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Ewan Harrison

@ewanharrison.bsky.social
367 followers 544 following 26 posts

Microbiologist at the Wellcome Sanger Institute and University of Cambridge.

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Reposted by Ewan Harrison
Nick Loman @pathogenomenick.bsky.social · 16/05/2026
Rapid release of multiplex PCR amplicon scheme for Andes hantavirus whole genome sequencing validated on control material: www.biorxiv.org/content/10.6... @scalene.bsky.social @stevepullan.bsky.social @ukhsa.bsky.social output from HPRU in Public Health Genomics
biorxiv.org
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Ewan Harrison @ewanharrison.bsky.social · 12/03/2026
Day 4 - part 2 AMR of Bacterial Pathogens - Africa course #AMRBactcourse on the sequencing practical with Nanopore led by @effkay88.bsky.social Huge thanks to the team from @nanoporetech.com South Africa @eventswcs.bsky.social @sangerinstitute.bsky.social
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Ewan Harrison @ewanharrison.bsky.social · 11/03/2026
Day 4 - AMR of Bacterial Pathogens - Africa course #AMRBactcourse. AMR testing results day… Results of disk testing, e-tests, and micro-dilution @eventswcs.bsky.social @sangerinstitute.bsky.social @cam.ac.uk
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Ewan Harrison @ewanharrison.bsky.social · 11/03/2026
Day 3 of AMR of Bacterial Pathogens - Africa course at NICD Johannesburg. Split day into the lab for AMR disk testing, MICs and broth micro-dilution. On the computers and lectures on online and command line AMR tools, MLST and phylogeny. Busy day! @sangerinstitute.bsky.social @engagewcs.bsky.social
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Ewan Harrison @ewanharrison.bsky.social · 09/03/2026
Fantastic second day of Antimicrobial Resistance of Bacterial Pathogens - Africa course at NICD Johannesburg. Packed day - covering the basics of genomics, the command line, QC, genotype-to-phenotype, assembly and alignments. @sangerinstitute.bsky.social @engagewcs.bsky.social @fcic.bsky.social
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masseylab.bsky.social @masseylab.bsky.social · 07/03/2026
Lovely work driven by Lizzie Ledger in the group: a new but druggable mechanism by which Staphs produce biofilm using components of human serum. First polysaccharides, then protein, then eDNA, now lipids too! bsky.app/profile/bior...
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Daniela Robles-Espinoza @daniela-oaks.bsky.social · 18/02/2026
We are very happy to see our study finally appear online @nature.com! This has been work of nearly 10 years in collaboration with the National Institute of Genome Medicine 🇲🇽, the National Cancer Institute 🇲🇽, the @sangerinstitute.bsky.social and others ⬇️ www.nature.com/articles/s41...
nature.com
Ancestry and somatic profile indicate acral melanoma origin and prognosis - Nature
Analysis of the somatic and transcriptomic profile of 123 acral melanoma samples from Mexican patients helps understand tumour origins and prognosis, and highlights the importance of including samples...
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Josie Bryant @josiebryant.bsky.social · 13/02/2026
Incredible time at #AIR2026 covering breadth of respiratory infection, microbiomes and immunology with some really beautiful biology. Thanks to fellow committee members @resp-micro.bsky.social @drclairesmith.bsky.social @ewanharrison.bsky.social , Alex Kayongo and organisers @eventswcs.bsky.social
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Dr Claire Smith @drclairesmith.bsky.social · 12/02/2026
Another insightful day of science, discussion and making new friends at #AIR2026 Day 2 Highlights: making sense of big data, spatial transcriptomics and in vitro modelling of respiratory infections @eventswcs.bsky.social @sangerinstitute.bsky.social
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John Lees @johnlees.bacpop.org · 06/01/2026
Our new preprint which reimplements "the NFDS model" (of Corander et al) to forecast populations after vaccination as a compartmental model, and uses new bioinformatic tools to create and process the pangenome data We look at which surveillance strategies are best to correctly forecast changes
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Ewan Harrison @ewanharrison.bsky.social · 16/12/2025
Brilliant news!
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Josie Bryant @josiebryant.bsky.social · 11/12/2025
Work on respiratory immunology or microbes? Interested in big data, omics or the latest in vitro models?... Treat your lab to a christmas present of AIR 2026 registration! Feb 11th-13th, registration closing soon: coursesandconferences.wellcomeconnectingscience.org/event/air-20...
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Ewan Harrison @ewanharrison.bsky.social · 02/12/2025
Great to share the latest work from our group and collaborators. First CARRIAGE study paper led by @drdaggarwal.bsky.social and the heroic efforts of Katie Bellis and Beth Blane in the lab plus all the team at @cambridge-ceu.bsky.social Huge thanks goes to the 22,000 participants of the study
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Josie Bryant @josiebryant.bsky.social · 25/11/2025
Really pleased to share the first paper to come out of the lab. We found that hospital patients were frequently colonised with P. aeruginosa and that the same clone was shared between the gut and the lung. The phylogenies indicate that the clones moved from lung->gut www.nature.com/articles/s41...
nature.com
High frequency body site translocation of nosocomial Pseudomonas aeruginosa - Nature Communications
Here, the authors report within-host diversity and body site translocation dynamics in hospital samples of Pseudomonas aeruginosa and reveal that body site sharing was likely due to within-patient tra...
