Sign in

Tim Frayling

@timfrayling.bsky.social
745 followers 210 following 183 posts

Human genetics, type 2 diabetes and obesity in today's environment. Cycling uphill. Team science. New shoots in Geneva & France, long roots in the UK & Exeter. www.unige.ch/medecine/gede/en/resea…

PostsRepliesMedia
Tim Frayling @timfrayling.bsky.social · 30/06/2026
Are you one of the >150,000 people in Geneva who have signed a general consent to allow researchers to securely reuse your data for medical research ? See below to find out how your data and samples could be helping us understand disease www.linkedin.com/feed/update/...
linkedin.com
#biohug #personalisedmedicine #translationalresearch | Faculty of Medicine - UNIGE
BioHUG Biobank: 10,000 DNA samples and counting! Launched in February 2025, BioHUG (UNIGE Faculty of Medicine & HUG) aims to collect 20,000 DNA samples by 2027 — a milestone that will place it among ...
022
Tim Frayling @timfrayling.bsky.social · 30/06/2026
Faites-vous partie des plus de 150 000 Genevois qui ont signé un consentement général autorisant les chercheurs à réutiliser vos données en toute sécurité à des fins de recherche médicale ? www.linkedin.com/feed/update/...
linkedin.com
#biohug #médecinepersonnalisée #recherchetranslationnelle | Faculty of Medicine - UNIGE
🧬 La biobanque BioHUG : déjà 10 000 échantillons d'ADN Créée en février 2025, BioHUG (Faculté de médecine UNIGE & HUG) vise à inclure 20 000 échantillons d'ADN d'ici à 2027 — seuil qui la placera par...
000
Tim Frayling @timfrayling.bsky.social · 17/06/2026
Messi, Haaland and Mbappé. 3 legends, 7 goals. No pressure on Christiano tonight.
000
Tim Frayling @timfrayling.bsky.social · 10/05/2026
Claude is helping me learn French . French native speakers would you get the grammar differences between these 2 phrases ?: "Hier matin, Sophie s'est coupée profondément en épluchant des légumes. Avant le déjeuner, ma fille s'est lavé soigneusement les mains.
110
Tim Frayling @timfrayling.bsky.social · 20/03/2026
Update from Claude
010
Tim Frayling @timfrayling.bsky.social · 08/03/2026
Catch up on Switzerland's mature Trusted Research Environment for working with sensitive data , including from multiple hospitals across the country. thanks to the hard work of Owen Appleton Sabine Österle , Shubham Kapoor & many others. www.youtube.com/watch?v=XsnE...
youtube.com
YouTube
Share your videos with friends, family, and the world
010
Tim Frayling @timfrayling.bsky.social · 07/03/2026
Learn about working securely with data from 10% of the Swiss population : 📚 The SPHN Federated Clinical Routine Dataset: 🗣 Referenten: Dr. Sabine Österle 📅 Wann: Dienstag, 10. März 2026, um 16:45 Uhr 📍 Wo: Online via Zoom: bit.ly/4e9p3Ka #SPHN
bit.ly
Join our Cloud HD Video Meeting
Zoom is the leader in modern enterprise cloud communications.
010
Tim Frayling @timfrayling.bsky.social · 25/02/2026
Fantastic opportunity en Suisse: www.linkedin.com/posts/swiss-...
linkedin.com
#hiring #healthdata #sphn #datasharing #fair #personalizedmedicine #collaboration #swisshds #sparql #snomedct #loinc #semantics #ehds | Swiss Personalized Health Network (SPHN)
📢 We’re hiring: Senior Software Developer (permanent, 80–100%) 📍 Basel (hybrid work possible) To strengthen its semantic layer, Swiss Personalized Health Network (SPHN) is seeking a Senior Software...
010
Tim Frayling @timfrayling.bsky.social · 25/02/2026
Amazing. UK leading the way . Finland in silver medal position ? and I predict Switzerland could join them on the podium at some point over the next year or two
011
Tim Frayling @timfrayling.bsky.social · 19/02/2026
yep. seems like we need to try, but also that most components of disease are on a continuous scale. Put people into groups based on those scales and they will look different, but are the separations real ? doesn't rule out the importance of stratification to get more bang for intervention buck
110
Tim Frayling @timfrayling.bsky.social · 12/02/2026
Congratulations @laferrat.bsky.social & team.
