iiinova — where your digital self keeps evolving

Cordero-Vásquez Lab @cvlab.bsky.social · 23/04/2026

We are so happy to see Vasanthi Jayaraman named chair of Biochemistry at UTHouston Vasanthi is not only a leader in biophysics and Editor-in-Chief of the Biophysical Journal, but also a wonderful colleague and mentor Congratulations @frettinglab.bsky.social med.uth.edu/blog/2026/04...

med.uth.edu

Jayaraman named chair of Biochemistry and Molecular Biology

McGovern Medical School is the eleventh largest medical school in the United States. Located in the heart of the Texas Medical Center, the school was established by the Texas Legislature in 1969 to ad...

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Cordero-Vásquez Lab @cvlab.bsky.social · 27/03/2026

Here is the morph video summarizing some of the changes we found in a TRPC3 hypermorphic variant (Science Advances, Science Magazine) (4/4)

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Cordero-Vásquez Lab @cvlab.bsky.social · 27/03/2026

We are grateful to all the authors and collaborators who made this study possible. Special thanks to everyone in the Cordero-Morales and Vásquez laboratories (especially Briar Bell, Angela Jaramillo-Granda, and Luis Romero), as well as to our collaborators. www.science.org/doi/10.1126/... (3/4)

science.org

Functional and structural basis of a hypermorphic TRPC3 variant

Structural snapshots capture an ataxia-linked overactive ion channel in its open state and reveal a druggable site for inhibition.

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Cordero-Vásquez Lab @cvlab.bsky.social · 27/03/2026

Using electrophysiology, cryo-EM, molecular simulations, and in vivo models, we also identify a druggable inhibitory site that could guide future therapies for cerebellar ataxia. (2/4)

science.org

Functional and structural basis of a hypermorphic TRPC3 variant

Structural snapshots capture an ataxia-linked overactive ion channel in its open state and reveal a druggable site for inhibition.

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Cordero-Vásquez Lab @cvlab.bsky.social · 27/03/2026

Excited to share our new paper in Science Advances @science.org In this work, we uncover how a disease-linked TRPC3 mutation, together with a cerebellum-specific splice isoform, stabilizes the channel in an open state, drives Calcium overload, and promotes neurodegeneration. (1/4)

science.org

Functional and structural basis of a hypermorphic TRPC3 variant

Structural snapshots capture an ataxia-linked overactive ion channel in its open state and reveal a druggable site for inhibition.

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Cordero-Vásquez Lab @cvlab.bsky.social · 27/01/2026

We have an outstanding speaker lineup, including Keynote Talks by Kenton Swartz, Nancy Carrasco, Miriam B. Goodman (@wormsense.bsky.social), and Francisco Bezanilla. Trailblazer Spotlights presented by Ed Twomey (@cryoet.bsky.social)and Theanne Griffith (@doctheagrif.bsky.social). 2/3

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Cordero-Vásquez Lab @cvlab.bsky.social · 27/01/2026

Sudha (@chakrapanilab.bsky.social) and Julio (@cvlab.bsky.social) are organizing the 2026 Ion Channel Gordon Research Conference: Ion Channels Across Scales — Bridging Molecular Events to Physiological Outcomes, to be held at Mount Holyoke College, July 12–17, 2026. 1/3

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Cordero-Vásquez Lab @cvlab.bsky.social · 02/01/2026

This work was a collaboration with Mat Baker (UTHealth Houston), the Chesler Lab @alexchesler.bsky.social (NIH), and the Sotomayor Lab (University of Chicago). 5/5

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Cordero-Vásquez Lab @cvlab.bsky.social · 02/01/2026

4. The pore-distal, N-terminal blade is dispensable for mechanoactivation: the intermediate isoform is not only functional, but also inactivates more slowly than the long isoform. 5. The intermediate isoform induces larger membrane deformation than the long isoform. 4/5

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Cordero-Vásquez Lab @cvlab.bsky.social · 02/01/2026

