Currently, there is an urgent need to evaluate the strengths and limitations of various probe-based full transcriptome methods for formalin-fixed paraffin-embedded tumor tissues. Here, the authors ana...

AbstractBackground. Glioblastoma (GB), particularly IDH-wildtype, is the most aggressive brain malignancy with a dismal prognosis. Despite advances in mole

The authors present a computational framework that leverages mechanical force inference and spatial transcriptomics to enable analyses of the interplay between the transcriptomic and mechanical state.

A method infers tension from spatial transcriptomic data on single cells in tissue context.

This study presents MetaVision3D, a pipeline to integrate mass spectrometry imaging sections into 3D reconstructions of metabolomic maps. The authors also provide a comprehensive 3D metabolome atlas o...

The use of two mouse models of pulmonary fibrosis helped the identification of the transcription factor RUNX2 as a regulator of the transition of alveolar fibroblasts to pathological fibroblasts.

118th Meeting of the British Neuropathological Society MARCH 2017 Symposium: 'Small Vessel Disease'

Insights into how cancer cells become unresponsive to therapy.

Improved imaging techniques are required to help advance our understanding of the complex role of the tumour microenvironment (TME). Here, the authors develop a high-throughput, highly multiplexed tis...

Approaches for profiling the spatial proteome in tissues are the basis of atlas-scale projects that are delivering on their promise for understanding biological complexity in health and disease.