iiinova — where your digital self keeps evolving

Reposted by Ed Griffen

Drugs for Neglected Diseases initiative (DNDi) @dndi.org · 22/09/2026

@covid-moonshot.bsky.social & @asapdiscovery.bsky.social researchers tell us how they developed innovative approaches to IP, enabling open science drug discovery while ensuring non-exclusive manufacturing & equitable access. 🎧 open.spotify.com/episode/5CBi... #UNGA81 #PandemicPrep #OpenScience

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Drugs for Neglected Diseases initiative (DNDi) @dndi.org · 27/08/2026

New in @jamanetworkopen.com: Phase 2 results for Dengue-mAb show the first proof of concept for an antiviral as a treatment for confirmed dengue patients seeking medical care. At 5–7mg/kg, it rapidly cut viremia and fever, with no related serious AEs. 📄 Study: jamanetwork.com/journals/jam... 1/2

jamanetwork.com

Safety and Preliminary Efficacy of Dengue Monoclonal Antibody in Adult Patients

This randomized clinical trial examines dengue monoclonal antibody (Dengue-mAb) as a potential therapeutic option for adults infected with dengue virus in India.

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Drugs for Neglected Diseases initiative (DNDi) @dndi.org · 24/07/2026

Dengue is no longer just a tropical disease. As the climate warms, the dengue-carrying mosquito is expanding its reach to new regions. Despite this growing global threat, there is still no specific treatment for dengue. Together with our partners, we're working to change this!

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Reposted by Ed Griffen

C&EN (Chemical & Engineering News) @cenmag.bsky.social · 23/07/2026

Motivated by a joint goal to make machine learning work for drug development, pharmaceutical companies are collaborating with one another and with public consortia to close the data gap. cen.acs.org/pharmaceutic... #chemsky 🧪

Pharma learns to share as their AI demands more data.
Companies aim to improve drug discovery by training AI on one another’s data and generating large, open datasets.
by Eva Amsen.
Black silhouettes of people stand in front of rows of squares, with each person in front of one square. The squares have colorful illustrations with dots and lines.
Credit: Matt Chinworth/Theispot

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Reposted by Ed Griffen

Larry the Cat @number10cat.bsky.social · 17/07/2026

Welcome to the most important job you'll ever have @andyburnham.bsky.social Cartoon brilliance by @bjennings90.bsky.social for @theguardian.com

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Martin Stoermer @martinstoermer.bsky.social · 28/03/2026

Nae king! Nae quin! Nae laird! Nae master! We willnae be fooled again! ― Terry Pratchett, Wee Free Men 2003

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Ed Griffen @griffen-ed.bsky.social · 27/03/2026

Working on new antivirals with the whole team in the @asapdiscovery.bsky.social consortium is incredible, great science, superb committed team all focussed on current and potential future viral threats. Front rank science applied to reducing human suffering ✅.

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Ed Griffen @griffen-ed.bsky.social · 20/03/2026

This is why we do medicinal chemistry: www.science.org/content/blog.... @dndi.org

science.org

The Best Weapon Yet Against Sleeping Sickness

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Reposted by Ed Griffen

Derek Lowe @dereklowe.bsky.social · 13/03/2026

Chemistry in current events: the connections between fertilizer, the Haber-Bosch process, and the Persian Gulf. Read this and your knowledge will exceed that of most of our current political leadership after only a few minutes of light work:

science.org

Nitrogen, Ammonia, and the Strait of Hormuz

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Ed Griffen @griffen-ed.bsky.social · 06/03/2026

If you have anything to do with young people(I’m a a High School Trustee, my wife is a Girl Guide Commissioner) the scars are still clear, if you take even a moment to look.

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Reposted by Ed Griffen

Colin Carlson @colincarlson.bsky.social · 08/01/2026

Something incredible I learned (re-learned?) tonight is that the blog post where the first SARS-CoV-2 genome was shared - six years ago on Saturday - included the most iconic footnote of all time

1 We know that “data” is plural but we were in a hurry.

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Ed Griffen @griffen-ed.bsky.social · 25/11/2025

If you’ve ever worked in cancer research, this: xkcd.com/3172/

xkcd.com

Fifteen Years

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Reposted by Ed Griffen

Greg Landrum @greglandrum.bsky.social · 21/10/2025

Save the date! Next year's European #RDKit UGM will take place from 16-18 September in Darmstadt, Germany. Pre-registration will open in early 2026.

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Reposted by Ed Griffen

Drugs for Neglected Diseases initiative (DNDi) @dndi.org · 24/09/2025

Great news! 🎉 Following an independent expert review, we have formally nominated the broad-spectrum pan-coronavirus antiviral ASAP-0017445 as a pre-clinical drug candidate. 🔗Read the press release here: dndi.org/press-releas...