020
Tim Frayling @timfrayling.bsky.social · 11/02/2026
slightly random reminder of this paper from 2019 from Exeter colleagues that shows how heterogeneity of disease, in this case diabetes, is best dealt with by using continuous clinical variables not cluster assignment: www.sciencedirect.com/science/arti...
sciencedirect.com
Disease progression and treatment response in data-driven subgroups of type 2 diabetes compared with models based on simple clinical features: an analysis using clinical trial data
Research using data-driven cluster analysis has proposed five subgroups of diabetes with differences in diabetes progression and risk of complications…
031
Tim Frayling @timfrayling.bsky.social · 11/02/2026
excellent opportunity with SPHN , making health data from > 10% of the Swiss population safely reusable for research apply.refline.ch/499599/0353/...
apply.refline.ch
Senior Software developer
About Us The Swiss Personalized Health Network (SPHN) is a national network mandated by the State Secretariat for Education, Research and Innovation (SERI) to enable the secure reuse of health data fo...
000
Reposted by Tim Frayling
Robert Warmerdam @robertwarmerdam.bsky.social · 06/02/2026
🧬 New preprint alert! After years of collaborative work across 52 datasets we are presenting eQTLGen phase 2: a genome-wide eQTL meta-analysis covering 43,301 blood samples: www.medrxiv.org/content/10.6... (1/8)
13921
Tim Frayling @timfrayling.bsky.social · 07/02/2026
Using genetics to understand multi morbidity, including neat R package to "subtract" effects of critical risk factors such as obesity : www.nature.com/articles/s43...
nature.com
Genetics identifies obesity as a shared risk factor for co-occurring multiple long-term conditions - Communications Medicine
Mounier et al., analyse whether obesity, measured by body mass index (BMI) affects the shared genetic risk between 71 long-term health conditions including diabetes, heart disease and arthritis. Healt...
020
Tim Frayling @timfrayling.bsky.social · 06/02/2026
great work & just as interesting is use of this approach to estimate the shared genetics between pairs of conditions whilst "subtracting" the effects of obesity. Interesting that T2D-Osteoarthritis genetic link estimated as 100% about obesity, other pairs clearly have strong non obesity components
020
Tim Frayling @timfrayling.bsky.social · 06/02/2026
The Exeter team seem to be the Alex Honnold of human genetics. Most sane people on seeing the challenge of meta analysing >1billion variants & 10,000s aggregates across ~100% of the genome would opt for the safety rope of the exome. Not these guys.
171
Tim Frayling @timfrayling.bsky.social · 27/01/2026
ten percent of the Swiss population: Medical meta data update: www.linkedin.com/posts/swiss-...
linkedin.com
#sphn #healthdata #datasharing #fair #personalizedmedicine #collaboration #swisshds #snomedct #loinc #semantics #ehds | Swiss Personalized Health Network (SPHN)
🔓📊 Clinical data from 800,000 patients unlocked: Empowering health research with a large-scale, FAIR dataset from Switzerland 🇨🇭 Swiss Personalized Health Network is proud to have released the metad...
021
Tim Frayling @timfrayling.bsky.social · 14/01/2026
Learning more about the brilliance of the medical record data at the University Hospital Geneva. This plot, from pubmed.ncbi.nlm.nih.gov/34643542/ shows how medical informatics researchers have introduced , & clinicians passively adopted, a set list of phrases, reducing new free text.
010
Tim Frayling @timfrayling.bsky.social · 25/11/2025
Interesting development in ”non-personalised Medicine” from UK: the government will reduce the current lower threshold at which Soft drink industry levy applies from 5g of total sugars per 100ml to 4.5g & will remove the current exemption for milk-based drinks with added sugar
030
Tim Frayling @timfrayling.bsky.social · 08/11/2025
Rarely in the entire history of science, has QC been a topic of such passion, importance and impact. If only the French and Americans had adopted such rigor when they messed up the design of that multi billion $ telescope because one was using the metric system, the other the imperial system.