1. The longest isoform resembles a Mercedes-Benz steering wheel in top view. 2. The long and intermediate isoforms are semi-flattened and differ from the mammalian domes. 3. Multiple blade–cap contacts stabilize a “toggle-down” conformation. 3/5

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Cordero-Vásquez Lab @cvlab.bsky.social · 02/01/2026

Briar and Angela (CV Lab) solved three structures from heavily spliced worm isoforms. Along the way —while solving the structures, characterizing their function, and evaluating effects on membrane curvature— we ran into several surprises: 2/5

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Cordero-Vásquez Lab @cvlab.bsky.social · 02/01/2026

The Cordero Vásquez Lab is starting the year on a high wheel (see below) with our latest work on the C. elegans PIEZO channel: “Structures of invertebrate PEZO-1 isoforms with a compact architecture and a dispensable pore-distal N-terminal blade”: www.sciencedirect.com/science/arti... 1/5

sciencedirect.com

Structures of invertebrate PEZO-1 isoforms with a compact architecture and a dispensable pore-distal N-terminal blade

PIEZO channels are mechanosensitive ion channels conserved from plants to humans, yet structures exist for only a few mammalian orthologs. We define t…

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Cordero-Vásquez Lab @cvlab.bsky.social · 06/11/2025

Thanks to our team members (Luis Romero, Manisha Bade, Sonia Paz-López) and collaborators (Elisa Carrillo, Vasanthi Jayaraman @frettinglab.bsky.social , Syed Hasan, William James Antonisamy, and Zahoor Shah) 6/6

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Cordero-Vásquez Lab @cvlab.bsky.social · 06/11/2025

Our results highlight cytoskeletal dysregulation as a key driver of ion channel and behavioral deficits, and suggest that actin-binding proteins may be targets to enhance motor coordination and spatial learning in AS. 5/6

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Cordero-Vásquez Lab @cvlab.bsky.social · 06/11/2025

currents in hippocampal neurons, and improves rotarod and T-maze performance in AS mice. 4/6

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Cordero-Vásquez Lab @cvlab.bsky.social · 06/11/2025

In Angelman syndrome (AS), disrupted F-actin affects mechanosensitive and glutamatergic signaling. We show that a first-in-class, selective cofilin inhibitor (SZ-3) stabilizes the actin cytoskeleton, increases cellular stiffness, restores PIEZO2 function in DRG neurons and glutamate-evoked 3/6

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Ishmail Abdus-Saboor @ishmailsaboor.bsky.social · 02/11/2025

Great series and this game7 was one of the greatest games Ive ever seen! Congrats Dodgers! Yamamoto has to be MVP of this series.

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Cordero-Vásquez Lab @cvlab.bsky.social · 21/10/2025

(TMC, the world’s largest medical complex). 2/2

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Cordero-Vásquez Lab @cvlab.bsky.social · 21/10/2025

The Department of Biochemistry and Molecular Biology at UTHealth Houston has an open search for a tenure-track faculty position. If you are ready (or know someone that is) to start looking for positions, this will be a great opportunity to join the Texas Medical Center. See flyer below. 1/2

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Ardem Patapoutian @ardemp.bskyverified.social · 10/10/2025

The Nobel Peace Committee sent a clear message to someone else in awarding the Prize to Ms. Machado: ”But democracy is also in retreat internationally. Democracy – understood as the right to freely express one’s opinion, …is the foundation of peace both within countries and between countries.” 👏

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Valeria Vásquez R @valeriavasquez.bsky.social · 10/10/2025

“The Nobel Peace Prize for 2025 goes to a brave and committed champion of peace – to a woman who keeps the flame of democracy burning amid a growing darkness.” www.nobelprize.org/prizes/peace...

nobelprize.org

Nobel Peace Prize 2025

The Nobel Peace Prize 2025 was awarded to Maria Corina Machado "for her tireless work promoting democratic rights for the people of Venezuela and for her struggle to achieve a just and peaceful transi...

