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The ASAP Discovery Consortium @asapdiscovery.bsky.social · 30/09/2025

Read more about ASAP's new pan-coronavirus antiviral designed to keep us safe from future pandemics!

Reposted by The ASAP Discovery Consortium

John Chodera @jchodera.bsky.social · 29/09/2025

"If funding isn’t restored soon, Chanda says, promising antivirals will be lost, and the world will be defenseless against the next pandemic." cen.acs.org/pharmaceutic...

cen.acs.org

He was making drugs for the next pandemic. Then the feds canceled his project

Sumit Chanda's search for antivirals is in limbo after NIH halted its pandemic-preparedness program

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The ASAP Discovery Consortium @asapdiscovery.bsky.social · 10/09/2025

ASAP is incredibly proud to work with superstar antiviral discovery scientists at Mount Sinai: Briana McGovern, Meg Gordon, Dr. Kris White, Dr. Suazo, and Jared Benjamin, among others! Read about their important work here: health.mountsinai.org/blog/stories...

Members of Dr. White’s lab, from left to right, wearing white lab coats: Briana McGovern, BS, Senior Research Associate; Meg Gordon, BA, Research Associate; Dr. White; Dr. Suazo; Jared Benjamin, MS, Research Associate.

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The ASAP Discovery Consortium @asapdiscovery.bsky.social · 18/06/2025

Next up in today's Antiviral Drug Discovery Open Science Forum is Peter Sjö (@dndi.org) and Annette von Delft (@cmd.ox.ac.uk) of ASAP talking about DNDi-6510, the preclinical candidate from the COVID Moonshot! asapdiscovery.org/forum

Peter Sjö giving an overview of the COVID Moonshot progression of antivirals from the COVID Moonshot Science paper: https://www.science.org/doi/10.1126/science.abo7201

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The ASAP Discovery Consortium @asapdiscovery.bsky.social · 18/06/2025

First up in today's Antiviral Drug Discovery Open Science Forum is Jeroen Kruter and Ingrid de Visser-Kamerling of INFECTA: infecta.org asapdiscovery.org/forum/

Jeroen Kruter presenting a slide about INFECTA:

INFECTA: Dedicated facility
To accelerate pharmaceutical development for infectious diseases through innovative research methodologies, strategic collaborations, with a commitment to improving global health outcomes.

Realization of early phase clinical research infection unit:
- INFECTA-NL servers as supervisory board for INFECTA
- Private Limited Company is overseen by directors Ingrid de Visser and Meta Rostenberg
- Non-profit purpose

Purpose build:
- 20 isolation beds (BSL3)
- Outpatient clinic
- Lab facilities including BSL3/GMP manufacturing

Strong legacy from Centre for Human Drug Research and Leiden Medical Center

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The ASAP Discovery Consortium @asapdiscovery.bsky.social · 17/06/2025

Join us for the Wed 18 Jun Antiviral Drug Discovery Open Science Forum at 11A ET to hear from Ingrid de Visser-Kamerling and Jeroen Kruter of INFECTA on Controlled Human Infection Models, as well as Annette von Delft and Peter Sjö of ASAP on the discovery of DNDi-6510! asapdiscovery.org/forum/

asapdiscovery.org

Antiviral Drug Discovery (AViDD) Open Science Forum

A public venue to enable NIH-funded AViDD Centers to openly exchange and disseminate information in a pre-competitive fashion.

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The ASAP Discovery Consortium @asapdiscovery.bsky.social · 21/05/2025

Next up in today's Antiviral Drug Discovery Open Science Forum is Juan C. de la Torre of CAMPP @scripps.edu talking about antiviral discovery for mammarenaviruses. asapdiscovery.org/forum

Slide presented by Juan C. de la Torre:

Impact of mammarenaviruses on human health:
* Lassa virus (LASV): The underrated human pathogen of West Africa
* South American hemorrhagic fever mammarenaviruses
* The globally distributed prototypic mammarenaviruses LCMV as a neglected human pathogen
* Recently discovered mammarenaviruses of unknown pathogenic potential for humans

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The ASAP Discovery Consortium @asapdiscovery.bsky.social · 21/05/2025

First up in today's Antiviral Drug Discovery Open Science Forum is Warren Thompson ASAP @diamondlightsource.bsky.social showing automated fragment progression capabilities that Diamond Light Source users will soon be able to access! asapdiscovery.org/forum/ www.diamond.ac.uk/Instruments/...

