Sign in

Matt Collie

@mottcallie.bsky.social
438 followers 567 following 64 posts

🧠 neuroscientist. 🍌 postdoc in the bean lab (harvard) developing new ion channel-targeted drugs and characterizing pain-sensing neurons.

PostsRepliesMedia
Reposted by Matt Collie
John Tuthill @tuthill.bsky.social · 12/06/2026
A glowing profile of my post-doc advisor. As @yvetteefisher.bsky.social says in the piece, Rachel is truly "...one of these generational scientists who thinks extremely incisively about both the details and the big-picture frameworks." magazine.hms.harvard.edu/articles/stu...
magazine.hms.harvard.edu
By Studying Fruit Flies, Rachel Wilson Is Changing How We Understand the Brain
14918
Reposted by Matt Collie
Wei-Chung Allen Lee @darbly.bsky.social · 12/06/2026
A great privilege of science is working with remarkable people. A nice piece highlighting @mindyisminsu.bsky.social. Her grit, esp through the pandemic, was foundational to the #BANC project. hms.harvard.edu/news/making-...
hms.harvard.edu
Making Connections, in the Brain and in Science
PhD student Minsu Kim gained confidence, experience in the lab of neurobiologist Wei-Chung Allen Lee
0165
Reposted by Matt Collie
Jan Drugowitsch @jdrugowitsch.bsky.social · 09/06/2026
Please check out @darbly.bsky.social & @asbates.bsky.social 's thread at bsky.app/profile/darb..., or HMS News at hms.harvard.edu/news/researc... for a quick overview, or read the full paper at doi.org/10.1038/s415... for details.
hms.harvard.edu
Researchers Publish First Complete Connectome of Fruit Fly Brain and ‘Spinal Cord’
Open-source resource poised to propel research on how nervous systems work
073
Reposted by Matt Collie
Wei-Chung Allen Lee @darbly.bsky.social · 09/06/2026
Now published - the #BANC! A full central nervous system (CNS) connectome of a limbed animal at single-synapse resolution, enabling us to follow sensory-motor arcs and understand how the CNS controls the body. rdcu.be/fncjS. #neuroscience. Video by @quorumetrix.bsky.social 1/18
214984
Matt Collie @mottcallie.bsky.social · 24/03/2026
Hey if the model models 🤷
000
Reposted by Matt Collie
The Brain Prize @brainprize.org · 05/03/2026
Warm congratulations to The Brain Prize winners 2026, Professor David Ginty and Professor Patrik Ernfors, for their pioneering work on how the nervous system detects and processes touch and pain. Karolinska Institutet HHMI #Neuroscience #BrainPrize2026
18536
Matt Collie @mottcallie.bsky.social · 18/02/2026
Thrilled to share that my graduate work is officially published in Neuron! 🎉 www.cell.com/neuron/fullt...
cell.com
Specialized parallel pathways for adaptive control of visual object pursuit
Collie et al. show how adaptive control in Drosophila visual pursuit arises from two parallel pathways: one steers objects from the periphery toward the center, while the other maintains central fixat...
34810
Reposted by Matt Collie
Chris J Dallmann @chrisjdallmann.bsky.social · 05/01/2026
How does the brain control locomotion? In our new preprint, we uncover a brain circuit in Drosophila that controls forward walking independently of turning. This dedicated locomotor circuit enables flexible motor control and might reflect a shared principle across species. doi.org/10.64898/202...
37927
Reposted by Matt Collie
Jan M. Ache @jan-ache.bsky.social · 19/12/2025
How do animals channel sensory information into motor pathways to generate flexible behavioral output? Excited to share a new preprint addressing this question by leveraging the new #maleCNS connectome, behavioral experiments, and in-vivo recordings: doi.org/10.64898/202.... A long🧵...
Landing and takeoff sensorimotor pathways illustrated alongside fly drawings showing behavioral responses.
