Rossi and colleagues assemble an in vitro enzymatic pipeline using enzymes from distinct domains of life to recapitulate eukaryotic N-glycosylation. This work advances the synthesis of bespoke glycope...

Multiscale cryo-EM of centrioles reveals the structure and polymorphism of the A-C linker connecting microtubule triplets.

Adhesive, filamentous type 1 pili are critical virulence factors in urinary tract infections. Here, the authors describe the cryo-EM structures of the entire type 1 pilus with all its structural compo...

Chemist and microbiologist Jörn Piel combs through the vast world of bacteria for new natural substances to combat the antibiotic crisis. The ETH professor has now been honoured for his research with ...

The scientific community must take a strong and active stand against vaccine revisionism — the false narrative that there is insufficient evidence to support the safety and efficacy of vaccines.

Statement on the impact and safety of vaccines led by the American Association of Immunologists and the American College of Physicians.

Mycobacterium tuberculosis has a proteasome similar to eukaryotes. This study reveals how the activator Bpa recruits its substrate HspR, providing structural and mechanistic insights. The authors iden...

The virus targets certain types of immune cells in the body, destroying them in the process.

Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics that...

Genetically modified mice have traits geared towards cold tolerance, in step towards modifying elephants

The 2025 Gordon Research Conference on Biology of Mycobacteria will be held in Pomona, California. Apply today to reserve your spot.

The midnolin-proteasome pathway degrades many nuclear proteins without ubiquitination, but how it operates mechanistically remains unclear. Here, we present structures of the midnolin-proteasome compl...