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Enric Llorens

@ellorens.bsky.social
679 followers 418 following 20 posts

Group Leader at the Karolinska Institutet. Applying genomics tools to study nervous system regeneration. Interested in…see below

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Enric Llorens @ellorens.bsky.social · 21/07/2026
Most recent work for context: www.nature.com/articles/s41... Please share, questions welcome. Apply by mid Aug.
nature.com
The regulatory code of injury-responsive enhancers enables precision cell-state targeting in the CNS - Nature Neuroscience
Zamboni et al. reveal how enhancers encode cell-type-specific responses to CNS injury. By combining multiomic profiling, deep learning and in vivo screening, they uncover injury-responsive enhancer lo...
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Enric Llorens @ellorens.bsky.social · 21/07/2026
Computational research assistant. To support genome deep learning modellng. ki.varbi.com/en/what:job/...
ki.varbi.com
Research assistant in bioinformatics applied to machine learning in regulatory genomics
Do you want to contribute to top quality medical research? The Department of Cell and Molecular Biology (CMB) is a department with a strong focus on basic science. CMB conducts research and education
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Enric Llorens @ellorens.bsky.social · 21/07/2026
Wet lab postdoc. Glia, molecular neuroscience, regenerative biology. ki.varbi.com/en/what:job/...
ki.varbi.com
Postdoctoral position in CNS regeneration
Do you want to contribute to top quality medical research? The Llorens laboratory offers a vibrant, stimulating and international environment. We are part of the Department of Cell and Molecular Biolo
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Enric Llorens @ellorens.bsky.social · 21/07/2026
Computational postdoc. Comparative gene regulation, GRN inference, deep learning. ki.varbi.com/en/what:job/...
ki.varbi.com
Postdoctoral studies in regulatory genomics in neuroscience (scholarship)
Postdoctoral studies in regulatory genomics in neuroscience (scholarship) Do you want to contribute to top quality medical research? The Llorens laboratory offers a vibrant, stimulating and internatio
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Enric Llorens @ellorens.bsky.social · 21/07/2026
We're hiring! 3 open positions. We study CNS regeneration: why some animals repair neural tissue and humans mostly can't. Genomics, cross-species comparisons, deep learning. If this sounds like your kind of problem, take a look 🧵
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Enric Llorens @ellorens.bsky.social · 23/04/2026
This is so cool!!
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Filipa Simões @simoesfilipa.bsky.social · 23/03/2026
Excited to share our #preprint showing that #macrophages in the regenerating #zebrafish #heart are shaped by local cardiac-immune microniches, with a fibroblast-to-macrophage signal promoting regeneration over fibrotic repair www.biorxiv.org/content/10.6... @idrm.ox.ac.uk @oxforddpag.bsky.social
biorxiv.org
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Enric Llorens @ellorens.bsky.social · 12/01/2026
We’re hiring a postdoc! If you’re interested in single-cell/spatial genomics, regulatory genomics, deep learning, or AAV engineering, join is @ki.se in Stockholm to help develop smarter CNS therapies: ki.varbi.com/en/what:job/jo… @erc.europa.eu
ki.varbi.com
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Enric Llorens @ellorens.bsky.social · 02/12/2025
Thanks Dinos!
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Enric Llorens @ellorens.bsky.social · 02/12/2025
This was spearheaded by brilliant postdoc @margheritazamboni.bsky.social with contributions from Adrian Martinez, Gabriel Rydholm, Timm Häneke, Laura Pintado, Deniz Secilmis and Chris Ziegenhain. Huge thanks to our funders SSF, VR, ERC @ki.se among others!
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Enric Llorens @ellorens.bsky.social · 02/12/2025
We're now really excited about having easy genetic access to reactive astrocytes and other cell states and even more to further exploit the precision with which we can now program gene expression in them! We're hiring at multiple levels (postdocs,...) so reach out if this sounds interesting!
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Enric Llorens @ellorens.bsky.social · 02/12/2025
Finally, we used enhancer AAVs to systematically test the DL model predictions in a candidate enhancer, validating the modular configuration to simultaneously encode injury-responsiveness and cell type specificity
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Enric Llorens @ellorens.bsky.social · 02/12/2025
We next used an AAV-based parallel reporter assay to screen reactive astrocyte enhancers using a single cell readout. With this we identified enhancers that selectively targeted reactive astrocytes in the injured brain and spinal cord even when systemically delivered pre-injury
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Enric Llorens @ellorens.bsky.social · 02/12/2025
we found that AP1 motifs in IRENs were in close proximity to motifs for cell identity TFs, and those were different for each cell type. Thus, instead of cell type specific TF induction, a modular 'AP1+lineage TF' architecture drives most enhancer activation after injury.
