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Reposted by MANIFEST IO

Jon Lim, FRCP PhD @drjonlim.bsky.social · 12/05/2025

Want to know more about #MANIFESTuk? To stimulate collaborations, we have openly shared our vision, workflow overview and long term plans in this latest perspective piece in Cancer Discovery. Check it out. @manifest-cirrp.bsky.social

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Reposted by MANIFEST IO

Jon Lim, FRCP PhD @drjonlim.bsky.social · 12/05/2025

🚀 We finally had our first in-person #MANIFESTuk consortium meeting @crick.ac.uk today. So delighted to welcome >100 colleagues from up & down the country 🇬🇧, including our industry partners, to discuss science & the vision + ambitions of MANIFEST. Let’s keep going! 🙌 @manifest-cirrp.bsky.social

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MANIFEST IO @manifest-cirrp.bsky.social · 12/05/2025

Our keynote speaker Elana Fertig (@univofmaryland.bsky.social) presenting some fantastic work on “Modelling the TME of clinical trials with virtual cells” 🦠🖥️

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MANIFEST IO @manifest-cirrp.bsky.social · 12/05/2025

Ajitha Rajan (@edinburgh-uni.bsky.social) joins us over the web to present on “Multimodal Data Integration” 🔬

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MANIFEST IO @manifest-cirrp.bsky.social · 12/05/2025

Up next, Santiago Zelenay (@cruk-mi.bsky.social) presents his work on setting up a “Patient Derived Tumour Fragment platform” 🧫

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MANIFEST IO @manifest-cirrp.bsky.social · 12/05/2025

Anne-Laure Cattin (@crick.ac.uk) starts the third session presenting some amazing work on “Deconvoluting the in situ tumour immune microenvironment” 🧫🔬

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MANIFEST IO @manifest-cirrp.bsky.social · 12/05/2025

Up next Dominic Rothwell (@cruknbc.bsky.social) presents “cfDNA methylation profiling as a precision medicine biomarker in cancer” 🧬🔍

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MANIFEST IO @manifest-cirrp.bsky.social · 12/05/2025

James Jones (@cruk-ci.bsky.social) presents amazing work on “Cytokine profiling in kidney cancer translational studies” 🏥

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MANIFEST IO @manifest-cirrp.bsky.social · 12/05/2025

@maxemmerichderm.bsky.social (@crick.ac.uk) kicks off the second session presenting “Comprehensive blood profiling to derive immune signatures predictive of checkpoint inhibitor response and toxicity”. 🩸☢️

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Reposted by MANIFEST IO

Jon Lim, FRCP PhD @drjonlim.bsky.social · 14/04/2025

💡Inspiring to be in amongst esteemed colleagues at BSI Cancer Immunotherapies Summit today at The Royal Society. Happy to share our vision & ambitions for #MANIFESTuk + how we can work collaboratively to tackle some of the biggest questions in immuno-oncology. @manifest-cirrp.bsky.social

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MANIFEST IO @manifest-cirrp.bsky.social · 30/03/2025

🚨Opportunity to join the MANIFEST team ‼️ We’re looking for: 💻 A Talented ML Engineer To: ➡️ Join a team of computational biologists 💊Deliver on integrated immune-oncology biomarker signatures 📍@crick.ac.uk @TurajlicLab 🧑‍💻manifest-io.org.uk Link 👇: crick.wd3.myworkdayjobs.com/External/job/L…

crick.wd3.myworkdayjobs.com

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MANIFEST IO @manifest-cirrp.bsky.social · 25/03/2025

Fantastic to see @manifest-cirrp.bsky.social represented at Manchester Immuno-Oncology Network (MION) Spring Event. 🏥 🧬 Criticial work will be led by colleagues & co-investigators: 🐝 @cruk-mi.bsky.social 🐝 @mcrcnews.bsky.social 🐝 @cruknbc.bsky.social 🐝 The Christie

