This scientific commentary refers to ‘High-frequency oscillations in epileptic and non-epileptic Alzheimer's disease patients and the differential effect o

Objective Epilepsy is a debilitating disorder affecting more than 50 million people worldwide, and one third of patients continue to have seizures despite maximal medical management. If patients' se...

The microglia–neuron interactions contributing to neuronal hyperexcitability are unclear. Here, the authors show how GABA and C3 signaling coordinate microglial engulfment of inhibitory synapses, driv...

Scientific Reports - Sleep regularity index as a novel indicator of sleep disturbance in stroke survivors: a secondary data analysis

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The brain and body are necessarily connected. Here the authors show that brain blood flow and electrical activity are coupled with systemic physiological changes in the body.

Neural mechanisms underlying thalamic contributions to evoked potentials by brain stimulation, which has been widely used for therapeutic interventions, are not fully understood. In this translational...

Using a mouse model of altered neurotransmission (Vamp2rlss), Guillaumin et al. show that differences typically observed between vigilance states in neural dynamics and spectral signatures can be mark...

Fabbri et al. report that spikes on ripples are promising biomarkers for identifying the epileptogenic zone and predicting outcome in drug-resistant epilep

D’Gama et al. studied a prospective patient cohort being evaluated with stereo-EEG electrodes for seizure localization. They identified somatic mosaic vari

Objective Memory impairment is common in people with temporal lobe epilepsy (TLE). Recent studies in healthy subjects showed a positive correlation between sleep spindles coupled to slow waves (SWs)...

Epidemiological evidence has demonstrated associations between sleep and epilepsy, but we lack a mechanistic understanding of these associations. In this Review, Sheybani et al. consider the associati...

Epilepsy is a cortico-subcortical network disorder. By analyzing thalamo-cortical relationships in 121 patients through stereotactic-EEG, Biagioni et al. i

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Arousal levels regulate sleep, but accurate noninvasive measures are lacking. Here, a novel method is introduced to track pupil-indexed arousal levels during human sleep, revealing pupil size changes ...

Pasquini et al. explore microstructural abnormalities in LC and SN through neuromelanin and diffusion MRI in Parkinson’s disease and iRBD. They also show a

A large-scale, phenome-wide study enables a holistic view of the role of sleep on human health, highlighting its potential as a modifiable risk factor for chronic disease.

Giampiccolo et al. review the anatomy and function of the inferior fronto-occipital fasciculus. They propose that it plays a role in visual cognitive contr

Objective In intraoperative electrocorticography (ioECoG)–tailored epilepsy surgery, standard low-density (LD) electrode grids (16–20 electrodes, 10 mm inter-electrode distance) are used, covering ±.....

In this cross-sectional study of 84 hippocampal sclerosis patients and 43 healthy controls, Fiore et al. linked verbal learning variability to cortical and

Electroencephalography (EEG) has been instrumental in epilepsy research for the past century, both for basic and translational studies. Its contributions have advanced our understanding of epilepsy, ...

Dream recall frequency in patients with epilepsy is modulated by determinants shared with healthy subjects (age, nocturnal awakenings, role of the parieto-occipital region) and by epilepsy-related fa...

Kollenburg et al report that the cingulum is a central area connecting various structures of the pain matrix and limbic system, hence raising interests in

Sarkis et al. prospectively recruited adults with late onset unexplained seizures and found a prevalence of mild cognitive impairment of 17%, and cognitive

Coleman et al. report a comprehensive study of the genetic, imaging and histopathologic findings in 59 children with infantile epileptic spasms syndrome du

Sleep need accumulates during waking and dissipates during sleep to maintain sleep homeostasis (process S). Besides the regulation of daily (baseli...

Gleichgerrcht et al. show that AI can detect temporal lobe epilepsy MRI abnormalities that were unseen by human experts, challenging traditional approaches

Pasquini et al. explore microstructural abnormalities in locus coeruleus and substantia nigra through neuromelanin and diffusion MRI in Parkinson’s Disease

In this Perspective, the authors propose that brain injury can result in sleep-like slowing of cortical EEG waves during wakefulness. The generation of these dynamics and their effects on brain networ...

Using functional MRI, the authors tracked memory recovery over a decade after epilepsy surgery, revealing key brain changes in spared medial temporal structures and contralateral regions, highlighting...

Objective Whereas a scalp electroencephalogram (EEG) is important for diagnosing epilepsy, a single routine EEG is limited in its diagnostic value. Only a small percentage of routine EEGs show inter...