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Enric Llorens @ellorens.bsky.social · 02/12/2025
While these were more common in astrocytes and ependymal cells, all glial cells used AP1 factors to comission injury induced enhancers (IRENs). But how were different enhancers selected in different cells then? Training ChromBPNet seq-2-accessibility DL models on resting vs reactive cell states...
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Enric Llorens @ellorens.bsky.social · 02/12/2025
while developing tools for cell state targeting. Using single cell multiomics @10xgenomics.bsky.social in the injured mouse spinal cord, we find thousands of enhancers with highly specific patterns of activity, tracking transient cell states across multiple glial lineages.
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Enric Llorens @ellorens.bsky.social · 02/12/2025
We are beginning to understand the code for cell type specific gene regulation. In parallel, atlasing efforts are mapping disease associated cell states. Comparatively, we know much less about the gene regulation of disease associated states, and we aimed to fill that gap...
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Enric Llorens @ellorens.bsky.social · 02/12/2025
First paper from the lab is now online @natneuro.nature.com ! We mapped injury induced enhancers in the mouse CNS and decoded their sequence architecture. Little 🧵 rdcu.be/eSQi1
rdcu.be
The regulatory code of injury-responsive enhancers enables precision cell-state targeting in the CNS
Nature Neuroscience - Zamboni et al. reveal how enhancers encode cell-type-specific responses to CNS injury. By combining multiomic profiling, deep learning and in vivo screening, they uncover...
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Enric Llorens @ellorens.bsky.social · 02/12/2025
Thanks Shane!!
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Sten Linnarsson @sten.linnarsson.org · 25/06/2025
A major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)
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Filipa Simões @simoesfilipa.bsky.social · 07/07/2025
🧪 Job alert 🔊 we are hiring a Research Assistant - join the Simões Group at DPAG-IDRM @ox.ac.uk supporting #cardiovascular development and regeneration research, working with #zebrafish and #human stem cell systems: my.corehr.com/pls/uoxrecru... @oxforddpag.bsky.social @idrm.ox.ac.uk (1/4)
my.corehr.com
Job Details
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Sten Linnarsson @sten.linnarsson.org · 01/04/2025
Are you an established (”distinguished”) researcher outside Europe? Thinking of moving here for some reason? Grant opportunity just dropped: www.vr.se/english/appl...
vr.se
Grant for recruiting international visiting researcher to Sweden
The purpose of the grant is to provide higher education institutions and other research organisations the opportunity to develop and strengthen a research field by recruiting a distinguished researche...
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Enric Llorens @ellorens.bsky.social · 21/03/2025
Join us @ki.se in Stockholm to work on spatial genomics. A few days left to apply to the open postdoc position in our lab 👇
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John Burn-Murdoch @jburnmurdoch.ft.com · 14/03/2025
NEW 🧵 Is human intelligence starting to decline? Recent results from major international tests show that the average person’s capacity to process information, use reasoning and solve novel problems has been falling since around the mid 2010s What should we make of this? www.ft.com/content/a801...
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Enric Llorens @ellorens.bsky.social · 13/03/2025
📢 We're hiring! Postdoc position available at our lab at the Karolinska Institute in beautiful Stockholm to work on exciting projects developing and applying spatial genomics. Apply here: ki.varbi.com/what:job/job... Email or dm to discuss @ki.se #PostdocPosition #Spatial #Stockholm #ScienceJobs
ki.varbi.com
Postdoctoral studies on spatial genomics (scholarship)
Postdoctoral studies in (scholarship) Do you want to contribute to top quality research in regenerative biology? The Llorens laboratory offers a vibrant, stimulating and international environment. We
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Wolfgang Huber @wkhuber.bsky.social · 08/03/2025
It's time for individuals and organizations in Europe and other democratic countries to move mission- or life-critical IT services and infrastructure outside the reach of the US government; noting that US tech companies have already largely subordinated themselves. www.huber.embl.de/group/posts/...
huber.embl.de
Digital sovereignty – Huber Group @ EMBL
The US is now a mafia-style extortionist you want to stay away from
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Anne Applebaum @anneapplebaum.wsocial.eu · 28/02/2025
"We’re witnessing the self-sabotage of the United States" from @davidfrum.bsky.social www.theatlantic.com/politics/arc...
theatlantic.com
At Least Now We Know the Truth
It’s ugly, but necessary to face.
