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Carlos Talavera-López

@cartalop.bsky.social
967 followers 265 following 91 posts

Director of Computational Target Biology at GSK Computational biologist | Clinician PhD @ki.se & @scilifelab.se Postdoc @crick.ac.uk @sangerinstitute.bsky.social @ebi.embl.org @teichlab.bsky.social I code in a suit | Nicaragüense | Childless cat lad 🇳🇮🇸🇪🇬🇧🇩🇪

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Reposted by Carlos Talavera-López
openRxiv @openrxiv.bsky.social · 01/06/2026
Introducing openRxiv Labs! 🔬 Growing from the strong foundation of bioRxiv & medRxiv, Labs is an experimental space for working with collaborators to push the boundaries of open scientific communication. 👉 Check it out and learn more: openrxiv.org/openrxiv-lab... #OpenScience #Preprints #Scicomm
openrxiv.org
Launching openRxiv Labs - openRxiv
Over the last thirteen years, bioRxiv and medRxiv have grown into widely used infrastructure for rapid research sharing in biology and medicine. The reliability and researcher-first values that have d...
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Reposted by Carlos Talavera-López
Gonçalo Castelo-Branco @gocastelobranco.bsky.social · 01/06/2026
Come and start your group at @ki.se! ki.se/en/about-ki/...
ki.se
Assistant Professor recruitment programme 2026
Karolinska Institutet continues to grow a global community of excellence. In summer 2026, KI is inviting applications for 21 Assistant Professor positions in medicine and health. We are once again loo...
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Reposted by Carlos Talavera-López
Romain Lopez @biologicalml.org · 29/05/2026
We built a joint experimental and computational platform for scalable multi-modal single-cell chemical screens — profiling RNA, protein (including phospho-signaling), and chromatin accessibility responses to thousands of small molecule perturbations in parallel. www.biorxiv.org/content/10.6...
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Reposted by Carlos Talavera-López
Martina Morchio @martina-m.bsky.social · 19/05/2026
Just analysed 48 single nuclei samples with scprocess and went from fastq files to cell-type annotation in a couple of weeks!! Really recommend this pipeline developed by @willmacnair.bsky.social and team, thank you for making it public!! github.com/marusakod/sc...
github.com
GitHub - marusakod/scprocess: Snakemake pipeline for processing single cell data
Snakemake pipeline for processing single cell data - marusakod/scprocess
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Reposted by Carlos Talavera-López
Santa Fe Institute @sfiscience.bsky.social · 09/04/2026
A simple baseline for AI forecasting in machine learning. In a recent paper, SFI Complexity Postdoctoral Fellow Yuanzhao Zhang and co-author William Gilpin show that a deceptively simple forecasting strategy — context parroting — can outperform several leading machine-learning forecasting models.
santafe.edu
A simple baseline for AI forecasting in machine learning
In a recent paper, SFI Complexity Postdoctoral Fellow Yuanzhao Zhang and co-author William Gilpin show that a deceptively simple forecasting strategy can outperform several leading machine learning forecasting models. Their method, called context parroting, relies on short stretches of time-series data (or context). As it moves through the time series, it scans for similar patterns or motifs that appeared earlier in the sequence, and uses those patterns to predict what might come next.
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Reposted by Carlos Talavera-López
Wolfgang Huber @wkhuber.bsky.social · 15/03/2026
1/ Apply for an inter-disciplinary postdoc position in Heidelberg with the Health & Life Science Alliance Deadline: **31 March** Project proposals can be self-designed or adapt one of the outlines on the website ("List of project outlines for download") www.health-life-sciences.de/opportunitie...
health-life-sciences.de
HEALTH + LIFE SCIENCE ALLIANCE | Interinstitutional Postdoc Call |…
Apply for the Alliance Interinstitutional Postdoc Program in health & life sciences. Two-year funded positions with interdisciplinary research support.