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Nature Reviews Microbiology @natrevmicro.nature.com · 24/11/2025
ICYMI: New online! Unpacking the spread of pathogens
nature.com
Unpacking the spread of pathogens
Nature Reviews Microbiology, Published online: 17 November 2025; doi:10.1038/s41579-025-01264-wThis Genome Watch discusses recent advances in genomic epidemiology that enable the reconstruction of transmission events, with greater resolution and across more complex settings at scale.
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Róisín Boggan @roisinboggan.bsky.social · 06/11/2025
Worried about identification of human samples from microbial sequencing? We were too- this is what we've done about it! www.sciencedirect.com/science/arti...
sciencedirect.com
Benchmarking of human read removal strategies for viral and microbial metagenomics
Human reads are a key contaminant in microbial metagenomics and enrichment-based studies, requiring removal for computational efficiency, biological a…
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Josie Bryant @josiebryant.bsky.social · 08/10/2025
featuring @duncan-ng.bsky.social @pathogenomenick.bsky.social @emmanuel-saliba.bsky.social @resp-micro.bsky.social @asthmaandlung.org.uk @ewanharrison.bsky.social @ryanthwaites.bsky.social and many many more I can't find on bluesky
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Josie Bryant @josiebryant.bsky.social · 08/10/2025
New respiratory 🫁 infection and microbiomes conference in Hinxton with stellar line up of speakers. 🚨 Submit your abstracts now! 🚨 Please RT coursesandconferences.wellcomeconnectingscience.org/event/air-20...
coursesandconferences.wellcomeconnectingscience.org
AIR 2026: Genomic and Systems Approaches to Respiratory Infection, Microbiomes and Immunity — 20260211
Course exploring how genomics, microbiome profiling, and systems biology reshape our understanding of respiratory infections and immune dynamics.
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Wellcome Sanger Institute @sangerinstitute.bsky.social · 26/09/2025
Samples from 1917 have helped identify the genetic culprits responsible for the spread of treatment-resistant infections 🔎 By mapping plasmid evolution since the pre-antibiotic era, experts found that a minority of plasmids cause most of the multidrug resistance in the world 🧵
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Carlos Serna @cserna.bsky.social · 17/07/2025
Our paper “Global dissemination of npmA mediated pan‑aminoglycoside resistance via a mobile element in Gram‑positive bacteria” is now in @natcomms.nature.com. Part of my freshly defended PhD, so doubly happy! 😄🎉 🧵 (1/14) www.doi.org/10.1038/s414...
doi.org
Global dissemination of npmA mediated pan-aminoglycoside resistance via a mobile genetic element in Gram-positive bacteria - Nature Communications
The authors investigate the distribution of the aminoglycoside resistance gene npmA in Gram-positive bacteria via a mobile genetic element, highlighting its global presence and cross-species transfer ...
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Engineer Like A Girl @engineerlikeagirl.bsky.social · 11/07/2025
More of this kind of thing.
A segregated cycle path and footpath, with a lady and a child walking away from the camera, whilst a group of about six young teenagers in school uniform cycle in the opposite direction.
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Pathoplexus @pathoplexus.org · 22/05/2025
📢Today Pathoplexus announces the inclusion of 2 new viral pathogens: RSV (A & B) and HMPV. These respiratory viruses cause a serious health burden, particularly in infants & the vulnerable, & Pathoplexus aims to support sequence sharing to improve understanding & response. 1/4
Screenshot of the homepage of Pathoplexus, showing tiles to navigate to the supported pathogens CCHF, Ebola Sudan, Ebola Zaire, HMPV, Mpox, RSV-A, RSV-B, and West Nile virus.
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Ewan Harrison @ewanharrison.bsky.social · 07/05/2025
Happy to share our first preprint looking at the nasal microbiome in ~1000 healthy adults from the CARRIAGE study of 20,000 healthy blood donors to understand nasal colonisation by Staphylococcus aureus. Ten years in the making! doi.org/10.21203/rs....
doi.org
The nasal microbiome redefines Staphylococcus aureus colonisation
Staphylococcus aureus colonises the nose in humans, with individuals defined as persistent, intermittent or non-carriers. Unlike the gut microbiome, the nasal microbiome has not been studied in large ...
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Josie Bryant @josiebryant.bsky.social · 01/05/2025
Happy to share the first preprint from my lab. Great work by Lewis Fisher and collaboration with Jukka Corander www.biorxiv.org/content/10.1...
biorxiv.org
High frequency body site translocation of nosocomial Pseudomonas aeruginosa
Pseudomonas aeruginosa is an important nosocomial pathogen which can cause serious infections across diverse anatomic locations. Infections can spread within an individual to different body sites, but...
