iiinova — where your digital self keeps evolving

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Oliver Barnstedt @obarnstedt.bsky.social · 29/09/2026

It was great fun talking science to Svilen. Thanks for having me!

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Stanley Heinze @stanley-heinze.bsky.social · 30/07/2026

New preprint! www.biorxiv.org/content/10.6... Nearly a decade after starting the project, the first major results from our comparative connectomics work is online! Comparing the head direction circuits of the central complex in bees, ants and flies, recapitulating >300million years of evolution.

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bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 25/07/2026

Distinct forms of dopamine transmission control locomotion and learning www.biorxiv.org/content/10.64898/20…

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Yvette Fisher @yvetteefisher.bsky.social · 07/07/2026

Thank you Natalia Mesa at the @thetransmitter.bsky.social for highlighting our labs preprint on synaptic mechanisms of head direction learning!! 🪰🧭 Work from @markplitt.bsky.social in my lab in collaboration with the Jayaraman lab! www.thetransmitter.org/learning-and...

thetransmitter.org

Unique learning mechanism drives navigation in fruit flies

The neuromodulator octopamine, the insect counterpart to norepinephrine, helps flies get their bearings in an unfamiliar environment.

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fatima1amin.bsky.social @fatima1amin.bsky.social · 04/07/2026

We, barnstedtlab.com, will be @ FENS Forum 2026. Check out the posters 👇👇 #fens2026

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Oliver Barnstedt @obarnstedt.bsky.social · 04/07/2026

Really looking forward to our #fens2026 satellite symposium tomorrow!

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Brad Hulse @bradkhulse.bsky.social · 21/05/2026

Story time friends... Ring attractor networks rely on fine-tuned symmetric connectivity. The fly head direction network has ring attractor dynamics but heterogeneous connectivity. How is this possible? 1/🧵 Link: www.biorxiv.org/content/10.6...

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fatima1amin.bsky.social @fatima1amin.bsky.social · 05/05/2026

Congratulations, @salilbidaye.bsky.social and the whole team for another stellar work!

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bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 01/05/2026

Object manipulation and affordance learning in Drosophila www.biorxiv.org/content/10.64898/20…

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Hannah Haberkern @hannah-haberkern.bsky.social · 19/03/2026

How does an animal choose between exploring for a better food source and taking advantage of a known one? Our recent work in Current Biology demonstrates how recent feeding and metabolic state dynamically influence fly local search. bit.ly/3PfrIv3 #Science #Neurosky #Foraging #Drosophila

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John Tuthill @tuthill.bsky.social · 12/03/2026

Flies beat their wings more than 200 times per second. How do proprioceptors rapidly sense and fine tune the wingstroke? @ellenlesser.bsky.social combined genetic tools with the connnectome to create an atlas of Drosophila wing proprioceptors. @elife.bsky.social elifesciences.org/articles/107...

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Karl Deisseroth @deisseroth.bsky.social · 15/03/2026

Great work from Claire, Ravi, and the whole team– the initial lifelong continuous screen of behaving vertebrates provided a wealth of ideas on progression/staging of brain function across lifespan. Behavior is unmatched as a noninvasive quantitative readout of brain function (and, one that matters).

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Johannes Felsenberg @felsenberg.bsky.social · 20/12/2025

Carolin Warnecke together with Hanna, Dennis, Bene & Kerstin from my lab show that re-exposure to reward diminishes multiple associated olfactory memories. We’re hiring 2 postdocs—DM/email me for details. #Postdoc #Hiring www.sciencedirect.com/science/arti...

sciencedirect.com

Re-exposure to reward re-evaluates related memories

To adapt behavior in changing environments, animals must continuously re-evaluate previously learned associations. This flexibility of memory systems …

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Bryon Silva @neurogut.bsky.social · 10/12/2025

Textbooks said neurons don’t burn fatty acids for energy🤔. Our study delivers the first in vivo demonstration that fatty acid oxidation in defined memory neurons fuels memory formation. Closing chapter of my PhD 🥳, out today in Nature Metabolism💥 @natmetabolism.nature.com

nature.com

Neuronal fatty acid oxidation fuels memory after intensive learning in Drosophila - Nature Metabolism

Neurons are shown to use fatty acid β-oxidation as a fuel source for memory formation upon intensive learning in Drosophila, challenging the view that neurons are unable to use fatty acids for energy ...

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John Tuthill @tuthill.bsky.social · 09/12/2025

How do neural circuits generate the walking rhythm? Using connectome simulations, @sarahpugly.bsky.social found a minimal central pattern generator (CPG) that produces oscillations in leg motor neurons. Same circuit motif for each 🪰 leg. w @bingbrunton.bsky.social www.biorxiv.org/content/10.1...

