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Maggie Smith

@factor50.bsky.social
128 followers 94 following 25 posts

Retired Professor of Microbiology in the UK. Love bacteriophages, Streptomyces, fun, outdoors, culture and politics.

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Reposted by Maggie Smith
Malcolm White @mfwhite2.bsky.social · 25/09/2026
New from the @multidefence.bsky.social consortium: a deep dive into MANTIS defence. Thanks to @ukri.org for funding. www.biorxiv.org/content/10.6...
biorxiv.org
Dual ATPase-activated DNA hemimethylation and cleavage by the MANTIS defence system
Bacterial defence systems are diverse and form major barriers to horizontal gene transfer and bacteriophage (phage) infection. Though restriction-modification systems were the first such defences disc...
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Julian Parkhill @julianparkhill.bsky.social · 08/09/2026
Chair in Bacteriology in Cambridge Department of Medicine. A great opportunity. Please circulate. www.cam.ac.uk/jobs/researc...
cam.ac.uk
Research Professor in the field of Bacteriology
Strengthening Cambridge's leadership in bacteriology research Bacterial infection and antimicrobial resistance remain among the most pressing global health challenges of our time. At Cambridge, the De...
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Curtis Suttle @virosphere.bsky.social · 13/08/2026
Professor in Bacteriophage Biology & Evolution at the University of British Columbia (UBC). Closing date 1 October, with an expected start date no earlier than January 1, 2027, and a salary within the range of $200,000 to $270,000 per year. For details: ubc.wd10.myworkdayjobs.com/en-US/ubcfac...
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Malcolm White @mfwhite2.bsky.social · 11/08/2026
Tim Blower and I are guest editing a Biochemical Journal @biochemsoc.bsky.social themed collection on: The Prokaryotic Immune System It's now open for research submissions and we'd welcome submission of research and review articles. More info: portlandpress.com/biochemj/pag...
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The Royal Society @royalsociety.org · 17/06/2026
Professor Colin Kleanthous FMedSci FRS is elected a Fellow of the Royal Society. He is a biochemist whose work has fundamentally changed our understanding of the outer membrane (OM) of Gram-negative bacteria. #RSFellows royalsociety.org/people/colin-klean…
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Susan Schlimpert @s-lab.bsky.social · 07/05/2026
Dear PhD students and postdocs — we want to hear about your science firsthand at our annual Early Career Microbiologists Mini-Symposium @johninnescentre.bsky.social (UK) this September. For more information and to apply: www.jic.ac.uk/event/early-...
jic.ac.uk
Early Career Microbiologists Mini-Symposium 2026 | John Innes Centre
The Department of Molecular Microbiology is organising a one and a half day Early- Career Microbiologists Mini-Symposium. The symposium will be held from Tuesday 22nd – Wednesday 23rd September 2026.
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Maggie Smith @factor50.bsky.social · 28/04/2026
A great lab to study in - PhD student hopefuls apply now!!
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Reposted by Maggie Smith
Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 23/04/2026
Come and study for a PhD with us on antibiotic-producing Streptomyces, trying to understand the roles of primary metabolic enzymes with additional cellular roles - Details below - please repost www.findaphd.com/phds/project...
findaphd.com
Primary metabolic enzymes in antibiotic-producing Streptomyces bacteria, but not as we know them! at University of Strathclyde on FindAPhD.com
PhD Project - Primary metabolic enzymes in antibiotic-producing Streptomyces bacteria, but not as we know them! at University of Strathclyde, listed on FindAPhD.com
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Maggie Smith @factor50.bsky.social · 18/03/2026
Just listened to this excellent podcast with @paulhoskisson.bsky.social Paul is such a great communicator and so articulate. Made a motorway drive (with hold ups) ALOT more pleasurable. Thanks. podcasts.apple.com/gb/podcast/m...
podcasts.apple.com
Matters Microbial #125: Antibiotics, Streptomyces and Evolution
Podcast Episode · Matters Microbial · 15 March · 1h 10m
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Andreas Haag @andreashaag.bsky.social · 25/02/2026
📢 Funded PhD in molecular microbiology & phage biology How do bacterial stress responses control prophage activation and horizontal gene transfer? Join us at St Andrews to dissect Clp protease–mediated regulation in Staphylococcus aureus. Apply: www.findaphd.com/phds/project...
findaphd.com
Protease-Controlled Prophage Activation in Staphylococcus aureus: New Mechanisms Driving Antimicrobial Resistance and Virulence at University of St Andrews on FindAPhD.com
PhD Project - Protease-Controlled Prophage Activation in Staphylococcus aureus: New Mechanisms Driving Antimicrobial Resistance and Virulence at University of St Andrews, listed on FindAPhD.com
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Maggie Smith @factor50.bsky.social · 23/02/2026
Looking forward to hearing this
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Maggie Smith @factor50.bsky.social · 20/02/2026
Streptomyces and other actinos are really fascinating bacteria. Always something new to discover.
