible by aggregating data from genome-wide association studies (GWAS) into polygenic risk scores (PRS). Combining multiple PRS for specific circulating blood lipids could improve risk prediction. Here, we sought to evaluate the performance of PRS derived from CAD and blood lipids GWAS to predict the incidence of CAD.

Scientific Data - Quality control and removal of technical variation of NMR metabolic biomarker data in ~120,000 UK Biobank participants

A suite of utilities for working with the UK Biobank &lt;<a href="https://www.ukbiobank.ac.uk/" target="_top">https://www.ukbiobank.ac.uk/</a>&gt; Nuclear Magnetic Resonance spectroscopy (NMR) metabol...