iiinova — where your digital self keeps evolving

Jon Lim, FRCP PhD @drjonlim.bsky.social · 27/08/2026

🎓 Massive congratulations to our fantastic Medical Oncology honorary consultant colleagues at The Christie NHS Foundation Trust on their promotions to 𝗖𝗹𝗶𝗻𝗶𝗰𝗮𝗹 𝗖𝗵𝗮𝗶𝗿𝘀 @manchester.ac.uk! 🌟Prof Sacha Howell 🌟Prof Natalie Cook 🌟Prof Colin Lindsay @uom-dcs.bsky.social @mcrcnews.bsky.social

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 03/08/2026

We're still early in the trial, but this feels like the right moment to recognise the multidisciplinary team who made it possible 🙌. Fiona & I couldn't be prouder of our team. Here's to creating more opportunities for patients through research. 💙 📻 𝗕𝗕𝗖 𝗥𝗮𝗱𝗶𝗼 𝟱 𝗟𝗶𝘃𝗲 [31 Jul 2026 | 1:26:37]

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 03/08/2026

𝗭𝗜𝗠𝗔-𝟭𝟬𝟭 is a 1st-in-human, 1st-in-class TCR-NK cell therapy trial, which is a true collaboration between our Advanced IO/Cell Therapy team at The Christie & the Zelluna team. Those in the know understand how much happens behind the scenes. Setting up a cell therapy study is never straightforward.

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 28/07/2026

This is only possible because of an incredible collaboration 🤝 between patients, clinicians, research teams, scientists, NHS partners, industry and funders. Thank you to everyone who has helped bring MANIFEST to this point! 4/4

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 28/07/2026

🔬 Through deep clinical and biological profiling, we are working to better understand why cancer immunotherapies succeed, why toxicities occur, and how we can deliver more precise, personalized treatment. @turajliclab.bsky.social @cruk-mi.bsky.social @cruknbc.bsky.social @crick.ac.uk 2/4

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 01/07/2026

🔬 Another fantastic 𝗠𝗮𝗻𝗰𝗵𝗲𝘀𝘁𝗲𝗿 𝗜𝗺𝗺𝘂𝗻𝗼-𝗢𝗻𝗰𝗼𝗹𝗼𝗴𝘆 𝗡𝗲𝘁𝘄𝗼𝗿𝗸 (𝗠𝗜𝗢𝗡) meeting! Great to bring together colleagues from academia, NHS & industry to showcase Manchester-led immuno-oncology research, celebrate recent presentations at major international 🌍 conferences. @mcrcnews.bsky.social

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 24/06/2026

Great to be in Porto 🇵🇹 for ASPIC International Congress. Looking forward to 2 days of science! Slightly shameless plug: if you’re interested in PhD, postdoc, clinician-scientist, group leader or Clinical Research Fellowship opportunities in Manchester, come say hello 👋 - I’d be happy to chat.

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 20/06/2026

🚀 𝗖𝗹𝗶𝗻𝗶𝗰𝗮𝗹 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗙𝗲𝗹𝗹𝗼𝘄𝘀𝗵𝗶𝗽 opportunities - come join us in Manchester! Looking to develop your career in Oncology? Interested in building a subspecialty interest? Keen to combine clinical excellence with research? Several exciting opportunities available at The Christie NHS Foundation Trust 👇

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 07/06/2026

Almost 2️⃣ years in… Our MANIFEST AGM convened scientists, clinicians, patient partners & industry. Keynotes from Prof Levesque & Prof Rattray + Prof Turajlić setting the course ahead. Big thank you to all for continuing to believe in the vision; to tackle the hard questions in #CancerImmunotherapy.

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 18/04/2026

Fantastic 2 days in San Diego 🌴 for the inaugural C8 Early Career Investigators Symposium. Happy to represent #TeamManchester + connect with an inspiring group 🌍. A reminder that we’re not navigating academia alone - great to hear re: lessons learned & tips for future 🤝. @mcrcnews.bsky.social

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 10/04/2026

Tumour infiltrating lymphocyte (TIL) therapy is here to stay...but toxicity may be the real bottleneck. Most of it is not the TILs - it’s everything around them. We unpack this in our latest review. Available #OpenAccess - 𝘑 𝘐𝘮𝘮𝘶𝘯𝘰𝘛𝘩𝘦𝘳 𝘊𝘢𝘯𝘤𝘦𝘳 @sitcancer.bsky.social👇 🔗 jitc.bmj.com/content/14/4...