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Reposted by Carlos Talavera-López
Richard McElreath 🐈‍⬛ @rmcelreath.bsky.social · 25/02/2026
I saw this when it was a preprint? They have a unique version of the estimand-estimator-estimates workflow, will be useful for may biologists, not just ecologists. We need more case studies for ecologists to emulate and for norms to shift so "regression and storytelling" becomes unpublishable.
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Reposted by Carlos Talavera-López
Alessandro Scacchetti @metalsga.bsky.social · 30/10/2025
RNAs outside of cells?! How did they get there? (Thread coming soon 👀) www.biorxiv.org/content/10.1...
biorxiv.org
Pseudouridine selects RNAs for extracellular transport
RNAs move through the extracellular space to transmit information between cells, including mammalian neurons, yet how specific RNAs are channeled into these extracellular routes is unknown. Using geno...
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Carlos Talavera-López @cartalop.bsky.social · 01/02/2026
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Reposted by Carlos Talavera-López
The Economist @economist.com · 25/01/2026
Britain is taking a novel approach to weighing up the risk of custom drugs for rare diseases and the almost inevitable suffering in their absence. Other countries should follow its lead
econ.st
Britain’s good idea for custom genetic medicines
A way to tackle the tricky economics of drugs designed for one person
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Reposted by Carlos Talavera-López
Richard McElreath 🐈‍⬛ @rmcelreath.bsky.social · 10/01/2026
Quick (20min) non-technical overview of genetic history of Europe by my colleague Johannes Krause @mpi-eva-leipzig.bsky.social. This talk is from Nov 2025. www.youtube.com/watch?v=Iyz_...
youtube.com
CARTA: The Genetic History of Europe with Johannes Krause
YouTube video by University of California Television (UCTV)
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Reposted by Carlos Talavera-López
Nature Reviews Genetics @natrevgenet.nature.com · 02/01/2026
New online! Let the data speak — single-cell analysis with CellWhisperer
nature.com
Let the data speak — single-cell analysis with CellWhisperer
Nature Reviews Genetics, Published online: 02 January 2026; doi:10.1038/s41576-025-00927-xIn this Tools of the Trade article, Moritz Schaefer introduces CellWhisperer, a multimodal machine learning model and software tool for the chat-based interrogation of single-cell RNA sequencing datasets.
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Reposted by Carlos Talavera-López
Lars Barquist @lbarquist.bsky.social · 17/12/2025
Our preprint on predicting drug resistance in bacteria is now out in @plosbiology.org. We show ignoring phylogenetic structure in genome collections leads to overly optimistic evaluations of machine learning methods for AMR prediction. Work from @yanyingyu.bsky.social with @nwheeler443.bsky.social.
journals.plos.org
Biased sampling driven by bacterial population structure confounds machine learning prediction of antimicrobial resistance
Machine learning methods have emerged as promising tools to predict antimicrobial resistance (AMR) and uncover resistance determinants from genomic data. This study shows that sampling biases driven b...
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Carlos Talavera-López @cartalop.bsky.social · 20/12/2025
Finally some time off to catch up with some fun reading 📖📄
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Reposted by Carlos Talavera-López
The Economist @economist.com · 14/12/2025
From “black British music” to “A Complicated Woman”, our selection has something for everyone
econ.st
The best albums of 2025
Emerging stars and established acts alike released remarkable records this year
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Reposted by Carlos Talavera-López
The Economist @economist.com · 24/11/2025
Even as the prices of these text snippets fall, better, more verbose models mean more tokens must be generated to complete a task
econ.st
AI tokens are surging, but are profits?
The tech world’s new favourite measure comes with several caveats
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Reposted by Carlos Talavera-López
Jeff Mold @jeffmold.bsky.social · 24/09/2025
Interesting finding on cancer lineage tracing for SCLC www.nature.com/articles/s41...
nature.com
Basal cell of origin resolves neuroendocrine–tuft lineage plasticity in cancer - Nature
Basal cells, rather than neuroendocrine cells, have been identified as the probable origin of small cell lung cancer and other neuroendocrine–tuft cancers, explaining neuroendocrine–tuft heterogeneity and offering new perspectives for targeting lineage plasticity.