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Piali Sengupta @senguptalab.bsky.social · 25/11/2025

Check out the newest Editors' (that would be me and Eunjoon Kim) Choice issue in Current Opinion in Neurobiology. Superbly guest edited by Stephen Liberles and @zknight.bsky.social >20 review articles on Interoception www.sciencedirect.com/special-issu...

sciencedirect.com

Current Opinion in Neurobiology | Interoception 2025 | ScienceDirect.com by Elsevier

Read the latest articles of Current Opinion in Neurobiology at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature

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John Tuthill @tuthill.bsky.social · 29/10/2025

Do flies feel pain? Spooky new preprint from our lab on the cells and circuits that mediate nociceptive behaviors in adult Drosophila, led by graduate student (and newly minted PhD!) @jonesjes.bsky.social. 🪰⚡👻🎃 www.biorxiv.org/content/10.1...

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Greg Jefferis @jefferis.bsky.social · 05/10/2025

Exciting news for #drosophila #connectomics and #neuroscience enthusiasts: the Drosophila male central nervous system connectome is now live for exploration. Find out more at the landing page hosted by our Janelia FlyEM collaborators www.janelia.org/project-team....

janelia.org

Male CNS Connectome

A team of researchers has unveiled the complete connectome of a male fruit fly central nervous system —a seamless map of all the neurons in the brain and nerve cord of a single male fruit fly and the ...

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fatima1amin.bsky.social @fatima1amin.bsky.social · 02/10/2025

What an exciting week!! Thanks to the Learning and Memory Conference and everyone 🙂🙂

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fatima1amin.bsky.social @fatima1amin.bsky.social · 26/09/2025

Can a PhD hat 👩‍🎓be cooler than this one? Nope. Thanks to my 2nd home (Gerber lab) for making this wonderful journey full of learning and memory. I am wholeheartedly thankful to my mentors, collaborators, advisors, well wishers, LIN, colleagues, friends, my flies, and my family. Thank you 🙏 26/09/25

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fatima1amin.bsky.social @fatima1amin.bsky.social · 04/09/2025

And here begins the 'LearnMamBo' era! Congratulations @obarnstedt.bsky.social as always!

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John Tuthill @tuthill.bsky.social · 02/08/2025

The first full central nervous system connectome dataset of an adult fly, with the most comprehensive annotation of sensory and motor neurons to date. A heroic effort with contributions from many groups, a product of the collaborative spirit of the Drosophila neuroscience community.

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fatima1amin.bsky.social @fatima1amin.bsky.social · 10/07/2025

🚨🚨My PhD work pre-print🚨🚨 Check it out 👇👇 'Avoidance engages dopaminergic punishment in Drosophila' It's a great collaborative enterprise and can't thank enough to my mentors and collaborators for the kindest efforts...fingers crossed 🤞🤞

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Ben Kanter @beneuroscience.bsky.social · 26/06/2025

Our new paper out now in Science explores how neural activity in the lateral entorhinal cortex (LEC) *drifts* over time - and *jumps* at key boundaries - to help organize events in memory. 🔗 www.science.org/doi/10.1126/... Here's a quick summary of what we found 🧵👇

science.org

Event structure sculpts neural population dynamics in the lateral entorhinal cortex

Our experience of the world is a continuous stream of events that must be segmented and organized at multiple timescales. The neural mechanisms underlying this process remain unknown. In this work, we...

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Lucia Prieto Godino @neuroluci.bsky.social · 12/06/2025

How do brain circuits evolve? We started looking for some answers by using synapse-resolution cross-species comparative connectomics on an entire olfactory circuit 👇 bit.ly/44aVm9E

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Yulong Li Lab @yulonglilab.bsky.social · 06/06/2025

Excited to share our Science paper on HaloDA1.0-the first genetically encoded far-red dopamine sensor! 🥳It enables powerful multiplex imaging in neurons, brain slices, and live animals.🧠🔬 #GRABsensors #Dopamine www.science.org/doi/10.1126/...

science.org

In vivo multiplex imaging of dynamic neurochemical networks with designed far-red dopamine sensors

Dopamine (DA) plays a crucial role in a variety of brain functions through intricate interactions with other neuromodulators and intracellular signaling pathways. However, studying these complex netwo...

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John Tuthill @tuthill.bsky.social · 03/06/2025

new preprint, led by @ellenlesser.bsky.social, on proprioceptive sensing of the Drosophila wing. tldr, there are a lot of proprioceptors out in the wing and they are wildly diverse and complex (eg, compared to the fly leg). just one example in this image...(1/4) www.biorxiv.org/content/10.1...

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Karl Deisseroth @deisseroth.bsky.social · 30/05/2025

Congratulations to our Human Neural Circuitry team; bit.ly/4dEyX7Z publishes today in Science! This was the hardest challenge of my career, but one of the most rewarding, after years of rebuilding– & expanding my inpatient neuropsychiatry in the service of basic discovery bsky.app/profile/deis...

bit.ly

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John Tuthill @tuthill.bsky.social · 19/05/2025

New preprint from the lab, led by grad student Brandon Pratt, on the encoding properties and sensorimotor function of proprioceptive limit detectors (ie, hair plates) in the fly leg. www.biorxiv.org/content/10.1...

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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 30/04/2025

How does a fly’s nervous system differ by sex? 🧠🪰 Led by Tomke Stürner & Paul Brooks, Greg Jefferis’ group, the Drosophila Connectomics group (University of Cambridge) & global colleagues publish a new atlas, revealing sex-specific neurons driving distinct behaviours. www.nature.com/articles/s41...

