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MedChemica @medchemica.com · 10/06/2025

New OpenBind consortium to make the UK a leader in AI-driven drug discovery-slashing the cost of drug discovery & development.. & MedChemica are at the heart of it! Click for the full gov.uk article and direct quote from our Technical Director @griffen-ed.bsky.social www.gov.uk/government/n...

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Reposted by MedChemica

The ASAP Discovery Consortium @asapdiscovery.bsky.social · 21/03/2025

Lead medicinal chemist Ed Griffen (@griffen-ed.bsky.social) will be disclosing the new ASAP MERS-CoV/SARS-CoV-2 oral antiviral at @acs.org on Tue 25 Mar! Tune in to this virtual session to hear about its discovery and development! acs.digitellinc.com/live/34/sess...

ACS talk 4181593 - Discovery of non-peptidomimetic oral combined MERS and SARS-CoV-2 anti-virals

Presented by Ed Griffen

Part of the session "Developing Countermeasures for Viruses of Pandemic Potential"

Room: Digital Session (Digital Meeting)

Overview:

The COVID-19 pandemic was a stark reminder that a barren global antiviral pipeline has grave humanitarian consequences. Pandemics could be prevented, in principle, by accessible, easily deployable broad-spectrum oral antivirals. Here we report the discovery of a family non-peptidomimetic spirolactams that target critical pathogenic coronaviridae including SARS-CoV-2 and MERS-CoV.
As part of the ASAP AViDD centre(www.asapdiscovery.org) we expanded the work of the COVID Moonshot's drug discovery campaign targeting the SARS-CoV-2 main protease to deliver orally active compounds with promising in vivo profiles. Using a combination of active learning based medicinal chemistry, alchemical free energy calculations and structure-based design we were able to extend the coronavirus spectrum and optimise the ADMET properties of the series leading to the first public disclosure of the preclinical candidate.

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Reposted by MedChemica

Drugs for Neglected Diseases initiative (DNDi) @dndi.org · 25/03/2025

📢Important announcement! Today, the @asapdiscovery.bsky.social consortium disclosed the structure of our preclinical candidate, ASAP-0017445, a promising broad-spectrum antiviral with potent activity against SARS-CoV2 and other viruses belonging to the same family. (1/10)

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MedChemica @medchemica.com · 05/03/2025

5 weeks to go🚀 @griffen-ed.bsky.social is presenting at the @conscience-network.bsky.social Symposium. Talk Title; "Balancing Open Science and Intellectual Property to Discover and Develop Medicines” @asapdiscovery.bsky.social Register now: conscience.ca/symposium202...

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MedChemica @medchemica.com · 27/02/2025

5 weeks to go! 🚀 Dr @griffen-ed.bsky.social is presenting at the ACS Spring Meeting & Expo. Talk Title; “Discovery of non-peptidomimetic oral combined MERS and SARS-CoV-2 anti-virals." @asapdiscovery.bsky.social @acs.org #ACSSpring2025 Click to register 🔗 www.acs.org/meetings/acs...

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MedChemica @medchemica.com · 25/02/2025

3 weeks to go🚀 @griffen-ed.bsky.social is presenting at #ICAR2025 the highlights of the discovery, in vitro and in vivo profile of the ASAP AViIDD Center’s pre-clinical candidate for treating 6 lethal coronavirus infections: ASAP-0017445. Register now 🔗 lnkd.in/gbBRZSz2 @asapdiscovery.bsky.social

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MedChemica @medchemica.com · 18/02/2025

Who is attending the 'Chemist In Industry' SCI conference at Alderley Park tomorrow? Our very own Dr @aldossetter.bsky.social is presenting an insightful talk on ‘Addressing ‘The Big Two.’ – Intrigued? You should be! See you all there! #SCI #ChemistInIndustry #DrugDiscovery #DrugDesign

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MedChemica @medchemica.com · 20/11/2024

Don't miss our very own Dr Ed Griffen @griffen-ed.bsky.social giving a talk today at the AViDD Open Science Forum...

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