073
Tim Frayling @timfrayling.bsky.social · 07/11/2025
Now a nice series of papers using genetics to "uncouple" excess adiposity from its adverse metabolic effects. Here for metabolic traits www.nature.com/articles/s42..., here including non metabolic traits elifesciences.org/articles/72452 & here using partitioned PRS www.nature.com/articles/s41...
cell.com
When more is not worse: Genetic subtypes of obesity challenge conventional risk paradigms
Emerging evidence challenges the view of obesity as a uniform metabolic risk. Spotlighting the recent Nature Medicine study by Chami et al. this piece discusses how “uncoupling” adiposity from its car...
1113
Tim Frayling @timfrayling.bsky.social · 26/10/2025
Nearly two years in for our new common disease genetics and genomics team at the University of Geneva. Already lots to be proud of. Here is Lauric talking about his award from the local Diabetes charity. fr.linkedin.com/posts/fondat...
fr.linkedin.com
Découvrez l'un de nos trois chercheurs, Lauric Ferrat de l'UNIGE, qui explique son projet primé par notre Prix 2025 sur l'optimisation et la rentabilitédu dépistage du diabète de type 1 en...
Découvrez l'un de nos trois chercheurs, Lauric Ferrat de l'UNIGE, qui explique son projet primé par notre Prix 2025 sur l'optimisation et la rentabilitédu dépistage du diabète de type 1 en Suisse.
020
Tim Frayling @timfrayling.bsky.social · 26/10/2025
I’m learning more and more about the extremely impressive Swiss personalised Health Network and the trusted research environment infrastructure that enables researchers to safely access & Analyse data from multiple hospitals in Switzerland www.sib.swiss/news/sphn-is...
sib.swiss
SPHN is a trusted partner between hospitals and private companies
A new collaboration framework allows private partners to transform sensitive Swiss health data into actionable insights while preserving patient privacy. The first pilot project examines risk factors ...
000
Tim Frayling @timfrayling.bsky.social · 30/09/2025
Congratulations to our Liza Darrous for winning the women in data science award last week:  tinyurl.com/lizaprize
tinyurl.com
Still buzzing from an incredible day at WiDS Belgium 2025 👩‍💻 ✨ ! Usually WiDS leaves me inspired by all the amazing women sharing their work on stage. This year, I had the chance to be on stage… | L...
Still buzzing from an incredible day at WiDS Belgium 2025 👩‍💻 ✨ ! Usually WiDS leaves me inspired by all the amazing women sharing their work on stage. This year, I had the chance to be on stage myse...
010
Tim Frayling @timfrayling.bsky.social · 08/09/2025
thanks to @laraedw001.bsky.social for highlighting this micro.green-park.co.uk/hdrs/. I suggest whoever gets this position, pops over to Switzerland as the SPHN have achieved great things with consented data from 10% of the population available for study a few months after application & in a TRE
micro.green-park.co.uk
HDRS
120
Tim Frayling @timfrayling.bsky.social · 05/09/2025
Oh dear. Sad and presumably another lead statistician to be fired ? www.bbc.com/news/live/c5...
bbc.com
US economy adds fewer jobs than expected in August, confirming slowdown
After the previous month's release, Trump fired then-Bureau of Labor Statistics chief Erika McEntarfer.
010
Tim Frayling @timfrayling.bsky.social · 20/08/2025
Amazing study. A simple but important question affecting up to 50% of the population yet previously understudied . And an exemplar in the power of multi-modal data linkage. www.bristol.ac.uk/alspac/news/...
bristol.ac.uk
2025: Periods and GCSE results | Avon Longitudinal Study of Parents and Children | University of Bristol
0123
Tim Frayling @timfrayling.bsky.social · 18/08/2025
Deadline 31/08. Join a friendly team in the heart of Europe. Build your research career in human genetics & genomics using data from millions of individuals to address important causes and consequences of disease. Apply here lnkd.in/dyZcgc-g More information on the team here: lnkd.in/dzZ2aU4Z
lnkd.in
LinkedIn
This link will take you to a page that’s not on LinkedIn
010
Tim Frayling @timfrayling.bsky.social · 18/08/2025
New position in Geneva jobs.unige.ch/www/wd_porta...