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 07/02/2026

🎓 New PhD Opportunity An exciting PhD opportunity at the Cancer Research UK Manchester Centre, supporting the next generation of leaders in cancer research. 📅 Deadline: Friday 3 April 🔗 For further information & to apply: ow.ly/ZWYs50Y7vHR @uom-dcs.bsky.social @manchester.ac.uk

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 03/02/2026

👉...cutting-edge science, clinical insights & discussions re: real-world implementation of TIL therapy. Featuring keynote speakers: Inge Marie Svane 🇩🇰 & Sebastian Klobuch 🇳🇱. @sklobuch.bsky.social @debrajosephs.bsky.social @turajliclab.bsky.social @beckilee.bsky.social

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 22/01/2026

🆕 New on the ESMO events calendar for 2026! Mark your calendar for the 𝗘𝗦𝗠𝗢 𝗣𝗿𝗲𝗰𝗲𝗽𝘁𝗼𝗿𝘀𝗵𝗶𝗽 𝗼𝗻 𝗧𝘂𝗺𝗼𝘂𝗿-𝗔𝗴𝗻𝗼𝘀𝘁𝗶𝗰 𝗖𝗮𝗻𝗰𝗲𝗿𝘀 𝗮𝗻𝗱 𝗖𝗮𝗻𝗰𝗲𝗿 𝗼𝗳 𝗨𝗻𝗸𝗻𝗼𝘄𝗻 𝗣𝗿𝗶𝗺𝗮𝗿𝘆 (𝗖𝗨𝗣) in Zurich: 18-19 September 2026. Chaired by the fantastic @oncocook.bsky.social & @benwestphalen.bsky.social. @myesmo.bsky.social

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 15/01/2026

🚀 Kicking off the new year with our next #ChristieFellowship session! How do we communicate science well - to patients, the public, and on social media? Join us for an interactive session on 𝗣𝘂𝗯𝗹𝗶𝗰 𝗖𝗼𝗺𝗺𝘂𝗻𝗶𝗰𝗮𝘁𝗶𝗼𝗻 with Prof @achoud72.bsky.social. @christieinstitute.bsky.social @mcrcnews.bsky.social

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 13/01/2026

🤔 Do patients with cancer and clinicians see disease status the same way? Our study highlights where understanding aligns - and where it doesn’t - underscoring the importance of clear communication in palliative care. Presented first at #ESMOGI24, now published in full: doi.org/10.1007/s003...

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 04/01/2026

The ‘Big Picture’: Immune Response produced by @wellcometrust.bsky.social. 🔗 www.stem.org.uk/resources/li...

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 02/01/2026

7/11 This suggested that DNGR-1–dependent cross-presentation preferentially reveals cytoskeletal neoantigens, placing immune pressure on tumours to lose them ⚖️. We tested this directly 🔬. Some predicted F-actin–binding protein neoantigens were: ✔️ able to bind MHC I ✔️ genuinely immunogenic 𝘪𝘯 𝘷𝘪𝘷𝘰

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 02/01/2026

6/11 That’s when things clicked 💡. Tumours from DNGR-1–deficient mice were enriched for mutations in 𝗙-𝗮𝗰𝘁𝗶𝗻–𝗯𝗶𝗻𝗱𝗶𝗻𝗴 𝗽𝗿𝗼𝘁𝗲𝗶𝗻𝘀 – which decorate F-actin, the ligand recognised by DNGR-1. Not microtubules ❌ Not random proteins ❌

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 02/01/2026

3/11 To address this, we turned to chemical carcinogenesis models 🐭, and subsequently generated >100 primary tumour cell lines 🧫. Tumours arising in DNGR-1–deficient mice behaved much like those from immunodeficient hosts i.e. often rejected when transplanted into immunocompetent mice.

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 02/01/2026

My main PhD paper is finally out! 🎉 After ~5 years, it’s published today in 𝘕𝘢𝘵𝘶𝘳𝘦 𝘐𝘮𝘮𝘶𝘯𝘰𝘭𝘰𝘨𝘺. @natimmunol.nature.com It all started with an unexpected observation 🔍: 👉 Mice lacking the dendritic cell receptor DNGR-1 developed tumours earlier ⏩ and more frequently 📈 than wild-type mice. 1/11 🧵

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 10/12/2025

✨ #ESMOImmuno25 @turajliclab.bsky.social presented the MANIFEST platform, recent progress & our ambitions at ESMO IO Congress here in London. The message from the 'Special Session with Industry': cross-sector collaboration is critical to accelerate discovery & develop safer/effective therapies.

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 09/12/2025

Really looking forward to catching up with colleagues and friends at #ESMOImmuno25 in London. If you’re attending, please stop by our team’s poster - presented by our Specialist Pharmacist Ragini Jethra. We highlight new insights from our systematic review on the safety profile of TIL therapy.