Warren Thompson presenting a slide showing the Diamond Light Source XChem facility capabilities for accelerated Design-Make-Test-Analyze cycles, including collaborative data dissemination, cloud-based digitised chemistry, high throughput automated beamline, and the creation of AI-data sources for predicting ligand binding for drug discovery.

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The ASAP Discovery Consortium @asapdiscovery.bsky.social · 21/05/2025

Join today's Antiviral Drug Discovery Open Science Forum at 11A ET to hear Warren Thompson (‪ASAP @diamondlightsource.bsky.social‬) discuss robotic fragment progression and Juan Carlos de la Torre (‪CAMPP @scripps.edu‬) present strategies to combat human mammarenaviruses: asapdiscovery.org/forum/

asapdiscovery.org

Antiviral Drug Discovery (AViDD) Open Science Forum

A public venue to enable NIH-funded AViDD Centers to openly exchange and disseminate information in a pre-competitive fashion.

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The ASAP Discovery Consortium @asapdiscovery.bsky.social · 27/04/2025

ASAP is incredibly proud to help pioneer new ways of making medicines globally affordable and accessible for all.

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The ASAP Discovery Consortium @asapdiscovery.bsky.social · 15/04/2025

This Wed 16 Apr at 11.00A ET, the Antiviral Drug Discovery Open Science Forum features talks on Dengue antiviral discovery and development from Xuping Xie (@utmbhealth.bsky.social) and Darlene Chen (@novartis.bsky.social) of the UNAPP AViDD! asapdiscovery.org/forum

asapdiscovery.org

Antiviral Drug Discovery (AViDD) Open Science Forum

A public venue to enable NIH-funded AViDD Centers to openly exchange and disseminate information in a pre-competitive fashion.

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Reposted by The ASAP Discovery Consortium

Ed Griffen @griffen-ed.bsky.social · 28/03/2025

Massive credit to all members of @asapdiscovery.bsky.social :- drug discovery is a massive team sport. Especially the chemists at Enamine working through the war.

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The ASAP Discovery Consortium @asapdiscovery.bsky.social · 04/04/2025

ASAP lead med chemist Ed Griffen (@griffen-ed.bsky.social) and @dndi.org Access Leader Pascale Boulet explain how ASAP is using patents to serve the common good by enabling globally equitable and affordable access to medicines in this feature in @cenmag.bsky.social: cen.acs.org/pharmaceutic...

cen.acs.org

Opinion: How patents can serve the common good

We want wide, fast, and affordable access for our new antiviral. It might sound counterintuitive, but a patent will help us do that

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Reposted by The ASAP Discovery Consortium

Drugs for Neglected Diseases initiative (DNDi) @dndi.org · 25/03/2025

📢Important announcement! Today, the @asapdiscovery.bsky.social consortium disclosed the structure of our preclinical candidate, ASAP-0017445, a promising broad-spectrum antiviral with potent activity against SARS-CoV2 and other viruses belonging to the same family. (1/10)

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The ASAP Discovery Consortium @asapdiscovery.bsky.social · 25/03/2025

Exciting news! The structure of the new MERS-CoV/SARS-CoV-2 oral antiviral developed by the ASAP Discovery consortium has been disclosed today. Read this thread for all the details:

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The ASAP Discovery Consortium @asapdiscovery.bsky.social · 25/03/2025

If you're attending the American Chemical Society (ACS) meeting either physically or virtually, tune in to today's talk disclosing ASAP's new oral antiviral candidate aiming to help protect against future pandemics.

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The ASAP Discovery Consortium @asapdiscovery.bsky.social · 22/03/2025

Three days to go until the unveiling of our MERS-CoV/SARS-CoV-2 oral antiviral candidate for preclinical development!

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Reposted by The ASAP Discovery Consortium

Conscience @conscience-network.bsky.social · 17/02/2025

✨Another symposium session reveal✨ Featuring Max Morgan and @griffen-ed.bsky.social, this session features speakers inventing and actively implementing new strategies that centre open science and collaboration to drive drug discovery! Register here: conscience.ca/symposium2025

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Reposted by The ASAP Discovery Consortium

MedChemica @medchemica.com · 27/02/2025

5 weeks to go! 🚀 Dr @griffen-ed.bsky.social is presenting at the ACS Spring Meeting & Expo. Talk Title; “Discovery of non-peptidomimetic oral combined MERS and SARS-CoV-2 anti-virals." @asapdiscovery.bsky.social @acs.org #ACSSpring2025 Click to register 🔗 www.acs.org/meetings/acs...