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Gabriele Pollara @gpollara.bsky.social · 31/03/2025
If you can't afford to use a diagnostic test, then its relative performance characteristics become irrelevant. Important issue raised re blood cultures 👇 @lancetmicrobe.bsky.social #ClinMicro #IDSky #AMR www.thelancet.com/journals/lan...
thelancet.com
The cost of blood cultures: a barrier to diagnosis in low-income and middle-income countries
The recent Editorial by The Lancet Microbe, titled Rethinking blood culture, highlights the blood culture bottle shortage in the USA and the overreliance on single manufacturers.1 The shortages of blo...
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Kai Kupferschmidt @kakape.bsky.social · 13/03/2025
There were more than 125,000 measles cases in the WHO European region in 2024 - the highest number since 1997! 38 deaths have been reported so far, every single one of them preventable. Worth remembering this also as we report on the measles outbreak in the US. 🧪 #IDsky
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Kristian G. Andersen @kgandersen.bsky.social · 09/02/2025
Weeks ago I highlighted the false balance of “if only scientists could communicate better”. One OpEd writer kindly reached out to me and I want to share my main response to them because I find it remarkable that people still can’t see what we are now all seeing has been under way for years. 🧵👇
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Francesc Coll @fcic.bsky.social · 14/01/2025
Happy to share the findings of our latest work on mutational adaptation of Staphylococcus aureus during colonisation now published on @NatureComms rdcu.be/d55l3
rdcu.be
The mutational landscape of Staphylococcus aureus during colonisation
Nature Communications - The authors applied a genomic and evolutionary approach to study Staphylococcus aureus in host adaptation during colonisation revealing signals of adaption in metabolic...
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Ewan Harrison @ewanharrison.bsky.social · 13/01/2025
Our paper investigating the mutational landscape during Staphylococcus aureus during colonisation is out now rdcu.be//d55l3 @fcic.bsky.social @sangerinstitute.bsky.social @ibv-csic.bsky.social University of Cambridge @julianparkhill.bsky.social
rdcu.be
The mutational landscape of Staphylococcus aureus during colonisation
Nature Communications - The authors applied a genomic and evolutionary approach to study Staphylococcus aureus in host adaptation during colonisation revealing signals of adaption in metabolic...
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Kate Baker @ksbakes.bsky.social · 19/12/2024
Certain sublineages of antimicrobial resistant bacteria dominate the surveillance landscape, but what causes them to become resistant? Check out our latest work in Shigella to find out and/or read the thread below www.medrxiv.org/content/10.1101/2024.10.27.24316207v2 1/n
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Josie Bryant @josiebryant.bsky.social · 11/12/2024
Frustrating - I reviewed a paper that was highly problematic, mainly in scientific rigour undermining most of the conclusions, so I recommend Reject. However the editor decides to Revise presumably due to the more positive comments from reviewer 2... /1
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Pathoplexus @pathoplexus.org · 09/12/2024
Today Pathoplexus announces the inclusion of a new viral pathogen: mpox (previously known as monkeypox). Within the context of the current mpox outbreaks and ongoing health concerns, Pathoplexus aims to support sequence sharing to improve both understanding and response. 1/7
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Joshua Wilson @oshuwilson.bsky.social · 01/12/2024
UK PhD stipends have not been increasing in line with the national minimum wage, and since the generous COVID increase haven’t even bothered to be anchored against an inflation metric. I’m lucky enough to have a spouse to support me but in what world is this not a barrier to entry for others?
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Treasa Ní Creabhín @treasac.bsky.social · 29/11/2024
Applied Bioinformatics & Public Health Microbiology (21-23 May 2025) is open for registrations! Spread the word - @happykhan.mstdn.science.ap.brid.gy @pathogenomenick.bsky.social @ewanharrison.bsky.social @wvschaik.bsky.social @ksbakes.bsky.social @firefoxx66.bsky.social @katholt.bsky.social
anharrison.bsky.social
Bluesky
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mara lawniczak @marakat.bsky.social · 25/11/2024
last couple days to apply (for free! from anywhere in the world!) to the Sanger 2025 PhD Programme — Deadline: 28th November 2024 (09:00 GMT) For more info, visit www.sanger.ac.uk/about/study/...
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Jasmin Islam @drjasislam.bsky.social · 22/11/2024
First @bsky.app post! Great session today #FISHIS about the importance of learning from the pandemic for the future. Thanks @hisinfection.bsky.social @marionkoopmans.bsky.social @ewanharrison.bsky.social
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Kate Baker @ksbakes.bsky.social · 15/11/2024
Antimicrobial resistance is rapidly rising in Shigella species. How up to date is your treatment guidance? Be sure to read our latest @LancetMicrobe comment to inform your thinking bit.ly/3Z6yNRa 1/10
bit.ly
Using demographics of patients to inform treatment of shigellosis in England
Shigellosis, caused by bacteria of the genus Shigella, is a diarrhoeal disease transmitted by the faecal–oral route.1 Rapid increases in the prevalence of extensively drug-resistant (XDR) Shigella iso...
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