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 29/11/2025

🚀 Save the Date! We’re excited to launch our flagship TIL Summit in Manchester: "Unlocking TIL Therapy: A New Era for Melanoma Care in the UK" 🗓 11 March 2026 📍 The Midland Hotel, Manchester

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 12/11/2025

🚨 Save the Date! Next #ChristieFellows session: “Preparing a Grant Proposal for PhD or Research Projects” 🎤 Dr Jamie Weaver 🗓️ Tue 18 Nov 2025 | 12:30–13:30 📍 Seminar 4&5, Edu Centre Learn how to pitch your idea & navigate the grant process from an early-career clinical academic. #TeamManchester 🐝

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 19/10/2025

Delighted to be part of the #ESMOAmbassadors team at #ESMO25! 🌍 Let’s connect and discuss the latest news here in Berlin >>> and beyond! #ONEOncologyCommunity @myesmo.bsky.social

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 18/10/2025

🌟 Tour de force proffered paper by Dr Charlotte Spencer, Histopathology SpR + recent PhD Fellow in @turajliclab.bsky.social @crick.ac.uk Huge congrats on the ESMO Merit Award 🎉 So well deserved — proud of you, my friend! 💫 #ESMO25 #TranslationalResearch #TRACERxRenal

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 18/10/2025

💥 Is it prime time for adoptive cell therapy in solid tumours? 📚 Special Educational Session on the state-of-the-art and future of cell therapies - evolving fast from promise to practice. 👀 Watch this space… #ESMO25 #ESMOAmbassadors #CellTherapy #Immunotherapy

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 17/10/2025

Strong representation from our Experimental Cancer Medicines Team (ECMT) at The Christie, led by Dr Matthew Krebs at #ESMO25. Mini-oral presentation re: global phase 1 data on divarasib (GDC-6036) - a next-gen KRAS G12C inhibitor with promising activity. #TeamManchester 🐝 @mcrcnews.bsky.social

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 17/10/2025

Proud of my colleague Prof Fiona Thistlethwaite - Chair and Abstract Discussant at the Developmental Therapeutics track here at #ESMO25. #AICTteam #TeamManchester 🐝 @mcrcnews.bsky.social

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 17/10/2025

Exciting days ahead in Berlin 🇩🇪 for #ESMO25! Some of our core team from @christieinstitute.bsky.social are here at the #ESMO25 Congress - come say hi 👋! Special shout-out to our #YoungOncologists colleagues - Always keen to connect, and discuss opportunities in Manchester. @mcrcnews.bsky.social

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 10/10/2025

🎓 Honoured to chair the PhD viva of Maitane Márquez López at @biogipuzkoa.bsky.social | @ehu.eus with Prof Iker Badiola 🇪🇸 and Prof Irina Estrela-Lopis 🇩🇪. Congrats to Maitane, and her supervisors Prof Charles Lawrie and Prof Andreas Seifert, on a successful defence! All the best for the future.

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 07/10/2025

🎓 Fully-funded 4-yr MRC PhD @officialuom.bsky.social! Join a world-class team exploring how the microenvironment drives CRS in CAR-T therapy. 🌍 Open globally | 💥 Translational science 🗓️ Apply by 8 Nov 2025 🔗 www.findaphd.com/phds/project... #PhDOpportunity #TeamManchester 🐝 @uom-dcs.bsky.social

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 03/10/2025

Great discussion today at @cgtcatapult.bsky.social & CERSI-AT on how #AI and #machinelearning is reshaping the development + testing of #AdvancedTherapies. Exciting times ahead for the field - collaboration between all stakeholders (NHS, academia, industry, regulators) is the key to success!

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 01/10/2025

🎓 New academic year, new opportunities! 🚀 Launching a refreshed Fellows’ Programme at @christieinstitute.bsky.social - focused on career development, leadership & opportunities to help trainees grow as future leaders, researchers & educators. All fellows & residents @mcrcnews.bsky.social welcome!

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 29/09/2025

Back from an inspiring trip to Toronto 🇨🇦 for the 1st C8 Symposium, hosted by @pmresearch-uhn.bsky.social team. Proud to represent #TeamManchester 🐝 & showcase our #immunotherapy + #celltherapy programmes, including #MANIFESTuk & soon-to-launch #RISE. Global collaboration drives progress! 🌍✨

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 03/09/2025

🔹 Priorities – prospective clinical recruitment across NHS sites & expanding our partner network. 🔹 Looking ahead – focusing on sustainability, long-term impact & training. Privileged to represent such a committed team & grateful to hear feedback/ideas as we continue to shape MANIFEST together 🚀.