jobs.unige.ch
Maître assistant-e - Fonds National (6461)
000
Reposted by Tim Frayling
fbm-unil.bsky.social @fbm-unil.bsky.social · 07/08/2025
Dirigée par @zkutalik.bsky.social et @rjhfmstr.bsky.social à la @fbm-unil.bsky.social, au @sib.swiss et à #unisanté, une nouvelle étude publiée dans @nature.com présente une méthode computationnelle innovante pour étudier ces effets liés à l’origine parentale. 🔗 www.nature.com/articles/s41...
nature.com
Parent-of-origin effects on complex traits in up to 236,781 individuals - Nature
A novel multistep strategy reveals how parent-of-origin effects shape complex traits in large-scale biobanks.
185
Tim Frayling @timfrayling.bsky.social · 02/08/2025
Best of British : Black Sabbath’s Paranoid played by the Coldstream guards to commemorate Ozzy Osborne
010
Tim Frayling @timfrayling.bsky.social · 01/08/2025
well done part I @erinltempleman.bsky.social
010
Tim Frayling @timfrayling.bsky.social · 14/07/2025
Which sports (and formats) come closest to test match cricket where no runs / points / goals / scores are being made but the tension and adrenaline levels are so high (for players and spectators alike )? www.espncricinfo.com/series/india...
espncricinfo.com
3rd Test, Lord's, July 10 - 14, 2025, India tour of England (Ravindra Jadeja 61*, Shoaib Bashir 1/6, ENG vs IND live score, 3rd Test, day 4, Lord's, London, July 10 - 14, 2025
Check England vs India 3rd Test 2025 live cricket score from London. Get the live score updates and ball by ball commentary of ENG vs IND 3rd Test, 2025. Fastest scorecard and detailed analysis of the...
000
Tim Frayling @timfrayling.bsky.social · 12/07/2025
Best wishes to this sports star Amanda Anismova. You don’t beat Anya Sabalenka in the semi finals of Wimbledon without being a superb tennis player : www.theguardian.com/sport/2025/j...
theguardian.com
Iga Swiatek races to first Wimbledon title with 6-0, 6-0 thrashing of Anisimova
Iga Swiatek crushed Amanda Anisimova in the most one-sided Wimbledon final for 114 years, racing to a 6-0, 6-0 victory in only 57 minutes
010
Tim Frayling @timfrayling.bsky.social · 09/07/2025
BBC radio 4´s more or less programme on obesity : www.bbc.co.uk/sounds/play/...
bbc.co.uk
More or Less - Can drinking one less bottle of coke a day halve obesity? - BBC Sounds
Plus, the UK’s expensive electricity, church counts and babies in the City of London.
000
Tim Frayling @timfrayling.bsky.social · 06/07/2025
Wow. Amazing investigative journalism: observer.co.uk/news/nationa...
observer.co.uk
The real Salt Path: how a blockbuster book and film were ...
Penniless and homeless, the Winns found fame and fortune with the story of their 630-mile walk to salvation. We can reveal that the truth behind it is ve...
000
Tim Frayling @timfrayling.bsky.social · 05/07/2025
Exciting, but wish the hype was dialled back. "This will enable identification & intervention for individuals at high risk of developing common diseases" probably better as "cheap once in lifetime test will nudge many people over & under certain thresholds for interventions.