37029
Matt Collie @mottcallie.bsky.social · 16/12/2025
🤩
010
Matt Collie @mottcallie.bsky.social · 04/11/2025
Always fun designing the most unnecessarily extravagant posters for our department happy hours 😁
030
Matt Collie @mottcallie.bsky.social · 03/11/2025
Delighted to share an updated pre-print on how adaptive control in visual pursuit is implemented at the circuit level. New behavior and neuronal data in females (!) shows how two AOTU pathways are key elements in both sexes. Check it out on @biorxiv-neursci.bsky.social : doi.org/10.1101/2025...
doi.org
Specialized parallel pathways for adaptive control of visual object pursuit
To pursue a moving visual object, the brain must generate motor commands that continuously steer the object to the center of the visual field via feedback. The gain of this control loop is flexible, y...
2145
Reposted by Matt Collie
John Tuthill @tuthill.bsky.social · 29/10/2025
Do flies feel pain? Spooky new preprint from our lab on the cells and circuits that mediate nociceptive behaviors in adult Drosophila, led by graduate student (and newly minted PhD!) @jonesjes.bsky.social. 🪰⚡👻🎃 www.biorxiv.org/content/10.1...
17629
Matt Collie @mottcallie.bsky.social · 23/10/2025
How it feels pushing a pre-print update (thread coming soon!)
010
Reposted by Matt Collie
Philipp Brand @pbrand.bsky.social · 16/10/2025
Excited to share our new #biorxivpreprint We discovered that the fruit fly #drosophila erecta requires food odor to mate and arousal is further enhanced by social group motion. Cross-species analysis of brain activity reveals a novel gate evolved from within a conserved circuit shorturl.at/gGYm7
a group of Drosophila erecta fruit flies on a small food patch. flies on white background
128444
Reposted by Matt Collie
Greg Jefferis @jefferis.bsky.social · 15/10/2025
Excited to share our new #biorxivpreprint: “Sexual dimorphism in the complete connectome of the Drosophila male central nervous system” www.biorxiv.org/content/10.1... We describe the #connectomics reconstruction and analysis of an entire adult #maleCNS #drosophila central nervous system. 1/10
112868
Matt Collie @mottcallie.bsky.social · 05/10/2025
😍
010
Reposted by Matt Collie
Bence Ölveczky @olveczky.bsky.social · 25/08/2025
Wrote a eulogy for the yellow letters in my office window. www.thecrimson.com/article/2025...
thecrimson.com
My Lab Displayed A Message of Solidarity on Our Windows. Harvard Took It Down. | Opinion | The Harvard Crimson
If we continue down this path, we risk not only Harvard’s future as an institution of free inquiry and expression but also its integrity and trustworthiness.
412051
Reposted by Matt Collie
Philipp Brand @pbrand.bsky.social · 21/08/2025
Exciting new Ruta lab preprint by @annaryba.bsky.social et al. on the neural underpinnings of intraspecific behavioral variation: Strain variation identifies a neural substrate for behavioral evolution Drosophila www.biorxiv.org/content/10.1...
biorxiv.org
Strain variation identifies a neural substrate for behavioral evolution in Drosophila
Sexual selection acts on heritable differences within species, driving the parallel diversification of signal production in one sex and behavioral responses in the other. This coevolution implies that...
12817
Reposted by Matt Collie
Greg Jefferis @jefferis.bsky.social · 21/08/2025
Neuronal diversity is written in transcriptional codes 🧬. But what is the logic of these codes that define cell types and wiring patterns? To find out we built a #scRNAseq developmental atlas of the Drosophila nerve cord and linked it to the #connectome 🪰🧠 #preprint thread ⬇️1/8
ALT text: A UMAP representation of a single cell RNAseq dataset from the Drosophila ventral nerve cord as well as images of the Drosophila nerve cord connectome and different stages of fly development.
612359
Reposted by Matt Collie
Bence Ölveczky @olveczky.bsky.social · 21/08/2025
And now for an update on my office window. www.thecrimson.com/article/2025...
thecrimson.com
Harvard To Remove Black Lives Matter Message From Biology Professors’ Office Windows | News | The Harvard Crimson
A Harvard administrator told two professors on Tuesday that a Black Lives Matter sign displayed in their office windows would be taken down by this Saturday, describing it as a violation of the Univer...