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Reposted by Ed Griffen

Laura Howes @laurahowes.bsky.social · 24/09/2025

I first wrote about some of the early stages of this project in March 2020 (cen.acs.org/pharmaceutic...). I've been privileged to follow along since then (cen.acs.org/pharmaceutic...). Congratulations to everyone who contributed.

cen.acs.org

Antiviral unveiled that goes after multiple coronaviruses

Open-science consortium discloses its lead candidate to fight SARS-CoV-2 and MERS-CoV

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Ed Griffen @griffen-ed.bsky.social · 12/09/2025

It’s the travel choice of the future…

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Ed Griffen @griffen-ed.bsky.social · 11/09/2025

And Milan Centrale is an architectural wonder!

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Ed Griffen @griffen-ed.bsky.social · 11/09/2025

Thanks to @greglandrum.bsky.social and all the #RDKit crew another great UGM,now back along the Elbe as the sun sets:

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Reposted by Ed Griffen

The ASAP Discovery Consortium @asapdiscovery.bsky.social · 10/09/2025

ASAP is incredibly proud to work with superstar antiviral discovery scientists at Mount Sinai: Briana McGovern, Meg Gordon, Dr. Kris White, Dr. Suazo, and Jared Benjamin, among others! Read about their important work here: health.mountsinai.org/blog/stories...

Members of Dr. White’s lab, from left to right, wearing white lab coats: Briana McGovern, BS, Senior Research Associate; Meg Gordon, BA, Research Associate; Dr. White; Dr. Suazo; Jared Benjamin, MS, Research Associate.

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Ed Griffen @griffen-ed.bsky.social · 10/09/2025

Down the Elbe to Prague, great way to get to #RDKit:

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Ed Griffen @griffen-ed.bsky.social · 08/09/2025

Sleeper Brussels to Prague, quite traditional for a game changer.

Picture shows the side of a European Sleeper carriage in maroon livery with “Euro-Express” text on the side.

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Ed Griffen @griffen-ed.bsky.social · 08/09/2025

Heading overland to the #RDKit UGM, trying out the sleeper Brussels ->Prague from a London-> Brussels Eurostar. But first:

Avanti West coast train, yellow and turquoise livery arriving at Macclesfield (UK) station under the bridge with the word Macclesfield written across it under a blue sky with thin white clouds.

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Conrad Hackett @conradhackett.bsky.social · 04/09/2025

Disease prevalence in US states before & after vaccine introduction 🧪 From Edward Tufte & graphics.wsj.com/infectious-d...

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Reposted by Ed Griffen

Adam Kucharski @adamjkucharski.bsky.social · 01/09/2025

Results so stunningly clear they inspired this classic xkcd (xkcd.com/2400/):

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Ed Griffen @griffen-ed.bsky.social · 10/06/2025

AI advances are all about getting enough good data. For the first time this is data at the scale we need it for faster drug discovery. This could make a difference to so many diseases.

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Reposted by Ed Griffen

Conscience @conscience-network.bsky.social · 02/06/2025

If you weren’t able to attend our Symposium on Open Drug Discovery in Montreal in April, you’re in luck - the recordings are now on YouTube and the slides are on Zenodo! 🎥 Watch the recordings: www.youtube.com/playlist?lis... 📄 Access the slides: zenodo.org/communities/...

youtube.com

Conscience Symposium on Open Drug Discovery 2025 - YouTube

Recordings of the talks that took place at the Conscience Symposium on Open Drug Discovery on April 7-8, 2025 in Montreal.

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Ed Griffen @griffen-ed.bsky.social · 02/06/2025

Learning about European approaches to Pandemic Preparedness “We’re not safe till we’re all safe”: @asapdiscovery.bsky.social at: health.ec.europa.eu/events/hera-... #HealthUnion

health.ec.europa.eu

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Ed Griffen @griffen-ed.bsky.social · 10/04/2025

Brilliant explainer from Pascale how to use patents as enablers in preparing for the next pandemic.

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Drugs for Neglected Diseases initiative (DNDi) @dndi.org · 08/04/2025

Today, @griffen-ed.bsky.social explains at the Open Drug Discovery Symposium how @asapdiscovery.bsky.social has developed a hybrid intellectual property model that counterintuitively uses patents to support open science innovation and ensure affordability & global access. 🔗 shorturl.at/gMY0t

shorturl.at

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Ed Griffen @griffen-ed.bsky.social · 04/04/2025

If this sparks your interest there's more of our background thinking published on open access in Wellcome Open Science: wellcomeopenresearch.org/articles/9-374

wellcomeopenresearch.org

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Reposted by Ed Griffen

Derek Lowe @dereklowe.bsky.social · 31/03/2025

Here’s a post on this molecule, and good luck to all involved!

science.org

A New Pan-Coronovirus Protease Inhibitor Possibility

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Ed Griffen @griffen-ed.bsky.social · 28/03/2025

Massive credit to all members of @asapdiscovery.bsky.social :- drug discovery is a massive team sport. Especially the chemists at Enamine working through the war.