242
Tim Frayling @timfrayling.bsky.social · 29/06/2025
interesting non-personalised medicine experiment about to happen in UK. Supermarkets will be asked to report data on sales & incentivised to increase healthier food sales, in ways they choose, using their extensive longitudinal data on our purchasing behaviour www.independent.co.uk/news/uk/poli...
independent.co.uk
Supermarkets could face fines for failing healthy eating targets in obesity crackdown
Labour health secretary issues warning over future of health service ‘unless we curb the rising tide of cost and demand’ caused by obesity epidemic
020
Reposted by Tim Frayling
Zoltán Kutalik @zkutalik.bsky.social · 27/06/2025
Lausanne Comp Bio Symposium 2025 (cbiosymposium.unil.ch) 🗓 Abstract deadline 30 June (𝟑 𝐝𝐚𝐲𝐬 𝐭𝐨 𝐠𝐨!!!) 🎤 Oral presentation notifications: 7 July ✅ Early Bird registration deadline: 11 July 💰 Registration fee for non-PI: 150 CHF
088
Tim Frayling @timfrayling.bsky.social · 20/06/2025
Danny Boyle «  The idea that we have a broadcaster that is part of our national identity but is also trusted around the world and that can’t be bought, can’t be subsumed into Meta or whatever, feels really precious » www.theguardian.com/film/ng-inte...
theguardian.com
‘You’d never make Slumdog today’: Danny Boyle on risks, regrets and returning to the undead
In 28 Years Later, zombies maraud over a Britain broken by more than Brexit. Its director discusses cultural baggage, catastrophising – and why his kids’ generation is an ‘upgrade’
011
Tim Frayling @timfrayling.bsky.social · 19/06/2025
I have just heard from a US visitor from San Diego. She discussed PhD students in her lab. US citizens of chinese and african ancestry. One a military veteran. Both have received knocks on the door with officials asking them for their birth certificates.
100
Tim Frayling @timfrayling.bsky.social · 19/06/2025
Mike’s on his next trip after we were lucky enough to host him in Geneva for a few hours . It was great to hear his measured and inspiring take on polygenic risk scores .
122
Tim Frayling @timfrayling.bsky.social · 14/06/2025
there's that big gap between MAF 0.01 and 0.001 again...
141
Reposted by Tim Frayling
Jack Kosmicki @jakphd.bsky.social · 13/06/2025
In the latest update to the 23andMe, Anne Wojcicki (i.e., not REGN) won the bidding war. www.wsj.com/tech/biotech...
wsj.com
Exclusive | Anne Wojcicki Wins Bidding for 23andMe
Regeneron is backing away from buying the DNA-testing company after a nonprofit controlled by co-founder Wojcicki made a higher bid.
232
Tim Frayling @timfrayling.bsky.social · 11/06/2025
Sad news. This song blew Paul McCartney away at the time apparently. I guess we're going to have to get used to this as the heroes of 1960s pop travel through their 80s (if they made it past 27) www.youtube.com/watch?v=lpd4...
youtube.com
The Beach Boys - God only knows (1966) fully restored video
YouTube video by Mike Adams
000
Tim Frayling @timfrayling.bsky.social · 09/06/2025
One of the things that is getting better.....
030
Reposted by Tim Frayling
Eric Fauman (he/him) @ericfauman.bsky.social · 07/06/2025
To add to your weekend reading, check out this nice report on the Genes & Health cohort from Hye In Kim, David van Heel and many many more: www.medrxiv.org/content/10.1...
medrxiv.org
Exome sequencing and analysis of 44,028 British South Asians enriched for high autozygosity
Genes and Health (G&H) is a biomedical study of adult British-Pakistani and -Bangladeshi research volunteers enriched for autozygosity. We performed whole exome sequencing in 44,028 G&H participants, ...
074
Tim Frayling @timfrayling.bsky.social · 08/06/2025
A big day for sport, after Coco Gauff yesterday. Maybe the first big insight into whether or not these two guys can replace the entertainment and drama provided by the big 3. www.bbc.com/sport/tennis...
bbc.com
French Open 2025: Jannik Sinner and Carlos Alcaraz meet in 'special' men's final
The latest chapter in the burgeoning rivalry between Jannik Sinner and Carlos Alcaraz will play out in Grand Slam final for the first time in Sunday's French Open showpiece.
100
Tim Frayling @timfrayling.bsky.social · 06/06/2025
Congratulations to Lauric Ferrat for this funding from the local Diabetes Suisse Romande foundation, for work he is leading in Type 1 diabetes. fondation-diabete.ch/res/Newslett...
fondation-diabete.ch
050