1318480
Reposted by Matt Collie
FlyBase @flybase.bsky.social · 15/08/2025
FlyBase needs your help! We ask that European labs continue to contribute to Cambridge, UK FlyBase, whereas US and other non-European labs can contribute to US FlyBase. For more information and how to donate: wiki.flybase.org/wiki/FlyBase...
wiki.flybase.org
FlyBase:Contribute to FlyBase - FlyBase Wiki
3130159
Reposted by Matt Collie
Minsu Kim @mindyisminsu.bsky.social · 05/08/2025
It’s surreal to think that every neuron and synapse in the fly brain + cord that was dissected almost five years ago (the photo’s still on the lab slack!) is now just a click away on Codex codex.flywire.ai?dataset=banc. This wouldn’t have been possible without the incredible team behind it!
1349
Matt Collie @mottcallie.bsky.social · 04/08/2025
We need more papers that start with Steve Urkel quotes. Thank you @kylethieringer.com and @tuthill.bsky.social for this wonderful and fun review of our recent paper describing limb feedback in the visual system! doi.org/10.1016/j.cu...
193
Reposted by Matt Collie
rachelirenewilson.bsky.social @rachelirenewilson.bsky.social · 03/08/2025
There is so much to learn from this dataset that it's overwhelming. It feels amazing to connect everything, from the "cognitive" regions of the brain all the way down to muscles, internal organs, and endocrine systems. With the analyses in our preprint, we've only just scratched the surface.
0134
Reposted by Matt Collie
Wei-Chung Allen Lee @darbly.bsky.social · 03/08/2025
Our data support an architecture of distributed, parallelized, and embodied control, reminiscent of “subsumption architectures” from autonomous robotics, where behavior-centric feedback loops are organized s that they can be combined or subsumed to generate complex or resolve competing behaviors.
Schematic example of subsumption architecture. This example has two local loops (behavior 1 and behavior 2), corresponding e.g.
the control of individual legs. Behavior 3 is positioned to take control of both local loops (subsumption), contingent on some input from
both sensors. Behavior 4 is positioned to subsume all other behaviors, based on some other input from both sensors.
172
Reposted by Matt Collie
Wei-Chung Allen Lee @darbly.bsky.social · 03/08/2025
Moreover, Zaki Ajabi developed a computationally efficient method for quantifying the “influence” any neuron has on any other neuron in the CNS. We applied this method to estimate the pairwise interactions between all cells in the CNS, amounting to more than 20 billion influence scores.
Cartoon of directed network graph and schematic depicting the influence of source cells on target cells is estimated via linear dynamical modeling.
162
Reposted by Matt Collie
Wei-Chung Allen Lee @darbly.bsky.social · 03/08/2025
How is the nervous system organized to coordinate behavior? To approach this massive question, a team led by @asbates.bsky.social, @jasper-tms.bsky.social, @mindyisminsu.bsky.social, & Helen Yang present the BANC: a Brain and Nerve Cord connectome. Preprint: doi.org/10.1101/2025... 🧪#Neuroskyence
412957
Reposted by Matt Collie
Meg Younger @megyounger.bsky.social · 31/07/2025
New preprint from @darbly.bsky.social‬ @briandepasquale.bsky.social‬ and my labs! If you love (or hate) mosquitoes, have a look: doi.org/10.1101/2025... We used TEM to describe the circuitry used for CO2 detection by mosquitoes. As usual with mosquitoes, nothing is as expected! 🌬️🦟
doi.org
Recurrent connectivity supports carbon dioxide sensitivity in Aedes aegypti mosquitoes
The mosquito Aedes aegypti′s human host-seeking behavior depends on the integration of multiple sensory cues. One of these cues, carbon dioxide (CO2), gates odorant and heat pathways and activates hos...
33214
Reposted by Matt Collie
Alexander Shakeel Bates @asbates.bsky.social · 02/08/2025
Public access to the first fly connectome that spans the whole CNS - BANC!: codex.flywire.ai?dataset=banc Different from prior connectomes - it is brain + cord (think spinal cord) We use it to ‘embody’ the system and find it resembles ‘subsumption architecture’ doi.org/10.1101/2025...