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Cordero-Vásquez Lab @cvlab.bsky.social · 03/10/2025

This study was a collaborative effort across multiple groups, led by our first graduate student, Dr. Luis Octavio Romero, in partnership with graduate student Manisha Bade. 3/3

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Cordero-Vásquez Lab @cvlab.bsky.social · 03/10/2025

PIEZO1 is abnormally overactive in sickle red blood cells (humans and mice). In mice, an EPA-enriched diet normalized PIEZO1 and reduced hemolysis, hypoxia-induced sickling, and downstream inflammation, suggesting a potential dietary strategy to support people living with sickle cell disease. 2/3

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Theanne Griffith, PhD 🇧🇧👩🏽‍🔬🇭🇷 @doctheagrif.bsky.social · 19/06/2025

I’m so honored to be selected as both a 2025 McKnight Scholar and 2025 HHMI Freeman Hrabowski Scholar. And I couldn’t be prouder to share these honors with awesome @ucdavis.bsky.social colleagues 💙💛💙💛 health.ucdavis.edu/news/headlin...

health.ucdavis.edu

UC Davis researchers honored by McKnight and Howard Hughes Medical Institute

UC Davis faculty Sergey Stavisky, Theanne Griffith and Elisa Zhang receive prestigious early-career recognition from McKnight Endowment Fund and the Howard Hughes Medical Institute.

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Drug Monkey @drugmonkey.bsky.social · 19/06/2025

Such fantastic news! Congratulations!

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Ardem Patapoutian @ardemp.bskyverified.social · 19/06/2025

I spoke with Jade Hindmon, host of @kpbssandiego.bsky.social Midday Edition, about the consequences of the current administration’s cuts to science funding. Please share to help spread the word and raise awareness. www.kpbs.org/podcasts/kpb...

kpbs.org

Nobel laureate on how Trump's cuts are hurting science

Neuroscientist, biologist and 2021 Nobel Prize winner Ardem Patapoutian joined Midday Edition to talk about how the Trump administration's effort to cut back on science spending is impacting researche...

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Kyle Clark @kylec.bsky.social · 26/02/2025

Colorado's Rep Brittany Pettersen (D) flew cross-country with her one-month-old to vote against the GOP budget tonight. Dems ended up one vote short. Pettersen was part of an unsuccessful bipartisan push to allow new mothers to vote remotely. #copolitics

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Rachel N. Arey @rnareylab.bsky.social · 23/02/2025

My colleague Dan beat me to the punch but I am so thankful that my hometown paper (and others) was willing to share this with the community.

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Mauricio A. Lillo @maurolillo.bsky.social · 22/02/2025

🚨🚨First paper of the year! I'm excited to share that our lab and collaborators have discovered that TRPV4/Cx43 hemichannels play a crucial role in endothelial hyperpolarization. Huge thanks to @piaburboa.bsky.social for continuing this fascinating work. physoc.onlinelibrary.wiley.com/doi/10.1113/...

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Harmit Singh Malik @harmitmalik.bsky.social · 28/01/2025

If you have been affected by the fires in LA, or are concerned about your ability to keep precious Drosophila strains going during the latest funding crisis, we will host your strains as a backup. Please email me. Please amplify. If you are also able to host fly strains, add your name as well.

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Anna Allen @akallen10.bsky.social · 28/01/2025

NSF has created an Executive Order Implementation webpage to ensure the widest dissemination of information and updates. We will continue to communicate with you as we receive additional guidance. new.nsf.gov/executive-or...

new.nsf.gov

NSF Implementation of Recent Executive Orders

Information for the NSF community regarding executive orders.

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Felix Viana @neuroviana.bsky.social · 27/01/2025

Please help us advertise this new opening 🧠 in our research group. I am happy to answer any queries about it.