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Reposted by Carlos Talavera-López
Nature Portfolio @natureportfolio.nature.com · 14/09/2025
Nature’s Careers team spoke to a group of researchers about why they love LinkedIn, and how other scientists can use it to their advantage to harness its career-boosting and collaboration potential. #Academicsky 🧪
go.nature.com
‘LinkedIn is like air to me’: the scientists who’ve cracked professional networking
Fans of the global social-media platform explain how best to harness its career-boosting and collaboration potential.
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Carlos Talavera-López @cartalop.bsky.social · 04/09/2025
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Reposted by Carlos Talavera-López
Valentine Svensson @nxn.se · 10/07/2025
A pre-trained t-test transformer - www.nxn.se/p/a-pre-trai...
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Reposted by Carlos Talavera-López
Anshul Kundaje @anshulkundaje.bsky.social · 28/06/2025
One thing that really bothers me with the new "virtual cell" terminology is that it is currently largely focused on a very narrow definition of models that can predict effects of trans perturbations (gene dosage, drugs etc) on gene expression. 1/
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Reposted by Carlos Talavera-López
The Atlantic @theatlantic.com · 24/06/2025
“SkinnyTok’s ruthless tone rings true to many women because they’re already being so ruthless toward themselves,” Annie Joy Williams writes:
bit.ly
When SkinnyTok Came for Me
The body positivity movement is over.
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Reposted by Carlos Talavera-López
Eric Topol @erictopol.bsky.social · 21/06/2025
Ultraprocessed foods have "contributed to high rates of chronic disease in the United States" They need to be regulated. @nejm.org today, the ways they can be reined in. www.nejm.org/media/doi/fu...
nejm.org
Medical Media Center: New England Journal of Medicine
Much of the food consumed in the United States is ultraprocessed. Evidence indicates that ultraprocessed food, as a class, has contributed to high rates of chronic diseases.
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Reposted by Carlos Talavera-López
Helmholtz Institute Würzburg @helmholtz-hiri.bsky.social · 05/06/2025
Let’s give a big round of applause to Jakob Jung, who has successfully defended his dissertation! 👏 Congratulations, @jabster93.bsky.social‬! The #HIRI family is celebrating with you! 🥳 Read more: www.helmholtz-hiri.de/en/newsroom/...
Jakob Jung (left) with thesis committee member Lars Barquist. Photo: HIRI / Luisa Härtig
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Reposted by Carlos Talavera-López
Lior Pachter @lpachter.bsky.social · 03/06/2025
liorpachter.wordpress.com/2025/06/03/e...
liorpachter.wordpress.com
Epistemic failure of epistemic failure
Earlier this year I came across this interesting post by mathematician Daniel Litt, where he pondered how many intrinsically true results in mathematics have been published with erroneous proofs: D…
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Reposted by Carlos Talavera-López
Stein Aerts @steinaerts.bsky.social · 04/06/2025
The deadline for the VIB.AI group leader positions is approaching - send in your CV and short research plan before 14th June to start your BioML research lab in Leuven or Ghent
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Carlos Talavera-López @cartalop.bsky.social · 01/06/2025
Experiments in infrared photography. 📷 Bronica S2 & Nikkor-P 75mm f/2.8 🎞️ Ilford SPX 200
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Reposted by Carlos Talavera-López
Eliisa Kekäläinen @eliisakekalainen.bsky.social · 27/05/2025
Personal news: I have been appointed by the rector of @helsinki.fi to a tenure-track associate prof position in Clinical Microbiology and Immunology! My affiliations are with the Faculty of Medicine and HiLIFE, Institute of Life Sciences @helsinki.fi . Humbled and excited to start this new journey!
