Reposted by David RobbeINMED @inmed.bsky.social · 27/08/2026 With profound sadness we announce the passing of our colleague and friend Antoine de Chevigny, an expert in cortical development respected for his creativity and curiosity and cherished for his kindness and joie de vivre. He leaves an immense void. Support for his partner: tinyurl.com/2yrh7huc 175
David Robbe @davidrobbe.bsky.social · 03/08/2026Congrats Ahmed and Zachary, looks great ....we should test some of these hypotheses in our foraging task for mice www.cell.com/iscience/ful...cell.comThe Tower Foraging Park: A paradigm for studying cognitive and motor processes underlying behavioral flexibility in freely moving miceBiological sciences; Behavioral neuroscience; Laboratory animal science 010
Reposted by David RobbeAhmed El Hady @zamakany.bsky.social · 03/08/2026New Study! @cbehav.bsky.social @mpi-animalbehav.bsky.social Often foraging models assume that the forager knows the environment and proceed to predict decision strategies but how does the foraging learn the structure of the environment ? A new preprint delves into this question 2266
David Robbe @davidrobbe.bsky.social · 10/07/2026Oh, and thanks to all the people (students, postdocs, and PIs) who took the time to engage with them yesterday and provide feedback and encouragement! 000
David Robbe @davidrobbe.bsky.social · 10/07/2026Zelda and Maud are 3rd and 4th year PhD students. Passionate, hardworking, and fun, they have developed skills in rodent behavior (freely moving foraging), data analysis, and perturbation experiments. They are looking for postdocs. Contact them if interested! 111
David Robbe @davidrobbe.bsky.social · 10/07/2026Zelda presented the work she has been doing in collaboration with Thomas Morvan on the complementary motivational functions of the dorsal and ventral striatum in rats performing an effort-based foraging task. You can check out the latest preprint here: www.biorxiv.org/content/10.1...biorxiv.orgComplementary contributions of dorsal and ventral striatum to cost-benefit vigor adaptationsHumans and other animals adjust when and how fast they execute goal-directed actions according to expected costs and benefits. Yet, the behavioral principles and brain regions underlying adaptive vigo... 100
David Robbe @davidrobbe.bsky.social · 10/07/2026@maudschaffh.bsky.social presented work on how unilateral perturbation of dSPN/iSPN affects the behavior of mice engaged in a novel foraging task with a lateralized procedural component. The work is based on a cool patch foraging task we just published. www.cell.com/iscience/ful...cell.comThe Tower Foraging Park: A paradigm for studying cognitive and motor processes underlying behavioral flexibility in freely moving miceBiological sciences; Behavioral neuroscience; Laboratory animal science 120
David Robbe @davidrobbe.bsky.social · 10/07/2026Zelda Timmel and Maud Schaffhauser @maudschaffh.bsky.social, 2 outstanding PhD students I am lucky to work with, had a blast yesterday at #FENS presenting their poster on the role of the striatum in decision making and motor control during foraging. 161
Reposted by David RobbeAhmed El Hady @zamakany.bsky.social · 02/07/2026Check this exciting new foraging paper. Very excited that we are currently collaborating with @davidrobbe.bsky.social group to model behavioral mechanisms underlying foraging startegies in the The Tower Foraging Park. 042
David Robbe @davidrobbe.bsky.social · 03/07/2026Merci Jérémie ! En effet, le comportement dans cette tache est vraiment sympa et il y plein de cool experiences+ modelisation à faire ... 010
David Robbe @davidrobbe.bsky.social · 02/07/2026by the way @maudschaffh.bsky.social will present another story on the role of dorsal striatum using this task at FENS. She is looking for postdoc and will have a poster Thursday afternoon (PS06-09PM-627) 122
David Robbe @davidrobbe.bsky.social · 02/07/2026Hardware, codes, and data are openly available. We hope the TFP becomes a useful platform for others studying decision-making, motor learning/control, motivation. With @aquineuro.bsky.social we are working to provide a fully functional set-up. Get in touch! 230
David Robbe @davidrobbe.bsky.social · 02/07/2026Thanks to @zamakany.bsky.social for suggesting the name of the task and @smondoloni.bsky.social for the nice artwork in the graphical abstract! 120