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Chris Addison @mrchrisaddison.bsky.social · 14/02/2026
TONIGHT!! 👇👇👇👇👇👇👇👇👇
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Maggie Smith @factor50.bsky.social · 07/02/2026
Great to see this is out now. Congratulations to all the authors.
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John Innes Centre @johninnescentre.bsky.social · 30/01/2026
📢 New plant science textbook Staff and alumni from our institute and @thesainsburylab.bsky.social have recently published Essential Plant Biology, a new textbook presenting current and comprehensive knowledge of plant biology 🌱
Alison Smith, Author and Emeritus Fellow at the John Innes Centre said, “We were inspired to write this book by the stimulating, creative and supportive environment provided by our JIC and TSL colleagues. It is intended to provide a new generation of plant scientists with an appreciation of the wealth and breadth of radically new knowledge and technologies in plant science. The book also reveals some of the exciting opportunities for fundamental discovery and innovation in plant science to help tackle global challenges including sustainable food production, environmental pollution, climate change and biodiversity loss.”
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Malcolm White @mfwhite2.bsky.social · 22/01/2026
Our latest CRISPR ring nuclease paper focusses on Csx15 - which seems to act as of a sponge as well as a canonical phosphodiesterase. Great work led by @haotianchi.bsky.social www.biorxiv.org/content/10.6...
biorxiv.org
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Maggie Smith @factor50.bsky.social · 21/01/2026
Catch this if you can! Highly recommended.
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The Fake History Hunter @fakehistoryhunter.net · 07/01/2026
Here's just a few about the middle ages... fakehistoryhunter.net/2019/09/10/m...
fakehistoryhunter.net
Medieval Myths Bingo
There is so much “fake history” going around about the Medieval Era that I decided to write this article and create this; There are a lot of myths and misconceptions about “The&#8…
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Maggie Smith @factor50.bsky.social · 20/12/2025
Congratulations Mike! Well deserved. 👏👏👏
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Michael Brockhurst @brockhurstlab.bsky.social · 20/12/2025
Manchester Institute of Biotechnology is looking for a new Professor. There are a few priority areas including microbial engineering (broadly defined, from pathways to cells to microbiomes). Closing 12 Jan. Join us in the best city in the UK 😜 www.jobs.manchester.ac.uk/Job/JobDetai...
jobs.manchester.ac.uk
Professorial Appointment within the Manchester Institute of Biotechnology:Manchester Institute of Biotechnology
Applications are invited for a professorial appointment to be based in the Manchester Institute of Biotechnology (MIB) at the University of Manchester (UoM). The successful candidate will join a dynamic research environment at an exciting time and will help shape the institute research priorities and national/international profile. We are open to high quality applications from across the broad engineering biology and biotechnology landscape. Specific areas of interest include but are not limited to chemical biology of disease related proteins, natural product biosynthesis and enzyme discovery; structural biology and mechanistic enzymology; and microbial engineering.
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Matt Hutchings @handle.invalid · 11/12/2025
So happy to see Mark recognised for his incredible work. Over a ~40 year career he and his group discovered ECF sigma factors, characterised many key developmental regulators of the Streptomyces lifecycle, and identified new mechanisms of bacterial gene regulation, antibiotic action and resistance.
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Multi-Defence @multidefence.bsky.social · 27/11/2025
Highlights from our recent participation! Members of the Multi-Defence Consortium presented both talks and posters on phage defence systems — showcasing exciting progress across the field. Great discussions, great science, and we’re excited to share more soon! #MicroEvo25
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Maggie Smith @factor50.bsky.social · 19/11/2025
Congratulations to all the Microbiology Society Prize winners!
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Maggie Smith @factor50.bsky.social · 14/11/2025
Congratulations!
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Mike Bottery @mbottery.bsky.social · 05/11/2025
Exciting news! I have two positions open in my lab at the UoManchester: one PDRA and one Research Tech. Join our team to study evolutionary mycology and help us understand antifungal resistance in fungal pathogens. A fantastic opportunity to join the brilliant Manchester Fungal Infection Group!
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Maggie Smith @factor50.bsky.social · 08/11/2025
Improved LSRs for integrating DNA into the human genome. Great work!
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Emmanuele Severi @emmseveri.bsky.social · 31/10/2025
#microsky #phagesky Mycobacterium #phage review by Graham Hatfull covering the state of the art www.pnas.org/doi/10.1073/...
pnas.org
All the world’s a phage | PNAS
A renewed interest in bacteriophages has emerged from the explosive discovery of the complex pan-immune bacterial defense system and a revival of t...
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Asaf Levy @asaflevylab.bsky.social · 26/10/2025
R.I.P Hamilton Smith, 1978 Nobel Laureate for the discovery of type II restriction-modification systems (HindII).
