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Thibault Mayor @cellsandprots.bsky.social · 02/09/2026

... this was not expected and I wished we had done RNA-Seq to better understand why the response differed... but Ryan had to graduate at some point :-) Big THANKS to @taniodraws.bsky.social for the main comics illustration

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Thibault Mayor @cellsandprots.bsky.social · 02/09/2026

We then examined closely related strains that differed in their ability to express two laccases and found that each displayed a distinct response, regardless of how efficiently it expressed the recombinant protein

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Thibault Mayor @cellsandprots.bsky.social · 02/09/2026

The initial goal of the study was to investigate more closely how the proteome adapts to the expression of a recombinant protein in a yeast host during batch fermentation

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Thibault Mayor @cellsandprots.bsky.social · 02/09/2026

Doing proteomics on different yeast biofactories showed us that strains from different origins respond differently to the stress caused by recombinant protein expression—something I had not expected. link.springer.com/article/10.1...

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Thibault Mayor @cellsandprots.bsky.social · 05/05/2026

Interestingly, we also see that additional pathways remain to be uncovered, as BAG6 knock down only partially stabilize misfolded proteins and degrons, highlighting to potential high redundancy in cytotolic protein quality control

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Thibault Mayor @cellsandprots.bsky.social · 05/05/2026

Tiling revealed multiple degrons in a misfolded protein, including a C-terminal motif degraded in a BAG6/RNF126-dependent manner.

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Thibault Mayor @cellsandprots.bsky.social · 05/05/2026

Using BioID, we surveyed multiple misfolded cytosolic proteins and observed broad chaperone recruitment, including BAG6 in some cases. RNAi confirmed BAG6 and RNF126 are required for efficient turnover of several mutants.

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Thibault Mayor @cellsandprots.bsky.social · 05/05/2026

We extend BAG6 and RNF126 roles in protein quality control by showing they target misfolded cytosolic proteins with missense mutations via exposure of degrons normally buried in native structures. #ubiquitin #proteasome

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Thibault Mayor @cellsandprots.bsky.social · 05/05/2026

BAG6 mediates the localization of the Tail anchored membrane proteins via the GET pathway and target for degradation mislocalized transmembrane proteins as well as aberrantly translated proteins– summarizing 20 years of work from the Kawahara, Hegde, Ye, Hartl, Wu and Elledge labs to name a few.

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Thibault Mayor @cellsandprots.bsky.social · 05/05/2026

Very excited to share our preprint on BAG6 and RNF126 in cytosolic protein quality control—from BioID to degron mapping. Along with @rhp-lab.bsky.social, we show this pathway plays a major role in targeting misfolded cytosolic proteins for degradation #proteostasis www.biorxiv.org/content/10.6...

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UBC Biochemistry & Molecular Biology @ubcbiochemistry.bsky.social · 13/11/2025

📢BMBDG Seminar! Join us November 27, 2025 for an in-person presentation by Dr. El Bachir Affar. 📷 November 27, 2025, 2:30 PM, LSC 3 Hope to see you there!

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Thibault Mayor @cellsandprots.bsky.social · 01/11/2025

Haha I used to read this🇨🇭newspaper back then and my mom still has a subscription. Fun read on a not so fun topic

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Thibault Mayor @cellsandprots.bsky.social · 24/05/2025

I survived the 2025 EMBO protein quality control meeting - it was amazing despite a defective projector on day 1, and epileptic crisis on day 2, a black out in day 3, and we all got a shaky wake up call ~6am on day 5 by an earthquake… never a dull moment but most importantly great science

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Thibault Mayor @cellsandprots.bsky.social · 11/05/2025

We ran over 200 eggaggregation experiments for Science Rendezvous - a blast!

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Thibault Mayor @cellsandprots.bsky.social · 05/04/2025

4 months after biorxiv submission sounds like a smooth ride - congrats

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Saccharomyces Genome Database @yeastgenome.bsky.social · 02/04/2025

Application deadline extended to Apr 15 for this summer's #Yeast #Genetics & #Genomics course at @cshlaboratory.bsky.social July22 - Aug12! Get a comprehensive education in all things yeast, from classical genetics through up-to-the-minute genomics. Don't miss out! meetings.cshl.edu/courses.aspx...

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Thibault Mayor @cellsandprots.bsky.social · 20/03/2025

Here’s a quick throwback to celebrate the last day of winter: curling with the lab!