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Andras Simon @andrassimon.bsky.social · 12/02/2025
A #Pleurodeles on the cover. Interested in this #giantgenome, #salamander #regeneration, #noncodingRNA landscape? Pls check out: www.cell.com/cell-genomic.... Many great labs involved, special thanks to co-senior authors @maxyunlab.bsky.social, and @niche-leigh.bsky.social
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Joanna Bagniewska @joannabagniewska.com · 07/02/2025
Hardly new info, but BSky should know: Warsaw's water quality is monitored by eight clams with magnets attached to their shells. If contamination in the water causes the clams to close, the magnets trigger an alarm and shut off the city's water supply. Thank you, little guardian molluscs. 🧪🌏🚰
A clam with a spring attached to the shell. The spring has a magnet placed above a sensor.
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Marc Somssich @somssich.bsky.social · 01/02/2025
Do you know Daisy Roulland-Dussoix? She is one of the discoverers of restriction enzymes, who’s findings paved the way for the development of recombinant DNA and cloning technologies. Accordingly, the finding was rewarded with a #NobelPrize. But the prize didn’t go to her. 🧵👇
A portrait of Daisy Roulland-Dussoix from Wikipedia: https://en.wikipedia.org/wiki/Daisy_Roulland-Dussoix
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TanentzapfLab @tanentzapflab.bsky.social · 31/01/2025
1. A thread about the value of doing "slow science": When I was in grad school I heard this (likely apocryphal) story about one of my favourite scientists: Barbara McClintock.
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Eleanor Morton @eleanormorton.bsky.social · 17/01/2025
Literally every company now youtube.com/shorts/hL9pl...
youtube.com
Literally every company now
YouTube video by Eleanor Morton
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Pedro Beltrao @pedrobeltrao.bsky.social · 16/01/2025
35% increase in applications to the ERC consolidator grants. This is not sustainable and it will result in too low acceptance rates. The ERC budget needs to be drastically increased. erc.europa.eu/news-events/...
erc.europa.eu
Applications for ERC Consolidator Grants 2025: Facts and figures
The ERC Consolidator Grants 2025 call closed for applications on 14 January 2025.These are the preliminary data on the submitted proposals:
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Marc Somssich @somssich.bsky.social · 20/05/2024
Do you know who Douglas Prasher is? Many don't, even though he is the person who cloned the original #GFP gene in the late 1980s. In my short history of plant light #microscopy I also cover a bit of his story - & why he is relatively unknown today, despite the importance of his work. See this 🧵👇
A profile picture of Douglas Prasher from Martin Chalfie's Nobel Lecture
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Jeremy Berg @jeremymberg.bsky.social · 10/12/2024
Bluetorial: What’s the worst that can happen? Meeting a scientific hero (Lots of chemical history today)
media.tenor.com
a cartoon says hey everybody an old man 's talking while bart simpson looks on
ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on
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Alfonso Valencia @alfonsovalencia.bsky.social · 07/12/2024
"Europa, en la encrucijada" por Xavier Ferras. " futuro incierto tras los fondos Next Generation...Sería una lástima que, cuando se agote la financiación europea, no seamos capaces de innovar con recursos propios." www.lavanguardia.com/dinero/20241...
lavanguardia.com
Europa, en la encrucijada, por Xavier Ferràs
En Copenhague se ha puesto en funcionamiento Gefion, un superordenador de inteligencia artificial (IA) de última generación, nombrado en honor a la diosa de la
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Madhu Pai, MD, PhD @madhupai.bsky.social · 05/12/2024
This is spot on
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Tim Behrens @behrenstimb.bsky.social · 01/12/2024
OK If we are moving to Bluesky I am rescuing my favourite ever twitter thread (Jan 2019). The renamed: Bluesky-sized history of neuroscience (biased by my interests)
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Dave Grainger @degrainger.bsky.social · 13/11/2024
Bluesky is cool and all but it is missing epigenetic hulk
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