38835
Reposted by Matt Collie
Wei-Chung Allen Lee @darbly.bsky.social · 03/08/2025
With @megyounger.bsky.social's lab, et al., we present the first connectomics work in the disease-vector mosquito Aedes aegypti, revealing how its brain is wired to detect host cues. Preprint: doi.org/10.1101/2025... #Neuroscience #Connectomics #vEM #VectorBiology 🧪
Diagrams (top-left) of an adult female Ae. aegypti head and (bottom) a basiconic sensillum on maxillary palp (gray) which contain dendritic processes of olfactory sensory neurons (OSNs), including CO2-sensitive Gr3-expressing OSNs. OSN axons project centrally to the antennal lobes in the brain. On the right is a volumetric rendering of the mosquito brain neuropils including the antennal lobes (light blue) (Heinze et al., 2021; Matthews et al., 2019). Scale bar 100 μm.
16024
Reposted by Matt Collie
Alexander Shakeel Bates @asbates.bsky.social · 02/08/2025
A massive community effort, centred on @harvardmed.bsky.social‬ @princetonneuro.bsky.social‬. EM data from @darbly.bsky.social‬ lab, collected by @jasper-tms.bsky.social‬ ‪@mindyisminsu.bsky.social‬.
152
Reposted by Matt Collie
Dionnet L Bhatti Mazo @victoryofflight.bsky.social · 16/06/2025
Our new preprint: 𝐅𝐞𝐚𝐭𝐮𝐫𝐞-𝐬𝐩𝐞𝐜𝐢𝐟𝐢𝐜 𝐭𝐡𝐫𝐞𝐚𝐭 𝐜𝐨𝐝𝐢𝐧𝐠 𝐢𝐧 𝐥𝐚𝐭𝐞𝐫𝐚𝐥 𝐬𝐞𝐩𝐭𝐮𝐦 𝐠𝐮𝐢𝐝𝐞𝐬 𝐝𝐞𝐟𝐞𝐧𝐬𝐢𝐯𝐞 𝐚𝐜𝐭𝐢𝐨𝐧. We describe how the LS guides defensive responses by forming critical computations built from functionally and molecularly distinct cells and their afferent inputs. www.researchsquare.com/article/rs-6...
researchsquare.com
Feature-specific threat coding in lateral septum guides defensive action
The ability to rapidly detect and evaluate potential threats is essential for survival and requires the integration of sensory information, with internal state and prior experience. The lateral septum...
42310
Reposted by Matt Collie
John Tuthill @tuthill.bsky.social · 02/08/2025
The first full central nervous system connectome dataset of an adult fly, with the most comprehensive annotation of sensory and motor neurons to date. A heroic effort with contributions from many groups, a product of the collaborative spirit of the Drosophila neuroscience community.
14012
Matt Collie @mottcallie.bsky.social · 01/08/2025
Happy Friday! The female adult fly brain-and-nerve-cord (BANC) connectome is now LIVE! Explore the data here: codex.flywire.ai?dataset=banc Check out the preprint here: doi.org/10.1101/2025...
media.tenor.com
a man with a mustache in a blue suit says tiny celebration in front of a group of people
ALT: a man with a mustache in a blue suit says tiny celebration in front of a group of people
24218
Reposted by Matt Collie
Jan M. Ache @jan-ache.bsky.social · 28/07/2025
Preprint Alert! Walking mostly feels natural and easy to us - but the neuronal control of walking is actually incredibly complex. We leveraged the fruit fly as a genetically tractable animal model with a compact nervous system to ask how the brain controls walking direction: tinyurl.com/flywalk. 🧵..
media.tenor.com
a baby wearing a black space racer shirt
ALT: a baby wearing a black space racer shirt
14622
Matt Collie @mottcallie.bsky.social · 24/07/2025
New week, new fun story! In a study led by Melanie Basnak, our lab shows how the Drosophila head direction system flexibly remaps by weighing how informative environment cues (e.g. sun, wind) are—prioritizing more reliable inputs when conflicting. www.nature.com/articles/s41...
nature.com
Multimodal cue integration and learning in a neural representation of head direction - Nature Neuroscience
Basnak et al. show that particularly informative spatial cues produce a higher and narrower bump of activity in the Drosophila head direction system. More informative cues can instruct the remapping o...
091
Matt Collie @mottcallie.bsky.social · 17/07/2025
New paper from our lab! This was such a fun project to be a part of - proof that sometimes following a spurious observations down the rabbit hole leads to awesome findings. www.cell.com/current-biol...
cell.com
A cell type in the visual system that receives feedback about limb movement
Hartman et al. describe a cell type in the Drosophila visual system that is activated during head grooming through visual and non-visual signals arising from foreleg movements. These neurons inhibit a...
