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Susie Yu Feng, PhD

@susieyufeng.bsky.social

Reposted by Susie Yu Feng, PhD

Denise J. Cai, Ph.D. @denisejcai.bsky.social · 14/07/2025

What’s better than a one-channel #Miniscope? 🥁 A TWO-CHANNEL Miniscope! Our new Miniscope2C is a dual-channel, open-source Miniscope that lets you record 2 fluorescent signals simultaneously in freely moving animals. Read the paper here: www.science.org/doi/10.1126/... (1/10)

Screenshot of the top of the article, including the title, authors, and abstract.

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Susie Yu Feng, PhD @susieyufeng.bsky.social · 11/09/2025

Couldn’t be more excited to see this work out!! Not just manipulating PV+ cell theta phase, but also shifting seizure susceptibility! how much cooler can it get?!!!

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Reposted by Susie Yu Feng, PhD

Tristan Shuman @tristanshuman.bsky.social · 28/01/2025

New paper out in Cell Reports! Led by @susieyufeng.bsky.social, we found that chronic epilepsy in mice drives distinct synchronization deficits in hippocampus and MEC, with early changes in HPC and late-onset changes in MEC that align with progressive memory impairment. www.cell.com/cell-reports...

Screenshot of article entitled "Distinct changes to hippocampal and medial entorhinal circuits emerge across the progression of cognitive deficits in epilepsy" by Yu Feng, Keziah S. Diego, Zhe Dong, ..., Nadia N. Khan, Denise J. Cai, and Tristan Shuman.

In brief: Feng et al. demonstrate that memory deficits in temporal lobe epilepsy involve multiple discrete mechanisms with distinct time courses. In epileptic mice, early-onset memory deficits are associated with disrupted hippocampal synchronization, while more severe, lateonset impairments are associated with disrupted synchrony of medial entorhinal cortex circuits.

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