Perception and action form a loop as an organism interacts with its environment. Here, we probe the interdependence between the two in the context of choice-history effects, the tendency of past choic...

Neuronal firing patterns have significant spatiotemporal variability with no agreed-upon theoretical framework. Using a combined experimental and mode…

Economic choice entails computing and comparing the subjective values of different goods. Orbitofrontal cortex (OFC) is thought to contribute to both operations. However, previous work focused almost ...

Simultaneous recordings were made of hundreds of neurons in the rat frontal cortex and striatum, showing that decision commitment involves a rapid, coordinated transition in dynamical regime and neura...

Our visual capabilities depend on neural response properties in visual areas of our brains. Neurons exhibit a wide variety of selective response properties, but the reasons for this diversity are unkn...

Nature Communications - People often discard incoming information when it contradicts their pre-existing beliefs about the world. Here, the authors show that this discarded information is precisely...

At the end of a decision based on evidence accumulation, the neural representation of the accumulation is invariant across decisions. Zylberberg and Shadlen show, nonetheless, that accuracy can be dec...

Cognition unfolds dynamically over flexible timescales. A major goal of the field is to understand the computational and neurobiological principles that enable this flexibility. Here, we argue that th...

Behavioural experiments to study decision-making in response to context-dependent accumulation of evidence provide testable models that are consistent with the heterogeneity in neural signatures among...

Behavioural-state-dependent pyramidal neurons have a distinct pattern of long-range glutamatergic inputs, with a larger proportion of thalamic versus motor cortex inputs compared with non-behavio...

Behavioural-state-dependent pyramidal neurons have a distinct pattern of long-range glutamatergic inputs, with a larger proportion of thalamic versus motor cortex inputs compared with non-behavio...

The brain uses different valuation schemes across contexts. Elston and Wallis show this is supported by hippocampal encoding of context that is broadcast to prefrontal value subcircuits via theta sync...

Measuring metacognitive ability is one of the enduring challenges in cognitive science. The current paper develops formal tests of the quality of different measures and assesses how current metrics pe...

To what extent does concept formation require language? Here, we exploit color to address this question and ask whether macaque monkeys have color ...

Animals capable of complex behaviors tend to have more distinct brain areas than simpler organisms, and artificial networks that perform many tasks tend to self-organize into modules (1-3). This sugge...

Royal Society Francis Crick Prize Lecture by Professor Stephen Fleming.

The director of the U.S. National Institutes of Health calls BRAIN a “high priority” but acknowledges that difficult decisions lie ahead if federal budgets remain flat.

The ability to use subjective, latent contextual representations to influence decision-making is crucial for everyday life. The hippocampus is hypothesized to bind together otherwise abstract combinat...

Tang et al. show that OFC plays a more important role in learning from symbolic reinforcers than subcortical structures. OFC computes reinforcement signals and sends the information to the VS through ...

Lab webpage for the Visual Learning Lab at UCSD, lead by Dr. Bria Long, Ph.D. Launching in July 2024!

Studies linking the brain’s dopamine signals with learning and decision making have enjoyed enormous progress using predominantly value-based decision…

Cognition is produced by the continuous interactions between many regions across the brain, but has typically been studied one brain region at a time. How signals in different regions coordinate to ac...