Nardone et al. elucidate the mechanism of the midnolin-proteasome pathway, showing how midnolin achieves nuclear substrate selection and how established proteasomal components are repurposed to enable...

Establishing the composition of RNAs and proteins that defines the identities and functions of cells relies not only on the regulated biosynthesis of these molecules, but also equally importantly, on…

The midnolin-proteasome pathway degrades many nuclear proteins without ubiquitination, but how it operates mechanistically remains unclear. Here, we present structures of the midnolin-proteasome compl...

The midnolin-proteasome pathway degrades many nuclear proteins without ubiquitination, but how it operates mechanistically remains unclear. Here, we present structures of the midnolin-proteasome compl...