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Reposted by Carlos Talavera-López
Eva Holtkamp @evaholtkamp.bsky.social · 25/05/2025
Excited to be back at #eshg2025! Come by my poster today to check out fresh results on how rare high impact variants influence gene expression across immune cells—analyzed in 5,000 UK Biobank participants
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Reposted by Carlos Talavera-López
Stockholm University @stockholm-uni.bsky.social · 22/05/2025
A research team led from Stockholm University & @scilifelab.se has answered a long-standing question in cell biology, uncovering how the cell’s main energy currency, ATP, is transported into the endoplasmic reticulum (ER). The study is published in @nature.com.web.brid.gy www.su.se/department-o...
su.se
Scientists reveal how energy is delivered into the cells major “shipping port” - Department of Biochemistry and Biophysics
Scientists reveal how energy is delivered into the cells major “shipping port” - Department of Biochemistry and Biophysics
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Reposted by Carlos Talavera-López
Julio Saez-Rodriguez @juliosaezrod.bsky.social · 16/05/2025
join us at ISMB iscb.bsky.social & @dreamchallenges.bsky.social - benchmarking foundation models w. @anshulkundaje.bsky.social @oldbap.bsky.social G. Stolovitzky @bowang87.bsky.social @mariabrbic.bsky.social K. Kalantar, J. Guinney supported by @ebi.embl.org @cziscience.bsky.social Tempus AI
iscb.bsky.social
ISCB News (@iscb.bsky.social)
Empowering Computational Biology, Transforming Global Science! The International Society for Computational Biology is a scholarly society for advancing understanding of living systems through comput...
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Reposted by Carlos Talavera-López
bioRxiv Genomics @biorxiv-genomic.bsky.social · 16/05/2025
Tissue-specific restriction of TE-derived regulatory elements safeguards cell-type identity www.biorxiv.org/content/10.1101/202…
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Carlos Talavera-López @cartalop.bsky.social · 13/05/2025
📷 Zorki-1 & Industar-22 50mm f/3.5 🎞️ Fujifilm Color 400
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Carlos Talavera-López @cartalop.bsky.social · 11/05/2025
Please! No more UMAPs/t-SNEs 👇👇👇
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Carlos Talavera-López @cartalop.bsky.social · 09/05/2025
📷 Minolta Autocord I & Rokkor 75mm f/3.5 🎞️ Eastman Kodak double XX 250
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Carlos Talavera-López @cartalop.bsky.social · 09/05/2025
📷 Nikon-F2 & Voigtländer Nokton 58mm f/1.4 🎞️ CineStill D50
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Reposted by Carlos Talavera-López
Tuuli Lappalainen @tuuliel.bsky.social · 05/05/2025
New preprint! My (now former) postdoc @kvastad.bsky.social led this integration of GWAS and spatial transcriptomics (ST) data to identify tissue structures with enrichment of disease-implicated genes = likely causal drivers of disease biology. www.biorxiv.org/content/10.1...
biorxiv.org
Spatial transcriptomics and genetically implicated genes identify putative causal tissue structures for complex traits
Spatially resolved transcriptomics is transforming our understanding of cellular and molecular diversity of tissues. Here, to identify tissue structures that are enriched for putatively causal disease...
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Reposted by Carlos Talavera-López
bioRxivpreprint @biorxivpreprint.bsky.social · 06/05/2025
Single molecule imaging reveals extracellular signal-regulated kinases dependent signal responsive spatial regulation of translation in cardiomyocytes www.biorxiv.org/content/10.1101/202…
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Reposted by Carlos Talavera-López
European Research Council (ERC) @erc.europa.eu · 05/05/2025
The ERC welcomes the offer of substantial additional budget from @ec.europa.eu for the development of a new ERC funding instrument offering larger, longer-term grants, as announced by President Ursula Von der Leyen at the Sorbonne this morning. 👉 europa.eu/!NTYTTV
europa.eu
Choose Europe for Science: ERC welcomes new budget for 'super grants'
The Scientific Council of the European Research Council welcomes the offer of substantial additional budget from the European Commission for the development of a new ERC funding instrument offering la...