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Reposted by Ed Griffen

John Chodera @jchodera.bsky.social · 28/03/2025

If you, like me, do not particularly want to die by bleeding out of your eye sockets from diseases like Ebola, and think it's dumb to cut funding for viral countermeasures for future pandemics "because the COVID pandemic is over", here's something you can do about it: resist.bot/petitions/PX...

resist.bot

Reinstate funding for pandemic prevention research and preparedness

Text SIGN PXNIDH to 50409 to send this to your officials.

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Reposted by Ed Griffen

Rowan Walrath @rowanwalrath.bsky.social · 26/03/2025

New pancoronavirus antiviral targets the main protease (Mpro) of the two different coronaviruses that cause Middle East respiratory syndrome (MERS) and COVID-19. Via @laurahowes.bsky.social @cenmag.bsky.social cen.acs.org/acs-news/acs...

cen.acs.org

Antiviral unveiled that goes after multiple coronaviruses

Open-science consortium discloses its lead candidate to fight SARS-CoV-2 and MERS-CoV

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Reposted by Ed Griffen

The ASAP Discovery Consortium @asapdiscovery.bsky.social · 22/03/2025

Three days to go until the unveiling of our MERS-CoV/SARS-CoV-2 oral antiviral candidate for preclinical development!

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Reposted by Ed Griffen

The ASAP Discovery Consortium @asapdiscovery.bsky.social · 21/03/2025

Lead medicinal chemist Ed Griffen (@griffen-ed.bsky.social) will be disclosing the new ASAP MERS-CoV/SARS-CoV-2 oral antiviral at @acs.org on Tue 25 Mar! Tune in to this virtual session to hear about its discovery and development! acs.digitellinc.com/live/34/sess...

ACS talk 4181593 - Discovery of non-peptidomimetic oral combined MERS and SARS-CoV-2 anti-virals

Presented by Ed Griffen

Part of the session "Developing Countermeasures for Viruses of Pandemic Potential"

Room: Digital Session (Digital Meeting)

Overview:

The COVID-19 pandemic was a stark reminder that a barren global antiviral pipeline has grave humanitarian consequences. Pandemics could be prevented, in principle, by accessible, easily deployable broad-spectrum oral antivirals. Here we report the discovery of a family non-peptidomimetic spirolactams that target critical pathogenic coronaviridae including SARS-CoV-2 and MERS-CoV.
As part of the ASAP AViDD centre(www.asapdiscovery.org) we expanded the work of the COVID Moonshot's drug discovery campaign targeting the SARS-CoV-2 main protease to deliver orally active compounds with promising in vivo profiles. Using a combination of active learning based medicinal chemistry, alchemical free energy calculations and structure-based design we were able to extend the coronavirus spectrum and optimise the ADMET properties of the series leading to the first public disclosure of the preclinical candidate.

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Reposted by Ed Griffen

Conscience @conscience-network.bsky.social · 17/02/2025

✨Another symposium session reveal✨ Featuring Max Morgan and @griffen-ed.bsky.social, this session features speakers inventing and actively implementing new strategies that centre open science and collaboration to drive drug discovery! Register here: conscience.ca/symposium2025

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Reposted by Ed Griffen

MedChemica @medchemica.com · 25/02/2025

3 weeks to go🚀 @griffen-ed.bsky.social is presenting at #ICAR2025 the highlights of the discovery, in vitro and in vivo profile of the ASAP AViIDD Center’s pre-clinical candidate for treating 6 lethal coronavirus infections: ASAP-0017445. Register now 🔗 lnkd.in/gbBRZSz2 @asapdiscovery.bsky.social

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Reposted by Ed Griffen

MedChemica @medchemica.com · 05/03/2025

5 weeks to go🚀 @griffen-ed.bsky.social is presenting at the @conscience-network.bsky.social Symposium. Talk Title; "Balancing Open Science and Intellectual Property to Discover and Develop Medicines” @asapdiscovery.bsky.social Register now: conscience.ca/symposium202...

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Reposted by Ed Griffen

MedChemica @medchemica.com · 27/02/2025

5 weeks to go! 🚀 Dr @griffen-ed.bsky.social is presenting at the ACS Spring Meeting & Expo. Talk Title; “Discovery of non-peptidomimetic oral combined MERS and SARS-CoV-2 anti-virals." @asapdiscovery.bsky.social @acs.org #ACSSpring2025 Click to register 🔗 www.acs.org/meetings/acs...

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Paul Bassett Davies @thewritertype.bsky.social · 22/02/2025

Ok, we need a new James Bond AND a new Archbishop of Canterbury, and pretty soon it'll be time for another new Willy Wonka and a new Doctor Who. We need to economise. They should all be amalgamated into a single new character called Archdoctor Bondwonka.

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John Chodera @jchodera.bsky.social · 21/02/2025

Excited to share what I’ve been working on with @tkaraletsos.bsky.social to transform the field of drug discovery with atomistic foundation simulation models! I could not be more thrilled to be working with this dream team. achira.ai

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Ed Griffen @griffen-ed.bsky.social · 18/02/2025

Should be a fascinating session looking at real life challenges in open science drug discovery.

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