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Emmanuele Severi @emmseveri.bsky.social · 16/10/2025
www.biorxiv.org/content/10.1... #phagesky on BREX #phage defence
biorxiv.org
Expanding the Landscape of BREX Diversity: Uncovering Multi-Layered Functional Frameworks and Identification of Novel BREX-Related Defense Systems
Despite extensive scrutiny of BREX systems, several overarching questions persist regarding the functional modalities of individual components and the collective mechanistic framework underlying their...
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Chris Addison @mrchrisaddison.bsky.social · 10/10/2025
TONIGHT! Come along if you’re within reach of Sheffield and/or on a mercy dash from the south to get some Hendo’s. This is going to be fab. I’m (a) super excited; (b) on my way! musicintheround.co.uk/events/chris...
musicintheround.co.uk
CHRIS ADDISON'S INCOMPLETE GUIDE TO CHAMBER MUSIC
CHRIS ADDISON'S INCOMPLETE GUIDE TO CHAMBER MUSIC - Music in the Round %
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Three Acres And A Cow @threeacresacow.bsky.social · 10/10/2025
Thanks Sheffield, that was a super fun evening!
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Maggie Smith @factor50.bsky.social · 10/10/2025
This was really fun. See it if you can.
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Emmanuele Severi @emmseveri.bsky.social · 09/10/2025
hosting.northumbria.ac.uk/nu-omics/vom... #phagesky #phage #microsky Come and join us for Viruses of Microbes UK 2026 at @northumbriauni.bsky.social ! Fantastic chance for ECRs to showcase their work 🙂
hosting.northumbria.ac.uk
VOM-UK Conferences - NU-OMICS
Viruses of Microbes UK (VoM-UK) Conference The Virus of Microbes UK (VoM-UK) Conference is hosted by Microbiome Excellence Peak of Excellence at Northumbria University. This two-day conference takes place annually at the end of January/beginning of February and is a chance for researchers to gather and share their knowledge. The VoM-UK conference is designed to […]
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Microbiology Society @microbiologysociety.org · 07/10/2025
Huge congratulations to Emma Davis, the winner of 2025's Early Career Microbiologist of the Year prize! We agree with Emma that all of the finalists' talks were brilliant and a massive well done to everyone involved!
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Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 30/09/2025
Come and work with me and @ariannebabina.bsky.social on #Streptomyces evolution and antibiotic production Origins of a tangled bank: Adaptation and evolution in antibiotic-producing Streptomyces www.gla.ac.uk/postgraduate... please repost
gla.ac.uk
University of Glasgow - Postgraduate study - Centres for Doctoral Training - NorthWest Biosciences - Our Projects - Underpinning Bioscience - Paul A Hoskisson
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Nature @nature.com · 18/07/2025
Nature research paper: Prophages block cell surface receptors to preserve their viral progeny go.nature.com/3IwINxb
go.nature.com
Prophages block cell surface receptors to preserve their viral progeny - Nature
Zip promotes the accumulation of free phages in bacterial lysogen communities, safeguarding phage progeny.
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Michael Brockhurst @brockhurstlab.bsky.social · 15/07/2025
Super proud of amazing lab alumnus @mbottery.bsky.social who has been awarded a prestigious @wellcometrust.bsky.social fellowship to grow his lab @officialuom.bsky.social studying the evolution of fungal pathogens! Mike has multiple postdoc positions available on his exciting project (details 👇)
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Mark A. Hanson @hansonmark.bsky.social · 03/06/2025
URGENT: FlyBase has lost practically all its funding overnight; even user fees are tied up in denied grant funding. 🤬🤯 Any lab using @flybase.bsky.social please donate using the link in post below. This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.
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Maggie Smith @factor50.bsky.social · 02/06/2025
Please support this… chng.it/q4t8VxQgSf
chng.it
Sign the Petition
Not in our name: Women in support of the trans+ community
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Maggie Smith @factor50.bsky.social · 22/05/2025
Congratulations to Professor Graham Hatfull on being elected as a Royal Society Fellow!! So pleased to see this. royalsociety.org/people/james...
royalsociety.org
Fellow Detail Page | Royal Society
Explore the history of the Royal Society, including our motto and discover our timeline of key events.
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Michael Brockhurst @brockhurstlab.bsky.social · 06/03/2025
Like antibiotics, we know antimicrobial peptides select for resistance in bacteria, but worse that peptide resistance can also cross-protect against host peptides, potentially undermining immunity. Caution required, not talk of “goldmines” on R4 Today
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Michael Brockhurst @brockhurstlab.bsky.social · 06/03/2025
Given hyperbole about this paper www.nature.com/articles/s41... in the news today (eg www.bbc.co.uk/news/article...) it is a good day to post this classic from >20 years ago: www.microbiologyresearch.org/content/jour...
microbiologyresearch.org
Arming the enemy: the evolution of resistance to self-proteins
A remarkable range of novel antibiotics is attracting increasing interest as a major new weapon in the campaign against bacterial infection. They are based on the toxic peptides that provide the innat...
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