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Reposted by The ASAP Discovery Consortium

MedChemica @medchemica.com · 05/03/2025

5 weeks to go🚀 @griffen-ed.bsky.social is presenting at the @conscience-network.bsky.social Symposium. Talk Title; "Balancing Open Science and Intellectual Property to Discover and Develop Medicines” @asapdiscovery.bsky.social Register now: conscience.ca/symposium202...

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The ASAP Discovery Consortium @asapdiscovery.bsky.social · 21/03/2025

Lead medicinal chemist Ed Griffen (@griffen-ed.bsky.social) will be disclosing the new ASAP MERS-CoV/SARS-CoV-2 oral antiviral at @acs.org on Tue 25 Mar! Tune in to this virtual session to hear about its discovery and development! acs.digitellinc.com/live/34/sess...

ACS talk 4181593 - Discovery of non-peptidomimetic oral combined MERS and SARS-CoV-2 anti-virals

Presented by Ed Griffen

Part of the session "Developing Countermeasures for Viruses of Pandemic Potential"

Room: Digital Session (Digital Meeting)

Overview:

The COVID-19 pandemic was a stark reminder that a barren global antiviral pipeline has grave humanitarian consequences. Pandemics could be prevented, in principle, by accessible, easily deployable broad-spectrum oral antivirals. Here we report the discovery of a family non-peptidomimetic spirolactams that target critical pathogenic coronaviridae including SARS-CoV-2 and MERS-CoV.
As part of the ASAP AViDD centre(www.asapdiscovery.org) we expanded the work of the COVID Moonshot's drug discovery campaign targeting the SARS-CoV-2 main protease to deliver orally active compounds with promising in vivo profiles. Using a combination of active learning based medicinal chemistry, alchemical free energy calculations and structure-based design we were able to extend the coronavirus spectrum and optimise the ADMET properties of the series leading to the first public disclosure of the preclinical candidate.

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The ASAP Discovery Consortium @asapdiscovery.bsky.social · 19/02/2025

Next up for our Antiviral Drug Discovery Open Science Forum Jingyue Ju (Columbia University) of the Metropolitan AntiViral Drug Accelerator (MAVDA), discussing inhibitors of RNA synthesis for coronaviruses and other viruses of pandemic potential. Check out his talk here: openantivirals.org

Jinyue Ju presenting his titles slide:

Discovery and Optimization of RNA Synthesis Inhibitors for Coronavirus and other Viruses of Pandemic Potential

Jingyue Ju

Departments of Chemical Engineering &
Molecular Pharmacology and Therapeutics

Center for Genome Technology & Biomolecular Engineering

Columbia University

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The ASAP Discovery Consortium @asapdiscovery.bsky.social · 19/02/2025

Tem Morrison (University of Colorado School of Medicine) is up next in this month's Antiviral Drug Discovery Open Science Forum, discussing the debilitating effects of Chikungunya virus (CHIKV) and the high need for antivirals. Tune in now, or watch his presentation later: openantivirals.org

Tem Morrison presents a slide illustrating debilitating effects of Chikungunya infection:

* Clinical disease---it's all in the name
chikungunya: "that which bends up"
o'nyong-nyong: "painful weakening of the joints"

* Three clinical stages (CHIKV)

Acute (1-3 weeks)
* Sudden fever, arthralgia, arthritis, rash
* Wrists, angles, phalanges (commonly up to 16 joints)
* Atypical presentations occur but are rare (0.5%)

Post-acute (3 weeks - 3 months)
* Persistent joint pain, arthritis, tenosynovitis
* >50% of patients

Chronic (>3 months)
* Similar to post-acute stage
* 10-50% of patients; recent meta-analysis of 60 studies across 38 countries estimates 51%

On the right is an illustration of which joints are affected by acute and chronic chikungunya infections, as well as photos of hands with severely inflamed, bent joints.