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Thibault Mayor @cellsandprots.bsky.social · 04/03/2025

Some of you will recognize this - I am done with our CIHR application. Just in time to start teaching a big course section ✌️

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Wyeth Wasserman @wywywa.bsky.social · 27/02/2025

Bioinformatics Job Opportunity Research Associate / Staff Scientist Vancouver Canada Join the Silent Genomes Project to provide an outstanding genetic variation database for Indigenous peoples of Canada to improve rare disease diagnosis tinyurl.com/bm4ptux3 Priority to Canadians Please repost

tinyurl.com

Research Associate

Academic Job Category Faculty Non Bargaining Job Title Research Associate Department Wasserman Laboratory | Department of Medical Genetics | Faculty of Medicine (Wyeth Wasserman) Posting End Date Febr...

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Pablo Nepomnaschy @pablonep.bsky.social · 22/02/2025

Job available for Full Professor Tier 1 Canada Research Chair (CRC) - Indigenous Health and Well-Being at the Faculty of Health Science, Simon Fraser University (RT 🙏🏼 please): www.sfu.ca/vpacademic/a...

sfu.ca

Canada Research Chair - Indigenous Health and Well-Being

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Thibault Mayor @cellsandprots.bsky.social · 07/02/2025

I enjoyed both @cherisirois.bsky.social presentation and conversation about the publishing world and Cell Press today

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Thibault Mayor @cellsandprots.bsky.social · 28/01/2025

With the help of e@UBC our BMB and MSL postdocs organized this great 1/2 day Academia to Industry workshop with a focus on entrepreneurship today

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Thibault Mayor @cellsandprots.bsky.social · 27/01/2025

You almost look like Leonard on that picture ;-) Happy birthday- enjoy the rest of the trip

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Thibault Mayor @cellsandprots.bsky.social · 15/01/2025

Even though David Baker's presentation was online, it was rad and inspiring. I really enjoyed today's session on machine learning at the 2025 PepTalk & BioLogic Summit

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Amanda Moehring @flybehaviour.bsky.social · 14/01/2025

Calling early-career colleagues with stories of racism / sexism / microaggressions to share (anonymously or not) for an article someone I know is doing! Please send me a DM asap. They'd need to interview you tomorrow (Tues). It's important these stories are shared, so please do reach out!

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Thibault Mayor @cellsandprots.bsky.social · 10/01/2025

Many people contributed to this project led by @hthrbaker.bsky.social with help from @shriyakamat.bsky.social and great collaborators in @miketilapia.bsky.social and Brian Raught's labs The illustration was created by @taniodraws.bsky.social our go-to freelance artist for summarizing our studies.

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Thibault Mayor @cellsandprots.bsky.social · 10/01/2025

One limitation of our study is the use of rapidly dividing cells, where the protein homeostasis network likely differs from that in differentiated cells with lower protein production. Despite our efforts, we have yet to identify the E3 ligase involved—but we’re not giving up, so stay tuned!

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Thibault Mayor @cellsandprots.bsky.social · 10/01/2025

In this case, the disease-associated mutation increases interaction with the DNAJA2 chaperone, which appear to be dispensable for the folding of the wild-type protein. This interaction delays the proteolysis of the mutant protein, potentially buffering its deleterious effects.

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Thibault Mayor @cellsandprots.bsky.social · 10/01/2025

Using BioID, we identified chaperones, including the co-chaperone DNAJA2, that interact more with the unstable thiopurine S-methyltransferase (TPMT) variant than the wild type. DNAJA2 deletion accelerates degradation of the mutated TPMT but does not affect the wild-type protein

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Thibault Mayor @cellsandprots.bsky.social · 10/01/2025

Many disease-associated mutations are missense mutations causing single amino acid changes that signal proteins for degradation. We surveyed 18 unstable variants from 13 cytosolic proteins and found that all but one are at least partially degraded via proteasome- and ubiquitin-dependent pathways.

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Thibault Mayor @cellsandprots.bsky.social · 10/01/2025

Protein quality control is a tug-of-war between degradation machinery and chaperones that promote folding. Thrilled to see our latest manuscript is now published! 👇 Follow 🧵 for quick summary journals.biologists.com/jcs/article-...

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Thibault Mayor @cellsandprots.bsky.social · 21/12/2024

Congratulations to the whole team!

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Marc Johnson (he/him) @evoecolab.bsky.social · 10/12/2024

CONGRATS to @supportourscience.bsky.social, Dr. Kaitlin Kharas, @sarahlaframboise.bsky.social & @cdrobich.bsky.social who were named "Nature's 10", a list of people who shaped science in 2024. #SupportOurScience achieved amazing things. The advocacy continues! www.nature.com/articles/d41...

nature.com

This PhD student helped to win a major pay hike for Canadian researchers

Kaitlin Kharas is part of Nature’s 10, a list of people who shaped science in 2024.