David Robbe @davidrobbe.bsky.social · 02/07/2026Huge thanks to @maudschaffh.bsky.social , Tom Orjollet-Lacomme, Kenza Amroune, and Thomas Morvan, four amazing PhD students (2 former, 2 current) who each brought distinct, complementary contributions and agreed to share first authorship. This project started in 2020!! 130
David Robbe @davidrobbe.bsky.social · 02/07/2026This paper also makes a broader argument: patch foraging in freely moving animals can provide an intermediate between trial-based tasks (with their pros and cons) and more naturalistic approaches that lack the experimental perturbations necessary to understand the logic of adaptive behavior. 110
David Robbe @davidrobbe.bsky.social · 02/07/2026Finally, both groups faced a harder challenge: after leaving a tower, the next rewarded tower and direction were picked at random. Mice previously trained on daily reversals outperformed those trained on a fixed rule, suggesting the reversal training made them more adaptive when foraging is harder. 100
David Robbe @davidrobbe.bsky.social · 02/07/2026Protocol 2 (n=32 mice): rewarded direction switched every day. Each morning mice started by testing the previous day's direction before switching, and across days they got progressively faster at adapting, a form of meta-learning. Uncoupling of speed and trajectory variance adaptation 100
David Robbe @davidrobbe.bsky.social · 02/07/2026After 6 days, the rewarded direction was reversed. Mice persisted briefly in the now unrewarded direction, then adapted. Strikingly, turn trajectory variability was immediately increased by unrewarded outcome while speed remained fast, revealing unexpected uncoupling of these 2 parameters 100
David Robbe @davidrobbe.bsky.social · 02/07/2026Protocol 1 (n=19 mice): only one turning direction rewarded, abrupt depletion, two 12-min sessions/day. Mice developed a strong directional preference within just a few sessions, and only rewarded turns got progressively faster and less variable in trajectory. 100
David Robbe @davidrobbe.bsky.social · 02/07/2026In the Tower Foraging Park (TFP), mice harvest water by making quarter-turns around towers. Each tower eventually depletes, so mice must decide when to leave and explore another, the classic explore/exploit dilemma. Here, we ran two main protocols, adding a procedural learning/flexibility twist 100
David Robbe @davidrobbe.bsky.social · 02/07/2026Excited to share our new paper: "The Tower Foraging Park: A paradigm for studying cognitive and motor processes underlying behavioral flexibility in freely moving mice,". Out now in @cp-iscience.bsky.social 🧵1/9 www.cell.com/iscience/ful...cell.comThe Tower Foraging Park: A paradigm for studying cognitive and motor processes underlying behavioral flexibility in freely moving miceBiological sciences; Behavioral neuroscience; Laboratory animal science 33410
Reposted by David RobbeMatteo Carandini @carandinilab.net · 01/06/2026Neuropixels + Optogenetics = Neuropixels Opto Combining high-resolution electrophysiology and optogenetics. 960 sites, 28 emitters, 2 colors. Today in @natmethods.nature.com doi.org/10.1038/s415... Thanks to @wellcometrust.bsky.social, @alleninstitute.org, @hhmijanelia.bsky.social & team. 115753
David Robbe @davidrobbe.bsky.social · 31/12/2025Just seeing this! We should have you come give a talk in Marseille. How long will you be around ? Many people with interest in motor control, evo/devo, spinal/cord .....plus the 🌊 and the 🌞 000
David Robbe @davidrobbe.bsky.social · 31/12/2025I am not even sure that clocks count. As you said, clocks just generate a regular movement. We use clock to read and measure time. Or am I wrong? 110
David Robbe @davidrobbe.bsky.social · 30/12/2025This will never cease to astonish me. Not only the nonsense of the request, but also the time pressure. Does this strategy work? Do people really send preprints to these journals? 130
David Robbe @davidrobbe.bsky.social · 27/12/2025Sensorimotor organoids....🤔 what a nice oxymoron. Do they form internal models ? 110