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Reposted by The ASAP Discovery Consortium

Cole Group @colegroupncl.bsky.social · 29/01/2025

Our team is having fun trying out the binding pose challenge! Check it out below, the organisers have done a great job making the data easy to access and understand!

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Reposted by The ASAP Discovery Consortium

Polaris @polarishub.io · 17/02/2025

⚡ The intermediate leaderboard for the antiviral challenge is now live! 👀 See how you placed: antiviral.polarishub.io The challenge officially ends on March 10th, but there's one last leaderboard update before the final results. Submit before midnight on Feb 26th! polarishub.io/competitions

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The ASAP Discovery Consortium @asapdiscovery.bsky.social · 19/02/2025

This month's Antiviral Drug Discovery Open Science Forum kicks off with Margaret Kielian (@einsteinmededu.bsky.social), part of the Antiviral Countermeasures Development Center (AC/DC AViDD), focusing on developing antivirals to alphaviruses! Join now, or watch later: openantivirals.org

Margaret Kielan presents her first slide:
Antiviral Countermeasures Development Center (AC/DC) Project 2: Development of Antivirals against Alphaviruses

Three-part interactive team, groups of:

Margaret Kielian, Albert Einste College of Medicine, NY
Andres Merits, University of Tartu, Estonia
Tem MOrrison, University of Colorado School of Medicine, CO

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The ASAP Discovery Consortium @asapdiscovery.bsky.social · 15/01/2025

Next up at the Antiviral Drug Discovery Open Science Forum is Charles Craik (UCSF QCRG AViDD Center) talking about the discovery of broad-spectrum coronavirus Mpro inhibitors! openantivirals.org

Charles Craik presenting his title slide, "Structure-based discovery of highly bioavailable, covalent, broad-specftrum coronavirus-Mpro inhibitors with potent in vivo efficacy"

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The ASAP Discovery Consortium @asapdiscovery.bsky.social · 15/01/2025

First up in today's Antiviral Drug Discovery Open Science Forum is Sara Cherry, who works with both CAMPP and READDI-AC AViDD Centers to discover antivirals for emerging RNA viruses! openantivirals.org

Sara Cherry introduces her title slide, "Antiviral Discovery Pipeline: Emerging and Re-Emerging Viruses"

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The ASAP Discovery Consortium @asapdiscovery.bsky.social · 15/01/2025

Working on predictive models for drug discovery? Here's your chance to see how well your models actually work! Together with @polarishub.io and OpenADMET, we've launched a blind prospective challenge to see how well predictive models for drug discovery can actually predict real drug discovery data!

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The ASAP Discovery Consortium @asapdiscovery.bsky.social · 15/01/2025

Join us for the next Antiviral Drug Discovery Open Science Forum on Wed 15 Jan at 11A ET as Sara Cherry (CAMPP) and Charles Craik (UCSF QCRG) discuss antiviral discovery for coronaviruses and emerging RNA viruses! openantivirals.org

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The ASAP Discovery Consortium @asapdiscovery.bsky.social · 18/12/2024

Next up in today's Antiviral Drug Discovery Open Science Forum is Mei Hong (MIT) of the QCRG AViDD Center, talking about solid state NMR of the SARS-CoV-2 E protein: asapdiscovery.org/forum/#sched...

Mei Hong narrates her slide, "E: A drug-targeted cation channel of SARS-CoV-2". The slide shows the life cycle of SARS-CoV-2 infection, and highlights the role of E (envelope) protein.

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The ASAP Discovery Consortium @asapdiscovery.bsky.social · 18/12/2024

First up in today's Antiviral Drug Discovery Open Science Forum is Peter Brown of UNC Chapel Hill and READDI-AC talking about the discovery of covalent chemical probes for CHIKV nsP2 protease: asapdiscovery.org/forum/#sched...

Peter Brown narrates his slide, "Alphavirus (CHIKV) replication complex", which shows the structure of the nsP2 protease and neighboring proteins along with substrate cleavage preferences.

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The ASAP Discovery Consortium @asapdiscovery.bsky.social · 18/12/2024

Today's Antiviral Drug Discovery Open Science Forum starts at 11A ET and features Peter Brown of the READDI-AC AViDD Center and Mei Hong of the UCSF QCRG AViDD Center talking about CHIKV and SARS-CoV-2! asapdiscovery.org/forum/#sched...

asapdiscovery.org

Antiviral Drug Discovery (AViDD) Open Science Forum

A public venue to enable NIH-funded AViDD Centers to openly exchange and disseminate information in a pre-competitive fashion.