Map showing descending and ascending neurons across Drosophila sexes, using three electron microscopy datasets. Neurons are coloured by type.

A complete connectomic map of ascending and descending neurons in three electron microscopy datasets, reveals female (white) and male (red) specific neurons.

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Matt Collie @mottcallie.bsky.social · 28/04/2025

Many animals use "adaptive control" to pursue moving objects, relying on flexible feedback loops to adjust their movement gain over time. But how do neural circuits actually implement this? Here, we show how adaptive control in Drosophila pursuit involves two specialized parallel feedback loops.

doi.org

Specialized parallel pathways for adaptive control of visual object pursuit

To pursue an unpredictably moving visual object, the brain must generate motor commands that continuously steer the object to the midline of the visual field via feedback. Behavior implies that visual...

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Talia Lerner @talialerner.bsky.social · 22/04/2025

Pleased to share the final published version of @glopez.bsky.social's work in @currentbiology.bsky.social! www.sciencedirect.com/science/arti... "Region-specific nucleus accumbens dopamine signals encode distinct aspects of avoidance learning" Congrats, Gaby!!!

sciencedirect.com

Region-specific nucleus accumbens dopamine signals encode distinct aspects of avoidance learning

Avoidance learning—learning to avoid bad outcomes—is an essential survival behavior. Dopamine signals are widely observed in response to aversive stim…

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Fly Journal @fly-journal.bsky.social · 17/04/2025

Fly journal is now on BlueSky! The world’s only academic journal dedicated to research on Drosophila & cognate insects. A fully open-access journal that combines rapid publication with high standards of peer-review. For further info and how to submit your work, see the link.

tandfonline.com

Fly

Open access research on Drosophila developmental/evolutionary biology, organogenesis, neurobiology, circadian rhythms, learning & memory, sex determination

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eLife @elife.bsky.social · 18/04/2025

Why do some neurons say “sleep” while others shout “stay awake!” — inside the same brain? In fruit flies, researchers just mapped the molecular chaos behind this nightly tug-of-war. And it’s wilder than we thought. buff.ly/nA9M8EM

Individual cells within the indicated cell types with the indicated split-GAL4 lines

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Kadjita Asumbisa @kasumbisa.bsky.social · 15/04/2025

Excited to share the sequel to our 2022 paper! In this follow-up, we show that the stable head direction (HD) signals we reported in blind mice rely on stereo olfaction—that is, the comparison of odor info. between the two nostrils. Link: www.nature.com/articles/s41... 🧵highlights below

nature.com

Stereo olfaction underlies stable coding of head direction in blind mice - Nature Communications

Stereo olfaction involves comparing odor differences between the two nostrils. Here, using neuronal recordings and a behavioral test, the authors demonstrate that blind mice use stereo olfaction to fo...

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Michael Reiser @michaelreiser.bsky.social · 27/03/2025

I know there's a 𝒍𝒐𝒕 going on right now, but I couldn’t be prouder to share this long-incubated labor of love: the complete connectome of the male 𝐷𝑟𝑜𝑠𝑜𝑝ℎ𝑖𝑙𝑎 optic lobe 🧠🪰 🔗 www.nature.com/articles/s41...

nature.com

Connectome-driven neural inventory of a complete visual system - Nature

A connectome of the right optic lobe from a male fruitfly is presented together with an extensive collection of genetic drivers matched to a comprehensive neuron-type catalogue.

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Johannes Felsenberg @felsenberg.bsky.social · 18/02/2025

Open positions in our lab. Just sayin…

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iBehave @ibehave.bsky.social · 17/02/2025

🐝 iBehave Seminar: 'The Neural Basis of the Honey Bee Dance Language' 🔬 Join us for a fascinating talk by Prof. Dr. Barbara Webb @edinburghuni.bsky.social hosted by Prof. Dr. Ansgar Büschges from @unicologne.bsky.social 📅 Feb 24, 2025 | 🕓 16:00 CET 💻 Zoom details: ibehave@uni-bonn.de #seminar

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Alberto Mazzoni @Sant'Anna Pisa @albmazz.bsky.social · 09/01/2025

First post on @bsky.app to announce my first paper published @science.org! How much do we know about how the cortex encodes the same movement when it is performed in arbitrarily different contexts? Find out here: www.science.org/doi/10.1126/...

science.org

Neuroethology of natural actions in freely moving monkeys

The current understanding of primate natural action organization derives from laboratory experiments in restrained contexts (RCs) under the assumption that this knowledge generalizes to freely moving ...

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Scott Waddell @scottishwaddell.bsky.social · 17/12/2024

Pleasing to see that our Krashes et al 2009 study in the fly is the way it is in the mouse in 2024/5. www.biorxiv.org/content/bior...

biorxiv.org

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Oliver Barnstedt @obarnstedt.bsky.social · 15/12/2024

Pls reskeet! Just five more days to apply for this cool (admittedly, I'm biased) and fully-funded #PhD project in our lab!

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