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Mike Bottery

@mbottery.bsky.social
535 followers 81 following 27 posts

Microbial Evolution - AMR - University of Manchester

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Reposted by Mike Bottery
Fungal One Health and Antimicrobial Resistance (F1AMR) Network @f1amr-network.bsky.social · 03/07/2026
"Fungal resistance is a silent and underestimated threat. The same substances helping to protect crops are also reducing the effectiveness of essential medicines. If we fail to act, we risk losing critical treatments and putting lives at risk” @mbottery.bsky.social www.fungalamr.org/post/three-u...
fungalamr.org
Three urgent actions to tackle fungal antimicrobial resistance in the UK: a new paper
“Fungal resistance is a silent and underestimated threat. The same substances helping to protect crops are also reducing the effectiveness of essential medicines. If we fail to act, we risk losing cri...
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Reposted by Mike Bottery
MEEhubs @meehubs.bsky.social · 18/03/2026
MEEHubs2026 registration and abstract submission is now online! 🚨🦠✨ Join us Aug 3 - 5, 2026 at one of the 7 hubs or online. We are incredibly excited about our lineup of speakers, and hope that you submit an abstract to contribute too! More information and registration links at: meehubs.org
meehubs.org
Home
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Mike Bottery @mbottery.bsky.social · 19/02/2026
PhD Opportunity: Are you interested in evolutionary biology and the global challenge of antifungal resistance? We are seeking a motivated candidate for a President’s Doctoral Scholar Award 📅Deadline: March 16 2026 📍Location: @manchester.ac.uk @fbmh-uom.bsky.social www.findaphd.com/phds/project...
findaphd.com
(PDS) Targeting Septal Plugging to Disrupt the Evolution of Antifungal Resistance in Hyphal Networks at The University of Manchester on FindAPhD.com
PhD Project - (PDS) Targeting Septal Plugging to Disrupt the Evolution of Antifungal Resistance in Hyphal Networks at The University of Manchester, listed on FindAPhD.com
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Mike Bottery @mbottery.bsky.social · 04/12/2025
Presenting my perspective on the role of academic science on the issues of antifungal dual use at the Brazilian Network Meeting on Aspergillus fumigatus Antimicrobial Resistance. @f1amr-network.bsky.social @fbmh-uom.bsky.social
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Mike Bottery @mbottery.bsky.social · 05/11/2025
Exciting news! I have two positions open in my lab at the UoManchester: one PDRA and one Research Tech. Join our team to study evolutionary mycology and help us understand antifungal resistance in fungal pathogens. A fantastic opportunity to join the brilliant Manchester Fungal Infection Group!
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Reposted by Mike Bottery
Natalie Bennett @nataliegreenpeer.bsky.social · 16/09/2025
Currently hosting event on antifungals in medicine and agriculture, focusing on #AntiMicrobialResistance #AMR. With 6.5 million invasive infections globally each year, and 3.8 million deaths attributable to them. Area of fast-rising concern!
Graph: global incidence and mortality of sever fungal disease
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Mike Bottery @mbottery.bsky.social · 08/09/2025
Very proud of Ed's first conference talk at #BSMM2025 did great despite the technical hiccups!!
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Reposted by Mike Bottery
Bertuzzi Lab @bertuzzilab.bsky.social · 04/07/2025
Interested in working on Mucorales adaptation? Thanks to new funding from @wellcometrust.bsky.social, we will have two postdoc and a technician positions advertised very soon! if interested, please get in touch for more information.
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Mike Bottery @mbottery.bsky.social · 08/07/2025
Thrilled to announce I've been awarded a @wellcometrust.bsky.social Career Development Award at @fbmh-uom.bsky.social , University of Manchester! My research will investigate the remarkable adaptability of Aspergillus fumigatus, a deadly fungal pathogen, to help combat drug resistance.
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UK Health Security Agency @ukhsa.bsky.social · 04/06/2025
The MHRA today released new guidance for #Phage therapy in the UK. This will provide direction for scientists and researchers working to make this treatment a reality for patients. 🔬 🧪 🔗 www.gov.uk/government/n...
Dr Colin Brown, deputy director at the UK Health Security Agency, responsible for AMR, said: 
 