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Reposted by Carlos Talavera-López
Ursula von der Leyen @vonderleyen.ec.europa.eu · 05/05/2025
Europe’s choice is clear. To put science at the heart of its economy. To become the home of scientific freedom and collaboration. And to welcome talent from all over the world. I’m glad to present the first elements of our Choose Europe Initiative. → europa.eu/!TTbWbJ
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Carlos Talavera-López @cartalop.bsky.social · 01/05/2025
Experiments on infrared 📷 Pentax Spotmatic & Carl Zeiss Jena Pancolar 50mm f/1.8 🎞️ Rollei Infrared 400
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Carlos Talavera-López @cartalop.bsky.social · 01/05/2025
Půlka, the photogenic cat.
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Sigrid Jusélius Foundation @sigridjuselius.bsky.social · 30/04/2025
CALL FOR APPLICATIONS: The Sigrid Jusélius Foundation is announcing a global call for 1-3 positions as Sigrid Jusélius Professors in the fields of basic, clinical, or translational medicine. Read more on our webpage: sigridjuselius.fi/en/apurahat/...
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Carlos Talavera-López @cartalop.bsky.social · 26/04/2025
Finally, the set up is complete! 🎧🎶🎻🎺🎷
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bioRxivpreprint @biorxivpreprint.bsky.social · 23/04/2025
Fine-Tuning Protein Language Models Unlocks the Potential of Underrepresented Viral Proteomes www.biorxiv.org/content/10.1101/202…
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Bastian Grossenbacher-Rieck @pseudomanifold.topology.rocks · 23/04/2025
As part of my attempt to make academia more transparent, here is a brief analysis of my papers and their rejections: 🔥 If At First You Don’t Succeed… — Counting Paper Rejections 🔥 #AcademicBlogging #AcademicSky #MachineLearning bastian.rieck.me/blog/2025/re...
bastian.rieck.me
If At First You Don’t Succeed… — Counting Paper Rejections
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Carlos Talavera-López @cartalop.bsky.social · 18/04/2025
📷 Nikon-F & Nikkor-S Auto 50mm f/1.4 🎞️ Kodak Gold 200
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Santa Fe Institute @sfiscience.bsky.social · 10/04/2025
SFI’s Complexity podcast is up for a Webby Award! Nominated in the Science & Education category, Episode 2 of the most recent season explores the relationship between language and thought with guests Evelina Federenko, Steve Piantadosi, and Gary Lupyan. vote.webbyawards.com/PublicVoting...
vote.webbyawards.com
Vote for the best of the internet
I just voted in The Webby People's Voice Awards and checked my voter registration.
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Reposted by Carlos Talavera-López
Stein Aerts @steinaerts.bsky.social · 04/04/2025
Very proud of two new preprints from the lab: 1) CREsted: to train sequence-to-function deep learning models on scATAC-seq atlases, and use them to decipher enhancer logic and design synthetic enhancers. This has been a wonderful lab-wide collaborative effort. www.biorxiv.org/content/10.1...
biorxiv.org
CREsted: modeling genomic and synthetic cell type-specific enhancers across tissues and species
Sequence-based deep learning models have become the state of the art for the analysis of the genomic regulatory code. Particularly for transcriptional enhancers, deep learning models excel at decipher...
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Reposted by Carlos Talavera-López
Quanta Magazine @quantamagazine.org · 04/04/2025
Quanta’s mission is to illuminate basic science and mathematics. Help us get recognized among the internet’s best in the The Webby Awards. Vote here: vote.webbyawards.com/PublicVoting...
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