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Reposted by The ASAP Discovery Consortium

OMSF @omsf.io · 03/12/2024

If you woke up today and thought, "hm, I'd really like to compete against the best and brightest in a robust, friendly drug discovery challenge that pushes the envelope of what open science is capable of," then we have great news for you!

news.omsf.io

Challenge: Revolutionizing Small Molecule Drug Discovery

The Open Molecular Software Foundation (OMSF) OpenADMET project is proud to collaborate with the ASAP Discovery Consortium to launch an exciting computational blind challenge in small molecule drug di...

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The ASAP Discovery Consortium @asapdiscovery.bsky.social · 03/12/2024

We're excited to work with @omsf.io OpenADMET and @polarishub.io to bring you this blind predictive modeling community challenge! If you're developing predictive models for drug discovery---potency or ADMET---here's your chance to test them prospectively on real discovery data from ASAP!

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Reposted by The ASAP Discovery Consortium

Polaris @polarishub.io · 22/11/2024

🧵 We highlighted some orgs that are helping advance open science through the release of new data: - @asapdiscovery.bsky.social for antivirals - OpenADMET consortium - @recursionpharma.bsky.social and their [rxrx.ai](rxrx.ai) collection of phenomics datasets + the latest release - RxRx3-core

rxrx.ai

RXRX

Datasets released from Recursion's automated cellular imaging and deep learning platform, to enable new machine learning tools and discover new biology.

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Reposted by The ASAP Discovery Consortium

Ed Griffen @griffen-ed.bsky.social · 28/11/2024

The great Diamond team, part of the @asapdiscovery.bsky.social and @covid-moonshot.bsky.social backbone.

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The ASAP Discovery Consortium @asapdiscovery.bsky.social · 21/11/2024

Did you miss one of our Antiviral Drug Discovery Open Science Forum talks? Check out all of the talks archived here to learn more about drug discovery for pandemic preparedness! www.youtube.com/@AViDD-OSF/v...

youtube.com

AViDD Open Science Forum

A public venue to enable NIH-funded AViDD Centers to openly exchange and disseminate information in a pre-competitive fashion. The Open Science Forum will hold virtual events on the third Wednesday ...

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The ASAP Discovery Consortium @asapdiscovery.bsky.social · 21/11/2024

Our predecessor project, the COVID Moonshot (@covid-moonshot.bsky.social), is now on Bluesky! Give them a follow for updates on that project!

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The ASAP Discovery Consortium @asapdiscovery.bsky.social · 20/11/2024

ASAP lead medicinal chemist Ed Griffen (@griffen-ed.bsky.social) is talking about ASAP's IP strategy to enable global equitable and affordable access in today's Antiviral Drug Discovery Open Science Forum: asapdiscovery.org/forum

Ed Griffen (ASAP lead medicinal chemist) presents a slide entitled "Better Pandemic Preparedness needs licenses and therefore pantents". The slides show a logical flow:
Box 1: global equitable access holds viral threats early -- "outbreaks not pandemics"
This requires Box 2: Licensing to avoid defensive positions in HICs, which aims to be maximally permissive.
This requires Box 3: Patents to make licenses enforceable, which is the minimally viable defensive patent.

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The ASAP Discovery Consortium @asapdiscovery.bsky.social · 20/11/2024

Tune in Wed 20 Nov at 11A ET for our Antiviral Drug Discovery Open Science Forum to hear Ed Griffen (@griffen-ed.bsky.social) [MedChemica @medchemica.bsky.social] and Pascale Boulet [DNDi @dndi.bsky.social] discuss enabling affordable access with creative IP agreements! asapdiscovery.org/forum/

asapdiscovery.org

Antiviral Drug Discovery (AViDD) Open Science Forum

A public venue to enable NIH-funded AViDD Centers to openly exchange and disseminate information in a pre-competitive fashion.

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The ASAP Discovery Consortium @asapdiscovery.bsky.social · 20/11/2024

The ASAP Discovery Consortium is now on Bluesky! Check out our open science pipeline for antiviral drug discovery here: asapdiscovery.org

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