iiinova — where your digital self keeps evolving

Reposted by Céline Loot

Eduardo Rocha @epcrocha.bsky.social · 08/04/2026

Our ms on re-sampling 4 years apart vibrio phage in natural environments is now out with some improvements. First, clearer evidence of cryptic population dynamics between phage and vibrio, presumably because of genetic diversity. www.nature.com/articles/s41...

nature.com

Complex temporal dynamics of phage-bacteria populations in an animal-associated marine system - Nature Communications

It remains unclear how viral genomes remain relatively stable over time, given the rapid co-evolution seen within hosts. Here, authors explore complex marine phage-bacteria dynamics using over 1000 ph...

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Reposted by Céline Loot

Olaya Rendueles @olayarendueles.bsky.social · 15/01/2026

My team at @cbitoulouse.bsky.social is recruiting a postdoc #bioinformatics with solid experience in metagenomic analyses. Interest in evolution, ecology & MGEs is important. The offer stands until the perfect candidate is found, and it could be you 🫵 🔁 🙏 #microSky #phagesky #UTIsky @cnrs.fr

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Reposted by Céline Loot

Melanie Blokesch @mblokesch.bsky.social · 22/05/2025

Exciting news!! Our latest paper is out in Nat. Microbiol. @natmicrobiol.nature.com We show that a sub-lineage of 7th pandemic V. cholerae has acquired mobile genetic elements packed with phage defense systems—rendering it multi-phage resistant 😳 ..... 1/3 www.nature.com/articles/s41...

nature.com

West African–South American pandemic Vibrio cholerae encodes multiple distinct phage defence systems - Nature Microbiology

The West African–South American lineage of Vibrio cholerae contains multiple distinct anti-phage defence systems that provide resistance to various phage families, including vibriophage ICP1, a key pr...

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Céline Loot @celineloot.bsky.social · 11/05/2025

Merci Erwan. Oui c'est un beau travail collaboratif

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Reposted by Céline Loot

Eduardo Rocha @epcrocha.bsky.social · 09/05/2025

WARNING: We have a postdoc position to work on the follow-up of this work. If you're interested, the deadline is tomorrow !!! (but I'll wait a few more days for interested candidates). research.pasteur.fr/fr/job/postd...

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Céline Loot @celineloot.bsky.social · 09/05/2025

At least 10% of the V. cholerae integron cassettes have novel antiphage activities (see below). Considering that there are 25,000 distinct cassettes of unknown function, integrons constitute an extraordinary and almost inexhaustible reservoir of antiphage functions!

science.org

Sedentary chromosomal integrons as biobanks of bacterial antiphage defense systems

Integrons are genetic systems that drive bacterial adaptation by acquiring, expressing, and shuffling gene cassettes. While mobile integrons are well known for spreading antibiotic resistance genes, t...

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Reposted by Céline Loot

Baptiste Darracq @baptistedarracq.bsky.social · 09/05/2025

White smoke, we have a new pope and also 16 new anti-phages systems in sedentary integrons (SCIs) ! In collaboration with the Rocha lab, we show in our new paper that cassettes of these large platforms encode many known anti-phage defenses, and uncovered 16 new ones. www.science.org/doi/10.1126/...

science.org

Sedentary chromosomal integrons as biobanks of bacterial antiphage defense systems

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Reposted by Céline Loot

Alf Soler-Bistué 🦠🔬🧫 @alfmicrobe.bsky.social · 15/04/2025

And its out! Last work of the lab: "Evolutionary Constraints on RNA Polymerase Gene Positioning in the Genome of Fast-Growing Bacteria." We show how the genomic location of RNA polymerase impacts cell physiology. www.biorxiv.org/cgi/content/...

biorxiv.org

Evolutionary Constraints on RNA Polymerase Gene Positioning in the Genome of Fast-Growing Bacteria..

The influence of gene order within the chromosome on cellular homeostasis and genome evolution remains unclear. Bacterial chromosomes are structured along the replication origin ( oriC )-terminus ( te...

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Reposted by Céline Loot

Aude Bernheim @audeber.bsky.social · 13/01/2025

👋 Hi antiphage defense community, we are soon releasing an update of DefenseFinder. We are doing our best to include all the great discoveries from the community, but with so much going on we might miss things. Please answer wt preprints/papers with new systems or mail/git them to us. 🙏

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Reposted by Céline Loot

David Bikard @dbikard.bsky.social · 14/01/2025

Very happy to see Institut Pasteur on Bluesky !!!

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Reposted by Céline Loot

Institut Pasteur | 130 years of biomedical research @pasteur.fr · 14/01/2025

Welcome to the official Bluesky page of the Institut Pasteur! 🔬 Explore with us the frontiers of biomedical research 🧪 Follow us to uncover groundbreaking discoveries 💡 Share knowledge for global health 🌍 Join a community passionate about progress and open science.

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Reposted by Céline Loot

Didier Mazel @amazeld.bsky.social · 05/01/2024

nature.com/articles/s41... a collaborative success of CelineLoot (+ the rest of the PGB lab) with @epcrocha.bsky.social and the Biomics hub from the Pasteur

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Reposted by Céline Loot

Jose A Escudero @jaescudero.bsky.social · 21/11/2023

Check out our last work with Celine Loot, Ole Skovgaard, @amazeld.bsky.social and @sanmillan.bsky.social. We have deleted the Superintegron from V. cholerae! A long-awaited feat in the field!! Despite losing 3% of the genome, the strain remains phenotipically identical across Manu conditions!! 😵

biorxiv.org

Chromosomal Integrons are Genetically and Functionally Isolated Units of Genomes

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

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