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Juha Huiskonen

@juhahuiskonen.bsky.social

472 followers 238 following 7 posts

Director of the Institute of Biotechnology and Professor of Structural Biology at the University of Helsinki #cryoEM #LocalizedReconstruction

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Juha Huiskonen @juhahuiskonen.bsky.social · 08/01/2026

I am pleased to share our new paper in Molecular Cell: “Capsid restructuring activates semi-conservative dsRNA transcription in cystovirus ɸ6.” We visualized, in structural detail, how a double-stranded RNA virus switches from a quiescent to a transcriptionally active state. Link in the comments

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Juha Huiskonen @juhahuiskonen.bsky.social · 25/07/2025

Excited to share our latest preprint "Capsid Restructuring Activates Semi-Conservative dsRNA Transcription in Cystovirus ɸ6". We show that nucleotide-triggered disassembly of the outer capsid layer is followed by expansion of the inner layer and the stepwise assembly of transcription complexes.

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Juha Huiskonen @juhahuiskonen.bsky.social · 08/07/2025

In our latest preprint on bioRxiv, we present the in situ structure of the human gap junction at 14 Å resolution using cryo-ET. The structure provides a blueprint for investigating how connexin regulation shapes intercellular communication in health and disease.

CryoET tomogram with the gap junction (green), ribosomes (cyan) and microtubules (pink)

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