Nature Reviews Immunology - Adaptive immunity is indispensable to vertebrates, yet most living organisms defend themselves perfectly well without it. Here, I ask why somatically diversified antigen...

Tracy Tomlinson was offered the clinical trial for ovarian cancer at The Christie hospital in Manchester.

Mark England says numb fingers help him play guitar as researchers hope to change how disease is treated by investigating why immunotherapy does not benefit all

Mark England was diagnosed with bladder cancer in early December last year. He is the first patient to join the MANIFEST study, one of the largest immunotherapy studies in the country.

Mark England says numb fingers help him play guitar as researchers hope to change how disease is treated by investigating why immunotherapy does not benefit all

A major new UK study, led by The Christie NHS Foundation Trust and The University of Manchester, has been launched to help patients with cancer better tolerate cutting-edge immunotherapy treatments li...

Cancer Research UK is increasing our Institute annual core funding to more than £17m a year as of 2026, a 50% increase in support of patient-benefitting research here in the North West

Cancer Research UK Manchester Institute says the extra cash will make a "huge difference" to its work.

Read about our Christie International Fellowship Programme

Every year, thousands of cancer patients treated at The Christie NHS Foundation Trust, Manchester University NHS Foundation Trust and Northern Care Alliance NHS Foundation Trust choose to donate tissue samples to the Manchester Cancer Research Centre Biobank.

Here the authors show DNGR-1 expressed by cDC1s promotes CD8⁺ T cell priming to cytoskeletal neoantigens from dying tumor cells, thereby shaping cancer immune visibility and tumor evolution through im...

Cell therapy has revolutionised the landscape of cancer treatment, with therapies such as Chimeric Antigen Receptor T cells (CAR-T cells), showing remarkable efficacy in haematological malignancies, a...

New research has uncovered an unexpected way to stimulate the immune system against cancer: by subtly disrupting how tumour cells manufacture their proteins.