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Reposted by MANIFEST IO

Jon Lim, FRCP PhD @drjonlim.bsky.social · 27/02/2025

🚀 First set of results since launch of #MANIFESTuk - our wide-utility multiomic platform for cancer immunotherapy. Congratulations to our very own @maxemmerichderm.bsky.social for the oral presentation at the inaugural #AACRIO25 Congress - HD-immunoprofiling from blood 🩸. Check it out 👇

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MANIFEST IO @manifest-cirrp.bsky.social · 26/02/2025

🚨First output from the MANIFEST platform‼️ 🩸PBMC derived immune signatures can predict ICI response & tox! 🧑‍💻 Hugely collaborative effort led by @maxemmerichderm.bsky.social & Turajlic Lab in conjunction with #IMUBiosciences 📍Watch this space for multimodal composite biomarkers

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MANIFEST IO @manifest-cirrp.bsky.social · 16/02/2025

Opportunity to reflect on the challenges of biomarker discovery in RCC‼️#GU25 Need for: 📊 Sample & Data Harmonisation 🔴 Overcome pervasive heterogeneity 🩸Incorporation of dynamic measures 🧠 Collaborative efforts ➡️ Generation of multimodal biomarker signatures 🧑‍💻: manifest-io.org.uk

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MANIFEST IO @manifest-cirrp.bsky.social · 15/02/2025

Fantastic to see integrated translational analyses presented on the podium at #GU25 🧬🔬 Elegantly presented by Prof Albiges 🚨 Watch this space for integrated molecular & spatial profiling in advanced ccRCC for patients undergoing ICI therapies 👇🏾 🧑‍💻manifest-io.org.uk

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MANIFEST IO @manifest-cirrp.bsky.social · 14/02/2025

🔦 Spotlight on ctDNA as Biomarker in Bladder Ca. 🔴 Emerging role as a surrogate for path response & survival ‼️ Need for: 💉 Prospective efforts w/ embedded sampling timepoints 🧑‍💻 Combinatorial Biomarkers 📊 Data Harmonisation #GU25

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Reposted by MANIFEST IO

Zayd Tippu @zaydtippu.bsky.social · 14/02/2025

🚨Follow @manifest-cirrp.bsky.social 🧬 Aiming to generate multimodal biomarker signatures incl & beyond ctDNA & PD-L1 expression in Bladder Ca 🧑🏾‍💻 manifest-io.org.uk #GU25

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MANIFEST IO @manifest-cirrp.bsky.social · 03/02/2025

Excited to contribute to this space‼️ Critical to this will be a strong theme of cross-collaboration 🏥🧬 & knowledge-sharing 🧠 Great to see members of the consortium together at #Immuno25

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MANIFEST IO @manifest-cirrp.bsky.social · 27/12/2024

🌟 More exciting opportunities to join the @manifest-cirrp.bsky.social consortium at @crick.ac.uk! We are looking for: 💻 ML engineer 🔬 Senior Laboratory Research Scientist (Spatial Profiling) 🧑‍🔬 Senior Laboratory Research Scientist (Flow Cytometry) Apply now 👉 www.crick.ac.uk/careers-and-...

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MANIFEST IO @manifest-cirrp.bsky.social · 19/12/2024

📢 New job opportunities open in computational modelling, genomics and imaging for Postdoctoral and Senior Scientists based @crick.ac.uk! 🧑‍🔬 Become part of MANIFEST, a UK-wide consortium of 14 academic institutions, 6 NHS trusts and several industry partners all tackling challenges in #immunotherapy

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MANIFEST IO @manifest-cirrp.bsky.social · 18/12/2024

🦋 MANIFEST is excited to join the @bsky.app community! 🧑‍🔬 We are looking forward to connecting with academics, clinicians, patients and industry with interests in #immunotherapy, #immunooncology, #clinicaltrials, #translationalresearch and more 🤝 Together, we can advance cancer care for patients

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