Epilepsy increases sharply after symptomatic Alzheimer's disease onset in people with Down syndrome. The association of epilepsy with reduced survival and accelerated cognitive decline underscores the...

INTRODUCTION The long-standing cholinergic hypothesis posits that cholinergic signaling is uniformly deficient in Alzheimer's disease (AD) and Down syndrome (DS). We tested the hypothesis that this ...

Advanced EEG technology has revealed that epileptiform activity occurs more frequently in Alzheimer’s disease (AD) than previously recognized, prompti…

This scientific commentary refers to ‘High-frequency oscillations in epileptic and non-epileptic Alzheimer's disease patients and the differential effect o

INTRODUCTION Alzheimer's disease (AD) dementia has near full penetrance in adults with Down syndrome (DS) and is strongly linked to late-onset myoclonic epilepsy in Down syndrome (LOMEDS). However, ...

INTRODUCTION Down syndrome (DS) is a genetic form of Alzheimer's disease (AD), with a high prevalence of sleep disorders, but data in adults with DS and dementia are lacking. We aim to assess sleep ...

If  you determine at the last minute that you cannot travel to Verona, you will have the option of providing a video of your presentation, which will be played in the session in which you are...

Learn how Alzheimer's and dementia research targets have evolved.

Objective To test the hypothesis that high-frequency oscillations (HFOs) between 250 and 500 Hz occur in mouse models of Alzheimer's disease (AD) and thus are not unique to epilepsy. Methods Exper.....

Electroencephalography (EEG) has been instrumental in epilepsy research for the past century, both for basic and translational studies. Its contributions have advanced our understanding of epilepsy, ...

The temporal microstructure of the brain can multiplex distinct cognitive processes during sleep to support continuous learning.

Hippocampal area CA2 is unique in many ways, largely based on the complement of genes expressed there. We and others have observed that CA2 neurons exhibit a uniquely robust tropism for adeno-associat...

Launched in 2013, the BRAIN Initiative (BRAIN) in the United States aimed to unlock the mysteries of the brain and develop new treatments for neurological and neuropsychiatric disorders. The success o...