Regulation of membrane receptors governs extracellular matrix homeostasis and host-pathogen interactions. Here, authors show that reversible S-acylation controls CMG2 maturation, trafficking, and sign...

To Penguin Random House, HarperCollins, Simon & Schuster, Hachette Book Group, Macmillan, and all other publishers of America: We are standing on a precipice. At its simplest level, our job as …

This study identifies ANTXR2 as the cellular receptor for Clostridium perfringens toxin NetF and determines its structure bound to the toxin using cryo-EM, revealing a distinct lateral binding mechani...

YouTube video by Max Planck Institute of Molecular Physiology

Wang et al. present an optimized labeling strategy for cryo-electron tomography based on genetically encoded FerriTag. This system uses rapamycin to recruit iron-loaded ferritin to target proteins, en...

Vitreous sectioning (CEMOVIS) is an alternative to FIB milling for generating thin samples suitable for cryo-EM imaging. We show that CEMOVIS samples preserve the high-resolution structural details of...

The structure and function of membrane proteins depend on their interactions with the lipid molecule

Aerolysin is a β-pore-forming toxin produced by most Aeromonas bacteria, which has attracted large attention in the field of nanopore sensing due to its narrow and charged pore lumen. Structurally sim...