We report the development of a selective and scalable Shono oxidation process of Boc-l-proline methyl ester (Boc-l-Pro-OMe) using flow electrosynthesis. A key feature of the reaction is the preferenti...

Enabling technologies are perceived as inherently sustainable, due to the replacement of stoichiometric oxidants and reductants with traceless redox mediators such as photons or electrons. However, th...

Bayesian optimization enables the exploration of complex chemical spaces to obtain optimized conditions in an expedited fashion. By leveraging this machine learning technique, an autonomous electrochemical flow platform was developed, integrating a liquid handling robot and online analytics. Using this platform, three different electrochemical transformations toward the synthesis of densely functionalized molecules were optimized by tuning a wide range of input variables.

N,N-Dimethylformamide is a widely used solvent, which can be employed as a reagent under certain conditions. Among the different ionic and radical activation approaches, the direct single-electron red...

Electrochemical update to a classic reaction trades cryogenic conditions for room temperature, to selectively convert primary and secondary alcohols into aldehydes and ketones

A tutorial review on how to build an automated electrochemical flow platform, including the most relevant progresses and the future directions of the field, is studied.

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SYNLETT now integrated as a destination journal for ChemRxiv authors Stuttgart, November 2024 – Thieme and ChemRxiv are pleased to report that authors who post preprints on ChemRxiv can now quickly su...

Selective semi-hydrogenation to generate alkenes from alkynes is an invaluable method to access olefins for materials, pharmaceuticals, and nat-ural products. Electrochemical transition-metal-catalyze...

Organoboron compounds are indispensable in modern organic synthesis and biomedical research. This study describes the first synthesis of bench-stable boryl dicationic compound via chemical or electroc...

Elsevier retracts dozens of journal articles that were published based on “fictitious” reviews

Alt: a close up of a Sauron’s eye with fire coming out of it

An automated electrochemical flow platform is shown to enhance reaction efficiency, minimize material use, and accelerate data generation. Through Design of Experiments, the platform optimized a react...