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Cheshire @thatsregrettab1.bsky.social · 16/12/2024

ICYMI: Finland downgrades a bunch of Frontiers and MDPI journals to level 0. julkaisufoorumi.fi/en/news/chan...

julkaisufoorumi.fi

Changes to the classification

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Thibault Mayor @cellsandprots.bsky.social · 12/12/2024

🤔 a lot of us will have to leave. Yes I am co-author on a MPDI journal 😬 But yeah if a see a lot of these journals in a CV, it will dampen my enthusiasm for an application We first need to better educate our trainees about the issue (e.g. does your grad program cover the topic in a course?)

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Thibault Mayor @cellsandprots.bsky.social · 11/12/2024

Thanks – who doesn't love to ride good vibes?! P.S. I'm fine, just wanted to share this hiccup since we often tend to overemphasize our successes on SM

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Thibault Mayor @cellsandprots.bsky.social · 10/12/2024

When I was on the bench It wasn't uncommon for experiments to fail, then fail again, and again (you probably know the feeling). A rejected grant is not that different In most cases, it’s not the fall that matters but how we bounce back. Each trial makes us more experienced; well that’s the theory 😉

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Thibault Mayor @cellsandprots.bsky.social · 10/12/2024

Failures in Science - I just received a negative decision on a grant proposal—my fifth in a row. It’s a though streak but not the first one, and I just wanted to share. short 🧵👇

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Center for Biological Diversity @biologicaldiversity.org · 06/12/2024

Will U.S. government scientists soon face the “muzzling” their Canadian counterparts experienced under right-wing Prime Minister Stephen Harper? David Shiffman spoke to several people whose work was affected by Harper’s regressive policies, and they have advice to help prepare for Trump 2.0. ⬇️

therevelator.org

Advice for U.S. Government Scientists: Lessons Learned From the ‘Muzzling’ of Their Canadian Counterparts • The Revelator

The next four years will be awful for the science and conservation community. By learning from past experiences, we can minimize the damage.

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Jim Johnson 🇨🇦 @jimjohnsonsci.bsky.social · 04/12/2024

ubc.wd10.myworkdayjobs.com/en-US/ubcfac... We are looking for an imaging master to run a very cool shared microscope - Raman label-free, 2-photon, FLIM, high-res, fast capture, thick live tissue, organoids, high-content screening. We are a dynamic and supportive and fun environment.

ubc.wd10.myworkdayjobs.com

Research Associate

Academic Job Category Faculty Non Bargaining Job Title Research Associate Department Johnson Laboratory | Department of Cellular and Physiological Sciences | Faculty of Medicine (James Johnson) Postin...

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Thibault Mayor @cellsandprots.bsky.social · 03/12/2024

Makes sense - btw is SIFI still a RING ligase or we need to create RING-like category

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Michael Bertram @michaelgbertram.bsky.social · 03/12/2024

Earlier this year, I received news that fake peer reviews were allegedly being submitted impersonating me and approximately six others I shared my story with Science to, hopefully, reduce the chance of this kind of breach happening again www.science.org/content/arti...

science.org

‘It felt very icky’: This scientist’s name was used to write fake peer reviews

Elsevier retracts dozens of journal articles that were published based on “fictitious” reviews

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Micha Rapé Lab @micharapelab.bsky.social · 03/12/2024

Very excited to present the structural and mechanistic basis for stress response silencing by the monster E3 ligase SIFI. www.biorxiv.org/content/10.1...

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Thibault Mayor @cellsandprots.bsky.social · 03/12/2024

This is amazing - congrats!!! How do you prevent HRI degradation before the stress ? I don’t recall HRI level to go up upon stress

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Thibault Mayor @cellsandprots.bsky.social · 02/12/2024

Congrats to Dane Sands in our lab for his Zymeworks Fellowships Award in Advanced Protein Therapeutics

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Thibault Mayor @cellsandprots.bsky.social · 01/12/2024

Great quick read and a reminder that we first need to admit and accept our ignorance—that's what makes science so fun!

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SFB Targeted Protein Degradation @sfb-tpd-vienna.bsky.social · 29/11/2024

SAVE THE DATE 🗓️Ubiquitin & Friends Symposium: 8-9 May 2025 in Vienna! Registration will open🔜 Keep an eye out for the announcement 👀 ✨guest speaker lineup👇🧵 +talks from abstracts! Great chance for #ECRs to meet with peers & experts in a friendly setting! 🔗 www.protein-degradation.org/symposium/

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Thibault Mayor @cellsandprots.bsky.social · 29/11/2024

That’s encouraging. It is important for us to know this is happening without revealing technical details - we need to keep trusting some aspect of the system as well as help our trainees navigate this new reality

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Thibault Mayor @cellsandprots.bsky.social · 29/11/2024

Along the fact data can now be AI generated (see @thatsregrettab1.bsky.social nice demo a few months ago) we need to change how we report data - I am curious to hear how publishers and editors want to tackle this

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