Reposted by David RobbeDrew Schreiner @schreinerdrew.bsky.social · 21/12/2025Cool basal ganglia preprints today! 2 on DA/ACh 1. @paulkramer.bsky.social www.biorxiv.org/content/10.6... 2. @arifahamid.bsky.social www.biorxiv.org/content/10.6... Motor learning @juangallego.bsky.social and @clopathlab.bsky.social www.biorxiv.org/content/10.6...biorxiv.orgExcitatory nicotinic signaling drives action potential bursting in dopaminergic axonsAxons of dopamine (DA) neurons express nicotinic receptors (nAChRs) that have been shown to both facilitate and suppress striatal DA release, but the mechanisms underlying these opposing actions are u... 0348
Reposted by David RobbeCurrent Biology @currentbiology.bsky.social · 19/12/2025HAPPY HOLIDAYS TO ALL OF YOU!🎄✨ 434064
David Robbe @davidrobbe.bsky.social · 16/12/2025Looks like a very exciting study! Congrats Guiseppe and all collaborators! 010
Reposted by David RobbeAndrew Pruszynski @andpru.bsky.social · 11/12/2025Peer review is important and useful but we should focus our efforts on a small number of papers that matter (making big claims, using new approaches) and let the vast majority of work live on a preprint server to be judged by their utility over time to domain experts. 2266
David Robbe @davidrobbe.bsky.social · 10/12/2025I am neuroscientist Nicole. I trained with Gyorgy Buzsaki. I learned with him than when two things change together this does not necessarily mean that one causes the other. We're not discussing nonmaterial souls. Things are just a bit more complicated than that 😉 110
David Robbe @davidrobbe.bsky.social · 10/12/2025And don't get me wrong: I am fascinating by the brain too. I am just skeptic of where this kind of approach is leading us. Let see where this ship goes (the captain is definitely amazing), without neglecting alternative routes ..... 110
David Robbe @davidrobbe.bsky.social · 10/12/2025Neuroscience seems stuck with very old-fashioned reductionist/materialist ideas whose shortcomings have already been exposed. More electrodes, more AI… it all sounds like "une fuite en avant" to me. 110
David Robbe @davidrobbe.bsky.social · 10/12/2025To me, what is thrilling (and a bit scary too) is to be in an era in which we might be so wrong about our understanding of the relationship between brain and behavior/cognition. I just don't see how the idea that the brain generates consciousness or perception can lead to falsifiable experiments. 320
David Robbe @davidrobbe.bsky.social · 10/12/2025I am hesitating to say this is also true of men who think critically. Thank God there are few of them. 170
Reposted by David RobbeIris van Rooij 💭 @irisvanrooij.bsky.social · 09/12/2025“Women who think critically are always labeled difficult because it saves the world from admitting they’re right” — bell hooks Repost of Charmaine Simpson, on LinkendIN: www.linkedin.com/posts/blackh... 321165
Reposted by David RobbeKevin Mitchell @wiringthebrain.bsky.social · 10/12/2025Direct Fit to Nature: An Evolutionary Perspective on Biological and Artificial Neural Networks www.sciencedirect.com/science/arti... - thought-provoking (2019) paper from @urihasson.bsky.social and colleaguessciencedirect.comDirect Fit to Nature: An Evolutionary Perspective on Biological and Artificial Neural NetworksEvolution is a blind fitting process by which organisms become adapted to their environment. Does the brain use similar brute-force fitting processes … 3155
David Robbe @davidrobbe.bsky.social · 10/12/2025I am reading it and and find it HUGELY misguided philosophically speaking. Ideas such as the brain produces consciousness or perception lead only to experimental dead-ends. I don't know if an engineering approach is needed. I'd say we need the opposite. So yeah ...let's see where this goes... 120
David Robbe @davidrobbe.bsky.social · 09/12/2025I wonder whether thinking that animals tend to waste energy (most likely for good reasons) was compatible with this very cartesian rat. This was meant as a friendly joke 😜 . BTW, I entirely agree with your thread , thanks for sharing 110
Reposted by David RobbeLuke Sjulson @lukesjulson.bsky.social · 08/12/2025Soapbox time: the problem with metabolic efficiency arguments in neuroscience is that they often confuse energy efficiency with energy expenditure. Biological systems are optimized for energy efficiency, but that does NOT imply they are optimized for low energy expenditure 🧵 1/ 57030
David Robbe @davidrobbe.bsky.social · 08/12/2025And all of a sudden, it became personal. As long as the incentives to do science are wrong, whatever we call it (a job or a way of life) is going to be toxic. 030