“Phage therapy truly has the potential to transform the way we treat bacterial infections, especially as resistance to antibiotics grows. At UKHSA, we’re developing new ways to help increase phage therapy use and research, including a bacteriophage collection where scientists can both access and deposit phages. In time, we hope solutions like phage therapy can become a first-line treatment option.”
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Reposted by Mike Bottery
Michael Brockhurst @brockhurstlab.bsky.social · 16/04/2025
New preprint with nice detective work by PhD student Khadija Hanga: gain of pOXA MDR plasmid is facilitated by chromosomal mutations affecting OmpF which act synergistically with the plasmid’s carbapenamase to give high level resistance. Led by @mbottery.bsky.social www.biorxiv.org/content/10.1...
biorxiv.org
Chromosomal resistance mutations facilitate acquisition of multidrug-resistance plasmids in Escherichia coli
Bacteria can gain multiple resistance mechanisms in a single step by the acquisition of multidrug-resistance (MDR) plasmids, but it is unclear how antibiotic selection during the acquisition of MDR pl...
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Mike Bottery @mbottery.bsky.social · 01/04/2025
@wellcometrust.bsky.social Thanks for organizing the ERC meeting. I found the research culture activity really helpful, so many great thought-provoking ideas
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Mike Bottery @mbottery.bsky.social · 19/12/2024
Beautiful day to get out of the office and do some fieldwork! Soil samples + 🍄 #failsafe #mycology @normanvanrhijn.bsky.social
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Mike Bottery @mbottery.bsky.social · 16/12/2024
New in Nature Comms, we show that azole-resistant Aspergillus fumigatus are more likely to evolve resistance to new antifungals due to variants in their DNA mismatch repair system rdcu.be/d3Iyc @natureportfolio.bsky.social #microsky #fungi #amr
rdcu.be
Elevated mutation rates in multi-azole resistant Aspergillus fumigatus drive rapid evolution of antifungal resistance
Nature Communications - Here, Bottery et al show that resistance to next generation antifungals is more likely to occur within azole resistant Aspergillus fumigatus due to the close linkage between...
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Reposted by Mike Bottery
Michael Brockhurst @brockhurstlab.bsky.social · 04/12/2024
In case you missed it: @matthewjshepherd.bsky.social surveyed the clinical literature to reveal how #AMR evolves within patients, why eco/evo mechanisms vary among infections, & what we can do better to improve treatments www.nature.com/articles/s41... #MicroSky
nature.com
Ecological and evolutionary mechanisms driving within-patient emergence of antimicrobial resistance - Nature Reviews Microbiology
In this Review, Shepherd, Brockhurst and colleagues explore the clinical evidence in support of four major ecological and evolutionary mechanisms of within-patient antimicrobial resistance emergence i...
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Mike Bottery @mbottery.bsky.social · 03/12/2024
It was great fun to be part of this project! Super cool to see Rock-Paper-Scissors dynamics in real microbial populations
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Mike Bottery @mbottery.bsky.social · 28/11/2024
PhD studentship alert! Fully funded, co-supervised with @rokkrasovec.bsky.social and Prof Mike Bromley, University of Manchester Exploring routes of horizontal gene transfer in pathogenic fungi Exciting project, will be a bunch of fun! Come & join us 🔬 www.findaphd.com/phds/project...
findaphd.com
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Reposted by Mike Bottery
Chris Knight @knightjar.bsky.social · 27/11/2024
Soil microbiomes show consistent and predictable responses to extreme events We’re out in Nature !! doi.org/ntzk Very exciting for my first bluesky post! – it’s been a long haul by an excellent team from across Europe, led by @frantecol.bsky.social
doi.org
Soil microbiomes show consistent and predictable responses to extreme events - Nature
Soils from 30 grasslands across Europe were subjected to 4 contrasting extreme climatic events under drought, flood, freezing and heat conditions, with the results suggesting that soil microbiomes fro...
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Mike Bottery @mbottery.bsky.social · 23/11/2024
Fungal Genetics Stock Centre, there's something fishy going on here...
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Mike Bottery @mbottery.bsky.social · 21/11/2024
It was a pleasure to have the opportunity to present our work!
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Mike Bottery @mbottery.bsky.social · 21/11/2024
Excited to be giving a talk this afternoon on the risk of AMR evolution in fungal pathogens @newcastleuni.bsky.social #WAAW #AMR
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