34819
Reposted by Matt Collie
Eileen Clancy 🧿 @clancyny.bsky.social · 12/07/2025
Harvard seemingly caves to Trump, shuts down LGBTQ+ and women's center websites. By Ryan Adamczeski for the Advocate @helloryro.bsky.social @theadvocatebr.bsky.social
advocate.com
Harvard seemingly caves to Trump, shuts down LGBTQ+ and women's center websites
Harvard has removed websites for its women's, LGBTQ+, and multicultural student centers.
1015596
Reposted by Matt Collie
Stand Up for Science! @standupforscience.net · 09/06/2025
(5/5) 🚨 It’s time to flood the zone. NIH scientists just took a huge risk speaking out. Now it’s our turn. 📜 Read the Bethesda Declaration ✍️ Sign the Public Letter of Support 👯‍♀️Follow NIHers doing the work: @nihvigils.bsky.social Read and sign here 👉 www.standupforscience.net/bethesda-dec...
standupforscience.net
3452251
Reposted by Matt Collie
John Tuthill @tuthill.bsky.social · 03/06/2025
new preprint, led by @ellenlesser.bsky.social, on proprioceptive sensing of the Drosophila wing. tldr, there are a lot of proprioceptors out in the wing and they are wildly diverse and complex (eg, compared to the fly leg). just one example in this image...(1/4) www.biorxiv.org/content/10.1...
13611
Reposted by Matt Collie
Sweta Agrawal @hokuba.bsky.social · 02/05/2025
Happy to announce that our paper examining the function of leg mechanosensory neurons by way of their connectivity is finally officially published! rdcu.be/ekqVt
rdcu.be
Divergent neural circuits for proprioceptive and exteroceptive sensing of the Drosophila leg
Nature Communications - Determining whether somatosensory neurons are involved in internal or external sensing remains a challenge. Here, the authors show that analyzing connectivity is a powerful...
25219
Matt Collie @mottcallie.bsky.social · 01/05/2025
Every time I see my own pre-print in the wild 🤩
media.tenor.com
David Rose Schitts Creek GIF
ALT: David Rose Schitts Creek GIF
020
Matt Collie @mottcallie.bsky.social · 28/04/2025
Many animals use "adaptive control" to pursue moving objects, relying on flexible feedback loops to adjust their movement gain over time. But how do neural circuits actually implement this? Here, we show how adaptive control in Drosophila pursuit involves two specialized parallel feedback loops.
doi.org
Specialized parallel pathways for adaptive control of visual object pursuit
To pursue an unpredictably moving visual object, the brain must generate motor commands that continuously steer the object to the midline of the visual field via feedback. Behavior implies that visual...
13115
Reposted by Matt Collie
Scott Delaney @scott-delaney.bsky.social · 15/04/2025
As someone directly affected by this, let me be clear: I'd rather lose my job because Harvard chose to fight than keep my job and see a generation of white supremacists parade its corpse around like a war trophy.
371939385
Reposted by Matt Collie
MIT Press @mitpress.bsky.social · 08/04/2025
We're disappointed to see Ben Barres's powerful book "The Autobiography of a Transgender Scientist" among the ~400 titles removed from the Naval Academy Library. Needless to say, we're proud to have published his book and will keep it — and his memory — alive.
thereader.mitpress.mit.edu
The Coming Out of a Transgender Scientist
"I know that I am making the right decision because whenever I think about changing my gender role, I am flooded with feelings of relief."
182883913
Reposted by Matt Collie
Scott Waddell @scottishwaddell.bsky.social · 21/03/2025
elifesciences.org/articles/92618
elifesciences.org
Spatial transcriptomics in the adult Drosophila brain and body
Spatial transcriptomics of adult Drosophila brain and body sections determined the spatial expression for 150 genes, which identified the locations of unknown neuronal cell types and transcriptional d...
1107
Matt Collie @mottcallie.bsky.social · 10/03/2025
Harvard Medical School just announced a "temporary pause" on "all hiring, including academic and administrative positions" (via Dean Daley) so bracing for our funding to be pulled by end of week
021
Matt Collie @mottcallie.bsky.social · 07/03/2025
Boston Commons
031