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 03/09/2025

From vision to momentum: MANIFEST at 12 months 💡➡️📈 Honoured to share our progress at the UK Cancer Research Strategy Forum held in London today, chaired by Prof Peter Johnson, as part of the Office for Life Sciences Cancer Mission. On behalf of @turajliclab.bsky.social @manifest-cirrp.bsky.social

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 14/08/2025

🚀 Applications now open for the 2026 Tessa Jowell Neuro-oncology Fellowship! A prestigious 12-month funded post at The Christie to develop world-class clinical, research & leadership skills in brain tumour care, working with experts. Deadline: 5th Sep 2025 📥 For further information/to apply 👇

https://www.tessajowellbraincancermission.org/news/tessa-jowell-neuro-oncology-fellowship-manchester-applications-open/

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 30/07/2025

🎓 Another fantastic ESMO Course in Medical Oncology for Medical Students. 🌍 This year, we welcomed 93 students from 42 countries! The future is bright. Great to see so many budding oncologists; so engaged, inquisitive & eager to learn - looking forward to seeing you all grow & join the field 🤩🙌.

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 15/07/2025

The ESMO Communication Committee (in-person in Lugano + online) all hyped up - as we spent the past few weeks + all day today discussing & planning for #ESMO25 Congress. Watch the space for Berlin 2025 🙌! @myesmo.bsky.social #BreakingNews #PracticeChanging #ONEOncologyCommunity #educationforLIFE

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 10/07/2025

🆕 opportunity! 🧑‍⚕️Our Advanced Immunotherapy & Cell Therapy team at The Christie is growing! We have a new post for a Band 6 Clinical Research Nurse to join us. #TeamManchester 🐝 Deadline 23 July 2025.

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 07/07/2025

📚 Our inaugural Annual Fellows Showcase Event 2025. What an incredible event! 🤩 Fantastic to hear the breadth & depth of our fellowship programme at The Christie - thanks to all the fellows who presented flash talks & for attending. This makes us all really proud to be #TeamManchester 🐝 .

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 13/06/2025

Delighted to be in Warsaw 🇵🇱 for the 1st edition of the Polish Young Oncologists Forum. 🧑‍⚕️ An exciting forum to engage with enthusiastic clinicians & scientists working in cancer care & research. Very happy to share our experience launching @manifest-cirrp.bsky.social. Thanks for the invitation! 🙏

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 27/05/2025

🧑‍⚕️🎓 Fellowship opportunity! APPLY NOW for the inaugural TheChristie-PeterMac Senior Clinical Research Fellowship in Experimental Cancer Medicine - this is a unique new partnership where fellows spend 1 year in Manchester 🇬🇧 + 1 year in Melbourne 🇦🇺. 📥 Deadline 15 June apps.trac.jobs/job-advert/7...

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 21/05/2025

Yesterday was International Clinical Trials Day 🔬. 🧑‍⚕️ Delivering clinical trials is a multidisciplinary team effort - our clinical research nurses are dedicated to making sure all our patients receive the best care they can when on clinical trials. #TeamManchester 🐝 @mcrcnews.bsky.social

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 17/05/2025

⏰ Less than 6 weeks to go! You are invited to our inaugural 'Annual Clinical Fellows Showcase'! @christieinstitute.bsky.social All fellows, supervisors, students & researchers across the Manchester 🐝 ecosystem are welcome to attend. 🗳️ Please sign up: www.eventbrite.co.uk/e/annual-cli...

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 15/05/2025

🩸How is cDCpoiesis regulated? DNGR-1, or CLEC9A, most known as a cDC1 receptor for cross-presentation of dead-cell associated antigens - may play a role here. 🔬Great to see labour of love led by Ana finally out now in @jem.org. Available open access: hubs.la/Q03mg6Sc0 @reisesousalab.bsky.social

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 12/05/2025

Want to know more about #MANIFESTuk? To stimulate collaborations, we have openly shared our vision, workflow overview and long term plans in this latest perspective piece in Cancer Discovery. Check it out. @manifest-cirrp.bsky.social

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Jon Lim, FRCP PhD @drjonlim.bsky.social · 12/05/2025

🚀 We finally had our first in-person #MANIFESTuk consortium meeting @crick.ac.uk today. So delighted to welcome >100 colleagues from up & down the country 🇬🇧, including our industry partners, to discuss science & the vision + ambitions of MANIFEST. Let’s keep going! 🙌 @manifest-cirrp.bsky.social

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