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Jeremy Berg @jeremymberg.bsky.social · 27/01/2025

While I realize this is not relevant to many of the present day discussions, the remarkable similarity of organisms at the biochemical, genetic, cellular, and physiological levels is not understood by many people. 1/n

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Channels, Receptors & Transporters Subgroup of BPS @bpscrt.bsky.social · 19/01/2025

The Channels, Receptors & Transporters Subgroup of the @biophysicalsoc.bsky.social is excited to announce the final program for our 2025 Symposium. Please join us on Feb 15 to hear from @willowcoyote.bsky.social @drcontrexin.bsky.social @corrylab.bsky.social and others 👇Thanks to our sponsors!

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Marta Filizola @martafilizola.bsky.social · 16/01/2025

Just one month to go until the 2025 GRS/GRC in Molecular Pharmacology! Get ready for an extraordinary program packed with cutting-edge science and inspiring discussions. Full details here: www.grc.org/molecular-ph...

grc.org

2025 Molecular Pharmacology Conference GRC

The 2025 Gordon Research Conference on Molecular Pharmacology will be held in Ventura, California. Apply today to reserve your spot.

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UC Davis Physiology @ucd-physiology.bsky.social · 09/01/2025

New paper‼️— from #PMB Griffith Lab! They show that sodium channels play unique roles in proprioceptive encoding. They also studied effects on skeletal muscle, and a dev dependent role for Nav1.6 in proprioceptive spinal circuits. www.science.org/doi/10.1126/...

science.org

Differential encoding of mammalian proprioception by voltage-gated sodium channels

Voltage-gated sodium channels differentially encode mammalian proprioception via distinct cellular localization patterns.

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Theanne Griffith, PhD 🇧🇧👩🏽‍🔬🇭🇷 @doctheagrif.bsky.social · 08/01/2025

Thrilled to share the most recent pub from the Griffith Lab! We show that sodium channels play unique roles in proprioceptive encoding. We also found some really cool effects on skeletal muscle, and a dev dependent role for Nav1.6 in proprioceptive spinal circuits www.science.org/doi/10.1126/...

science.org

Differential encoding of mammalian proprioception by voltage-gated sodium channels

Voltage-gated sodium channels differentially encode mammalian proprioception via distinct cellular localization patterns.

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Black In Biophysics @blackinbiophys.bsky.social · 08/01/2025

Congratulations to #BlackInBiophysics Founder @stevenssostre.bsky.social and #BIBPS Board Member @jjalston.bsky.social on this extraordinary accomplishment!!! 🥳🥳🥳 We are PROUD of you and wish you the best in your careers! 👏🏾👏🏾👏🏾 @biophysicalsoc.bsky.social

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Dr. Michael D. L. Johnson @copperbae.bsky.social · 07/01/2025

Está invitado para CIENCIA EN ESPAÑOL I am hosting an event where University of Arizona scientists will speak about their science in Spanish. It is meant to be a community event with a Zoom option, so share with family too! events.trellis.arizona.edu/en/f44lNu67/... #CIENCIAENESPAÑOL

events.trellis.arizona.edu

The University of Arizona ⋮ Events

Discover events from The University of Arizona

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Miriam B. Goodman, PhD @wormsense.bsky.social · 01/01/2025

How hard do bacteria-eating nematodes bite in order to break the bacterial cell wall? Check out our new paper, led by Jason Casar & collab with Jen Dionne, using pressure sensing beads that change color upon compression (bluetorial coming soon) rdcu.be/d5n7v

rdcu.be

Upconverting microgauges reveal intraluminal force dynamics in vivo

Nature - Nanoparticle-based ‘microgauges’ are developed for in vivo force sensing and deployed in C. elegans to investigate how mechanical force correlates with electrical signalling in...

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Journal of General Physiology @jgp.org · 18/12/2024

New: McIlvried, @johndr01.bsky.social, Gereau et al. show that mechanisms of adaptive plasticity are engaged in mouse and human sensory neurons after sustained depolarization. This phenomenon is reversible and involves alterations of voltage-gated sodium channel currents. buff.ly/41JuRY7

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